当前位置： SCI文献检索 > Multiple Sclerosis and Related Disorders期刊下所有文献 > Elevated plasma fibrinogen levels in multiple sclerosis patients during relapse.

Elevated plasma fibrinogen levels in multiple sclerosis patients during relapse.

Abstract：

:Fibrinogen is a protein that plays a key role in blood coagulation and thrombosis and it is involved in several inflammatory processes; in multiple sclerosis (MS) may be related with blood-brain barrier (BBB) disruption. We analysed the relationship between plasma fibrinogen levels and the presence of active lesions on magnetic resonance imaging (MRI) during relapses of multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients. METHODS:We collected data of patients admitted to a tertiary-care hospital with relapse of MS and CIS from 2008 to 2013 and we analysed the relation between plasma fibrinogen levels (normal: 200mg/dl-417mg/dl) and the presence of active lesions on brain or spinal MRI. RESULTS:A total of 58 patients were included, 45 (77%) CIS patients, 12 (21%) relapsing-remitting MS (RR-MS) and 1 (2%) active progressive MS (P-MS). 17 patients had high plasma fibrinogen levels (> 417mg/dl). Among total of patients with elevated plasma fibrinogen, 15 (88%) had active lesions on MRI and only 2 (12%) did not have active lesion on MRI (p = 0,013) with a specificity of 95%. All patients with fibrinogen > 417mg/dl were CIS (p = < 0.05). DISCUSSION:We observed that high plasma fibrinogen levels had a high specificity high specificity, but low sensitivity (only 40%) for detection of active lesions on MRI during relapses of MS. These findings support the hypothesis that fibrinogen could play an important role on the development of MS lesions, however, additional studies are needed to confirm these results.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Miranda Acuña J,Hidalgo de la Cruz M,Ros AL,Tapia SP,Martínez Ginés ML,de Andrés Frutos CD

doi

10.1016/j.msard.2017.09.033

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

157-160

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(17)30244-4

journal_volume

18

pub_type

杂志文章

相关文献

Multiple Sclerosis and Related Disorders文献大全
  • Heart rate variability analysis in patients with multiple sclerosis.

    abstract：BACKGROUND:Multiple sclerosis can cause cardiovascular autonomic dysfunction. It is assumed that is caused by multiple demyelinating plaques localized in the brain stem and spinal cord. Previous studies have determined this using tilt table test, heart rate responses to Valsalva maneuver and deep breathing and heart ra...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.06.012

    authors： Damla O,Altug C,Pinar KK,Alper K,Dilek IG,Kadriye A

    更新日期：2018-08-01 00:00:00

  • Multiple intracranial lesions with lung adenocarcinoma: A rare case of MOG-IgG-associated encephalomyelitis.

    abstract：BACKGROUND:Myelin oligodendrocyte glycoprotein (MOG) is an important marker on the surface of oligodendrocytes and is associated with many demyelinating diseases. Recently, MOG-IgG-associated encephalomyelitis (MOG-EM) has been proposed as a disease entity with a preliminary diagnosis standard. Some patients with lung ...

    journal_title：Multiple sclerosis and related disorders

    pub_type：

    doi：10.1016/j.msard.2020.102064

    authors： Li K,Zhan Y,Shen X

    更新日期：2020-07-01 00:00:00

  • Visual pathway involvement in multiple sclerosis: Look straight in the eyes.

    abstract：:Visual symptoms are a common clinical manifestation of multiple sclerosis (MS) and are frequently due to acute optic neuritis (ON). However, the entire visual pathway can be involved throughout the disease course. We describe the case of a young MS patient who experienced visual symptoms that were eventually found to ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.08.008

    authors： Gaetani L,Iaccheri B,Cerquaglia A,Gentili L,Fiore T,Di Gregorio M,Mancini A,Calabresi P,Cagini C,Sarchielli P,Di Filippo M

    更新日期：2017-10-01 00:00:00

  • Neuromyelitis optica testing and treatment: Availability and affordability in 60 countries.

    abstract：BACKGROUND:We characterize the variations in availability and affordability of NMO diagnostic testing and treatment by geographic region and country-level income group. METHODS:A structured survey was distributed in English, French, and Spanish in late 2018 to neurologists and other physicians who encounter NMO patien...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.05.013

    authors： Holroyd K,Vogel A,Lynch K,Gazdag B,Voghel M,Alakel N,Patenaude BN,Chiong-Rivero H,Mateen FJ

    更新日期：2019-08-01 00:00:00

  • COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?

