Abstract:
:Previous studies have reported that intraoperative dexmedetomidine has morphine-sparing effects in patient-controlled analgesia (PCA). The present study was designed to investigate the possible sex differences in the morphine-sparing effects of intraoperative dexmedetomidine following general anesthesia. A total of 223 patients scheduled for surgeries under general anesthesia were divided into female and male groups. Each group was then subdivided into 2 subgroups that were maintained using propofol/remifentanil/dexmedetomidine (PRD) or propofol/remifentanil/saline (PRS). During the first 24 hours postsurgery, both female and male PRD patients had lower scores on a visual analog scale (VAS) (fPRS vs fPRD, P < 0.05 or P < 0.01; mPRS mPRD, P < 0.05, P < 0.01, or P < 0.001) and consumed less morphine than their controls from the PRS group (fPRS vs fPRD, P = 0.0392; mPRS vs mPRD, P = 0.0041). Interestingly, the female PRD patients had similar VAS scores (fPRD vs mPRD, P > 0.05) and consumed comparable morphine compared to the male PRD patients (fPRD vs mPRD, P = 0.4238). However, when normalized to body weight, they consumed much more morphine than male PRD patients (fPRD vs mPRD, P < 0.001), and this effect was not seen in the PRS patients. Intraoperative administration of dexmedetomidine appeared to have a stronger morphine-sparing effect in controlling postoperative acute pain in male patients than in female patients.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li YY,Ge DJ,Li JY,Qi Bdoi
10.1097/MD.0000000000003619subject
Has Abstractpub_date
2016-05-01 00:00:00pages
e3619issue
18eissn
0025-7974issn
1536-5964pii
00005792-201605030-00065journal_volume
95pub_type
杂志文章,随机对照试验相关文献
MEDICINE文献大全abstract::Pigmentary mosaicism of the (hypomelanosis of) Ito type is an umbrella term, which includes phenotypes characterized by mosaic hypopigmentation in the form of streaks, whorls, patchy, or more bizarre skin configurations (running along the lines of Blaschko): these cutaneous patterns can manifest as an isolated skin di...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002705
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:Pulmonary blastoma is a rare primary lung cancer that can be categorized into adult type and child type. The clinical symptoms and imaging features of pulmonary blastoma are nonspecific, making it difficult to diagnose preoperatively. Postoperative pathology with immunohistochemical staining can help diagnosi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008918
更新日期:2017-12-01 00:00:00
abstract::To determine which polysomnography parameters are associated with severity of hypertension.This retrospective study collected data on all patients admitted to our urban, academic center in Beijing with hypertension who had undergone polysomnograms (PSG) and were diagnosed with obstructive sleep apnea (OSA) (apnea-hypo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005493
更新日期:2016-11-01 00:00:00
abstract::Mental and physical stress is thought to play an important causative factor in apical ballooning syndrome (ABS) likely secondary to the vasomotor dysfunction. However, there are currently few data related to the impact of physical stress in this unique cardiomyopathy.A total 18 patients, including 8 females with histo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013841
更新日期:2019-01-01 00:00:00
abstract::Several scoring systems are commonly used to evaluate severity in patients with traumatic injuries. However, there is no generally accepted standard scoring system to assess the severity of thoracic trauma, specifically in patients who have sustained severe injuries. The present study aimed to evaluate the validity of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008317
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Lung cancer is a leading cause of morbidity diseases worldwide, but the key mechanisms of lung cancer remain elusive. This study aims to integrate of GSE 118370 and GSE 32863 profile and identify the key genes and pathway involved in human lung adenocarcinoma. METHODS:R software (RStudio, Version info: R 3....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022727
更新日期:2020-10-23 00:00:00
abstract::It is important to estimate motor recovery in the early phase after stroke. Many studies have demonstrated that both diffusion tensor tractography (DTT) and motor-evoked potentials (MEP) are valuable predictors of motor recovery, but these modalities do not directly reflect the status of the injured gray matter. We re...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003838
更新日期:2016-06-01 00:00:00
abstract:RATIONALE:Chylothorax remains a poorly understood phenomenon, and no optimal treatment or guidelines have been established. This is the first report of treating congenital chylothorax and lymphedema in a low-birth-weight infant by lymphovenous anastomosis (LVA). PATIENT CONCERNS:We report a case of successful LVA for ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017575
更新日期:2019-10-01 00:00:00
abstract::Since body fatness is a convincing risk factor for endometrial cancer, dietary fat intake was speculated to be associated with endometrial cancer risk. However, epidemiological studies are inconclusive. We aimed to conduct a meta-analysis to assess the associations between dietary fat intake and endometrial cancer ris...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000004121
更新日期:2016-07-01 00:00:00
abstract::Patients with nonspecific complaints (NSC) presenting to the emergency department (ED) are at risk of life-threatening conditions. New stress biomarkers such as the midregional portion of adrenomedullin (MR-proADM) promise to support decision-making. This study tested the following hypotheses: biomarker-assisted dispo...
