Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus.

abstract：BACKGROUND:The zebrafish is recognized as a versatile cancer and drug screening model. However, it is not known whether the estrogen-responsive genes and signaling pathways that are involved in estrogen-dependent carcinogenesis and human cancer are operating in zebrafish. In order to determine the potential of zebrafis...

journal_title：BMC medical genomics

authors： Lam SH,Lee SG,Lin CY,Thomsen JS,Fu PY,Murthy KR,Li H,Govindarajan KR,Nick LC,Bourque G,Gong Z,Lufkin T,Liu ET,Mathavan S

更新日期：2011-05-16 00:00:00

abstract：:In this issue of BMC Medical Genomics Griffin et al. present a user-friendly and freely accessible HIV-associated neurocognitive disorder (HAND) genomic database that compiles viral (HIV-1) genetic sequences and other relevant clinical and treatment data. We discuss the benefits and caveats of public data sharing in N...

journal_title：BMC medical genomics

authors： Cysique LA

更新日期：2015-11-11 00:00:00

abstract：BACKGROUND:Childhood asthma is a syndrome composed of heterogeneous phenotypes; furthermore, intrinsic biologic variation among racial/ethnic populations suggests possible genetic ancestry variation in childhood asthma. The objective of the study is to identify clinically homogeneous asthma subphenotypes in a diverse s...

journal_title：BMC medical genomics

authors： Ding L,Li D,Wathen M,Altaye M,Mersha TB

更新日期：2018-05-31 00:00:00

abstract：BACKGROUND:Inflammation is a hallmark of many human diseases. Elucidating the mechanisms underlying systemic inflammation has long been an important topic in basic and clinical research. When primary pathogenetic events remains unclear due to its immense complexity, construction and analysis of the gene regulatory netw...

journal_title：BMC medical genomics

authors： Chen BS,Yang SK,Lan CY,Chuang YJ

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:In addition to their well-documented ocular therapeutic effects, glucocorticoids (GCs) can cause sight-threatening side-effects including ocular hypertension presumably via morphological and biochemical changes in trabecular meshwork (TM) cells. In the present study, we directly compared the glucocorticoid r...

journal_title：BMC medical genomics

authors： Nehmé A,Lobenhofer EK,Stamer WD,Edelman JL

更新日期：2009-09-10 00:00:00

abstract：:During June 10-12, 2018, the International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held in Los Angeles, California, USA. The conference included 11 scientific sessions, four tutorials, one poster session, four keynote talks and four eminent scholar talks that covered a wide range of topics rang...

journal_title：BMC medical genomics

authors： Zhi D,Zhao Z,Li F,Wu Z,Liu X,Wang K

更新日期：2019-01-31 00:00:00

abstract：BACKGROUND:Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies for such a complex chronic illness is extremely expensive, carries a high probability of failur...

journal_title：BMC medical genomics

authors： Craddock TJ,Harvey JM,Nathanson L,Barnes ZM,Klimas NG,Fletcher MA,Broderick G

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:A molecular characterization of Alzheimer's Disease (AD) is the key to the identification of altered gene sets that lead to AD progression. We rely on the assumption that candidate marker genes for a given disease belong to specific pathogenic pathways, and we aim at unveiling those pathways stable across ti...

journal_title：BMC medical genomics

authors： Squillario M,Barla A

更新日期：2011-07-05 00:00:00

abstract：BACKGROUND:According to the Genetic Analysis Workshops (GAW), hundreds of thousands of SNPs have been tested for association with rheumatoid arthritis. Traditional genome-wide association studies (GWAS) have been developed to identify susceptibility genes using a "most significant SNPs/genes" model. However, many minor...

journal_title：BMC medical genomics

authors： Zhang L,Li W,Song L,Chen L

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:As the sixth most common cancer worldwide, head and neck squamous cell carcinoma (HNSCC) develops visceral metastases during the advanced stage of the disease and exhibits a low five-year survival rate. The importance of tumor microenvironment (TME) in tumor initiation and metastasis is widely recognized. In...

