Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature.

abstract：BACKGROUND:Few data exist regarding the clinical outcome of patients with Ewing sarcoma (EWS) treated with pencil beam scanning proton therapy (PT). We report the outcome of children, adolescents and young adults (AYA) treated with PT at the Paul Scherrer Institute. MATERIALS:Thirty-eight patients (median age, 9.9 yea...

journal_title：Pediatric blood & cancer

authors： Weber DC,Murray FR,Correia D,Bolsi A,Frei-Welte M,Pica A,Lomax AJ,Schneider R,Bachtiary B

更新日期：2017-12-01 00:00:00

abstract：:Bereaved families fear their child being forgotten by those who knew their loved child, including their child's oncology team. Thoughtfully timed, family-centric condolences shared by pediatric oncology team members have the potential to extend our compassion and kindness toward a family during the darkness of grief. ...

journal_title：Pediatric blood & cancer

authors： Weaver MS,Lichtenthal WG,Larson K,Wiener L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Because of major improvements in treatment protocols, the survival rate now exceeds 80%. However, ALL treatments can cause long-term neurocognitive sequelae, which negatively impact academic achievement and quality of life. Therefore, ...

journal_title：Pediatric blood & cancer

authors： Boulet-Craig A,Robaey P,Laniel J,Bertout L,Drouin S,Krajinovic M,Laverdière C,Sinnett D,Sultan S,Lippé S

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:NWTS-5 was a multi-institutional clinical trial for patients less than 16 years of age at diagnosis with specific renal neoplasms who were diagnosed between August 1, 1995 and May 31, 2002. A uniform approach to the treatment of patients with relapse was employed. PATIENTS AND METHODS:Seventy-two patients who ...

journal_title：Pediatric blood & cancer

authors： Green DM,Cotton CA,Malogolowkin M,Breslow NE,Perlman E,Miser J,Ritchey ML,Thomas PR,Grundy PE,D'Angio GJ,Beckwith JB,Shamberger RC,Haase GM,Donaldson M,Weetman R,Coppes MJ,Shearer P,Coccia P,Kletzel M,Macklis R,To

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Sorafenib targets multiple pathways thought to be crucial in growth of plexiform neurofibroma (PN) in children with neurofibromatosis type 1 (NF1). Sorafenib has been tolerated with manageable toxicities in adults and children with refractory cancer. We conducted a separate study in this population. Monitori...

journal_title：Pediatric blood & cancer

authors： Kim A,Dombi E,Tepas K,Fox E,Martin S,Wolters P,Balis FM,Jayaprakash N,Turkbey B,Muradyan N,Choyke PL,Reddy A,Korf B,Widemann BC

更新日期：2013-03-01 00:00:00

abstract：:It is unclear if dosing intervals for Erwinase can be extended with intramuscular (i.m.) versus intravenous (i.v.) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30 000-42 000 IU/m2 i.v. or i.m. I.m. Erwinase (n = 22) achieved activity above 0.1 IU/mL for longer than i.v. Erwinase (n = 33) (3....

journal_title：Pediatric blood & cancer

authors： Panetta JC,Liu Y,Swanson HD,Karol SE,Pui CH,Inaba H,Jeha S,Relling MV

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Regret about loss is one of the most intense types of regret experienced in life. Little is known about the bereavement regret of parents whose child has died of cancer. Although knowledge about parents' experiences after their child's death is vital for supporting these families, parents' regret is mostly...

journal_title：Pediatric blood & cancer

authors： Sim CW,Heuse S,Weigel D,Kendel F

更新日期：2020-06-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) accounts for approximately 15% of childhood NHL. Relapsed ALCL represents a formidable challenge because outcome is poor despite the use of high-dose chemotherapy regimens. We report two patients with relapsed T-type and 0-type ALCL who achieved long-term 3rd and 4th remissions wi...

journal_title：Pediatric blood & cancer

authors： Stockklausner C,Behnisch W,Mechtersheimer G,Möller P,Kulozik AE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The DNA methylating agent temozolomide was developed primarily for treatment of glioblastoma. However, preclinical data have suggested a broader application for treatment of childhood cancer. Temozolomide was tested against the PPTP solid tumor and ALL models. PROCEDURES:Temozolomide was tested against the ...

journal_title：Pediatric blood & cancer

authors： Keir ST,Maris JM,Reynolds CP,Kang MH,Kolb EA,Gorlick R,Lock R,Carol H,Morton CL,Wu J,Kurmasheva RT,Houghton PJ,Smith MA

