Dynamic population pharmacokinetic-pharmacodynamic modelling and simulation supports similar efficacy in glycosylated haemoglobin response with once or twice-daily dosing of canagliflozin.

abstract：:Twelve healthy habitual cigarette smokers and eight non-smokers participated in a double-blind placebo controlled study to determine the effect of smoking on the pharmacokinetics and pharmacodynamics of the H2-receptor antagonist famotidine. In smokers, cigarette smoking was standardised and started 1 h before (A), or...

journal_title：British journal of clinical pharmacology

authors： Baak LC,Ganesh S,Jansen JB,Lamers CB

更新日期：1992-02-01 00:00:00

abstract：:1 Herbal preparations containing atropine-like alkaloids are marketed as proprietory asthma remedies, typically in the form of cigarettes. 2 This randomised, cross-over study compares in six healthy volunteers the pharmacological effects caused by smoking a standard, medium tar, tobacco cigarette or a herbal cigarette...

journal_title：British journal of clinical pharmacology

authors： Elliott HL,Reid JL

更新日期：1980-11-01 00:00:00

abstract：AIMS:To examine how pharmaceutical products that were first marketed between 1950 and 1980 were promoted to physicians through advertisements and briefly review advertising regulations and accuracy of the advertisements in the light of modern knowledge. METHODS:We systematically reviewed advertisements promoting drugs...

journal_title：British journal of clinical pharmacology

authors： Green AR,Haddad PM,Aronson JK

更新日期：2018-08-01 00:00:00

abstract：:The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphi...

journal_title：British journal of clinical pharmacology

authors： Choonara I,Lawrence A,Michalkiewicz A,Bowhay A,Ratcliffe J

更新日期：1992-11-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:1. Oral micronized progesterone (P) is proposed for the treatment of certain endocrine gynaecological disorders. To examine the effects of P on performance and mood, a randomized, placebo-controlled study of 24 healthy females ages 18-24 years on low-dose oral contraceptives was conducted. 2. Subjects were admitted to...

journal_title：British journal of clinical pharmacology

authors： Freeman EW,Weinstock L,Rickels K,Sondheimer SJ,Coutifaris C

更新日期：1992-03-01 00:00:00

abstract：AIM:Lamivudine is used as first line therapy in HIV-infected children. Yet, like many other paediatric drugs, its dose rationale has been based on limited clinical data, without thorough understanding of the effects of growth on drug disposition. Here we use lamivudine to show how a comprehensive population pharmacokin...

journal_title：British journal of clinical pharmacology

authors： Piana C,Zhao W,Adkison K,Burger D,Jacqz-Aigrain E,Danhof M,Della Pasqua O

更新日期：2014-05-01 00:00:00

abstract：AIMS:We performed a prospective cohort study to gain more insight into risk factors for neuropsychiatric effects of mefloquine among tourists travelling to tropical areas. METHODS:We enrolled all patients who consulted the Travel Clinic of the Havenziekenhuis & Institute for Tropical Diseases Rotterdam for mefloquine ...

journal_title：British journal of clinical pharmacology

authors： van Riemsdijk MM,Sturkenboom MC,Ditters JM,Tulen JH,Ligthelm RJ,Overbosch D,Stricker BH

更新日期：2004-04-01 00:00:00

abstract：AIMS:The purposes of this work were to: (1) compare pharmacokinetic (PK) parameters for hydroxycarbamide in children receiving their first dose (HCnew ) vs. those receiving chronic therapy (HCchronic ), (2) assess the external validity of a published PK dosing strategy, and (3) explore the accuracy of dosing strategies...

journal_title：British journal of clinical pharmacology

authors： Estepp JH,Wiczling P,Moen J,Kang G,Mack JM,Liem R,Panepinto JA,Garg U,Kearns G,Neville KA

更新日期：2018-07-01 00:00:00

abstract：AIMS:The aim of this analysis was to develop a population pharmacokinetic model for Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) following subcutaneous administration to healthy postmenopausal women and to infertile patients undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS:...

journal_title：British journal of clinical pharmacology

authors： Goggin T,Nguyen QT,Munafo A

更新日期：2004-05-01 00:00:00

abstract：:1 Cumulative dose-response curves (FEV1) to pressurized aerosol salbutamol were established in 17 patients admitted to hospital with acute severe asthma. After the maximal pressurized aerosol effect had been achieved, a further dose (5 mg) of salbutamol was given by wet nebulizer and any further increment recorded. 2 ...

