Deep intracranial extension of squamous cell carcinoma of the scalp.

abstract：BACKGROUND:Distinguishing alveolar rhabdomyosarcoma (ARMS) from embryonal rhabdomyosarcoma (ERMS) has historically been of prognostic and therapeutic importance. However, classification has been complicated by shifting histologic criteria required for an ARMS diagnosis. Children's Oncology Group (COG) studies after IRS...

journal_title：Pediatric blood & cancer

authors： Rudzinski ER,Anderson JR,Chi YY,Gastier-Foster JM,Astbury C,Barr FG,Skapek SX,Hawkins DS,Weigel BJ,Pappo A,Meyer WH,Arnold MA,Teot LA,Parham DM

更新日期：2017-12-01 00:00:00

abstract：:A case of invasive, keratinizing squamous cell carcinoma of the larynx in an 8-year-old female treated with laryngectomy is presented. Perinatal exposure to human papilloma virus and constitutional heterozygosity for a FANCC mutation were identified, though FANCC heterozygosity is not known to be cancer predisposing. ...

journal_title：Pediatric blood & cancer

authors： D'Souza AM,Mark J,Demarcantonio M,Leino D,Sisson R,Geller JI

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The awareness that adolescents can have cancer is probably insufficient, not only among teenagers and their families, but also among physicians, and adolescent patients are reportedly often referred to qualified cancer institutes after a considerable delay. PROCEDURE:A prospective series of 425 patients (28...

journal_title：Pediatric blood & cancer

authors： Veneroni L,Mariani L,Lo Vullo S,Favini F,Catania S,Vajna de Pava M,Massimino M,Ferrari A

更新日期：2013-04-01 00:00:00

abstract：:Efficacy of therapeutic strategies relative to patient- and family-centered outcomes in pediatric oncology must be assessed. We sought to identify outcomes important to children with acute myeloid leukemia and their families related to inpatient versus at-home management of neutropenia. We conducted qualitative interv...

journal_title：Pediatric blood & cancer

authors： Szymczak JE,Getz KD,Madding R,Fisher B,Raetz E,Hijiya N,Gramatges MM,Henry M,Mian A,Arnold SD,Aftandilian C,Collier AB,Aplenc R

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Sorafenib is an inhibitor of multiple kinases (e.g., VEGF receptors, PDGFR, FLT3, RET, BRAF, KIT) and is approved by FDA for treatment of two adult cancers. The activity of sorafenib was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES:Sorafenib was evaluated against the PPTP in vitro pa...

journal_title：Pediatric blood & cancer

authors： Keir ST,Maris JM,Lock R,Kolb EA,Gorlick R,Carol H,Morton CL,Reynolds CP,Kang MH,Watkins A,Houghton PJ,Smith MA

更新日期：2010-12-01 00:00:00

abstract：:Hemophagocytic lymphohistioytosis (HLH) is a severe, life-threatening hyperinflammatory disorder that requires prompt diagnosis and treatment. Approximately, 25-50% of patients with HLH fail to achieve remission with established regimens that include dexamethasone and etoposide, or methylprednisolone and antithymocyte...

journal_title：Pediatric blood & cancer

authors： Marsh RA,Jordan MB,Talano JA,Nichols KE,Kumar A,Naqvi A,Vaiselbuh SR,Histiocyte Society Salvage Therapy Working Group.

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES), a highly aggressive tumor of children and young adults, is characterized most commonly by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in ES have been extensively re...

journal_title：Pediatric blood & cancer

authors： Nestheide S,Bridge JA,Barnes M,Frayer R,Sumegi J

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Stroke is a severe clinical disorder in sickle cell disease (SCD), and few studies have evaluated transcranial Doppler (TCD) flow velocities in hemoglobin SC disease (HbSC). The guidelines for stroke risk are based on evaluations in sickle cell anemia (SCA) or HbS/β thalassemia. PROCEDURE:In this study, we ...

journal_title：Pediatric blood & cancer

authors： Vieira C,de Oliveira CN,de Figueiredo LA,Santiago RP,Adanho CS,Santana SS,Burak CL,Lyra IM,Goncalves MS

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare disease, frequently affecting young children. PROCEDURE:We performed a retrospective study in patients younger than 16 years old manifesting with skin symptoms, and documented their different cutaneous lesions and systemic symptoms. We compared subgroups of chil...

journal_title：Pediatric blood & cancer

authors： Morren MA,Vanden Broecke K,Vangeebergen L,Sillevis-Smitt JH,Van Den Berghe P,Hauben E,Jacobs S,Van Gool SW

