Quantitative Magnetization Transfer MRI Measurements of the Anterior Spinal Cord Region are Associated With Clinical Outcomes in Cervical Spondylotic Myelopathy.

Abstract:

STUDY DESIGN:A case-control study. OBJECTIVE:The aim of this study was to understand the role of magnetization transfer ratio (MTR) in identifying patients with clinically significant myelopathy and disability. SUMMARY OF BACKGROUND DATA:MTR is a quantitative measure that correlates with myelin loss and neural tissue destruction in a variety of neurological diseases. However, the usefulness of MTR in patients with cervical spondylotic myelopathy (CSM) has not been examined. METHODS:We prospectively enrolled seven CSM patients and seven age-matched controls to undergo magnetic resonance imaging (MRI) of the cervical spine. Nurick, Neck Disability Index (NDI), and modified Japanese Orthopedic Association (mJOA) scores were collected for all patients. Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell. Reflex was simulated by quickly moving the joint from maximum flexion to maximum extension (300°/second). Anterior, lateral, and posterior cord MTR measurements were compared with clinical outcomes. RESULTS:Compared with controls, CSM patients had lower anterior cord MTR (38.29 vs. 29.97, Δ = -8.314, P = 0.0022), and equivalent posterior cord (P = 0.2896) and lateral cord (P = 0.3062) MTR. Higher Nurick scores were associated with lower anterior cord MTR (P = 0.0205), but not lateral cord (P = 0.5446) or posterior cord MTR (P = 0.1222). Lower mJOA was associated with lower anterior cord MTR (P = 0.0090), but not lateral cord (P = 0.4864) or posterior cord MTR (P = 0.4819). There was no association between NDI and MTR of the anterior (P = 0.4351), lateral (P = 0.7557), or posterior cord (P = 0.9171). There was a linear relationship between hyperreflexia and anterior cord MTR (slope = -117.3, R = 0.6598, P = 0.0379), but not lateral cord (P = 0.1906, R = 0.4511) or posterior cord (P = 0.2577, R = 0.3957) MTR. CONCLUSION:Anterior cord MTR correlates with clinical outcomes as measured by mJOA index, Nurick score, and quantitative hyperreflexia, and could play a role in the preoperative assessment of CSM. LEVEL OF EVIDENCE:2.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Cloney MB,Smith ZA,Weber KA 2nd,Parrish TB

doi

10.1097/BRS.0000000000002470

subject

Has Abstract

pub_date

2018-05-15 00:00:00

pages

675-680

issue

10

eissn

0362-2436

issn

1528-1159

pii

00007632-201805150-00004

journal_volume

43

pub_type

杂志文章

相关文献

SPINE文献大全
  • Esophageal Perforation in a Cervical Fracture Patient With Progressed Ankylosing Spondylitis: Case Report and Review of the Literature.

    abstract:STUDY DESIGN:Case report and review of relevant literature. OBJECTIVE:To report a rare complication of esophageal perforation in cervical fracture patient with progressive ankylosing spondylitis (AS) and review of relevant literature. SUMMARY OF BACKGROUND DATA:Esophageal perforation in cervical fracture is extremely...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0000000000001885

    authors: Wang J,Shi L,Chen H,Yuan W

    更新日期:2016-11-15 00:00:00

  • Comparison of TLIF with rhBMP-2 versus no TLIF and higher posterolateral rhBMP-2 dose at L5-S1 for long fusions to the sacrum with sacropelvic fixation in patients with primary adult deformity.

    abstract:STUDY DESIGN:Comparvative case series. Data was prospectively entered and retrospectively analyzed. OBJECTIVE:To evaluate the need for distal lumbar interbody fusion when sufficient recombinant human bone morphogenetic protein-2 (rhBMP-2) is used posterolaterally at L5-S1 in long spinal constructs for adult deformity ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000045

    authors: Rahman RK,Buchowski JM,Stephens B,Dorward IG,Koester LA,Bridwell KH

    更新日期:2013-12-15 00:00:00

  • Major complications in revision adult deformity surgery: risk factors and clinical outcomes with 2- to 7-year follow-up.