    abstract：BACKGROUND:Coronavirus disease 19 (COVID-19) is a novel disease entity that is spreading throughout the world. It has been speculated that patients with comorbidities and elderly patients could be at high risk for respiratory insufficiency and death. Immunosuppression could expose infected patients to even higher risks...

    journal_title：Multiple sclerosis and related disorders

    pub_type：

    doi：10.1016/j.msard.2020.102120

    authors： Novi G,Mikulska M,Briano F,Toscanini F,Tazza F,Uccelli A,Inglese M

    更新日期：2020-07-01 00:00:00

  • Could Sars-Cov2 affect MS progression?

    abstract：:A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2. These two mechanisms may cause a worsening of MS several months after the resolution of the infection. ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2020.102540

    authors： Di Stadio A,Romani L,Bernitsas E

    更新日期：2020-11-01 00:00:00

  • Fatigue, depression, and physical activity in relapsing-remitting multiple sclerosis: Results from a prospective, 18-month study.

    abstract：BACKGROUND:Fatigue, depression, and physical inactivity are common in multiple sclerosis (MS), but there is limited information on the bi-directional associations among those variables over a long period of time. OBJECTIVE:This study examined the hypothesis that fatigue and depression would predict change in physical ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2011.08.003

    authors： Motl RW,Suh Y,Weikert M,Dlugonski D,Balantrapu S,Sandroff B

    更新日期：2012-01-01 00:00:00

  • Usefulness of lyso-globotriaosylsphingosine in dried blood spots in the differential diagnosis between multiple sclerosis and Anderson-Fabry's disease.

    abstract：BACKGROUND:The presence of white mater lesions in the central nervous system forces the differential diagnosis between multiple sclerosis (MS) and Anderson-Fabry disease (FD). Due to the type of inheritance, linked to the X chromosome, the diagnosis of FD is especially difficult in women. Tissue´s deposits of globotria...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.101466

    authors： Olivera S,Iñiguez C,García-Fernández L,Sierra JL,Camón AM,Menao S,Torralba MÁ

    更新日期：2020-02-01 00:00:00

  • Validation of an algorithm to detect severe MS relapses in administrative health databases.

    abstract：BACKGROUND:Severe relapses that required treatment were important outcomes in the sentinel trials of disease-modifying therapy (DMT). Identifying such relapses in administrative data would allow comparative-effectiveness studies of DMTs to be conducted in real-world clinical settings. METHODS:All relapsing-remitting (...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.11.022

    authors： Marriott JJ,Chen H,Fransoo R,Marrie RA

    更新日期：2018-01-01 00:00:00

  • Cognitive and physical fatigue are associated with distinct problems in daily functioning, role fulfilment, and quality of life in multiple sclerosis.

    abstract：OBJECTIVE:To examine whether cognitive and physical fatigue are differentially associated with problems in self-care, mobility, relationships, participation, psychological well-being, and quality of life in people with multiple sclerosis. METHODS:A cross-sectional study involving seventy-four community-dwelling people...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.03.024

    authors： Gullo HL,Fleming J,Bennett S,Shum DHK

    更新日期：2019-06-01 00:00:00

  • Does natalizumab treatment increase the risk of herpes simplex encephalitis in multiple sclerosis? Case and discussion.

    abstract：:This report presents the 4th documented case worldwide of herpes simplex encephalitis in multiple sclerosis (MS) patients treated with natalizumab and the first case in the UK. Natalizumab is licensed for relapsing remitting multiple sclerosis in patients with high disease activity despite treatment with interferon-be...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2013.02.006

    authors： Sharma K,Ballham SA,Inglis KE,Renowden S,Cottrell DA

    更新日期：2013-10-01 00:00:00

  • Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.

    abstract：OBJECTIVE:To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome. METHODOLOGY:Case series. RESULTS:We present two cases. Case 1 is an 18-year-old woman who presented with headache, blurred vision, and papilledema and was initially diagnosed with pseudotumor cerebri syndrome. CSF showed mil...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.10.003

    authors： Narayan RN,Wang C,Sguigna P,Husari K,Greenberg B

    更新日期：2019-01-01 00:00:00

  • Olfactory identification associates with cognitive function and the third ventricle width in patients with relapsing-remitting multiple sclerosis.

    abstract：BACKGROUND:Olfactory dysfunction is a known clinical feature of multiple sclerosis (MS). Some studies have shown that odor identification impairment is an essential feature associated with cognitive function in MS. This study investigates the relationship between olfactory identification and the disease state, includin...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.101507

    authors： Okada K,Kakeda S,Tahara M

    更新日期：2020-02-01 00:00:00

  • 2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

    abstract：BACKGROUND:McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. OBJECTIVE:Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). METHODS:We retrospectively identified pat...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.008

    authors： Gobbin F,Zanoni M,Marangi A,Orlandi R,Crestani L,Benedetti MD,Gajofatto A

