The role of Cediranib in ovarian cancer.

abstract：BACKGROUND:Dexmethylphenidate is a single-isomer stimulant medication approved for the treatment of attention deficit hyperactivity disorder (ADHD). Single-isomer drugs have the potential for decreased undesired effects and improved therapeutic efficacy. Stimulant medications have been the mainstay treatments for ADHD ...

journal_title：Expert opinion on pharmacotherapy

authors： Coury D

更新日期：2009-11-01 00:00:00

abstract：:Thirty to forty percent of patients with idiopathic membranous nephropathy have persistent heavy proteinuria and may progress to end-stage kidney disease in 5 - 15 years. The ideal treatment for these patients is a matter of debate. Several nonspecific immunosuppressive regimens have been suggested with the aim of red...

journal_title：Expert opinion on pharmacotherapy

authors： Ruggenenti P,Cravedi P,Remuzzi G

更新日期：2007-12-01 00:00:00

abstract：:Motor fluctuations are common and distressing for patients with advanced Parkinson's disease. Subcutaneous apomorphine injections can be an extremely valuable adjunctive therapy. In this review, the authors discuss the history, pharmacology, efficacy, safety and proper administration of apomorphine for treating 'off' ...

journal_title：Expert opinion on pharmacotherapy

authors： Haq IU,Lewitt PA,Fernandez HH

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Panic disorder (PD) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks. PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide. PD should be treated effectively as soon as the symptoms emerge because the long...

journal_title：Expert opinion on pharmacotherapy

authors： Freire RC,Hallak JE,Crippa JA,Nardi AE

更新日期：2011-06-01 00:00:00

abstract：:Somatostatin and its long-acting analogues have been introduced for the treatment of endocrine tumours of the gastrointestinal tract as they have been shown to effectively control symptoms resulting from excessive hormone release in patients with carcinoid, Verner-Morrison and glucagonoma syndromes. This beneficial ef...

journal_title：Expert opinion on pharmacotherapy

authors： Arnold R,Wied M,Behr TH

更新日期：2002-06-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common skin disorder characterized by chronic inflammatory lesions that are frequently vexing for patients and difficult for physicians to treat. Although multiple therapeutic options are available, all have limitations. Topical preparations have issues with patient adherence, as compared to...

journal_title：Expert opinion on pharmacotherapy

authors： Shutty B,West C,Pellerin M,Feldman S

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Since the recognition of inherited sodium (Na(+)) channel disease, the cardiac Na(+) channel has been extensively studied. Both loss-of-function and gain-of-function mutations of the cardiac Na(+) channel are associated with cardiac arrhythmia and sudden cardiac death. Pathophysiological mechanisms that ma...

journal_title：Expert opinion on pharmacotherapy

authors： van Hoeijen DA,Blom MT,Tan HL

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Intravenous (I.V.) morphine administered through a patient-controlled system currently represents the gold standard treatment for moderate to severe acute postoperative pain. To fix the limitations showed by the available I.V. patient-controlled analgesia (PCA) systems that may restrict its use in the clin...

journal_title：Expert opinion on pharmacotherapy

authors： Fanelli A,Sorella MC,Chelly JE

更新日期：2016-01-01 00:00:00

abstract：:There has been an increase in the incidence and prevalence of gout in the past several decades. A distinction needs to be made between the treatment of gout as an acute inflammatory disease and the lowering of the serum urate (SU) levels into a normal range. Treating acute gout attacks alone is not sufficient to preve...

journal_title：Expert opinion on pharmacotherapy

authors： Schlesinger N,Dalbeth N,Perez-Ruiz F

更新日期：2009-06-01 00:00:00

abstract：:Ribavirin is a very broad-spectrum virustatic antiviral agent, first synthesised in 1972. It is characterised by low toxicity apart from reversible anaemia, usually mild. Its multiple mechanisms of action mean that viral resistance rarely develops. It can be administered orally, intravenously, or via a nebuliser. It h...

journal_title：Expert opinion on pharmacotherapy

authors： Snell NJ

更新日期：2001-08-01 00:00:00

abstract：:Autonomic dysreflexia is a potentially life-threatening hypertensive medical emergency that occurs most often in spinal cord-injured individuals with spinal lesions at or above the mid-thoracic spinal cord level. It is a condition that remains poorly recognised outside of spinal cord injury centres, which may result i...

journal_title：Expert opinion on pharmacotherapy

authors： Khastgir J,Drake MJ,Abrams P

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with a highly variable clinical course. Frontline treatments include cytotoxic chemotherapies, immunotherapies, and small molecule inhibitors. Clinical and molecular factors guide treatment initiation and selection. Over the last decade,...

journal_title：Expert opinion on pharmacotherapy

authors： Samples LS,Graf SA

更新日期：2018-10-01 00:00:00

abstract：:Staphylococcus aureus is a bacterial pathogen responsible for a variety of serious infections and is a frequent cause of nosocomial disease. During the last 60 years, S. aureus has developed increasing in vitro resistance to virtually all antimicrobials. In contrast, vancomycin has maintained a high degree of activity...

journal_title：Expert opinion on pharmacotherapy

authors： Pope SD,Roecker AM

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Much research has gone into developing medications that can be used to alleviate endometriosis-associated symptoms. In addition to already established medications, a new GnRH antagonist, elagolix, is in development. The novelty of this drug compared to other GnRH antagonists, is its nonpeptide structure, a...

journal_title：Expert opinion on pharmacotherapy

authors： Perricos A,Wenzl R

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Colorectal cancer (CRC) is the third most common cancer in the western world and also in Japan. The key factors in curing CRC are early detection, surgery and adequate adjuvant chemotherapy if needed. AREAS COVERED:Based on the results of following pivotal adjuvant trials, FOLFOX or XELOX are considered s...

