当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.

CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis.

Abstract：

:CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients. Interestingly, CCR5 CRPA correlated inversely with CD4 counts and CD4:CD8 ratio specifically in viremic patients. In normal individuals, the CRPA correlated with the number of CCR5+ CD4+ T cells in the peripheral blood suggesting an effect on CCR5 expression. In a subset of high viremic patients harboring R5 tropic HIV, there was a strong correlation between CCR5 CRPA and both CD4 counts and CD4 T cell apoptosis. Our study demonstrates that, CCR5 promoter polymorphisms correlate with CD4 T cell loss possibly by regulating CD4 T cell apoptosis in HIV patients. Furthermore, assigning CRPAs to each patient is a new method of translating genotype to phenotype.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Joshi A,Punke EB,Sedano M,Beauchamp B,Patel R,Hossenlopp C,Alozie OK,Gupta J,Mukherjee D,Garg H

doi

10.1038/s41598-017-00192-x

subject

Has Abstract

pub_date

2017-03-22 00:00:00

pages

232

issue

1

issn

2045-2322

pii

10.1038/s41598-017-00192-x

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts.

    abstract：:Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32993

    authors： Hu L,Wang J,Zhou X,Xiong Z,Zhao J,Yu R,Huang F,Zhang H,Chen L

    更新日期：2016-09-12 00:00:00

  • Trophic isotopic carbon variation increases with pond's hydroperiod: Evidence from an Austral ephemeral ecosystem.

    abstract：:Trophic variation in food web structure occurs among and within ecosystems. The magnitude of variation, however, differs from system to system. In ephemeral pond ecosystems, temporal dynamics are relatively more important than in many systems given that hydroperiod is the ultimate factor determining the presence of an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08026-6

    authors： Dalu T,Wasserman RJ,Froneman PW,Weyl OLF

    更新日期：2017-08-08 00:00:00

  • Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice.

    abstract：:Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional chal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10380-4

    authors： Sato N,Sudo K,Mori M,Imai C,Muramatsu M,Sugimoto M

    更新日期：2017-08-29 00:00:00

  • Genome-wide high-throughput screening of interactive bacterial metabolite in the algal population using Escherichia coli K-12 Keio collection.

    abstract：:Algae-bacteria interaction is one of the main factors underlying the formation of harmful algal blooms (HABs). The aim of this study was to develop a genome-wide high-throughput screening method to identify HAB-influenced specific interactive bacterial metabolites using a comprehensive collection of gene-disrupted E. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67322-w

    authors： Heo J,Cho K,Kim U,Cho DH,Ko S,Tran QG,Lee YJ,Ryu CM,Kim HS

    更新日期：2020-06-30 00:00:00

  • Publisher Correction: A Fast and Refined Cancer Regions Segmentation Framework in Whole-slide Breast Pathological Images.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-65026-9

    authors： Guo Z,Liu H,Ni H,Wang X,Su M,Guo W,Wang K,Jiang T,Qian Y

    更新日期：2020-05-20 00:00:00

  • An eigenvalue transformation technique for predicting drug-target interaction.

    abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13867

    authors： Kuang Q,Xu X,Li R,Dong Y,Li Y,Huang Z,Li Y,Li M

    更新日期：2015-09-09 00:00:00

  • Differential expression of genes in olive leaves and buds of ON- versus OFF-crop trees.

    abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72895-7

    authors： Dastkar E,Soleimani A,Jafary H,de Dios Alche J,Bahari A,Zeinalabedini M,Salami SA

    更新日期：2020-09-25 00:00:00

  • miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas.

    abstract：:Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03972-7

    authors： Tseng JH,Bisogna M,Hoang LN,Olvera N,Rodriguez-Aguayo C,Lopez-Berestein G,Sood AK,Levine DA,Jelinic P

    更新日期：2017-06-15 00:00:00

  • Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats.

    abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30943-3

    authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

    更新日期：2018-08-17 00:00:00

  • Interaction of Glycolipids with the Macrophage Surface Receptor Mincle - a Systematic Molecular Dynamics Study.

    abstract：:Synthetic analogues of mycobacterial trehalose-dimycolate such as trehalose acyl esters have been proposed as novel adjuvants for vaccination. They induce an immune response by binding to the macrophage C-type lectin receptor Mincle. The binding site of trehalose is known, but there is yet only very limited structural...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23624-8

    authors： Söldner CA,Horn AHC,Sticht H

    更新日期：2018-03-29 00:00:00

  • A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys.

    abstract：:Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after ma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45097

    authors： Dai P,Huang H,Zhang L,He J,Zhao X,Yang F,Zhao N,Yang J,Ge L,Lin Y,Yu H,Wang J

