Engineered bio-inspired coating for passive flow control.

abstract：:Grain growth under shear annealing is crucial for controlling the properties of polycrystalline materials. However, their microscopic kinetics are not well understood because individual atomic trajectories are difficult to track. Here, we study grain growth with single-particle kinetics in colloidal polycrystals using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Peng Y,Zhang Y,Still T,Yodh AG,Han Y

更新日期：2020-09-29 00:00:00

abstract：:Current understanding of the integration of cell division and expansion in the development of plant lateral organs such as leaves is limited. Cell number is established during a mitotic phase, and subsequent growth into a mature organ relies primarily on cell expansion accompanied by endocycles. Here we show that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dewitte W,Scofield S,Alcasabas AA,Maughan SC,Menges M,Braun N,Collins C,Nieuwland J,Prinsen E,Sundaresan V,Murray JA

更新日期：2007-09-04 00:00:00

abstract：:Ascorbic acid, at nontoxic concentrations, causes a substantial reduction in the ability of avian tumor viruses to replicate in both primary avian tendon cells and chicken embryo fibroblasts. The virus-infected cultures appear to be less transformed in the presence of ascorbic acid by the criteria of morphology, reduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bissell MJ,Hatie C,Farson DA,Schwarz RI,Soo WJ

更新日期：1980-05-01 00:00:00

abstract：:Distributions of sulfur isotopes in geological samples would provide a record of atmospheric composition if the mechanism producing the isotope effects could be described quantitatively. We determined the UV absorption spectra of 32SO2, 33SO2, and 34SO2 and use them to interpret the geological record. The calculated i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueno Y,Johnson MS,Danielache SO,Eskebjerg C,Pandey A,Yoshida N

更新日期：2009-09-01 00:00:00

abstract：:Rapid electrical conduction in the His-Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light on the regulation of early specification and morphogenesis of the His-Purkinje system, less is known about how transcriptional regulation establishes impulse con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang SS,Kim KH,Rosen A,Smyth JW,Sakuma R,Delgado-Olguín P,Davis M,Chi NC,Puviindran V,Gaborit N,Sukonnik T,Wylie JN,Brand-Arzamendi K,Farman GP,Kim J,Rose RA,Marsden PA,Zhu Y,Zhou YQ,Miquerol L,Henkelman RM,Sta

更新日期：2011-08-16 00:00:00

abstract：:Classification within the genus Pistacia has been based on leaf morphology and geographical distribution. Molecular genetic tools (PCR amplification followed by restriction analysis of a 3.2-kb region of variable chloroplast DNA, and restriction fragment length polymorphism analysis of the Pistacia cpDNA with tobacco ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parfitt DE,Badenes ML

更新日期：1997-07-22 00:00:00

abstract：:We describe an active polymer network in which processive molecular motors control network elasticity. This system consists of actin filaments cross-linked by filamin A (FLNa) and contracted by bipolar filaments of muscle myosin II. The myosin motors stiffen the network by more than two orders of magnitude by pulling ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenderink GH,Dogic Z,Nakamura F,Bendix PM,MacKintosh FC,Hartwig JH,Stossel TP,Weitz DA

更新日期：2009-09-08 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are neuronal non-voltage-gated cation channels that are activated when extracellular pH falls. They contribute to sensory function and nociception in the peripheral nervous system, and in the brain they contribute to synaptic plasticity and fear responses. Some of the physiologic cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petroff EY,Price MP,Snitsarev V,Gong H,Korovkina V,Abboud FM,Welsh MJ

更新日期：2008-02-26 00:00:00

abstract：:Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Low RL,Rashbaum SA,Cozzarelli NR

更新日期：1974-08-01 00:00:00

abstract：:P/Q Ca(2+) channel activity is inhibited by G protein-coupled receptor activation. Channel inhibition requires a direct Gbetagamma binding onto the pore-forming subunit, Ca(v)2.1. It is characterized by biophysical changes, including current amplitude reduction, activation kinetic slowing, and an I-V curve shift, whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandoz G,Lopez-Gonzalez I,Grunwald D,Bichet D,Altafaj X,Weiss N,Ronjat M,Dupuis A,De Waard M

更新日期：2004-04-20 00:00:00

abstract：:Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman BG,Class Freeman AM

更新日期：2014-03-25 00:00:00

abstract：:The covalent attachment of heme to apocytochrome c, and therefore the import of cytochrome c into mitochondria, is dependent on both NADH plus a cytosolic cofactor that has been identified to be FMN or FAD. NADH in concert with flavin nucleotides mediates the reduction of heme. Heme in the reduced state is a prerequis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicholson DW,Neupert W

更新日期：1989-06-01 00:00:00

abstract：:A genomic clone coding for the alpha subunit of the mouse complement receptor type 3 and the cellular adhesion molecule Mac-1 has been isolated directly from a genomic library using synthetic oligonucleotide probes based on the amino-terminal amino acid sequence of the protein. The identity of the clone has been estab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sastre L,Roman JM,Teplow DB,Dreyer WJ,Gee CE,Larson RS,Roberts TM,Springer TA

更新日期：1986-08-01 00:00:00

abstract：:We analyze Niels Bohr's proposed two-slit interference experiment with highly charged particles which argues that the consistency of elementary quantum mechanics requires that the electromagnetic field must be quantized. In the experiment a particle's path through the slits is determined by measuring the Coulomb field...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baym G,Ozawa T