更新日期：2016-03-01 00:00:00

abstract：:X-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnos...

journal_title：Pediatric blood & cancer

authors： Sandlund JT,Shurtleff SA,Onciu M,Horwitz E,Leung W,Howard V,Rencher R,Conley ME

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Children and adolescents with Non-Hodgkin lymphoma (NHL) and mature B-cell leukemia (B-ALL) have an excellent prognosis with contemporary chemotherapy stratified according to the histologic subtype and clinical stage of disease. However, a small subset of patients does not respond to front-line therapy or su...

journal_title：Pediatric blood & cancer

authors： Attarbaschi A,Dworzak M,Steiner M,Urban C,Fink FM,Reiter A,Gadner H,Mann G

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Since 1975, childhood cancer incidence rates have gradually increased in the United States; however, few studies have conducted analyses across time to unpack this temporal rise. The aim of this study was to test the hypothesis that increasing cancer incidence rates are due to secular trends in pregnancy cha...

journal_title：Pediatric blood & cancer

authors： Kehm RD,Osypuk TL,Poynter JN,Vock DM,Spector LG

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure. PATIENTS AND METHODS:We compared carboplatin doses between two groups of children with r...

journal_title：Pediatric blood & cancer

authors： Allen S,Wilson MW,Watkins A,Billups C,Qaddoumi I,Haik BH,Rodriguez-Galindo C

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Wilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor. PROCEDURE:Gene expression profiles for 15 primary Wilms tu...

journal_title：Pediatric blood & cancer

authors： Chetcuti A,Aktas S,Mackie N,Ulger C,Toruner G,Alkan M,Catchpoole D

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Fever in neutropenic (FN) patients requires immediate broad-spectrum antibiotics, however, such patients do not represent a homogeneous population and the majority of them are at low risk of developing complication. Gatifloxacin (GA) is an alternative, though it has not been thoroughly studied in Pediatrics ...

journal_title：Pediatric blood & cancer

authors： Petrilli A,Altruda Carlesse F,Alberto Pires Pereira C

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PHT) may be the leading cause of death in β-thalassemia patients; however, its pathophysiologic mechanisms are still unclear. Recent studies indicate that asymmetric dimethylarginine (ADMA) plays a role in the initiation and progression of a variety of diseases, especially the cardiov...

journal_title：Pediatric blood & cancer

authors： Mohamed el-S,Ibrahim B,Amr D,Noha el-K,Mokhtar M

更新日期：2014-09-01 00:00:00

abstract：:Children with cancer and their families experience shifts in spiritual wellness from diagnosis through treatment and survivorship or bereavement. An interdisciplinary team conducted a systematic review of quantitative and qualitative research on spiritual assessments, interventions, and outcomes in childhood cancer fo...

journal_title：Pediatric blood & cancer

authors： Robert R,Stavinoha P,Jones BL,Robinson J,Larson K,Hicklen R,Smith B,Perko K,Koch K,Findley S,Weaver MS

更新日期：2019-09-01 00:00:00

abstract：:Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor arising mainly in the orofacial bones. Among more than 200 cases described in articles, only seven cases involved orbital regions. We present a case of newborn with recurrent MNTI in the lateral wall of right orbit. The patient underwent complete surgic...

journal_title：Pediatric blood & cancer

authors： Nakanishi K,Hori H,Matsubara T,Matsuda K,Deguchi T,Komada Y

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Infection in neutropenic children is a major cause of morbidity and mortality in children treated for cancer. In developing countries, children with cancer are often malnourished at diagnosis. In Blantyre, Malawi, children with Burkitt lymphoma are treated with a local protocol with limited toxicity. The aim...

journal_title：Pediatric blood & cancer

authors： Israëls T,van de Wetering MD,Hesseling P,van Geloven N,Caron HN,Molyneux EM

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Central nervous system (CNS) malignancies are the most common solid tumors among children, and novel therapies are needed to help improve survival. Pomalidomide is an immunomodulatory agent that displays antiangiogenic and cytotoxic activity, making it an appropriate candidate to explore in pediatric CNS tum...

journal_title：Pediatric blood & cancer

authors： Fangusaro J,Mitchell DA,Kocak M,Robinson GW,Baxter PA,Hwang EI,Huang J,Onar-Thomas A,Dunkel IJ,Fouladi M,Warren KE

