当前位置： SCI文献检索 > NEUROIMAGE期刊下所有文献 > Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses.

Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses.

Abstract：

:Successful behavior depends on the ability to detect and respond to relevant cues, especially under challenging conditions. This essential component of attention has been hypothesized to be mediated by multiple neuromodulator systems, but the contributions of individual systems (e.g., cholinergic, dopaminergic) have remained unclear. The present study addresses this issue by leveraging individual variation in regionally-specific cholinergic denervation in Parkinson's disease (PD) patients, while controlling for variation in dopaminergic denervation. Patients whose dopaminergic and cholinergic nerve terminal integrity had been previously assessed using Positron Emission Tomography (Bohnen et al., 2012) and controls were tested in a signal detection task that manipulates attentional-perceptual challenge and has been used extensively in both rodents and humans to investigate the cholinergic system's role in responding to such challenges (Demeter et al., 2008; McGaughy and Sarter, 1995; see Hasselmo and Sarter 2011 for review). In simple correlation analyses, measures of midbrain dopaminergic, and both cortical and thalamic cholinergic innervation all predicted preserved signal detection under challenge. However, regression analyses also controlling for age, disease severity, and other variables showed that the only significant independent neurotransmitter-related predictor over and above the other variables in the model was thalamic cholinergic integrity. Furthermore, thalamic cholinergic innervation exclusively predicted hits, not correct rejections, indicating a specific contribution to bottom-up salience processing. These results help define regionally-specific contributions of cholinergic function to different aspects of attention and behavior.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Kim K,Müller MLTM,Bohnen NI,Sarter M,Lustig C

doi

10.1016/j.neuroimage.2017.02.006

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

295-304

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(17)30110-6

journal_volume

149

pub_type

杂志文章

相关文献

NEUROIMAGE文献大全
  • Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment.

    abstract：:Recent research has shown an increased rate of conversion to dementia in subjects with mild cognitive impairment (MCI) compared to controls. However, there are no specific methods to predict who will later develop dementia. In the present study, 22 controls and 56 MCI subjects were followed on average for 37 months (m...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.06.016

    authors： Hämäläinen A,Tervo S,Grau-Olivares M,Niskanen E,Pennanen C,Huuskonen J,Kivipelto M,Hänninen T,Tapiola M,Vanhanen M,Hallikainen M,Helkala EL,Nissinen A,Vanninen R,Soininen H

    更新日期：2007-10-01 00:00:00

  • Phonological manipulation between speech perception and production activates a parieto-frontal circuit.

    abstract：:Repetition has been shown to activate the so-called 'dorsal stream', a network of temporo-parieto-frontal areas subserving the mapping of acoustic speech input onto articulatory-motor representations. Among these areas, a region in the posterior Sylvian fissure at the temporo-parietal boundary (also called 'area Spt')...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.07.025

    authors： Peschke C,Ziegler W,Eisenberger J,Baumgaertner A

    更新日期：2012-01-02 00:00:00

  • Reproducibility of importance extraction methods in neural network based fMRI classification.

    abstract：:Recent advances in machine learning allow faster training, improved performance and increased interpretability of classification techniques. Consequently, their application in neuroscience is rapidly increasing. While classification approaches have proved useful in functional magnetic resonance imaging (fMRI) studies,...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2018.06.076

    authors： Gotsopoulos A,Saarimäki H,Glerean E,Jääskeläinen IP,Sams M,Nummenmaa L,Lampinen J

    更新日期：2018-11-01 00:00:00

  • Evidence for similar patterns of neural activity elicited by picture- and word-based representations of natural scenes.

    abstract：:A long-standing core question in cognitive science is whether different modalities and representation types (pictures, words, sounds, etc.) access a common store of semantic information. Although different input types have been shown to activate a shared network of brain regions, this does not necessitate that there i...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.03.037

    authors： Kumar M,Federmeier KD,Fei-Fei L,Beck DM

    更新日期：2017-07-15 00:00:00

  • Reducing power line noise in EEG and MEG data via spectrum interpolation.

    abstract：:Electroencephalographic (EEG) and magnetoencephalographic (MEG) signals can often be exposed to strong power line interference at 50 or 60 Hz. A widely used method to remove line noise is the notch filter, but it comes with the risk of potentially severe signal distortions. Among other approaches, the Discrete Fourier...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.01.026

    authors： Leske S,Dalal SS

    更新日期：2019-04-01 00:00:00

  • Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry study.