    更新日期：2017-03-30 00:00:00

  • Gene expression data support the hypothesis that Isoetes rootlets are true roots and not modified leaves.

    abstract：:Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78171-y

    authors： Hetherington AJ,Emms DM,Kelly S,Dolan L

    更新日期：2020-12-09 00:00:00

  • Emergent complex network geometry.

    abstract：:Networks are mathematical structures that are universally used to describe a large variety of complex systems such as the brain or the Internet. Characterizing the geometrical properties of these networks has become increasingly relevant for routing problems, inference and data mining. In real growing networks, topolo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10073

    authors： Wu Z,Menichetti G,Rahmede C,Bianconi G

    更新日期：2015-05-18 00:00:00

  • System-specific periodicity in quantitative real-time polymerase chain reaction data questions threshold-based quantitation.

    abstract：:Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38951

    authors： Spiess AN,Rödiger S,Burdukiewicz M,Volksdorf T,Tellinghuisen J

    更新日期：2016-12-13 00:00:00

  • Disease control efficacy of 32,33-didehydroroflamycoin produced by Streptomyces rectiviolaceus strain DY46 against gray mold of tomato fruit.

    abstract：:Despite the efficacy of synthetic fungicides in controlling postharvest diseases, public concerns regarding chemical residues in food and an increase in drug-resistant strains of pathogens have led to a need for new agents to control postharvest diseases. The current study was performed to find control agents of micro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49779-6

    authors： Kim JD,Park MY,Jeon BJ,Kim BS

    更新日期：2019-09-19 00:00:00

  • Physical and mechanical properties of wood and their geographic variations in Larix sibirica trees naturally grown in Mongolia.

    abstract：:We examined the physical and mechanical properties of wood in Siberian larch (Larix sibirica) trees that grow naturally in five Mongolian provenances (Khentii, Arkhangai, Zavkhan, Khuvsgul, and Selenge) and the geographic variations between them. Five trees with stem diameters of 20 to 30 cm at 1.3 m above ground were...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69781-7

    authors： Tumenjargal B,Ishiguri F,Aiso H,Takahashi Y,Nezu I,Takashima Y,Baasan B,Chultem G,Ohshima J,Yokota S

    更新日期：2020-07-31 00:00:00

  • Audio motor training improves mobility and spatial cognition in visually impaired children.

    abstract：:Since it has been demonstrated that spatial cognition can be affected in visually impaired children, training strategies that exploit the plasticity of the human brain should be early adopted. Here we developed and tested a new training protocol based on the reinforcement of audio-motor associations and thus supportin...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-019-39981-x

    authors： Cappagli G,Finocchietti S,Cocchi E,Giammari G,Zumiani R,Cuppone AV,Baud-Bovy G,Gori M

    更新日期：2019-03-01 00:00:00

  • The effect of anxiety on brain activation patterns in response to inspiratory occlusions: an fMRI study.

    abstract：:Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. Ho...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51396-2

    authors： Chan PS,Wu YT,Hsu AL,Li CW,Wu CW,von Leupoldt A,Hsu SC

    更新日期：2019-10-21 00:00:00

  • Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.

    abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37051-2

    authors： Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

    更新日期：2019-01-24 00:00:00

  • Direct evidence of milk consumption from ancient human dental calculus.

    abstract：:Milk is a major food of global economic importance, and its consumption is regarded as a classic example of gene-culture evolution. Humans have exploited animal milk as a food resource for at least 8500 years, but the origins, spread, and scale of dairying remain poorly understood. Indirect lines of evidence, such as ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07104

    authors： Warinner C,Hendy J,Speller C,Cappellini E,Fischer R,Trachsel C,Arneborg J,Lynnerup N,Craig OE,Swallow DM,Fotakis A,Christensen RJ,Olsen JV,Liebert A,Montalva N,Fiddyment S,Charlton S,Mackie M,Canci A,Bouwman A,Rüh

    更新日期：2014-11-27 00:00:00

  • Investigation of Electric Field Induced Mixing in Silicon Micro Ring Resonators.

    abstract：:In this paper we present a detailed theoretical investigation of the electric field induced mixing effect, in which the up and down frequency-conversion processes are obtained by inducing an effective second order susceptibility via the periodic spatial distribution of reversed biased p-i-n junctions. The possibility ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03485-3

    authors： De Leonardis F,Soref RA,Passaro VMN

    更新日期：2017-06-13 00:00:00

  • Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models.

    abstract：:Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67514-4

    authors： Nono JK,Fu K,Mpotje T,Varrone G,Aziz NA,Mosala P,Hlaka L,Kamdem SD,Xu D,Spangenberg T,Brombacher F

