Abstract:
:To investigate the relationship among anemia, physiological serum bilirubin levels, and cardiovascular autonomic neuropathy (CAN) in subjects with type 2 diabetes. In total, 2230 subjects with type 2 diabetes were evaluated in this cross-sectional study. CAN was diagnosed with a cardiovascular reflex test. The prevalence of anemia was greater in subjects with CAN. In multivariable analysis, the relationship between anemia and CAN remained statistically significant after adjusting for the risk factors (odds ratio [OR] 1.39; 95% confidence interval [CI] 1.07-1.80, P = .015). Additional adjustment for serum bilirubin concentrations abolished this relationship (OR 1.20, 95% CI 0.91-1.58, P = .189). Anemia is positively associated with the prevalence of CAN in subjects with type 2 diabetes. In addition, our results suggest that the putative increased CAN risk associated with anemia might be mediated by a correlated decrease in serum bilirubin levels.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Chung JO,Park SY,Cho DH,Chung DJ,Chung MYdoi
10.1097/MD.0000000000006586subject
Has Abstractpub_date
2017-04-01 00:00:00pages
e6586issue
15eissn
0025-7974issn
1536-5964pii
00005792-201704140-00023journal_volume
96pub_type
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