    abstract:STUDY DESIGN:Retrospective cohort comparative study. OBJECTIVE:To determine the prevalence of major complications, identify risk factors, and assess long-term clinical benefit after revision adult spinal deformity surgery. SUMMARY OF BACKGROUND DATA:No study has analyzed risk factors for major complications in long r...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182217ab5

    authors: Cho SK,Bridwell KH,Lenke LG,Yi JS,Pahys JM,Zebala LP,Kang MM,Cho W,Baldus CR

    更新日期:2012-03-15 00:00:00

  • Bisphosphonate and Teriparatide Use in Thoracolumbar Spinal Fusion: A Systematic Review and Meta-analysis of Comparative Studies.

    abstract:STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To compare the efficacy of the use of either bisphosphonates or teriparatide on radiographic and functional outcomes of patients that had thoracolumbar spinal fusion. SUMMARY OF BACKGROUND DATA:Controversy exists as to whether bisphosphonates interfere with ...

    journal_title:Spine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/BRS.0000000000002608

    authors: Buerba RA,Sharma A,Ziino C,Arzeno A,Ajiboye RM

    更新日期:2018-09-01 00:00:00

  • Changes in physical function after palliative surgery for metastatic spinal tumor: association of the revised Tokuhashi score with neurologic recovery.

    abstract:STUDY DESIGN:A retrospective study of patients undergoing palliative surgery for metastatic spinal tumors. OBJECTIVE:To investigate short-term functional recovery and duration of improvement after palliative surgery, to correlate these outcomes with the revised Tokuhashi score, and to examine the relationship between ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181878733

    authors: Yamashita T,Aota Y,Kushida K,Murayama H,Hiruma T,Takeyama M,Iwamura Y,Saito T

    更新日期:2008-10-01 00:00:00

  • Experimental vertebroplasty using osteoconductive granular material.

    abstract:STUDY DESIGN:Osteoporotic human cadaveric thoracic vertebral bodies and vertebral bodies from mature sheep were used as model systems to assess coral resorption and new bone formation after injection of coral granules. OBJECTIVE:To evaluate the use of natural coral exoskeleton, an osteoconductive material, for the fil...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200005010-00006

    authors: Cunin G,Boissonnet H,Petite H,Blanchat C,Guillemin G

    更新日期:2000-05-01 00:00:00

  • Proximal Junctional Kyphosis After Posterior Spinal Instrumentation and Fusion in Young Children With Congenital Scoliosis: A Preliminary Report on its Incidence and Risk Factors.

    abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:To determine the incidence and risk factors of proximal junctional kyphosis (PJK) in young children who underwent posterior instrumented spinal fusion. SUMMARY OF BACKGROUND DATA:PJK is a well-recognized postoperative complication in adults and adolescents. However, there...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002109

    authors: Chen X,Chen ZH,Qiu Y,Zhu ZZ,Li S,Xu L,Sun X

    更新日期:2017-10-15 00:00:00

  • Roy-Camille plates in unstable spinal conditions. A preliminary report.

    abstract::From 1979 to 1982, 21 consecutive patients with posttraumatic or pathologic fractures of the spine were treated at the University of Sherbrooke by Roy-Camille plates to provide stabilization. Ten burst fractures and 11 fracture-dislocations were treated in this manner. Nine patients had complete paraplegia, 6 had vari...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198603000-00005

    authors: Kinnard P,Ghibely A,Gordon D,Trias A,Basora J

    更新日期:1986-03-01 00:00:00

  • Occult spinous process fractures associated with interspinous process spacers.

