Abstract:
:The genome-wide investigation of DNA methylation levels has been limited to reference transposable element positions. The methylation analysis of non-reference and mobile transposable elements has only recently been performed, but required both genome resequencing and MethylC-seq datasets. We have created epiTEome, a program that detects both new transposable element insertion sites and their methylation states from a single MethylC-seq dataset. EpiTEome outperforms other split-read insertion site detection programs, even while functioning on bisulfite-converted reads. EpiTEome characterizes the previously discarded fraction of DNA methylation at sites of new insertions, enabling future investigation into the epigenetic regulation of non-reference and transposed elements.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Daron J,Slotkin RKdoi
10.1186/s13059-017-1232-0subject
Has Abstractpub_date
2017-05-12 00:00:00pages
91issue
1eissn
1474-7596issn
1474-760Xpii
10.1186/s13059-017-1232-0journal_volume
18pub_type
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