    abstract：:Traumatic brain injury (TBI) is one of the most common causes of long-term disability. Despite the importance of identifying neuropathology in individuals with chronic TBI, methodological challenges posed at the stage of inter-subject image registration have hampered previous voxel-based MRI studies from providing a c...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.10.005

    authors： Kim J,Avants B,Patel S,Whyte J,Coslett BH,Pluta J,Detre JA,Gee JC

    更新日期：2008-02-01 00:00:00

  • Sliding window correlation analysis: Modulating window shape for dynamic brain connectivity in resting state.

    abstract：:The sliding window correlation (SWC) analysis is a straightforward and common approach for evaluating dynamic functional connectivity. Despite the fact that sliding window analyses have been long used, there are still considerable technical issues associated with the approach. A great effort has recently been dedicate...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.02.001

    authors： Mokhtari F,Akhlaghi MI,Simpson SL,Wu G,Laurienti PJ

    更新日期：2019-04-01 00:00:00

  • Subthalamic nucleus activity dissociates proactive and reactive inhibition in patients with Parkinson's disease.

    abstract：:Models of action selection postulate the critical involvement of the subthalamic nucleus (STN), especially in reactive inhibition processes when inappropriate responses to a sudden stimulus must be overridden. The STN could also play a key role during proactive inhibition, when subjects prepare to potentially suppress...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.10.070

    authors： Benis D,David O,Lachaux JP,Seigneuret E,Krack P,Fraix V,Chabardès S,Bastin J

    更新日期：2014-05-01 00:00:00

  • Detecting white matter activity using conventional 3 Tesla fMRI: An evaluation of standard field strength and hemodynamic response function.

    abstract：:Detection of functional magnetic resonance imaging (fMRI) activation in white matter has been increasingly reported despite historically being controversial. Much of the development work to-date has used high-field 4 T MRI and specialized pulse sequences. In the current study, we utilized conventional 3 T MRI and a co...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.12.008

    authors： Courtemanche MJ,Sparrey CJ,Song X,MacKay A,D'Arcy RCN

    更新日期：2018-04-01 00:00:00

  • Functional MRI with variable echo time acquisition.

    abstract：:A new functional MRI protocol that integrates variable echo time (TE) acquisition and a block-design paradigm is proposed and evaluated with finger-tapping motor task. Simulations and experimental data show that the blood oxygenation level-dependent (BOLD) sensitivity achieved with this approach is comparable to that ...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2003.08.013

    authors： Chen NK,Egorova S,Guttmann CR,Panych LP

    更新日期：2003-12-01 00:00:00

  • Patient classification as an outlier detection problem: an application of the One-Class Support Vector Machine.

    abstract：:Pattern recognition approaches, such as the Support Vector Machine (SVM), have been successfully used to classify groups of individuals based on their patterns of brain activity or structure. However these approaches focus on finding group differences and are not applicable to situations where one is interested in acc...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2011.06.042

    authors： Mourão-Miranda J,Hardoon DR,Hahn T,Marquand AF,Williams SC,Shawe-Taylor J,Brammer M

    更新日期：2011-10-01 00:00:00

  • The effect of switching between sequential and repetitive movements on cortical activation.

    abstract：:We used whole-head functional magnetic resonance imaging (fMRI) to investigate the effect of switching between different sequential and repetitive movements in the context of conditional and fixed tasks. Four different movement tasks were applied: (1) unpredictable switching between two movement sequences comprising s...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1006/nimg.2000.0626

    authors： Jäncke L,Himmelbach M,Shah NJ,Zilles K

    更新日期：2000-11-01 00:00:00

  • Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants.

    abstract：:Positive affect elicited in a mother toward her newborn infant may be one of the most powerful and evolutionarily preserved forms of positive affect in the emotional landscape of human behavior. This study examined the neurobiology of this form of positive emotion and in so doing, sought to overcome the difficulty of ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2003.10.005

    authors： Nitschke JB,Nelson EE,Rusch BD,Fox AS,Oakes TR,Davidson RJ

    更新日期：2004-02-01 00:00:00

  • Neural correlates of experimentally induced flow experiences.