    更新日期：2019-04-01 00:00:00

  • Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support.

    abstract：BACKGROUND:Social support has been identified as a buffering or intervening variable in stressful life events. Research has demonstrated that greater social support is associated with better mental health in multiple sclerosis (MS), but little is known about its links to specific aspects of mental health. We therefore ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.09.039

    authors： Henry A,Tourbah A,Camus G,Deschamps R,Mailhan L,Castex C,Gout O,Montreuil M

    更新日期：2019-01-01 00:00:00

  • Erythroblastaemia in natalizumab-treated patients with multiple sclerosis.

    abstract：BACKGROUND:Natalizumab is a monoclonal antibody that significantly reduces the occurrence of relapses in relapse-remitting multiple sclerosis (RRMS) patients. Early papers on the clinical use of natalizumab in RRMS patients reported erythroblastemia as occasional and transient. OBJECTIVES:to determine the prevalence a...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.05.020

    authors： La Gioia S,Seghezzi M,Barcella V,Dominoni P,Mecca T,Frigeni B,Conti MZ,Vedovello M,Vidali M,Rottoli M,Buoro S

    更新日期：2016-07-01 00:00:00

  • Mining healthcare data for markers of the multiple sclerosis prodrome.

    abstract：BACKGROUND:Previous studies suggest the existence of a prodromal period in multiple sclerosis, but little is known about the phenotypic characteristics. This study aims to characterize the multiple sclerosis (MS) prodrome using data mining analytics in the healthcare setting. METHODS:We identified people with MS and m...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.08.007

    authors： Högg T,Wijnands JMA,Kingwell E,Zhu F,Lu X,Evans C,Fisk JD,Marrie RA,Zhao Y,Tremlett H

    更新日期：2018-10-01 00:00:00

  • Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis.

    abstract：BACKGROUND:Numerous factors can affect multiple sclerosis (MS) patients' quality of life (QoL). We investigated how physical impairment, upper extremity function, cognitive impairment, cognitive reserve, symptoms of psychological distress, depression, fatigue as well as age and disease duration contribute to patient-re...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.049

    authors： Yalachkov Y,Soydaş D,Bergmann J,Frisch S,Behrens M,Foerch C,Gehrig J

    更新日期：2019-05-01 00:00:00

  • Integration of the Extreme Gradient Boosting model with electronic health records to enable the early diagnosis of multiple sclerosis.

    abstract：BACKGROUND:Delayed multiple sclerosis (MS) diagnoses are not uncommon, an early diagnostic tool is urgently warranted. We aimed to develop an effective tool through electronic health records and machine learning techniques to early recognize MS patients from hospital visitors in China. METHODS:Two case sets were colle...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102632

    authors： Wang R,Luo W,Liu Z,Liu W,Liu C,Liu X,Zhu H,Li R,Song J,Hu X,Han S,Qiu W

    更新日期：2020-11-18 00:00:00

  • Evaluation of types of psychological disorders in patients with neuromyelitis optica spectrum disorder (NMOSD).

    abstract：BACKGROUND:Neuromyelitis Optica Spectrum Disorder (NMOSD), commonly characterized by affecting optic nerves and spinal cord can be regarded as one of uncommon diseases of the central nervous system. Although the evidence presented in the literature supports cognitive impairments, psychological aspects of the disease an...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102128

    authors： Ebadi Z,Saeedi R,Hashemi SN,Gheini MR,Sahraian MA,Naser Moghadasi A

    更新日期：2020-07-01 00:00:00

  • Olfactory dysfunction in multiple sclerosis.

    abstract：BACKGROUND:Multiple sclerosis (MS) is a common chronic neurological disease that causes disability. MS can have various clinical manifestations, one of which is olfactory dysfunction. In clinical practice, olfactory disturbances are usually underdiagnosed. The aim of our study is to assess olfactory function and its re...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.02.032

    authors： Atalar AÇ,Erdal Y,Tekin B,Yıldız M,Akdoğan Ö,Emre U

    更新日期：2018-04-01 00:00:00

  • Application of the 2015 diagnostic criteria for neuromyelitis optica spectrum disorders in a cohort of Latin American patients.