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The outcome for patients with Ewing sarcoma family of tumors (ESFTs) of bone with metastases at diagnosis remains poor despite new approaches to treatment. We evaluated whether a dose-intensity chemotherapy regimen improved survival for patients with ESFTs of bone with metastases at diagnosis. METHODS:We en...

journal_title：Pediatric blood & cancer

authors： Miser JS,Goldsby RE,Chen Z,Krailo MD,Tarbell NJ,Link MP,Fryer CJ,Pritchard DJ,Gebhardt MC,Dickman PS,Perlman EJ,Meyers PA,Donaldson SS,Moore SG,Rausen AR,Vietti TJ,Grier HE

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The Wnt/β-catenin pathway plays a central role in the pathogenesis of most hepatoblastomas (HBs), that is, up to 60-80% carry activating CTNNB1 mutations. HBs can however also be the first manifestation of familial adenomatous polyposis (FAP). As this is a severe disease, it is important for the patient and ...

journal_title：Pediatric blood & cancer

authors： Dubbink HJ,Hollink IHIM,Avenca Valente C,Wang W,Liu P,Doukas M,van Noesel MM,Dinjens WNM,Wagner A,Smits R

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Clinical outcomes of children with sickle cell disease (SCD) who undergo total or partial splenectomy (PS) are poorly defined. The purpose of this retrospective study was to initiate an Internet-based registry to facilitate analysis of clinical outcomes for these children. We hypothesized that both surgical ...

journal_title：Pediatric blood & cancer

authors： Mouttalib S,Rice HE,Snyder D,Levens JS,Reiter A,Soler P,Rothman JA,Thornburg CD

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:Children treated with cranial radiotherapy (CRT) for leukemia are at risk of developing central nervous system injuries. Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating radiation-induced brain complications. The purpose of this report is to describe the spectrum of...

journal_title：Pediatric blood & cancer

authors： Faraci M,Morana G,Bagnasco F,Barra S,Polo P,Hanau G,Fioredda F,Caruso S,Rossi A,Spaziante R,Haupt R

更新日期：2011-08-01 00:00:00

abstract：:Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice. For this report cytarabine was studied in v...

journal_title：Pediatric blood & cancer

authors： Houghton PJ,Morton CL,Kang M,Reynolds CP,Billups CA,Favours E,Payne-Turner D,Tucker C,Smith MA

更新日期：2010-12-01 00:00:00

abstract：:Hemoglobin O-Arab [Beta 121 Glu → Lys] (Hb O-Arab) is a rare abnormal hemoglobin (Hb) whose clinical and hematological features have been described in adults but not in children. We report three children, 9, 12, and 36 months of age, with homozygous Hb O-Arab and assess the value of supplementary folic acid as treatme...

journal_title：Pediatric blood & cancer

authors： Dror S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Children with hepatoblastoma (HB) are at risk of sarcopenia due to immobility, chemotherapy, and malnutrition. We hypothesized that children with HB have a low preoperative total psoas muscle area (tPMA), reflecting sarcopenia, which negatively impacts outcome. PROCEDURE:Retrospective study of children (1-1...

journal_title：Pediatric blood & cancer

authors： Ritz A,Kolorz J,Hubertus J,Ley-Zaporozhan J,von Schweinitz D,Koletzko S,Häberle B,Schmid I,Kappler R,Berger M,Lurz E

更新日期：2021-01-12 00:00:00

abstract：:Germline DICER1 pathogenic variants predispose to numerous benign and malignant tumors. In this report, we describe DICER1 gene analysis in an adolescent diagnosed with multinodular goiter, ovarian Sertoli-Leydig cell tumor, and lung cyst. DICER1 mutational screening at the DNA level failed to detect any pathogenic va...

journal_title：Pediatric blood & cancer

authors： Verrier F,Dubois d'Enghien C,Gauthier-Villars M,Bonadona V,Faure-Conter C,Dijoud F,Stoppa-Lyonnet D,Houdayer C,Golmard L

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis is a rare disease of unknown etiology. We wanted to assess the population-based incidence of LCH in a well-defined cohort of children. METHODS:We identified all children <15-years old treated with LCH during the 10 years period 1992-2001 at the Department of Pediatrics, Karolin...

journal_title：Pediatric blood & cancer

authors： Stålemark H,Laurencikas E,Karis J,Gavhed D,Fadeel B,Henter JI

更新日期：2008-07-01 00:00:00

abstract：:Aplastic anemia (AA) is an immune-mediated disease. Although most patients are responsive to immunosuppressive therapy (IST) with a combination of anti-thymocyte globulin (ATG) and cyclosporine (CsA), some patients relapse or are refractory to IST. Sirolimus (rapamysin) inhibits the serine-threonine kinase mammalian t...

