Anemia, bilirubin, and cardiovascular autonomic neuropathy in patients with type 2 diabetes.

Abstract:

:To investigate the relationship among anemia, physiological serum bilirubin levels, and cardiovascular autonomic neuropathy (CAN) in subjects with type 2 diabetes. In total, 2230 subjects with type 2 diabetes were evaluated in this cross-sectional study. CAN was diagnosed with a cardiovascular reflex test. The prevalence of anemia was greater in subjects with CAN. In multivariable analysis, the relationship between anemia and CAN remained statistically significant after adjusting for the risk factors (odds ratio [OR] 1.39; 95% confidence interval [CI] 1.07-1.80, P = .015). Additional adjustment for serum bilirubin concentrations abolished this relationship (OR 1.20, 95% CI 0.91-1.58, P = .189). Anemia is positively associated with the prevalence of CAN in subjects with type 2 diabetes. In addition, our results suggest that the putative increased CAN risk associated with anemia might be mediated by a correlated decrease in serum bilirubin levels.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Chung JO,Park SY,Cho DH,Chung DJ,Chung MY

doi

10.1097/MD.0000000000006586

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

e6586

issue

15

eissn

0025-7974

issn

1536-5964

pii

00005792-201704140-00023

journal_volume

96

pub_type

杂志文章

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