更新日期：2009-03-03 00:00:00

abstract：:We introduce a quantitative framework for assessing the generation of crossovers in DNA shuffling experiments. The approach uses free energy calculations and complete sequence information to model the annealing process. Statistics obtained for the annealing events then are combined with a reassembly algorithm to infer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore GL,Maranas CD,Lutz S,Benkovic SJ

更新日期：2001-03-13 00:00:00

abstract：:We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary adenocarcinomas. To assess whether mammary tumorigenesis in this model is influenced by the developmental window of expression, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrechek ER,Hardy WR,Laing MA,Muller WJ

更新日期：2004-04-06 00:00:00

abstract：:Theories of general anesthesia have shifted in focus from bulk lipid effects to specific interactions with membrane proteins. Target receptors include several subtypes of pentameric ligand-gated ion channels; however, structures of physiologically relevant proteins in this family have yet to define anesthetic binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heusser SA,Lycksell M,Wang X,McComas SE,Howard RJ,Lindahl E

更新日期：2018-10-16 00:00:00

abstract：:Small molecules of biological origin continue to yield the most promising leads for drug design, but systematic approaches for exploring nature's cache of structural diversity are lacking. Here, we demonstrate the use of 2D NMR spectroscopy to screen a library of biorationally selected insect metabolite samples for pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deyrup ST,Eckman LE,McCarthy PH,Smedley SR,Meinwald J,Schroeder FC

更新日期：2011-06-14 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian W,Kumar N,Roginskaya V,Fouquerel E,Opresko PL,Shiva S,Watkins SC,Kolodieznyi D,Bruchez MP,Van Houten B

更新日期：2019-09-10 00:00:00

abstract：:Because mouse models play a crucial role in biomedical research related to the human nervous system, understanding the similarities and differences between mouse and human brain is of fundamental importance. Studies comparing transcription in human and mouse have come to varied conclusions, in part because of their re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JA,Horvath S,Geschwind DH

更新日期：2010-07-13 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:Movement over and colonization of surfaces are important survival strategies for bacteria, and many find it advantageous to perform these activities as a group, using quorum sensing to sample population size and synchronize behavior. It is puzzling however, that swarming-proficient and virulent strains of Vibrio parah...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trimble MJ,McCarter LL

更新日期：2011-11-01 00:00:00

abstract：:A hybrid bacteriophage, P420, was constructed in vitro; it contains part of bacteriophage P4 and a 3.6-kilobase derivative of plasmid ColE1. In Escherichia coli, the plasmid-phage hybrid can exist as a stable plasmid or can be packaged into infective bacteriophage particles. Replication of P420, directed by the ColE1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn M,Helinski DR

更新日期：1978-05-01 00:00:00

abstract：:A biomimetic hydrogel platform was designed to signal encapsulated cells using immobilized cell-cell communication cues, with a focus on enhancing the survival and function of encapsulated pancreatic β-cells to treat type 1 diabetes. When MIN6 cells, a pancreatic β-cell line, were encapsulated in poly(ethylene glycol)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CC,Anseth KS

更新日期：2011-04-19 00:00:00

abstract：:P elements have been cloned and sequenced from Drosophila nebulosa. Their sequences have diverged less than 6% from P elements of Drosophila melanogaster. However D. nebulosa P elements have nucleotide changes that close all four open reading frames found in the D. melanogaster P element. Microinjection experiments sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansman RA,Shade RO,Grigliatti TA,Brock HW

更新日期：1987-09-01 00:00:00

abstract：:The importance of receptor binding in the potent immunogenicity of Escherichia coli heat-labile enterotoxin B subunit (EtxB) was tested by comparing its immunogical properties with those of a receptor binding mutant, EtxB(G33D). Subcutaneous immunization of EtxB(G33D) resulted in 160-fold reduction in antibody titer c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nashar TO,Webb HM,Eaglestone S,Williams NA,Hirst TR

更新日期：1996-01-09 00:00:00

abstract：:Activation of the c-abl protooncogene occurs in Abelson murine leukemia virus, in Hardy-Zuckerman 2 feline sarcoma virus, and during the chromosomal translocations that generate BCR-ABL gene fusion products. To study the molecular mechanism involved in the c-abl activation, we have created a series of modifications in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shore SK,Bogart SL,Reddy EP

更新日期：1990-09-01 00:00:00

abstract：:"Evolution behaves like a tinkerer" (François Jacob, Science, 1977). Software systems provide a singular opportunity to understand biological processes using concepts from network theory. The Debian GNU/Linux operating system allows us to explore the evolution of a complex network in a unique way. The modular design d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fortuna MA,Bonachela JA,Levin SA

更新日期：2011-12-13 00:00:00

abstract：:Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens. Mycobacterial IdeR is an iron-dependent repressor that shows 80% identity in the functional domains with its corynebacterial homologue, DtxR (diphtheria toxin repressor)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manabe YC,Saviola BJ,Sun L,Murphy JR,Bishai WR

更新日期：1999-10-26 00:00:00

abstract：:Fully atomistic molecular-dynamics (MD) simulations of perfluoroalkylalkane molecules at the surface of water show the spontaneous formation of aggregates whose size and topography closely resemble the experimentally observed hemimicelles for this system. Furthermore, the grazing incidence X-ray diffraction (GIXD) pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva GMC,Morgado P,Lourenço P,Goldmann M,Filipe EJM

更新日期：2019-07-23 00:00:00