    abstract:STUDY DESIGN:Prospective observational study. OBJECTIVE:To provide a more accurate estimate of the rate of acute spinous process fractures associated with IPS surgery. SUMMARY OF BACKGROUND DATA:Biomechanical cadaveric studies have suggested adequate spinous process strength to support placement of interspinous proce...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:10.1097/BRS.0b013e318204066a

    authors: Kim DH,Tantorski M,Shaw J,Martha J,Li L,Shanti N,Rencu T,Parazin S,Kwon B

    更新日期:2011-07-15 00:00:00

  • Survivorship analysis of VSP spine instrumentation in the treatment of thoracolumbar and lumbar burst fractures.

    abstract::We used survivorship analysis to study 21 burst fractures that were treated with posterior VSP spine implant and fusion, each of which was over two motion segments. There were two treatment classes: 1) eight patients whose surgery included anterior bone grafting (augmentation), seven of which were done by the transped...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Ebelke DK,Asher MA,Neff JR,Kraker DP

    更新日期:1991-08-01 00:00:00

  • Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation.

    abstract:STUDY DESIGN:A new way to study pain in experimental animals without handling of the animals and based on registration of spontaneous behavior using video recordings. OBJECTIVES:To evaluate if experimental disc herniation in the rat may induce changes in spontaneous behavior. SUMMARY OF BACKGROUND DATA:The knowledge ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200206150-00013

    authors: Olmarker K,Størkson R,Berge OG

    更新日期:2002-06-15 00:00:00

  • Fine Configuration of Thoracic Type II Meningeal Cysts: Macro- and Microscopic Cadaveric Study Using Epoxy Sheet Plastination.

    abstract:STUDY DESIGN:A cadaveric study OBJECTIVE.: The aim of this study was to analyze the in situ macro- and microscopic configuration of the type II cyst and its anatomic relationship with surrounding structures. SUMMARY OF BACKGROUND DATA:The lack of consensus of surgical strategy to manage symptomatic type II meningeal c...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001587

    authors: Thorpe Lowis CG,Zhang M,Amin NF

    更新日期:2016-10-15 00:00:00

  • Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA:Results of studies analyzing the impact of smoking on complication and pseudarthr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000527

    authors: Bydon M,De la Garza-Ramos R,Abt NB,Gokaslan ZL,Wolinsky JP,Sciubba DM,Bydon A,Witham TF

    更新日期:2014-10-01 00:00:00

  • Anatomic consideration in the anterior approach to the sacro-iliac joint.

    abstract::Anatomical study of L4 nerve branch, L5 nerve root, and bony stock in the sacroiliac region was performed in cadaveric specimens to provide anatomical references for anterior fixation of the sacroiliac joint. At 1 cm intervals along the sacro-iliac joint, the distance to the lateral border of the L4 nerve branch (to t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199403001-00014

    authors: Ebraheim NA,Padanilam TG,Waldrop JT,Yeasting RA

    更新日期:1994-03-15 00:00:00

  • Posterior instrumentation and anterior interbody fusion for tuberculous kyphosis of dorsal and lumbar spines.

    abstract:STUDY DESIGN:Thirty-nine adults and five children with active spinal tuberculosis and resulting kyphosis of the dorsal and lumbar spine who had combined posterior instrumentation and anterior interbody fusion were observed to determine whether the corrected spinal deformity could be maintained until solid fusion. OBJE...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199509000-00013

    authors: Moon MS,Woo YK,Lee KS,Ha KY,Kim SS,Sun DH

    更新日期:1995-09-01 00:00:00

  • Digital assessment of MRI for lumbar disc desiccation. A comparison of digital versus subjective assessments and digital intensity profiles versus discogram and macroanatomic findings.

    abstract::During magnetic resonance imaging, a vast amount of digital data on anatomic structures is translated into images, which are then assessed subjectively. The development of an objective, sensitive method to directly assess the digital data would have clear benefits, particularly for clinical research on disc degenerati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199401001-00014

    authors: Videman T,Nummi P,Battié MC,Gill K

    更新日期:1994-01-15 00:00:00

  • A randomized study of closed wound suction drainage for extensive lumbar spine surgery.