journal_title：BMC medical genomics

authors： Zhong Z,Hong M,Chen X,Xi Y,Xu Y,Kong D,Deng J,Li Y,Hu R,Sun C,Liang J

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnormalities display profoundly different global gene expression profiles. However, it is largely unknown...

journal_title：BMC medical genomics

authors： Andersson A,Edén P,Olofsson T,Fioretos T

更新日期：2010-03-08 00:00:00

abstract：BACKGROUND:Recent advances in omics technologies have raised great opportunities to study large-scale regulatory networks inside the cell. In addition, single-cell experiments have measured the gene and protein activities in a large number of cells under the same experimental conditions. However, a significant challeng...

journal_title：BMC medical genomics

authors： Wei J,Hu X,Zou X,Tian T

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treated diabetic...

journal_title：BMC medical genomics

authors： Verschuren L,Wielinga PY,Kelder T,Radonjic M,Salic K,Kleemann R,van Ommen B,Kooistra T

更新日期：2014-06-17 00:00:00

abstract：BACKGROUND:Small non-coding regulatory RNAs control cellular functions at the transcriptional and post-transcriptional levels. Oral squamous cell carcinoma is among the leading cancers in the world and the presence of cervical lymph node metastases is currently its strongest prognostic factor. In this work we aimed at ...

journal_title：BMC medical genomics

authors： Severino P,Oliveira LS,Andreghetto FM,Torres N,Curioni O,Cury PM,Toporcov TN,Paschoal AR,Durham AM

更新日期：2015-06-24 00:00:00

abstract：BACKGROUND:Insulin resistance (IR) is accompanied by chronic low grade systemic inflammation, obesity, and deregulation of total body energy homeostasis. We induced inflammation in adipose and liver tissues in vitro in order to mimic inflammation in vivo with the aim to identify tissue-specific processes implicated in ...

journal_title：BMC medical genomics

authors： Szalowska E,Dijkstra M,Elferink MG,Weening D,de Vries M,Bruinenberg M,Hoek A,Roelofsen H,Groothuis GM,Vonk RJ

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:Non-coding RNA has been shown to participate in numerous biological and pathological processes and has attracted increasing attention in recent years. Recent studies have demonstrated that long non-coding RNA and micro RNA can interact through various mechanisms to regulate mRNA. Yet the gene-gene interactio...

journal_title：BMC medical genomics

authors： Liao J,Wang J,Liu Y,Li J,Duan L

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. Approximately 95% of patients with Type 1 diabetes develop some degree of retinopathy within 25 years of diagnosis despite normalization of blood glucose by insulin therapy. The goal of this study was to identify molecular chang...

journal_title：BMC medical genomics

authors： Bixler GV,Vanguilder HD,Brucklacher RM,Kimball SR,Bronson SK,Freeman WM

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:Chiari Type I Malformation (CMI) is characterized by herniation of the cerebellar tonsils through the foramen magnum at the base of the skull, resulting in significant neurologic morbidity. As CMI patients display a high degree of clinical variability and multiple mechanisms have been proposed for tonsillar ...

journal_title：BMC medical genomics

authors： Markunas CA,Lock E,Soldano K,Cope H,Ding CK,Enterline DS,Grant G,Fuchs H,Ashley-Koch AE,Gregory SG

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16). The aim of this gene expression profiling study was to evaluate to what extent suboptimal samples with low leu...

journal_title：BMC medical genomics

authors： de la Blétière DR,Blanchet O,Cornillet-Lefèbvre P,Coutolleau A,Baranger L,Geneviève F,Luquet I,Hunault-Berger M,Beucher A,Schmidt-Tanguy A,Zandecki M,Delneste Y,Ifrah N,Guardiola P

更新日期：2012-01-30 00:00:00

abstract：:This editorial summarizes eight research articles included in this supplement issue for the 2020 International Conference on Intelligent Biology and Medicine (ICIBM 2020) conference, that was held on August 9-10, 2020 (virtual conference), with a topic on data-driven analytics in biomedical genomics. These articles co...