    更新日期：2020-06-30 00:00:00

  • Retrospective Study of Hemodynamic Changes Before and After Carotid Stenosis Formation by Vessel Surface Repairing.

    abstract：:Prospective observation of hemodynamic changes before and after the formation of atherosclerotic stenosis in the carotid artery is difficult. Thus, a vessel surface repairing method was used for retrospective hemodynamic study before and after atherosclerotic stenosis formation in carotid artery. The three-dimensional...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23842-0

    authors： Li X,Sun B,Zhao H,Ge X,Liang F,Li X,Xu J,Liu X

    更新日期：2018-04-03 00:00:00

  • Stainless steel bipolar plate coated with polyaniline/Zn-Porphyrin composites coatings for proton exchange membrane fuel cell.

    abstract：:The proton exchange membrane fuel cells are the promising sustainable energy sources. The present study focuses on the enhancement the fuel cell performance and the protection of the stainless steel bipolar plate from the corrosion using polyaniline/Zn-Porphyrin composites coatings. The electrochemical properties (pol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60288-9

    authors： Deyab MA,Mele G

    更新日期：2020-02-24 00:00:00

  • Antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable polysaccharides by Dictyophora indusiata.

    abstract：:Hyperlipidemia, a very common disease throughout the world, usually gives rise to severe liver damages. The current experiment was to investigate the antihyperlipidemic and hepatoprotective properties of alkali- and enzyme-extractable Dictyophora indusiata polysaccharides (Al-DPS and En-DPS) on the hyperlipidemic mice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50717-9

    authors： Wang W,Liu H,Zhang Y,Feng Y,Yuan F,Song X,Gao Z,Zhang J,Song Z,Jia L

    更新日期：2019-10-03 00:00:00

  • Enhancing the durable performance of LiMn2O4 at high-rate and elevated temperature by nickel-magnesium dual doping.

    abstract：:Various nickel and magnesium dual-doped LiNixMg0.08Mn1.92-xO4 (x ≤ 0.15) were synthesized via a modified solid-state combustion method. All as-prepared samples show typical spinel phase with a well-defined polyhedron morphology. The Ni-Mg dual-doping obviously decreases the lattice parameter that gives rise to the lat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53494-7

    authors： Yu Y,Guo J,Xiang M,Su C,Liu X,Bai H,Bai W,Duan K

    更新日期：2019-11-14 00:00:00

  • Segregation of age-related skin microbiome characteristics by functionality.

    abstract：:Although physiological changes are the most evident indicators of skin aging by alteration of the skin's structure and function, we question whether skin aging is also affected by the structure and assembly process of the skin microbiome. We analysed the skin microbiomes of 73 healthy Chinese women in two age groups (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53266-3

    authors： Kim HJ,Kim JJ,Myeong NR,Kim T,Kim D,An S,Kim H,Park T,Jang SI,Yeon JH,Kwack I,Sul WJ

    更新日期：2019-11-14 00:00:00

  • Maternal stress or sleep during pregnancy are not reflected on telomere length of newborns.

    abstract：:Telomeres play an important role in maintaining chromosomal integrity. With each cell division, telomeres are shortened and leukocyte telomere length (LTL) has therefore been considered a marker for biological age. LTL is associated with various lifetime stressors and health-related outcomes. Transgenerational effects...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71000-2

    authors： Ämmälä AJ,Vitikainen EIK,Hovatta I,Paavonen J,Saarenpää-Heikkilä O,Kylliäinen A,Pölkki P,Porkka-Heiskanen T,Paunio T

    更新日期：2020-08-19 00:00:00

  • Dike intrusions during rifting episodes obey scaling relationships similar to earthquakes.

    abstract：:As continental rifts evolve towards mid-ocean ridges, strain is accommodated by repeated episodes of faulting and magmatism. Discrete rifting episodes have been observed along two subaerial divergent plate boundaries, the Krafla segment of the Northern Volcanic Rift Zone in Iceland and the Manda-Hararo segment of the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03886

    authors： Passarelli L,Rivalta E,Shuler A

    更新日期：2014-01-28 00:00:00

  • Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC.

    abstract：:Streptococcus pneumoniae (S. pneumoniae) is a leading human pathogen, which takes large responsibility for severe otitis media, acute meningitis and septicaemia. It encodes up to three distinct sialidases: NanA, NanB and NanC, which are promising drug targets. Recent experimental studies have shown that these three si...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-38131-z

    authors： Xiao K,Wang X,Yu H

    更新日期：2019-02-15 00:00:00