journal_title:Medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/MD.0000000000002395
更新日期:2016-01-01 00:00:00
abstract:ABSTRACT:This study aimed to examine whether marginal sinus placenta previa, defined as when the marginal sinus just reaches the internal cervical os and placental parenchyma might be >2 cm from the internal cervical os, can be diagnosed using ultrasonography (US). We identified the placenta previa cases that underwent...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000024253
更新日期:2021-01-08 00:00:00
abstract::Aberrant glycosylated IgA1 molecules, mainly galactose-deficient IgA1 (Gd-IgA1), are important causal factors in IgA nephropathy; however, the underlying mechanism for the production of aberrantly glycosylated IgA1 is unknown. A recent genome-wide association study identified a novel IgAN susceptibility gene, TNFSF13,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003099
更新日期:2016-03-01 00:00:00
abstract::Stereotactic body radiation therapy (SBRT) for inoperable hepatocellular carcinoma (HCC) offers excellent local control rates. This study retrospectively analyzed the influence of different tumor size on treatment outcomes after SBRT.Between December 2008 and February 2014, 141 HCC patients were treated with Cyberknif...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009249
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Albeit it is rare, the authors report a stage 3 Kummell disease case. It is diagnosed by dynamic thoracic magnetic resonance imaging (MRI). Because there is no established strategy on stage 3 Kummell disease, we performed percutaneous kyphoplasty at first, but unfortunately made a revision surgery to remove t...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000008895
更新日期:2017-11-01 00:00:00
abstract::The purpose of this study was to perform a meta-analysis on the efficacy of ibandronate by evaluating the effect sizes of different dosing regimens.Major electronic databases were searched from 1985 to February 2015. A random effects meta-analysis was performed in STATA.Data from 34 studies (13,639 patients) were incl...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001007
更新日期:2015-07-01 00:00:00
abstract::Pedunculated hepatocellular carcinoma (P-HCC) is rare type of HCC. The study aimed to evaluate the clinical features and outcomes of unresectable P-HCC treated with transcatheter arterial chemoembolization (TACE) and percutaneous chemotherapeutic agents lipiodol emulsion (CALE) injection. The clinical features and out...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007650
更新日期:2017-07-01 00:00:00
abstract::This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013206
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:B-type Raf kinase (BRAF) mutation is proved to be a critical predictive factor in papillary thyroid cancer (PTC) with aggressive characteristics. However, the association between BRAF mutation and cervical lymphatic metastasis in PTC is controversial. METHODS:We searched papers on the study of BRAF mutation...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018917
更新日期:2020-01-01 00:00:00
abstract::Curative treatments for very early-stage hepatocellular carcinoma (HCC), defined as single HCC with a maximum diameter of <2 cm in patients with well-preserved liver function, consist of surgical resection or radiofrequency ablation (RFA). In this retrospective study, we compared the efficacy of both treatments in 154...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016279
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with P...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000005541
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS. METHODS:Databases including PubMed, Embase, Web of Science, and C...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016948
更新日期:2019-08-01 00:00:00
abstract::Internet gaming disorder (IGD) contributes to poor quality of life (QOL) and cognitive dysfunction and is increasingly recognized as a social problem in various countries. However, no evidence exists to determine whether QOL and cognitive dysfunction stabilize after appropriate management. The present study addressed ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005695
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Shexiang Baoxin Pills (SBP) is widely used for the treatment of unstable angina pectoris (UAP) in China. However, the clinical evidence on the efficacy of SBP for the treatment of UAP is not well concluded. METHODS:Seven electronic databases will be searched for eligible studies: MEDLINE, EMBASE, The Cochra...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017119
更新日期:2019-09-01 00:00:00
abstract::The aim of this study was to evaluate the safety of acute normovolemic hemodilution (ANH) for patients undergoing intracranial meningioma resection.Eighty patients (aged 48-65 years) with American Society of Anesthesiologists physical status I-II undergoing intracranial meningioma resection were included in this prosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008093
更新日期:2017-09-01 00:00:00
abstract::In 23 adult women having uncomplicated recurrent urinary tract infections treated with 10 days of appropriate antibiotic for each infection, the following findings were noted. 1. The attack rate was 0.17 infections per month. 2. 94% of infections has associated symptoms. 3. 73% of symptomatic episodes had an associate...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Total hip arthroplasty (THA) for high congenital hip dislocation (CHD) is technically demanding. The purpose of this retrospective study was to evaluate the results of cementless THA combined with extended sliding trochanteric osteotomy. We also assessed whether chronic low back pain was relieved after surgery.The stu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006581
更新日期:2017-04-01 00:00:00
abstract::The purpose of this study is to evaluate the susceptibility trend of vancomycin, teicoplanin, daptomycin, and linezolid against methicillin-resistant Staphylococcus aureus (MRSA) blood isolates of different clones over an 11-year period.From 2000 to 2010, all bloodstream MRSA isolates from Chang Gung Memorial Hospital...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005060
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:This study will specifically investigate the effect of butylphthalide on hemodynamics in patients with watershed stroke (WS). METHODS:We will search the following databases from their inceptions to the March 1, 2020: Cochrane Library, MEDLINE, EMBASE, PsycINFO, Web of Science, Cumulative Index to Nursing an...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020151
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Chronic low back pain (CLBP) is a clinically common and recurrent disease. However, many trials have shown that auriculotherapy (AT) can effectively treat CLBP. There are currently no systematic reviews of this therapy. The plan aims to evaluate the effectiveness and safety of this treatment in patients with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019722
更新日期:2020-04-01 00:00:00
abstract::Uremic pruritus is common and bothersome in patients receiving either peritoneal dialysis (PD) or hemodialysis (HD). To date, the preferred dialysis modality regarding the alleviation of uremic pruritus remains controversial. We conducted this cross-sectional study to compare the prevalence, intensity, and characteris...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002935
更新日期:2016-03-01 00:00:00