    abstract:STUDY DESIGN:A prospective randomized study. OBJECTIVES:To study the risk of infection, hematoma, and neurologic deficits following extensive lumbar spine surgery in patients with or without prophylactic closed wound suction drain placement. SUMMARY OF BACKGROUND DATA:One randomized study assessing prophylactic drain...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007632-200405150-00003

    authors: Brown MD,Brookfield KF

    更新日期:2004-05-15 00:00:00

  • Solid Organ Transplant Is Associated With Increased Morbidity and Mortality in Patients Undergoing One or Two-level Anterior Cervical Decompression and Fusion.

    abstract:STUDY DESIGN:Retrospective database review OBJECTIVE.: The aim of this study was to analyze the implications of solid organ transplant (SOT) on postoperative outcomes following elective one or two-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Although SOTs have been associated with i...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003230

    authors: Labaran LA,Harris AB,Puvanesarajah V,Amin R,Raad M,Jain A,Hassanzadeh H

    更新日期:2020-02-01 00:00:00

  • Influence of the Preoperative Neurological Status on Survival After the Surgical Treatment of Symptomatic Spinal Metastases With Spinal Cord Compression.

    abstract:STUDY DESIGN:Consecutive case-series. OBJECTIVE:The main purpose of this study was to analyze the relationship between the preoperative neurological status and subsequent survival of patients undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA:The survival of cancer patients ha...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001141

    authors: Vanek P,Bradac O,Trebicky F,Saur K,de Lacy P,Benes V

    更新日期:2015-12-01 00:00:00

  • The use of mathematical models for studies of scoliosis biomechanics.

    abstract::The use of mathematical and other types of models for the study of the biomechanics of scoliosis is reviewed in this article. The article is based on a talk presented at the 1987 Meeting of the Scoliosis Research Society. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199110000-00014

    authors: Schultz AB

    更新日期:1991-10-01 00:00:00

  • Direct current electrical bone growth stimulation for spinal fusion.

    abstract::An electronic bone growth stimulator (EBGS) had been devised to facilitate lumbosacral fusion in the early 1970s, using a totally implanted device which delivers a steady 5 microA at each of four cathodes. The use of the device is reserved for patients in whom painful and abnormal motion is demonstrated to be the majo...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007632-198803000-00026

    authors: Kane WJ

    更新日期:1988-03-01 00:00:00

  • Patient characteristics associated with diagnostic imaging evaluation of persistent low back problems.

    abstract:STUDY DESIGN:Post hoc analysis of data from the National Low Back Pain Study, a prospective observational multicenter study of patients referred for the evaluation and treatment of persistent low back problems. OBJECTIVE:To identify patient characteristics associated with use of particular diagnostic imaging examinati...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00007632-199707150-00021

    authors: Ackerman SJ,Steinberg EP,Bryan RN,BenDebba M,Long DM

    更新日期:1997-07-15 00:00:00

  • Comparing Nonrandomized Observational Studies With Randomized Controlled Trials in Cervical Disc Arthroplasty: A Meta-analysis.

    abstract:STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To compare the treatment effects of observational studies versus randomized controlled trials (RCTs) in cervical disc arthroplasty. SUMMARY OF BACKGROUND DATA:RCTs can be logistically challenging and sometimes insufficiently generalizable; well-designed obse...

    journal_title:Spine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/BRS.0000000000001377

    authors: Jee YM,Bak JS,Weinlander E,Anderson PA

    更新日期:2016-03-01 00:00:00

  • Efficacy of percutaneous vertebroplasty in the treatment of intravertebral pseudarthrosis associated with noninfected avascular necrosis of the vertebral body.

