Gene expression reveals evidence for EGFR-dependent proximal-distal limb patterning in a myriapod.

Abstract:

:Evolution of segmented limbs is one of the key innovations of Arthropoda, allowing development of functionally specific specialized head and trunk appendages, a major factor behind their unmatched evolutionary success. Proximodistal limb patterning is controlled by two regulatory networks in the vinegar fly Drosophila melanogaster, and other insects. The first is represented by the function of the morphogens Wingless (Wg) and Decapentaplegic (Dpp); the second by the EGFR-signaling cascade. While the role of Wg and Dpp has been studied in a wide range of arthropods representing all main branches, that is, Pancrustacea (= Hexapoda + Crustacea), Myriapoda and Chelicerata, investigation of the potential role of EGFR-signaling is restricted to insects (Hexapoda). Gene expression analysis of Egfr, its potential ligands, and putative downstream factors in the pill millipede Glomeris marginata (Myriapoda: Diplopoda), reveals that-in at least mandibulate arthropods-EGFR-signaling is likely a conserved regulatory mechanism in proximodistal limb patterning.

journal_name

Evol Dev

journal_title

Evolution & development

authors

Janssen R

doi

10.1111/ede.12222

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

124-135

issue

3

eissn

1520-541X

issn

1525-142X

journal_volume

19

pub_type

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