Factors Associated with Endocrine Therapy Non-Adherence in Breast Cancer Survivors.


BACKGROUND:For women with hormone receptor positive breast cancer, long-term endocrine therapy (ET) can greatly reduce the risk of recurrence, yet adherence is low- particularly among traditionally underserved populations. METHODS:The Carolina Breast Cancer Study oversampled Black and young women (<50 years of age). Participants answered an ET-specific medication adherence questionnaire assessing reasons for non-adherence. We used principal factor analysis to identify latent factors describing ET non-adherence. We then performed multivariable regression to determine clinical and demographic characteristics associated with each ET non-adherence factor. RESULTS:1,231 women were included in analysis, 59% reported at least one barrier to ET adherence. We identified three latent factors which we defined as: habit - challenges developing medication-taking behavior; tradeoffs - high perceived side effect burden and medication safety concerns; and resource barriers - challenges related to cost or accessibility. Older age (50+) was associated with less reporting of habit (Adjusted Risk Ratio (aRR) 0.54[95% CI: 0.43-0.69] and resource barriers (aRR 0.66[0.43-0.997]), but was not associated with tradeoff barriers. Medicaid-insured women were more likely than privately-insured to report tradeoff (aRR:1.53 [1.10-2.13]) or resource barriers (aRR:4.43[2.49-6.57]). Black race was associated with increased reporting of all factors (habit: aRR 1.29[1.09-1.53]; tradeoffs: 1.32[1.09-1.60], resources: 1.65[1.18-2.30]). CONCLUSION:Barriers to ET adherence were described by three distinct factors, and strongly associated with sociodemographic characteristics. Barriers to ET adherence appear inadequately addressed for younger, Black, and publicly-insured breast cancer survivors. These findings underscore the importance of developing multi-faceted, patient-centered interventions that address a diverse range of barriers to ET adherence.






Spencer JC,Reeve BB,Troester MA,Wheeler SB




Has Abstract


2020-04-01 00:00:00












  • Psychotropic drug metabolism in the cancer patient: clinical aspects of management of potential drug interactions.

    abstract::An overview of drug metabolism, with particular focus on the cytochrome p450 system, is provided in this review. To date, there has been a growing body of literature concerning the cytochrome p450 enzyme, drug-drug interactions and the role of psychotropic medications when co-administered with medications prescribed i...


    pub_type: 杂志文章,评审


    authors: Kalash GR

    更新日期:1998-07-01 00:00:00

  • Providing care to parents dying from cancer with dependent children: Health and social care professionals' experience.

    abstract:OBJECTIVE:Parents often feel ill-equipped to prepare their dependent children (<18 years old) for the death of a parent, necessitating support from professionals. The aim of this study is to explore health and social care professionals' (HSCPs) experiences and perceptions of providing supportive care to parents regardi...


    pub_type: 杂志文章


    authors: Hanna JR,McCaughan E,Beck ER,Semple CJ

    更新日期:2020-10-22 00:00:00

  • Fear of recurrence and psychological distress in head and neck cancer patients and their carers.

    abstract:BACKGROUND:Fear of recurrence (FOR) has been increasingly recognised as an issue of significant burden for most cancer patients, and has been associated with psychological morbidity and reduced quality of life. More recently, the impact of recurrence fears has been indicated in the families of cancer patients. However,...


    pub_type: 杂志文章,多中心研究


    authors: Hodges LJ,Humphris GM

    更新日期:2009-08-01 00:00:00

  • Dyadic coping in specialized palliative care intervention for patients with advanced cancer and their caregivers: Effects and mediation in a randomized controlled trial.

    abstract:OBJECTIVE:Specialized palliative care (SPC) interventions increasingly include patient-caregiver dyads, but their effects on dyadic coping are unknown. We investigated whether an SPC and dyadic psychological intervention increased aspects of dyadic coping in patients with advanced cancer and their caregivers, whether d...


    pub_type: 杂志文章,随机对照试验


    authors: von Heymann-Horan A,Bidstrup PE,Johansen C,Rottmann N,Andersen EAW,Sjøgren P,von der Maase H,Timm H,Kjellberg J,Guldin MB

    更新日期:2019-02-01 00:00:00

  • Caregiving experiences of Korean family caregivers of cancer patients: An integrative literature review.

    abstract:OBJECTIVE:The purpose of this study was to describe the experiences of Korean family caregivers of patients with cancer by reviewing recent literature. METHODS:Five electronic databases were searched-MEDLINE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PubMed for English literature, and ...


    pub_type: 杂志文章,评审


    authors: Lee EE,Lee SY

    更新日期:2020-10-01 00:00:00

  • Relationship between hot flashes and distress in men receiving androgen deprivation therapy for prostate cancer.

    abstract:OBJECTIVE:Side effects of cancer treatment have been found to have a significant impact on patients' psychological well-being. Each of the primary treatment options for prostate cancer is associated with significant side effects that can have a dramatic impact on quality of life. Hot flashes are a notable side effect o...