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:A feature often seen in adolescent patients with cancer is a lengthy symptom interval, especially in comparison with children. It has been suggested that inadequate awareness of cancer risk among adolescents may play an important role in this study. METHODS:The Società Italiana Adolescenti con Malattie Onco...

journal_title：Pediatric blood & cancer

authors： Magni C,Segrè C,Finzi C,Veneroni L,Clerici CA,Massimino M,Casanova M,Martinella V,Chiaravalli S,Ricci A,Biondi A,Ferrari A

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Alvespimycin (17-DMAG, KOS-1022), a potent small-molecule inhibitor of the protein chaperone Hsp90, is being developed as an anticancer agent because of the multiple Hsp90 client proteins involved in cancer cell growth and survival. PROCEDURES:Alvespimycin was tested against the in vitro panel of the Pediat...

journal_title：Pediatric blood & cancer

authors： Smith MA,Morton CL,Phelps DA,Kolb EA,Lock R,Carol H,Reynolds CP,Maris JM,Keir ST,Wu J,Houghton PJ

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Children with cancer have high utilization of the emergency department (ED), but little is known about which outcomes are most important to them and their caregivers when they seek care in the ED. PROCEDURE:A qualitative evaluation of ED experience for children with cancer and their caregivers was performed...

journal_title：Pediatric blood & cancer

authors： Mueller EL,Cochrane AR,Lynch DO,Cockrum BP,Wiehe SE

更新日期：2019-10-01 00:00:00

abstract：:Immunotherapy with the anti-GD2 monoclonal antibody ch14.18, or dinutuximab, represents an important therapeutic advance in the treatment of pediatric high-risk neuroblastoma and is now considered part of standard of care in this patient population. To date, transverse myelitis as a result of dinutuximab therapy has n...

journal_title：Pediatric blood & cancer

authors： Ding YY,Panzer J,Maris JM,Castañeda A,Gomez-Chiari M,Mora J

更新日期：2018-01-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects the oxidative mechanism of microbial killing of phagocytic cells. The defect is characterized by a lack or severely reduced superoxide anion (O2-) production by phagocytes. Seventy percent of CGD cases are X-linked (X-CGD) and they are caus...

journal_title：Pediatric blood & cancer

authors： Barese CN,Copelli SB,De Matteo E,Zandomeni R,Salgueiro F,Di Giovanni D,Heyworth P,Rivas EM

更新日期：2005-04-01 00:00:00

abstract：:Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event...

journal_title：Pediatric blood & cancer

authors： Sekimizu M,Mori T,Kikuchi A,Mitsui T,Sunami S,Kobayashi R,Fujita N,Inada H,Takimoto T,Saito AM,Watanabe T,Fujimoto J,Nakazawa A,Ohshima K,Horibe K,Tsurusawa M,Lymphoma Committee of the Japanese Pediatric Leukemia\/Lymphom

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Compared to X-ray radiation therapy, proton therapy (PT) reduces the radiation dose to organs at risk, which is expected to translate into fewer second cancers and less cardiac morbidity decades after treatment. The Children's Oncology Group high-risk pediatric Hodgkin lymphoma (PHL) protocol, AHOD1331, allo...

journal_title：Pediatric blood & cancer

authors： Wray J,Flampouri S,Slayton W,Joyce M,Sandler E,Morris CG,Li Z,Indelicato DJ,Mendenhall NP,Hoppe BS

更新日期：2016-09-01 00:00:00

abstract：:The treatment of malignancy in cancer predisposition syndromes that also confer exquisite sensitivity to standard chemotherapy and radiation regimens remains a challenge. Bloom syndrome is one such disorder that is caused by a defect in DNA repair, predisposing to the development of early-onset age-related medical con...

journal_title：Pediatric blood & cancer

authors： Fein Levy C,Presswala LS,Slomovic A,Stiefel J,Schulman-Rosenbaum R

更新日期：2021-02-01 00:00:00

abstract：:Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly a...

journal_title：Pediatric blood & cancer

authors： Singh SA,Koumbourlis AC,Aygun B

更新日期：2008-06-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an immune deficiency characterized by defective neutrophil function and increased risk of life-threatening infections. Allogeneic hematopoietic cell transplantation is curative for CGD, and conditioning regimen impacts transplant-related outcomes. We report a single-center prospe...

journal_title：Pediatric blood & cancer

authors： Bhatt ST,Schulz G,Hente M,Slater A,Murray L,Shenoy S,Bednarski JJ

更新日期：2020-01-01 00:00:00