Abstract:
:Animal development is the product of distinct components and interactions-genes, regulatory networks, and cells-and it exhibits emergent properties that cannot be inferred from the components in isolation. Often the focus is on the genotype-to-phenotype map, overlooking the process of development that turns one into the other. We propose a move toward micro-evolutionary analysis of development, incorporating new tools that enable cell type resolution and single-cell microscopy. Using the sex determination pathway in Drosophila to illustrate potential avenues of research, we highlight some of the questions that these emerging technologies can address. For example, they provide an unprecedented opportunity to study heterogeneity within cell populations, and the potential to add the dimension of time to gene regulatory network analysis. Challenges still remain in developing methods to analyze this data and to increase the throughput. However this line of research has the potential to bridge the gaps between previously more disparate fields, such as population genetics and development, opening up new avenues of research.
journal_name
Evol Devjournal_title
Evolution & developmentauthors
Signor SA,Arbeitman MN,Nuzhdin SVdoi
10.1111/ede.12187subject
Has Abstractpub_date
2016-05-01 00:00:00pages
201-9issue
3eissn
1520-541Xissn
1525-142Xjournal_volume
18pub_type
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