iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations.

Abstract:

:The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we resolve the interfaces of all known transcription factor (TF)-TF, TF-DNA and chromatin-chromatin interactions for the analysis of both coding and non-coding disease-associated mutations to obtain mechanistic insights into their functional impact. Using iRegNet3D, we find that disease-associated mutations may perturb the regulatory network through diverse mechanisms including chromatin looping. iRegNet3D promises to be an indispensable tool in large-scale sequencing and disease association studies.

journal_name

Genome Biol

journal_title

Genome biology

authors

Liang S,Tippens ND,Zhou Y,Mort M,Stenson PD,Cooper DN,Yu H

doi

10.1186/s13059-016-1138-2

subject

Has Abstract

pub_date

2017-01-18 00:00:00

pages

10

issue

1

eissn

1474-7596

issn

1474-760X

pii

10.1186/s13059-016-1138-2

journal_volume

18

pub_type

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