Abstract:
:Aplastic anemia (AA) is an immune-mediated disease. Although most patients are responsive to immunosuppressive therapy (IST) with a combination of anti-thymocyte globulin (ATG) and cyclosporine (CsA), some patients relapse or are refractory to IST. Sirolimus (rapamysin) inhibits the serine-threonine kinase mammalian target of rapamysin (mTOR), and blocks CsA-resistant and calcium-independent pathways late in the progression of the T-cell cycle. We report two cases of AA which relapsed after CsA and ATG plus CsA, respectively. They achieved transfusion independence after retreatment with sirolimus in combination with a CsA.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
He G,Zhang X,Wu D,Sun A,Wang Xdoi
10.1002/pbc.22865subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1133-5issue
7eissn
1545-5009issn
1545-5017journal_volume
56pub_type
杂志文章abstract::Spermatogonial stem cells open novel strategies for preservation of testicular tissue and fertility preservation in boys and men exposed to gonadotoxic therapies. This review provides an update on the physiology of spermatogonial stem cells in rodent and primate testes. Species-specific differences must be considered ...
journal_title:Pediatric blood & cancer
pub_type: 杂志文章,评审
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journal_title:Pediatric blood & cancer
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pub_type: 临床试验,杂志文章
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