Abstract：
OBJECTIVES:To investigate differentially expressed salivary peptides in the development of early childhood caries (ECC) in 3-4 year-old children. MATERIALS AND METHODS:Eighty-two caries-free children at baseline were followed-up for 1year, during which period 15 of them had developed ECC (Group C), whilst another 15 cases out of the 31 individuals who remained healthy were marked as Group H. Stimulated whole saliva samples were collected at 0, 6 and 12 months, and analyzed using weak cation exchange magnetic beads combined with matrix assisted laser desorption/ionization time-of-flight mass spectrometry. Corresponding peptide mass fingerprints were obtained to develop a discriminating model for ECC development. Q-Exactive mass spectrometry was then performed to identify the possible proteins where these peptides might derive from. RESULTS:Nine peptide peaks were found to be significantly different in Group C among the three sampling time points and might correlate with development of caries. Levels of three of them increased over time, whilst that of the other six decreased gradually. We chose three peptides (1346.6, 2603.5 and 3192.8Da) which exhibited the best capability of classification, to establish a model for children at high risk of caries. One peptide (1346.6Da) was identified to be salivary histatin-rich peptide. CONCLUSIONS:Our results indicate that peptidomic methods can be applied to help identify new candidate biomarkers for the occurrence and development of ECC. CLINICAL SIGNIFICANCE:The change of salivary peptides may be an indicator of ECC, facilitating more effective measures to be taken in prevention of this disease.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Ao S,Sun X,Shi X,Huang X,Chen F,Zheng Sdoi
10.1016/j.jdent.2017.04.006subject
Has Abstractpub_date
2017-06-01 00:00:00pages
21-27eissn
0300-5712issn
1879-176Xpii
S0300-5712(17)30090-8journal_volume
61pub_type
杂志文章abstract：OBJECTIVES:The aim of this in vitro study was to evaluate the penetration of an infiltrant and a sealant, when applied as recommended, into fissure caries lesions. METHODS:The fissure systems of extracted human teeth were classified according to the international caries detection and assessment system (ICDAS, codes: 0...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2014.01.006
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify factors influencing the selection of restorative materials. METHODS:In 1992, a random sample of Finnish dentists working in the public and private health care sectors were asked to provide information on restorative treatments during a given period. The study material co...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)00070-4
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate the effects of a home bleaching gel containing 15% carbamide peroxide on the surface microhardness of four tooth-colored restorative materials in situ. METHODS:Four types of tooth-colored restorative materials, including a nanocomposite resin (Filtek Z350), a packab...
journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2008.01.008
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:This study evaluated the inhibitory effect of proanthocyanidin (PA), a natural collagen cross-linker, on soluble and matrix-bound proteases, which are responsible for progressive degradation of exposed collagen fibrils within the hybrid layer and resin-dentine bond failure over time. METHODS:The inhibitory e...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.06.002
更新日期：2013-09-01 00:00:00
abstract：:Meta-analysis is a formalized method of combining results of different studies to provide conclusions about the effectiveness of a treatment modality. The aims of this study were to use meta-analysis to determine the clinical performance of posterior composite restorations using the assessment criteria of the USPHS gu...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析
doi：10.1016/0300-5712(94)90143-0
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:To analyse the DIAGNOdent's performance to longitudinally monitor the arrestment of non-cavitated carious lesions in occlusal surfaces. METHODS:The sample consisted of 15 children (12-13 years old) with 40 active non-cavitated lesions. The protocol for the examinations was: prophylaxis, drying teeth for 30s;...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2007.05.005
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:After removal of dentine caries lesions, cavity lining has been advocated. Non-clinical data support this approach, but clinical data are sparse and ambiguous. We aimed at evaluating the benefits and harms of cavity lining using meta-analysis and Trial Sequential Analysis. DATA:We included randomized clinic...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/j.jdent.2015.07.017
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:The present study tested the central hypothesis that selective demineralisation of dentine extrafibrillar minerals by lowering the phosphoric acid concentration improves the quality of the resin-dentine interface. METHODS:Dentine surfaces were etched with different concentrations of phosphoric acid (1, 5, 10...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2016.07.008
更新日期：2016-09-01 00:00:00
abstract：:The bacteriological contamination of pumice slurry in polishing units in a dental clinical area (high risk), a production laboratory (medium risk), and a non-clinical teaching laboratory (low risk), was investigated. Slurry samples taken from all three areas were found to be heavily contaminated with pathogenic organi...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(90)90030-i
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVES:Previously, we have reported that dental composite incorporating the new monomer methacryloyloxydodecylpyridinium bromide (MDB) showed no release of antibacterial components after being cured but still exhibited antibacterial activity against Streptococcus mutants on its surface. In this study, in order to e...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)93576-n
更新日期：1995-06-01 00:00:00
abstract：OBJECTIVES:This study aimed to evaluate posterior restorations placed in young adults, investigating the association between social determinants experienced during the life course and the quality of tooth fillings. METHODS:A representative sample (n=720) of all 5914 individuals who were born in Pelotas in 1982 was pro...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.02.010
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the influence of a fiber post on the fracture mechanics of zirconia crowns inserted over endodontically treated teeth with different extent of coronal damage. METHODS:Endodontically treated human molars with three types of coronal damage received fiber posts before ce...