    abstract:STUDY DESIGN:A retrospective clinical study on the effect of percutaneous vertebroplasty (PVP) in the treatment of intravertebral pseudarthrosis caused by avascular necrosis of a vertebral body. OBJECTIVES:To evaluate the efficacy of PVP in the treatment of spinal instability associated with avascular necrosis. SUMMA...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Jang JS,Kim DY,Lee SH

    更新日期:2003-07-15 00:00:00

  • Combined spinal cord monitoring using neurogenic mixed evoked potentials and collision techniques.

    abstract:STUDY DESIGN:Neurogenic mixed evoked potentials are used routinely to monitor the spinal cord during spine surgery. This study investigates the differential sensory-motor contribution by using collision techniques. OBJECTIVE:To demonstrate that neurogenic mixed evoked potentials do contain a motor component. SUMMARY ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200207150-00017

    authors: Péréon Y,Nguyen The Tich S,Delécrin J,Pham Dang C,Bodin J,Drouet JC,Passuti N

    更新日期:2002-07-15 00:00:00

  • Mismatch Between Proximal Rod Contouring and Proximal Junctional Angle: A Predisposed Risk Factor for Proximal Junctional Kyphosis in Degenerative Scoliosis.

    abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:To investigate whether the mismatch between proximal junctional angle (PJA) and the proximal rod contouring contributed to the occurrence of postoperative proximal junctional kyphosis (PJK) in degenerative scoliosis. SUMMARY OF BACKGROUND DATA:PJK is one of the complicati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001883

    authors: Yan P,Bao H,Qiu Y,Bao M,Varghese JJ,Sun X,Liu Z,Zhu Z,Qian B,Zheng M,Zhu F

    更新日期:2017-03-01 00:00:00

  • Increased expression of vascular endothelial growth factor protein in dorsal root ganglion exposed to nucleus pulposus on the nerve root in rats.

    abstract:STUDY DESIGN:An experimental rat study. OBJECTIVE:To assess pain-related behavior and vascular endothelial growth factor (VEGF) expression induced by nucleus pulposus (NP) applied to nerve roots in rats. SUMMARY OF BACKGROUND DATA:Radiculopathy from disc herniation is caused by nerve compression and chemical inflamma...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Miyoshi S,Sekiguchi M,Konno S,Kikuchi S,Kanaya F

    更新日期:2011-01-01 00:00:00

  • The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease.

    abstract:STUDY DESIGN:The authors retrospectively reviewed 28 patients with multilevel Pott disease who underwent anterior radical débridement, decompression, and fusion with anterior spinal instrumentation and fibular allograft replacement. OBJECTIVES:To assess the efficacy of allograft fibular fusion and anterior spinal stab...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000048666.17934.17

    authors: Ozdemir HM,Us AK,Oğün T

    更新日期:2003-03-01 00:00:00

  • Gender difference in association between low back pain and metabolic syndrome: locomotive syndrome and health outcome in Aizu cohort study (LOHAS).

    abstract:STUDY DESIGN:Cross-sectional survey. OBJECTIVE.: To investigate the relationship between low back pain (LBP) and metabolic syndrome (Mets) in community-based Japanese subjects. SUMMARY OF BACKGROUND DATA.: Relatively few reports have demonstrated a relationship between general pain and Mets, and none have addressed the...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31824231b8

    authors: Ono R,Yamazaki S,Takegami M,Otani K,Sekiguchi M,Onishi Y,Hayashino Y,Kikuchi S,Konno S,Fukuhara S

    更新日期:2012-06-01 00:00:00

  • Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes.

    abstract:STUDY DESIGN:Descriptive histologic analysis of spinal cord gene therapy. OBJECTIVE:To maximize protein expression in rat spinal cord using recombinant adenoassociate virus viral vector. SUMMARY OF BACKGROUND DATA:There are few reports of spinal cord genetic transfer. There have been no reports that compare technique...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000147909.59083.da

    authors: Harrop JS,Poulsen DJ,Xiao W,Freese A,During MJ

    更新日期:2004-12-15 00:00:00