journal_title：Pediatric blood & cancer

authors： He G,Zhang X,Wu D,Sun A,Wang X

更新日期：2011-07-01 00:00:00

abstract：:We report a novel glucose-6-phosphate dehydrogenase (G6PD) mutation, which we propose to name G6PD Cincinnati (c.1037A > T, p.N346I), found in combination with G6PD Gastonia (c.637G > T, p.V213L) in an infant who presented with neonatal cholestasis. The G6PD Cincinnati mutation results in a non-conservative amino acid...

journal_title：Pediatric blood & cancer

authors： Mizukawa B,George A,Pushkaran S,Weckbach L,Kalinyak K,Heubi JE,Kalfa TA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Primary hemophagocytic lymphohistiocytosis (HLH) represents a group of inherited hyperinflammatory immunodeficiencies, including familial HLH (FHL), Griscelli syndrome type 2 (GS2), and X-linked lymphoproliferative syndrome (XLP). We previously reported an annual incidence of suspected primary HLH in Sweden ...

journal_title：Pediatric blood & cancer

authors： Meeths M,Horne A,Sabel M,Bryceson YT,Henter JI

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Adolescents with cancer report a strong desire to be actively involved in personal healthcare decision making. The purpose of this study was to examine adolescent cancer patients' involvement in conversations about relapsed and refractory disease, to characterize the content of patient-clinician communicatio...

journal_title：Pediatric blood & cancer

authors： Frederick NN,Mack JW

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

journal_title：Pediatric blood & cancer

authors： Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Abandonment of treatment is one of the toughest challenges to deal with in pediatric oncology. It leads to unnecessary mortality and morbidity in patients from low- and middle-income countries. PROCEDURE:The objective of our retrospective study was to determine the prevalence and predictors for abandonment ...

journal_title：Pediatric blood & cancer

authors： Siddiqui DE,Ashraf MS,Iftikhar S,Belgaumi AF

更新日期：2018-02-01 00:00:00

abstract：:In HLH-94, the first prospective international treatment study for hemophagocytic lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hemophagocytosis). In HLH-2004 three additional criteria are introduced; low/absent NK...

journal_title：Pediatric blood & cancer

authors： Henter JI,Horne A,Aricó M,Egeler RM,Filipovich AH,Imashuku S,Ladisch S,McClain K,Webb D,Winiarski J,Janka G

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Solid pseudopapillary pancreatic tumors (SPPT) are an extremely rare entity in pediatric patients. Even if the role of radical surgical resection as primary treatment is well established, data about follow-up after pancreatic resection in children are scant. METHODS:A retrospective review of data from the I...

journal_title：Pediatric blood & cancer

authors： Crocoli A,Grimaldi C,Virgone C,De Pasquale MD,Cecchetto G,Cesaro S,Bisogno G,Cecinati V,Narciso A,Alberti D,Ferrari A,Dall'Igna P,Spada M,Inserra A

更新日期：2019-03-01 00:00:00

abstract：:This review of the experience of high dose chemotherapy in patients with recurrent or refractory intracranial germ cell tumor confirms that sustained tumor control can be achieved with this modality both in germinoma and non-germinomatous germ cell tumors. Data from cooperative groups in Europe and North America sugge...

journal_title：Pediatric blood & cancer

authors： Bouffet E

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Males have a higher incidence of medulloblastoma (MB) than females, but the effect of gender on survival is unclear. Studies have yielded conflicting results, possibly due to small sample sizes or differences in how researchers defined MB. We aimed to determine the effect of gender on survival in MB using a ...

journal_title：Pediatric blood & cancer

authors： Curran EK,Sainani KL,Le GM,Propp JM,Fisher PG

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:While adolescents and adults with sickle cell disease (SCD) have reported using religion to cope with SCD, there is no data examining religious coping in young children with SCD. The purpose of this qualitative study was to: (1) describe the types of religious coping used by children with SCD; (2) describe t...

journal_title：Pediatric blood & cancer

authors： Cotton S,Grossoehme D,McGrady ME

更新日期：2012-02-01 00:00:00

abstract：:The global burden of sickle cell disease (SCD) is now being increasingly realized. SCD poses a significant public health problem in sub-Saharan Africa, the Middle East, some regions of India, the Caribbean, and Brazil. In many of these regions, progress in the management of SCD has been slow. Long-term North-South and...

journal_title：Pediatric blood & cancer

authors： Aygun B,Odame I

更新日期：2012-08-01 00:00:00