journal_title：Expert opinion on pharmacotherapy

authors： Tsuji Y,Sugihara K

更新日期：2016-01-01 00:00:00

abstract：:Valproic acid (VPA) is considered to be a drug of first choice and one of the most frequently-prescribed antiepileptic drugs worldwide for the therapy of generalized and focal epilepsies, including special epileptic. It is a broad-spectrum antiepileptic drug and is usually well tolerated. Rarely, serious complications...

journal_title：Expert opinion on pharmacotherapy

authors： Gerstner T,Bell N,König S

更新日期：2008-02-01 00:00:00

abstract：:Gestational diabetes (GD) develops because pregnancy increases requirements for insulin secretion while increasing insulin resistance. Women with GD often have impaired pancreatic beta-cell compensation for insulin resistance. The nature of GD is currently contentious, with debate about its existence, diagnosis and ra...

journal_title：Expert opinion on pharmacotherapy

authors： Glueck CJ,Goldenberg N,Streicher P,Wang P

更新日期：2002-11-01 00:00:00

abstract：INTRODUCTION:Paget's disease of the bone is a common condition in some populations, affecting almost 10% of older adults in western Europe. Though frequently asymptomatic, it can sometimes result in severe disabilities. Timely intervention is now able to arrest disease progression in the majority of patients. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Reid IR

更新日期：2012-04-01 00:00:00

abstract：:Bupropion, a noradrenaline and dopamine re-uptake inhibitor, has long been indicated for the treatment of depression. Recent studies have demonstrated additional benefits in depression, including: prevention of the recurrence of seasonal affective disorder in depressive subtypes with decreased energy, pleasure and int...

journal_title：Expert opinion on pharmacotherapy

authors： Clayton AH

更新日期：2007-03-01 00:00:00

abstract：:Introduction: Multiple sclerosis (MS) is a demyelinating disease, causing axonal damage and disability. Dalfampridine (DAL) is an extended-release formulation of 4-aminopyridine (4AP) and broad-spectrum voltage-dependent potassium channel blocker that is reported to improve motor, visual and cognitive functions. Furth...

journal_title：Expert opinion on pharmacotherapy

authors： Foschi M,Lugaresi A

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Clostridium difficile infection (CDI) has become a significant healthcare-associated infection and is strongly associated with antibiotic use. Practice guidelines have recently been revised incorporating updated recommendations for diagnosis, treatment, and prevention. AREAS COVERED:This review discusses ...

journal_title：Expert opinion on pharmacotherapy

authors： Daniels LM,Kufel WD

更新日期：2018-11-01 00:00:00

abstract：:The objective of this article is to evaluate the roles of the lipid-lowering class of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in reducing cardiovascular events and to review their mechanism of action based on in vitro and in vivo studies. The clinical outcome of 15 major clinical...

journal_title：Expert opinion on pharmacotherapy

authors： Moghadasian MH,Mancini GB,Frohlich JJ

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future. AREAS COVERED:Recent (post 2013) phase III clinical trials of schizophrenia-targeted the...

journal_title：Expert opinion on pharmacotherapy

authors： Garay RP,Citrome L,Samalin L,Liu CC,Thomsen MS,Correll CU,Hameg A,Llorca PM

更新日期：2016-01-01 00:00:00

abstract：:Screening for sexually transmitted diseases is included in routine health care for several infectious agents in many western European countries. Current considerations on extensions of these programs include widespread screening strategies for Chlamydia trachomatis. In women, C. trachomatis infection may lead to seque...

journal_title：Expert opinion on pharmacotherapy

authors： Postma MJ,Welte R,Morré SA

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Following more than 20 years of Interferon (IFN)-based treatment for hepatitis C virus (HCV), the understanding of viral life cycle led to the development of new antiviral drugs directly targeting HCV replication steps. Daclatasvir (DCV) is a potent inhibitor of non-structural NS5A HCV protein with pangeno...

journal_title：Expert opinion on pharmacotherapy

authors： Degasperi E,Aghemo A,Colombo M

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Gout is a common disease responsible for recurrent flares triggered by the deposition of monosodium urate crystals secondary to longstanding hyperuricaemia. The management of gout implies both the treatment of flares and the treatment of hyperuricaemia itself. Recent improvement in the understanding of the...

journal_title：Expert opinion on pharmacotherapy

authors： Pascart T,Richette P

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to analyze and compare the efficacy outcomes associated with the fentanyl iontophoretic transdermal system (ITS) and morphine intravenous (IV) patient-controlled analgesia (PCA) in the management of postoperative pain. RESEARCH DESIGN AND METHODS:This meta-analysis assessed t...

journal_title：Expert opinion on pharmacotherapy

authors： Sinatra RS,Viscusi ER,Ding L,Danesi H,Jones JB,Grond S

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：:Symptomatic and asymptomatic peripheral arterial occlusive disease (PAD) is indicative of widespread atherosclerosis. The major threat is from cardiovascular ischaemic events; thus, an important therapeutic goal is to modify atherosclerotic risk factors. Data from several large drug trials indicate that patients with ...

journal_title：Expert opinion on pharmacotherapy

authors： Baumgartner I

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is the leading cause of pain, loss of function and disability in the elderly, with the knee being the most impactful joint affected. Currently, there is still no 'cure' in OA treatment. AREAS COVERED:The authors review the current and emerging therapies for knee OA including traditiona...

journal_title：Expert opinion on pharmacotherapy

authors： Cao P,Li Y,Tang Y,Ding C,Hunter DJ

更新日期：2020-05-01 00:00:00