Abstract:
OBJECTIVE:This study evaluated the inhibitory effect of proanthocyanidin (PA), a natural collagen cross-linker, on soluble and matrix-bound proteases, which are responsible for progressive degradation of exposed collagen fibrils within the hybrid layer and resin-dentine bond failure over time.
METHODS:The inhibitory effects of PA (1%, 2%, 3%, 4.5% and 6%) on soluble recombinant matrix metalloproteinases (MMP-2, -8 and -9) and cysteine cathepsins (cathepsin B and K) were evaluated using MMP and cysteine cathepsins fluorometric assay kits. Chlorhexidine (CHX) was used as an inhibitor control. The effect of PA on endogenous matrix-bound proteases was examined by determining the change in dry mass of demineralized dentine beams and solubilized collagen peptides over 30 days. Two-way ANOVA and Tukey multiple comparison tests were used to analyze the effect of PA and proteases on the percentage inhibition of soluble proteases (α=0.05). Kruskal-Wallis one-way ANOVA and Dunn's multiple comparison tests were used to analyse the effect of PA on loss of dry mass and hydroxyproline content over time (α=0.05).
RESULTS:Proanthocyanidin inactivated more than 90% of soluble recombinant MMP-2, -8 and -9 and around 75-90% of cysteine cathepsin B and K, which was significantly higher than CHX (P<0.05). The inhibition of endogenous proteases by PA increased in a dose-dependent manner. The loss of dry mass and hydroxyproline release in the medium over time was the lowest in dentine beams pretreated with PA journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract:OBJECTIVES:To examine the removal rate of sound and carious dentine using bioactive glass air-abrasion and investigate abrasive particle retention of alumina and bioactive glass on abraded dentine. METHODS:Crushed bioactive glass was investigated as an alternative air-abrasive to alumina at air pressures of 138, 413 a...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2007.12.004
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVES:Dentine modifies pulpward diffusion of monomers leaching from restorative materials. Thus, remaining dentine thickness must be taken into account during in vitro cytotoxicity tests. This in vitro study was designed to determine the influence of dentine permeability on the outcome of a cytotoxicity test. MET...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(98)00019-0
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the effects of a home bleaching gel containing 15% carbamide peroxide on the surface microhardness of four tooth-colored restorative materials in situ. METHODS:Four types of tooth-colored restorative materials, including a nanocomposite resin (Filtek Z350), a packab...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2008.01.008
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Understanding the mechanical properties of dentine is of importance as adhesive restorative materials mainly achieve their bonding to the tooth structure through dentine. The current study measures the hardness and modulus of elasticity of primary molar dentine using an Ultra-Micro-Indentation System (UMIS),...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(03)00045-9
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy of different bleaching systems on artificially created stained-remineralized caries lesions; and to assess the susceptibility of the bleached lesions to further demineralization. METHODS:Human enamel specimens were sectioned, polished, demineralized, and randomly divided into six gr...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2018.12.008
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To investigate the flexural strength and fluoride release of four conventional glass-ionomer cements: Ketac-Molar (KM), HiFi (HF), Vivaglass Fil (VF), Ketac-Fil (KF) and a newly developed glass polyphosphonate cement, Diamond Carve (DC). METHOD:Disc specimens (10 mm diameter, 1 mm thick) were prepared and mo...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(98)00061-x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVES:Three strength tests (compressive, three point flexure and biaxial) were performed on three glass ionomer (GI) restoratives to assess the most appropriate methodology in terms of validity and reliability. The influence of mixing induced variability on the data sets generated were eliminated by using encapsul...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2011.12.002
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:Traditional mechanical methods of retaining restorative materials have been replaced to a large extent by tooth conserving adhesive restorative techniques. Because adhesives have been evolving so rapidly for the last few years, the timing is right for evaluating the clinical status of present day adhesives. ...
journal_title:Journal of dentistry
pub_type: 杂志文章,评审
doi:10.1016/s0300-5712(96)00070-x
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:A monomer methacryloyloxydodecylpyridinium bromide (MDPB) has antibacterial activity before polymerization. Furthermore, the antibacterial agent is immobilized by the polymerization of MDPB and the resin-based material incorporating MDPB is able to show an antibacterial effect even after being cured. The pur...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(97)00013-4
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the prevalence of direct restorations in posterior teeth in children aged 12, from a birth cohort, and to test the association between the quality of the restorations and individual variables experienced in the life cycle. METHODS:All live-born children in Pelotas, in 200...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2019.103183
更新日期:2019-10-01 00:00:00
abstract::This paper reviews the effect of dentine permeability on the bond strength of dentinal bonding systems and its relationship with the morphology of dentine. Deep dentine is more permeable than superficial dentine. Demineralization of dentine surfaces with acidic conditioners significantly increases permeability with re...