    abstract：BACKGROUND:The 2015 International Panel for neuromyelitis optica (NMO) spectrum disorders (NMOSD) diagnosis (IPND) criteria was recently proposed. However, because there are no studies evaluating application of the IPND criteria in Latin American populations, we aimed to assess whether these new criteria improve the di...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.01.001

    authors： Carnero Contentti E,Soto de Castillo I,Daccach Marques V,López PA,Antunes Barreira A,Armas E,de Aquino Cruz C,Rubstein A,Lavigne Moreira C,Molina OM,Soto A,Tkachuk V

    更新日期：2018-02-01 00:00:00

  • Willingness to obtain COVID-19 vaccination in adults with multiple sclerosis in the United States.

    abstract：BACKGROUND:As vaccines for the coronavirus become available, it will be important to know the rate of COVID-19 vaccine acceptability in adults with multiple sclerosis (MS), given that vaccination will be a key strategy for preventing SARS-CoV-2 infections. Using a national sample of adults with MS in the United States ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2021.102788

    authors： Ehde DM,Roberts MK,Herring TE,Alschuler KN

    更新日期：2021-01-22 00:00:00

  • Clinical outcomes and predictive factors related to good outcomes in plasma exchange in severe attack of NMOSD and long extensive transverse myelitis: Case series and review of the literature.

    abstract：OBJECTIVE:To investigate the predictive factors associated with good outcomes of plasma exchange in severe attacks through neuromyelitis optica spectrum disorder (NMOSD) and long extensive transverse myelitis (LETM). In addition, to review the literature of predictive factors associated with the good outcomes of plasma...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.02.015

    authors： Aungsumart S,Apiwattanakul M

    更新日期：2017-04-01 00:00:00

  • Optic neuropathy: A 15-year retrospective observational study.

    abstract：BACKGROUND:Optic neuropathies (ON) have several aetiologies and sometimes the diagnosis established ab initio is redefined after further investigations and/or new neurological events. We aim with this study to report clinical, paraclinical findings, treatment choices and disease course in patients admitted with a suspi...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102337

    authors： Alves JM,Seabra M,Braz L,Guimarães J

    更新日期：2020-09-01 00:00:00

  • Does vagotomy protect against multiple sclerosis?

    abstract：OBJECTIVES:To examine the association between vagotomy and multiple sclerosis. METHODS:We conducted a matched cohort study of all patients who underwent truncal or super-selective vagotomy and a comparison cohort, by linking Danish population-based medical registries (1977-1995). Hazard ratios (HRs) for multiple scler...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.04.009

    authors： Sundbøll J,Horváth-Puhó E,Adelborg K,Svensson E

    更新日期：2017-07-01 00:00:00

  • Factors associated with adherence to disease modifying therapy in multiple sclerosis: An observational survey from a referral center in Lithuania.

    abstract：AIM OF THE STUDY:To investigate adherence to disease modifying therapy (DMT) in Lithuanian population of multiple sclerosis patients and factors associated to it. METHODS:Patients receiving one of the following DMT's: Interferon β 1a (Rebif) 44 micrograms three times a week subdermally (s/c) or Interferon β 1a (Avonex...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.02.016

    authors： Duchovskiene N,Mickeviciene D,Jurkeviciene G,Dirziuviene B,Balnyte R

    更新日期：2017-04-01 00:00:00

  • Capillary leak syndrome in neuromyelitis optica treated with rituximab.

    abstract：:61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. W...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.06.001

    authors： Fuentes Fernandez I,Hernandez-Clares R,Carreón Guarnizo E,Meca Lallana JE

    更新日期：2017-08-01 00:00:00

  • FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) unmasked by withdrawal of immunosuppression for Crohn's disease?

    abstract：:A 31-year-old pregnant woman presented with headache, fever and left-sided focal motor seizures, which progressed to bilateral tonic-clonic seizures. Her medical history included Crohn's disease treated with azathioprine and adalimumab, which were discontinued when she became pregnant. Her cerebro-spinal fluid was ent...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 信件

    doi：10.1016/j.msard.2020.102729

    authors： Stamenova S,Redha I,Schmierer K,Garcia ME

    更新日期：2020-12-31 00:00:00

  • Aphasic status epilepticus preceding tumefactive left hemisphere lesion in anti-MOG antibody associated disease.

    abstract：INTRODUCTION:Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have recently been associated with epilepsy with FLAIR hyperintense cortical lesions on MRI. Association between anti-MOG antibodies and epilepsy without detectable structural brain lesion on MRI is unknown. CASE REPORT:A 48-year-old right-handed m...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.10.012

    authors： Katsuse K,Kurihara M,Sugiyama Y,Kodama S,Takahashi M,Momose T,Yumoto M,Kaneko K,Takahashi T,Kubota A,Hayashi T,Toda T

    更新日期：2019-01-01 00:00:00