    pub_type: 杂志文章


    authors: Ulloa EW,Salup R,Patterson SG,Jacobsen PB

    更新日期:2009-06-01 00:00:00

  • Assessing unmet supportive care needs in partners of cancer survivors: the development and evaluation of the Cancer Survivors' Partners Unmet Needs measure (CaSPUN).

    abstract:BACKGROUND:Partners of cancer patients typically provide the majority of patients' emotional and physical care. Partners may be profoundly affected by the cancer and may experience ongoing supportive care needs across the survivorship continuum. Research has been restricted by a lack of psychometrically evaluated measu...


    pub_type: 杂志文章


    authors: Hodgkinson K,Butow P,Hobbs KM,Hunt GE,Lo SK,Wain G

    更新日期:2007-09-01 00:00:00

  • The epidemiology of psychiatric disorders among women with breast cancer in South Korea: analysis of national registry data.

    abstract:OBJECTIVE:Population-based data on the epidemiology of psychiatric disorders in patients with breast cancer are lacking. Because the National Health Insurance (NHI) Program in South Korea is a compulsory social insurance system covering the entire Korean population, the NHI is a good source of information for epidemiol...


    pub_type: 杂志文章


    authors: Kang JI,Sung NY,Park SJ,Lee CG,Lee BO

    更新日期:2014-01-01 00:00:00

  • Cancer survivorship and psychological distress in later life.

    abstract::Recent research in psychosocial oncology has pointed to the traumatic nature of the stress experienced by cancer survivors. Most of this research has focused on children, young adults survivors and their families. This investigation proposes a conceptual model for understanding general psychological distress (anxiety,...


    pub_type: 杂志文章


    authors: Deimling GT,Kahana B,Bowman KF,Schaefer ML

    更新日期:2002-11-01 00:00:00

  • Hostility in cancer patients as an underexplored facet of distress.

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    pub_type: 杂志文章


    authors: Grassi L,Belvederi Murri M,Riba M,de Padova S,Bertelli T,Sabato S,Nanni MG,Caruso R,Ounalli H,Zerbinati L

    更新日期:2020-11-18 00:00:00

  • Individual quality of life of patients undergoing autologous peripheral blood stem cell transplantation.

    abstract:BACKGROUND:Most quality-of-life (QoL) studies in autologous Peripheral Blood Stem Cell Transplantation (PBSCT) are descriptive and concentrate on symptom severity and functional deficits. The aim of this study is to compare individual QoL (iQoL) with health-related QoL (hrQoL) and functional status of patients before h...


    pub_type: 杂志文章


    authors: Frick E,Borasio GD,Zehentner H,Fischer N,Bumeder I

    更新日期:2004-02-01 00:00:00

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    abstract:OBJECTIVES:The nature and magnitude of the problems facing caregivers remain largely unknown in developing countries of the world. This study addresses these issues in a group of caregivers of patients with cancer in Zaria, Nigeria. METHOD:One hundred and three patients attending an oncology outpatient clinic at the A...


    pub_type: 杂志文章


    authors: Yusuf AJ,Adamu A,Nuhu FT

    更新日期:2011-08-01 00:00:00

  • 2016 President's Plenary International Psycho-Oncology Society: challenges and opportunities for growing and developing psychosocial oncology programmes worldwide.

    abstract::Consistent with the International Psycho-Oncology Society's (IPOS) vision and goals, we are committed to improving quality cancer care and cancer policies through psychosocial care globally. As part of IPOS's mission, upon entering "Official Relations" for a second term with the World Health Organization (WHO), IPOS h...


    pub_type: 杂志文章


    authors: Travado L,Bultz BD,Ullrich A,Asuzu CC,Turner J,Grassi L,Jacobsen P

    更新日期:2017-09-01 00:00:00

  • Level of physical activity and characteristics associated with change following breast cancer diagnosis and treatment.

    abstract:OBJECTIVE:While the physical and psychosocial benefits of participating in physical activity (PA) during and following breast cancer treatment are well understood, less is known about rates and uptake of PA following diagnosis. This paper explores the levels and patterns of PA among women recently diagnosed with breast...


    pub_type: 杂志文章


    authors: Harrison S,Hayes SC,Newman B

    更新日期:2009-04-01 00:00:00

  • Effects of financial status on major depressive disorder and complicated grief among bereaved family members of patients with cancer.