journal_title:Journal of dentistry
pub_type: 杂志文章,评审
doi:10.1016/0300-5712(94)90005-1
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:The aim of this investigation was to compare the clinical survival rate of all-ceramic FPDs with failures during in vitro simulation. METHODS:40 anterior FPDs were manufactured from lithiumdisilicate ceramic and alumina-oxide ceramic. The FPDs were adhesively bonded to human teeth and artificially aged to in...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2008.09.001
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare the fracture strength of three techniques used to re-attach tooth fragments in sound and endodontically treated fractured teeth with or without fiber post placement. MATERIAL AND METHODS:Ninety human lower incisors were randomly divided into three groups of 30 teeth each...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2008.01.001
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:Systemic conditions may affect host susceptibility, disease progression and severity as well as treatment response. Previously, low oestrogen (E(2)) levels were associated with increased bone resorption, due to increased osteoclastogenesis and decreased osteoclast apoptosis. Osteoprotegerin (OPG) is an essen...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2012.01.013
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To compare near infrared transillumination device, DIAGNOcam (DC) and bitewing radiography (BW) for the detection of proximal caries. MATERIALS AND METHODS:This retrospective analysis of DC and BW images of 18 students in dental medicine who had consented to the anonymous use of their dental record. The data...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.12.008
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to evaluate the in vitro effectiveness of a new bioglass-containing and two commercial desensitising toothpastes on dentinal tubule occlusion after citric acid challenge or artificial saliva (AS) immersion. METHODS:One hundred dentin discs from human third molars were used. Spe...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2010.01.007
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:This study compared the antibacterial activities of two dentin bonding systems (ABF, Kuraray and Reactmer Bond, Shofu) by a conventional agar well technique and a newly designed in vitro test using tooth model. METHODS:In the agar well technique, the test materials were filled in the wells of Muller Hinton a...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(03)00006-x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:The aim of this in vivo study was to evaluate the effects of a home-bleaching agent on the color and surface properties of four tooth-colored restorative materials. METHODS:Two composite resins (a nano-hybrid and a packable), a polyacid-modified composite and a conventional glass-ionomer were tested. Specim...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2009.01.003
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the influence of different titanium zirconium (TiZr) alloy surfaces on primary human gingival fibroblasts (HGF) for improved soft tissue integration of dental implants. METHODS:TiZr polished, machined and machined+HCl/H2SO4 acid-etched surfaces were modified by cathodic...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2013.11.003
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To investigate differentially expressed salivary peptides in the development of early childhood caries (ECC) in 3-4 year-old children. MATERIALS AND METHODS:Eighty-two caries-free children at baseline were followed-up for 1year, during which period 15 of them had developed ECC (Group C), whilst another 15 c...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.04.006
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:This randomized controlled trial compared the survival of glass fibre and cast metal dental posts used to restore endodontically treated teeth with no remaining coronal wall. METHODS:Fifty-four participants (45 women) and 72 teeth were evaluated during a follow-up period of up to 3 years. Teeth were randomly...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2014.02.003
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Wear of dental hard tissues, e.g. dental erosion, is reported to be a growing problem. A non-destructive measurement of enamel layer thickness would provide the opportunity for both early diagnosis, and longitudinal measurement of progressive enamel loss. It was the aim of this study to investigate the poten...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/s0300-5712(99)00063-9
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:To integrate items from two widely used oral health-related quality of life (OHRQoL) questionnaires, the General Oral Health Assessment Index (GOHAI) and the Oral Impacts on Daily Performances (OIDP), as well as culturally-specific items of the Oral Health Impact Profile (OHIP) into a four-dimensional OHRQoL...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2016.06.006
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the effect of low-fluoride toothpastes with calcium glycerophosphate (CaGP) on enamel remineralization in situ. METHODS:Volunteers (n=10) wore palatal devices holding four bovine enamel blocks. The treatments involved 5 experimental phases of 3 days each according to the followi...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2014.09.001
更新日期:2014-12-01 00:00:00
abstract::Clinical experience suggests that severe alveolar bone resorption can limit the success of complete denture wearing. The loss of bone mineral with age occurs throughout the skeleton, which contributes to the high incidence of bone fractures later in life. Women are more commonly affected by some of these fractures. Th...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/0300-5712(89)90141-3
更新日期:1989-04-01 00:00:00
abstract::The Annual Conference of the British Association of Teachers of Conservative Dentistry (BATCD) was held in Sheffield on 16 and 17 September 1993. The main programme addressed educational issues in three areas: the undergraduate/vocational-trainee interface, the teaching of implants in the undergraduate curriculum, and...
journal_title:Journal of dentistry
pub_type:
doi:10.1016/0300-5712(94)90069-8
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES:To measure the tooth whitening effects delivered immediately after brushing with silica-based toothpastes containing blue covarine in vitro and in vivo. METHODS:Salivary pellicle coated human extracted teeth were brushed with either a slurry of a toothpaste containing blue covarine (BC), a formulation conta...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.10.014
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to investigate the corrosion resistance of the prototype iron-platinum (FePt) magnets and non-encapsulated neodymium-iron-boron (NdFeB) magnets in three different pH environments. METHODS:The corrosion resistance of the magnets was studied using a corrosion indicator, the bre...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2004.02.007
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:Mutans streptococci and Lactobacilli on impressions of teeth and caries tests were used to identify caries prone subjects. METHODS:Twenty-seven dental students were examined for caries initially and after 4 years. At the initial examination plaque index; saliva flow, buffering capacity and lysozyme; sucrose...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2008.07.004
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The aim of this in vivo study was to investigate the influence of age on optical properties of pure enamel and enamel-dentine complex. METHODS:A spectrophotometric study was performed on two different age groups: young (10-35 years old) and adult (36-60 years old). In both groups, the tooth's total area of t...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2013.09.005
更新日期:2013-12-01 00:00:00