    abstract：:Flow refers to a positive, activity-associated, subjective experience under conditions of a perceived fit between skills and task demands. Using functional magnetic resonance perfusion imaging, we investigated the neural correlates of flow in a sample of 27 human subjects. Experimentally, in the flow condition partici...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2013.08.019

    authors： Ulrich M,Keller J,Hoenig K,Waller C,Grön G

    更新日期：2014-02-01 00:00:00

  • Mapping the orientation of intravoxel crossing fibers based on the phase information of diffusion circular spectrum.

    abstract：:A new method is presented to map the orientation of intravoxel crossing fibers by using the phase of the diffusion circular spectrum harmonics. In a previous study [Zhan, W., Gu, H., Xu, S., Silbersweig, D.A., Stern, E., Yang, Y., 2003. Circular spectrum mapping for intravoxel fiber structures based on high angular re...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2004.07.062

    authors： Zhan W,Stein EA,Yang Y

    更新日期：2004-12-01 00:00:00

  • Connectome-based predictive modeling of attention: Comparing different functional connectivity features and prediction methods across datasets.

    abstract：:Connectome-based predictive modeling (CPM; Finn et al., 2015; Shen et al., 2017) was recently developed to predict individual differences in traits and behaviors, including fluid intelligence (Finn et al., 2015) and sustained attention (Rosenberg et al., 2016a), from functional brain connectivity (FC) measured with fM...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2017.11.010

    authors： Yoo K,Rosenberg MD,Hsu WT,Zhang S,Li CR,Scheinost D,Constable RT,Chun MM

    更新日期：2018-02-15 00:00:00

  • Combined MEG and EEG show reliable patterns of electromagnetic brain activity during natural viewing.

    abstract：:Naturalistic stimuli such as movies are increasingly used to engage cognitive and emotional processes during fMRI of brain hemodynamic activity. However, movies have been little utilized during magnetoencephalography (MEG) and EEG that directly measure population-level neuronal activity at a millisecond resolution. He...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.03.066

    authors： Chang WT,Jääskeläinen IP,Belliveau JW,Huang S,Hung AY,Rossi S,Ahveninen J

    更新日期：2015-07-01 00:00:00

  • Limited microstructural and connectivity deficits despite subcortical volume reductions in school-aged children born preterm with very low birth weight.

    abstract：:Preterm birth and very low birth weight (VLBW, ≤1500 g) are worldwide problems that burden survivors with lifelong cognitive, psychological, and physical challenges. In this multimodal structural magnetic resonance imaging (MRI) and diffusion MRI (dMRI) study, we investigated differences in subcortical brain volumes a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.12.029

    authors： Sølsnes AE,Sripada K,Yendiki A,Bjuland KJ,Østgård HF,Aanes S,Grunewaldt KH,Løhaugen GC,Eikenes L,Håberg AK,Rimol LM,Skranes J

    更新日期：2016-04-15 00:00:00

  • Group differences in MEG-ICA derived resting state networks: Application to major depressive disorder.

    abstract：UNLABELLED:Functional magnetic resonance imaging (fMRI) studies have revealed the existence of robust, interconnected brain networks exhibiting correlated low frequency fluctuations during rest, which can be derived by examining inherent spatio-temporal patterns in functional scans independent of any a priori model. In...

    journal_title：NeuroImage

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neuroimage.2015.05.051

    authors： Nugent AC,Robinson SE,Coppola R,Furey ML,Zarate CA Jr

    更新日期：2015-09-01 00:00:00

  • Towards a fronto-temporal neural network for the decoding of angry vocal expressions.

    abstract：:Vocal expressions commonly elicit activity in superior temporal and inferior frontal cortices, indicating a distributed network to decode vocally expressed emotions. We examined the involvement of this fronto-temporal network for the decoding of angry voices during attention towards (explicit attention) or away from e...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2012.06.015

    authors： Frühholz S,Grandjean D

    更新日期：2012-09-01 00:00:00

  • Using a white matter reference to remove the dependency of global signal on experimental conditions in SPECT analyses.

    abstract：:Proportional scaling models are often used in functional imaging studies to remove confounding of local signals by global effects. It is generally assumed that global effects are uncorrelated with experimental conditions. However, when the global effect is estimated by the global signal, defined as the intracerebral a...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.03.025

    authors： Spence JS,Carmack PS,Gunst RF,Schucany WR,Woodward WA,Haley RW

    更新日期：2006-08-01 00:00:00

  • The relationship between BOLD and neural activity arises from temporally sparse events.