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    pub_type: 杂志文章


    authors: Aoyama M,Sakaguchi Y,Igarashi N,Morita T,Shima Y,Miyashita M

    更新日期:2021-01-28 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Given C,Given B,Rahbar M,Jeon S,McCorkle R,Cimprich B,Galecki A,Kozachik S,Devoss D,Brady A,Fisher-Malloy MJ,Courtney K,Bowie E

    更新日期:2004-11-01 00:00:00

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    abstract:BACKGROUND:A cancer diagnosis can have a profound impact on partners and close family members of patients. Little is currently known about the long-term impact. OBJECTIVES:The objective of this study is to describe health status, levels of anxiety and depression, unmet supportive care needs and positive outcomes in th...


    pub_type: 杂志文章


    authors: Turner D,Adams E,Boulton M,Harrison S,Khan N,Rose P,Ward A,Watson EK

    更新日期:2013-01-01 00:00:00

  • Quality of life and psychological distress are differentially associated with distinct symptom-functional states in terminally ill cancer patients' last year of life.

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    pub_type: 杂志文章


    authors: Wen FH,Chen JS,Chou WC,Hsieh CH,Chang WC,Shen WC,Tang ST

    更新日期:2018-09-01 00:00:00

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    pub_type: 杂志文章,meta分析


    authors: Xiao J,Chow KM,Liu Y,Chan CWH

    更新日期:2019-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Brain K,Henderson BJ,Tyndel S,Bankhead C,Watson E,Clements A,Austoker J,PIMMS Study Management Group.

    更新日期:2008-12-01 00:00:00

  • Trusting God and medicine: spirituality in advanced cancer patients volunteering for clinical trials of experimental agents.

    abstract::The purpose of this study was to examine the role of spirituality in terminally ill cancer patients who volunteer for clinical trials of experimental agents. Information about spirituality (FACIT-Sp), quality of life (FACT-G), awareness of prognosis, and decision-making preferences was obtained from 162 advanced cance...


    pub_type: 杂志文章


    authors: Daugherty CK,Fitchett G,Murphy PE,Peterman AH,Banik DM,Hlubocky F,Tartaro J

    更新日期:2005-02-01 00:00:00

  • Colorectal cancer patients can be advocates for colorectal cancer screening for their siblings: A study on siblings' perspectives.

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    pub_type: 杂志文章


    authors: Tan KK,Lim TZ,Chew E,Chow WM,Koh GC

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    abstract:OBJECTIVES:To examine cancer-related worry in adolescent and young adult (AYA) cancer survivors and its relationship with posttraumatic growth over time, as the relationship between these constructs has not been assessed longitudinally in this population. METHODS:A total of 153 AYA cancer survivors completed measures ...


    pub_type: 杂志文章


    authors: McDonnell GA,Pope AW,Schuler TA,Ford JS

    更新日期:2018-09-01 00:00:00

  • Spirituality is associated with less treatment regret in men with localized prostate cancer.

    abstract:BACKGROUND:Some patients with prostate cancer regret their treatment choice. Treatment regret is associated with lower physical and mental quality of life. We investigated whether, in men with prostate cancer, spirituality is associated with lower decisional regret 6 months after treatment and whether this is, in part,...


    pub_type: 杂志文章


    authors: Mollica MA,Underwood W 3rd,Homish GG,Homish DL,Orom H

    更新日期:2017-11-01 00:00:00

  • Providing psychosocial support for breast cancer patients based on screening for distress within a consultation-liaison service.

    abstract::In a consecutive sample of 100 breast cancer patients undergoing radiotherapy, cancer-related distress was assessed with the Hospital Anxiety and Depression Scale and patients' interest in and acceptance of psychosocial support with the Questionnaire for Psychosocial Support and the European Consultation Liaison Workg...


    pub_type: 杂志文章


    authors: Söllner W,Maislinger S,König A,Devries A,Lukas P

    更新日期:2004-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Canada AL,Murphy PE,Fitchett G,Peterman AH,Schover LR

    更新日期:2008-09-01 00:00:00

  • First use of antidepressant medication in male partners of women with breast cancer in Denmark from 1998 to 2011.

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    pub_type: 杂志文章


    authors: Cromhout PF,Latocha KM,Olsen MH,Suppli NP,Christensen J,Johansen C,Dalton SO

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  • Supporting 'work-related goals' rather than 'return to work' after cancer? A systematic review and meta-synthesis of 25 qualitative studies.

    abstract:BACKGROUND:This study aimed to systematically review and synthesise qualitative studies of employment and cancer. METHODS:A rigorous systematic review and meta-synthesis process was followed. A total of 13,233 papers were retrieved from eight databases; 69 were deemed relevant following title and abstract appraisal. F...


    pub_type: 杂志文章,meta分析,评审


    authors: Wells M,Williams B,Firnigl D,Lang H,Coyle J,Kroll T,MacGillivray S

    更新日期:2013-06-01 00:00:00

  • Posttraumatic growth, social support, and social constraint in hematopoietic stem cell transplant survivors.

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    pub_type: 杂志文章


    authors: Nenova M,DuHamel K,Zemon V,Rini C,Redd WH

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    pub_type: 杂志文章,评审


    authors: McLoone J,Menzies S,Meiser B,Mann GJ,Kasparian NA

    更新日期:2013-07-01 00:00:00