journal_title：Journal of dentistry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jdent.2008.03.014
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVES:Traditional mechanical methods of retaining restorative materials have been replaced to a large extent by tooth conserving adhesive restorative techniques. Because adhesives have been evolving so rapidly for the last few years, the timing is right for evaluating the clinical status of present day adhesives. ...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/s0300-5712(96)00070-x
更新日期：1998-01-01 00:00:00
abstract：UNLABELLED:Three types of fiber-reinforced composite (FRC) molar crowns were tested on their fracture resistance and marginal adaptation under simulated oral stress conditions. Two glass fiber systems, one processed with a vacuum/pressure system, the other by manual fiber adaptation, and a polyethylene fiber system wer...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(01)00007-0
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVES:This study aimed to analyse if children with untreated or treated caries (restorations/missing teeth) are perceived differently compared to children with healthy teeth and to explore possible differences in the perception by laypersons and dental experts. METHODS:Eye movements of female experts (n = 20) and...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2018.05.006
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:This study investigated the mechanism of action at the interface between a commercially available Y-TZP and its veneering ceramic after final firing. Particular attention was paid, from a microstructural point of view, to evaluating the effects of different surface treatments carried out on the zirconia. MET...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2014.07.019
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:Reattachment of the avulsed enamel-dentine coronal fragment to the remaining tooth structure has become an accepted clinical alternative to a resin composite build-up for the restoration of crown fractured teeth. Since little knowledge exists as to the pulpal response to this procedure, this study was design...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(98)00003-7
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVES:During laboratory fabrication procedures and/or clinical adjustments, pressable materials: IPS Empress and Empress 2, may be ground, polished or sandblasted. These treatments may affect their strength by introducing microscopic flaws and defects. This study investigates the effect of these procedures on the ...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2003.08.006
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVES:To evaluate the ability of a Near Infrared Light Transillumination (NILT) device to detect non-cavitated approximal caries lesions; and to compare its performance to Digital Radiography (DR). METHODS:Thirty human extracted premolars (sound to lesions into the outer one-third of dentin) were selected. Lesion...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2017.05.018
更新日期：2017-08-01 00:00:00
abstract：AIM:The aim of this study is to report the subsequent treatment provided, over the 11 years' data available, when a re-intervention was considered clinically necessary on a glass ionomer (GI) restoration. METHODS:A detailed sample of treatment records of patients has been established at the Dental Practice Division of...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2008.07.008
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:The use of thio-urethane oligomers has been shown to significantly improve the mechanical properties of resin cements (RCs). The aim of this study was to use thio-urethane-modified RC to potentially reinforce the porcelain-RC structure and to improve the bond strength to zirconia and lithium disilicate. MET...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2018.04.002
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:The main aim of this in vitro study was to evaluate the influence of Streptococcus mutans on the corrosion of titanium. METHODS:S. mutans biofilms were formed on commercially pure titanium (CP-Ti) square samples (10mm×10mm×1mm) using a culture medium enriched with sucrose. Open circuit potential (OCP) and el...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2013.03.008
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVES:This in vivo study compared the antibacterial effect of a self-etch adhesive with and without the brominated monomer 12-methacryloyloxydodecyl-pyridinium bromide (MDPB) on carious dentin after selective caries removal. METHODS:10 patients showing deep primary carious lesions at two posterior teeth without p...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103555
更新日期：2020-12-17 00:00:00
abstract：OBJECTIVES:The aetiology of orofacial pain (OFP) is not well understood. We aimed to determine the relationship between OFP and local mechanical factors in an unselected general population sample. METHODS:A cross-sectional population-based survey was conducted in the United Kingdom, involving 2504 participants (adjust...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(03)00108-8
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVES:To conduct a systematic review and meta-analysis to explore the association between erosive toothwear and gastro-oesophageal reflux disease or symptoms (GERD/S). SOURCES:Electronic searches were performed in Scopus, Embase, and Web of Science databases for the identification of relevant studies, from 1980 u...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析
doi：10.1016/j.jdent.2020.103284
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine whether conventional black tea and a herbal tea were capable of eroding dental enamel. A further aim was to investigate whether herbal tea of the type tested eroded dental hard tissues to a greater or lesser extent than conventional black tea. METHODS:Three groups of 2...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(01)00044-6
更新日期：2001-11-01 00:00:00
abstract：:The effects of sample thickness on the in vitro bond strength of two light-activated glass polyalkenoate cements to dentine have been investigated. The buccal and/or lingual surfaces of non-carious human third molar teeth were used for bonding. The tensile bond strengths to dentine of samples of the cements of 0.5 mm,...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(94)90123-6
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVES:Full-ceramic systems can be produced by different techniques (layering, heatpressing, CAD/CAM) and have various compositions with different crystalline contents that may affect the optical properties of laminate restorations. METHODS:A total of 60 specimens were prepared from e.max Press, e.max CAD, Empress...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2012.11.013
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:To validate a new questionnaire for evaluating the 'Oral aesthetic-related quality of life (OARQoL)' of prosthetically restored patients. 'OARQoL' assesses the impact of the self-perceived dental aesthetics on patients' well-being. METHODS:The 'Quality of Life associated with Dental Aesthetic Satisfaction (...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2015.08.010
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to measure the satisfaction of patients with respect to the aesthetics of veneer restorations (VRs) and to identify potential factors influencing their satisfaction. MATERIALS AND METHODS:One hundred and eighty VRs of three different types (direct composite, indirect composite and ...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-5712(96)00067-x
更新日期：1997-11-01 00:00:00