    abstract：:Resting state functional magnetic resonance (rs-fMRI) imaging offers insights into how different brain regions are connected into functional networks. It was recently shown that networks that are almost identical to the ones created from conventional correlation analysis can be obtained from a subset of high-amplitude...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2019.116390

    authors： Zhang X,Pan WJ,Keilholz SD

    更新日期：2020-02-15 00:00:00

  • Meta-analytic clustering of the insular cortex: characterizing the meta-analytic connectivity of the insula when involved in active tasks.

    abstract：:The human insula has been parcellated on the basis of resting state functional connectivity and diffusion tensor imaging. Little is known about the organization of the insula when involved in active tasks. We explored this issue using a novel meta-analytic clustering approach. We queried the BrainMap database asking f...

    journal_title：NeuroImage

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.neuroimage.2012.04.012

    authors： Cauda F,Costa T,Torta DM,Sacco K,D'Agata F,Duca S,Geminiani G,Fox PT,Vercelli A

    更新日期：2012-08-01 00:00:00

  • Mood-dependent integration in discourse comprehension: happy and sad moods affect consistency processing via different brain networks.

    abstract：:According to recent research on language comprehension, the semantic features of a text are not the only determinants of whether incoming information is understood as consistent. Listeners' pre-existing affective states play a crucial role as well. The current fMRI experiment examines the effects of happy and sad mood...

    journal_title：NeuroImage

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroimage.2014.09.008

    authors： Egidi G,Caramazza A

    更新日期：2014-12-01 00:00:00

  • Functional organization of human subgenual cortical areas: Relationship between architectonical segregation and connectional heterogeneity.

    abstract：:Human subgenual anterior cingulate cortex (sACC) is involved in affective experiences and fear processing. Functional neuroimaging studies view it as a homogeneous cortical entity. However, sACC comprises several distinct cyto- and receptorarchitectonical areas: 25, s24, s32, and the ventral portion of area 33. Thus, ...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.04.053

    authors： Palomero-Gallagher N,Eickhoff SB,Hoffstaedter F,Schleicher A,Mohlberg H,Vogt BA,Amunts K,Zilles K

    更新日期：2015-07-15 00:00:00

  • Adaptive behaviour and feedback processing integrate experience and instruction in reinforcement learning.

    abstract：:In any non-deterministic environment, unexpected events can indicate true changes in the world (and require behavioural adaptation) or reflect chance occurrence (and must be discounted). Adaptive behaviour requires distinguishing these possibilities. We investigated how humans achieve this by integrating high-level in...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.08.057

    authors： Schiffer AM,Siletti K,Waszak F,Yeung N

    更新日期：2017-02-01 00:00:00

  • Bilateral spatial filtering: refining methods for localizing brain activation in the presence of parenchymal abnormalities.

    abstract：:Functional MRI (fMRI) is an important tool for pre-surgical localization of eloquent cortex prior to resection of brain lesions. To increase the inherently low activation signal to noise ratio, fMRI pre-processing steps often include spatial smoothing. However, the effects of smoothing in the presence of brain lesions...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2006.06.051

    authors： Walker SA,Miller D,Tanabe J

    更新日期：2006-11-01 00:00:00

  • Reducing the unwanted draining vein BOLD contribution in fMRI with statistical post-processing methods.

    abstract：:Recent BOLD fMRI data analysis methods show promise in reducing contributions from draining veins. The phase regressor method developed by [Menon, R.S., 2002. Post-acquisition suppression of large-vessel BOLD signals in high-resolution fMRI. Magn. Reson. Med., 47, 1-9] creates phase and magnitude images, regresses mag...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2007.03.075

    authors： Nencka AS,Rowe DB

    更新日期：2007-08-01 00:00:00

  • Effects of magnetization transfer on T1 contrast in human brain white matter.

    abstract：:MRI based on T1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T1 relaxation rates is difficult due to the complexity of the con...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2015.12.032

    authors： van Gelderen P,Jiang X,Duyn JH

    更新日期：2016-03-01 00:00:00

  • People matter: Perceived sender identity modulates cerebral processing of socio-emotional language feedback.

    abstract：:How do human brains integrate content with social context in communication? Recent research demonstrates that the perceived communicative embedding of perceptually identical language messages alters their cortical processing. When emotional trait-adjectives are perceived as human-generated personality feedback, event-...

    journal_title：NeuroImage

    pub_type： 杂志文章

    doi：10.1016/j.neuroimage.2016.03.052

    authors： Schindler S,Kissler J

    更新日期：2016-07-01 00:00:00