journal_title：BMC medical genomics

authors： Shi X,Zhao Z,Wang K,Shen L

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Genes do not act in isolation but instead as part of complex regulatory networks. To understand how breast tumors adapt to the presence of the drug letrozole, at the molecular level, it is necessary to consider how the expression levels of genes in these networks change relative to one another. METHODS:Usin...

journal_title：BMC medical genomics

authors： Penrod NM,Moore JH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The early diagnosis of lung cancer has been a critical problem in clinical practice for a long time and identifying differentially expressed gene as disease marker is a promising solution. However, the most existing gene differential expression analysis (DEA) methods have two main drawbacks: First, these met...

journal_title：BMC medical genomics

authors： Zhao Z,Peng H,Zhang X,Zheng Y,Chen F,Fang L,Li J

更新日期：2019-12-20 00:00:00

abstract：BACKGROUND:The complexity of genome informatics is a recurring challenge for genome exploration and analysis by students and other non-experts. This complexity creates a barrier to wider implementation of experiential genomics education, even in settings with substantial computational resources and expertise. Reducing ...

journal_title：BMC medical genomics

authors： Linderman MD,McElroy L,Chang L

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:2q37 deletion syndrome is a rare congenital disorder that is characterized by facial dysmorphism, obesity, vascular and skeletal malformations, and a variable degree of intellectual disability. To date, common but variable phenotypes, such as skeletal or digit malformations and obesity, have been associated ...

journal_title：BMC medical genomics

authors： Sakai Y,Souzaki R,Yamamoto H,Matsushita Y,Nagata H,Ishizaki Y,Torisu H,Oda Y,Taguchi T,Shaw CA,Hara T

更新日期：2014-04-22 00:00:00

abstract：BACKGROUND:With the introduction of increasingly powerful mass spectrometry (MS) techniques for clinical research, several recent large-scale MS proteomics studies have sought to characterize the entire human plasma proteome with a general objective for identifying thousands of proteins leaked from tissues in the circu...

journal_title：BMC medical genomics

authors： Saha S,Harrison SH,Shen C,Tang H,Radivojac P,Arnold RJ,Zhang X,Chen JY

更新日期：2008-04-25 00:00:00

abstract：BACKGROUND:Preeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential...

journal_title：BMC medical genomics

authors： Lang X,Liu W,Hou Y,Zhao W,Yang X,Chen L,Yan Q,Cheng W

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical expression. Since modifiers are likely to be common alleles, this problem is not tractable by tradi...

journal_title：BMC medical genomics

authors： West J,Cogan J,Geraci M,Robinson L,Newman J,Phillips JA,Lane K,Meyrick B,Loyd J

更新日期：2008-09-29 00:00:00

abstract：BACKGROUND:Uric acid is the primary byproduct of purine metabolism. Hyperuricemia is associated with body mass index (BMI), sex, and multiple complex diseases including gout, hypertension (HTN), renal disease, and type 2 diabetes (T2D). Multiple genome-wide association studies (GWAS) in individuals of European ancestry...

journal_title：BMC medical genomics

authors： Charles BA,Shriner D,Doumatey A,Chen G,Zhou J,Huang H,Herbert A,Gerry NP,Christman MF,Adeyemo A,Rotimi CN

更新日期：2011-02-04 00:00:00

abstract：BACKGROUND:Rapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer (DTC) genetic testing companies, such as 23andMe, allow consumers to access their genetic information directly through an online service without the involvement of hea...

journal_title：BMC medical genomics

authors： Lu M,Lewis CM,Traylor M

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND:Genomic copy number alterations are widely associated with a broad range of human tumors and offer the potential to be used as a diagnostic tool. Especially in the emerging era of personalized medicine medical informatics tools that allow the fast visualization and analysis of genomic alterations of a patien...

journal_title：BMC medical genomics

authors： Kotliarov Y,Bozdag S,Cheng H,Wuchty S,Zenklusen JC,Fine HA

更新日期：2010-04-09 00:00:00