Abstract:
BACKGROUND:Hepatocellular carcinoma (HCC) is the second leading cancer-related cause of mortality worldwide. Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited. OBJECTIVE:The present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population-based study. METHODS:The nationwide population-based study herein using Taiwan's National Health Insurance Research Database included a total of 59 859 cases with HCC and 285 124 matched controls. Conditional logistic regression analyses were adjusted for confounding variables. RESULTS:All common kinds of SSRIs including fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and fluvoxamine were associated with lower HCC risk, and the findings were dose-dependent (eg, fluoxetine: 1-28 DDD [defined daily dose]: adjusted odds ratio [aOR]: 0.81, 95% confidence interval [CI], 0.73-0.89; 29-365 DDD: aOR: 0.71, 95% CI, 0.64-0.79; and ≥366 DDD: aOR: 0.55, 95% CI, 0.45-0.67) (P for trend < .001). CONCLUSIONS:All kinds of SSRIs were associated with decreased risk of HCC.
journal_name
Psychooncologyjournal_title
Psycho-oncologyauthors
Chan HL,Chiu WC,Chen VC,Huang KY,Wang TN,Lee Y,McIntyre RS,Hsu TC,Lee CT,Tzang BSdoi
10.1002/pon.4493subject
Has Abstractpub_date
2018-01-01 00:00:00pages
187-192issue
1eissn
1057-9249issn
1099-1611journal_volume
27pub_type
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