journal_title：British journal of clinical pharmacology

authors： Tarala RA,Madsen BW,Paterson JW

更新日期：1980-10-01 00:00:00

abstract：:1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

journal_title：British journal of clinical pharmacology

authors： Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

更新日期：1974-06-01 00:00:00

abstract：:Children are not small adults. However, the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often, it is assumed that drug effects differ in children but in reality this perception often arises because the drugs have no...

journal_title：British journal of clinical pharmacology

authors： Stephenson T

更新日期：2005-06-01 00:00:00

abstract：:1. A survey has been conducted amongst 459 members of the Clinical Section of the British Pharmacological Society to ascertain facts about the administration of drugs to healthy volunteers over the period October 1986 to September 1987. 2. A response rate of 87.1% was obtained with 114 individuals being involved in he...

journal_title：British journal of clinical pharmacology

authors： Orme M,Harry J,Routledge P,Hobson S

更新日期：1989-02-01 00:00:00

abstract：AIMS:To compare the lung delivery of salbutamol from a commonly used constant output open vent jet nebuliser (Sidestream) with use of both a conventional large volume plastic spacer (Volumatic) and a novel small volume metal spacer (NebuChamber). This was assessed using the early lung absorption profile of salbutamol o...

journal_title：British journal of clinical pharmacology

authors： Lipworth BJ,Clark DJ

更新日期：1998-02-01 00:00:00

abstract：:1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months tr...

journal_title：British journal of clinical pharmacology

authors： Carlson LA,Ribacke M,Terent A

更新日期：1987-01-01 00:00:00

abstract：:1 An in vitro investigation showed that pivampicillin tablets disintegrated more rapidly than pivampicillin capsules. This result was demonstrated and confirmed by gastroscopy in a cross-over study in healthy volunteers. 2 There were no differences in serum levels of ampicillin obtained with the two preparations, but ...

journal_title：British journal of clinical pharmacology

authors： Hey H,Matzen P,Andersen JT,Didriksen E,Nielsen B

更新日期：1979-09-01 00:00:00

abstract：:The kinetics of a single 0.5 mg oral dose of the triazolobenzodiazepine hypnotic triazolam, were studied in 54 healthy young men aged 20-44 years, with a mean body weight of 77 kg. Triazolam kinetics were determined from multiple plasma concentrations measured during 14 h post-dose. The overall mean +/- s.e. mean (wit...

journal_title：British journal of clinical pharmacology

authors： Friedman H,Greenblatt DJ,Burstein ES,Harmatz JS,Shader RI

更新日期：1986-12-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a haematopoietic stem cell disorder, that is characterized by the clonal expansion of myeloid blasts and suppression of normal haematopoiesis. The 3 + 7 regimen is the backbone of standard first-line induction therapy among young/fit patients. However, in elderly and/or unfit patients ...

journal_title：British journal of clinical pharmacology

authors： Kucukyurt S,Eskazan AE

更新日期：2019-12-01 00:00:00

abstract：:1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectr...

journal_title：British journal of clinical pharmacology

authors： Martinez JG,Murakami SI,Scheinberg MA

更新日期：1986-01-01 00:00:00

abstract：:We have traced the historical link between the Law of Mass Action and clinical pharmacology. The Law evolved from the work of the French chemist Claude Louis Berthollet, was first formulated by Cato Guldberg and Peter Waage in 1864 and later clarified by the Dutch chemist Jacobus van 't Hoff in 1877. It has profoundly...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Aronson JK

更新日期：2016-01-01 00:00:00

abstract：:1. We present a novel index for expressing the exposure of the infant to drugs in breast milk, which unifies two independent factors: a pharmacokinetic parameter, drug clearance, and a physiochemical parameter, i.e. milk-to-maternal plasma drug concentration ratio (M/P ratio). 2. During breast-feeding by a woman recei...

journal_title：British journal of clinical pharmacology

authors： Ito S,Koren G

更新日期：1994-08-01 00:00:00

abstract：:1. The in vitro metabolism of omeprazole was studied in human liver microsomes in order to define the secondary metabolic pathways and identify the cytochrome P450 (CYP) isoforms responsible for the formation of the secondary metabolites of omeprazole. 2. The major secondary omeprazole metabolite was the hydroxysulpho...

journal_title：British journal of clinical pharmacology

authors： Andersson T,Miners JO,Veronese ME,Birkett DJ

更新日期：1994-06-01 00:00:00

abstract：:After many years of basic research we have now begun to learn how to manipulate the serotonergic mechanisms within the gut. This has lead to a number of significant advances including 5HT3 antagonists for the treatment of functional diarrhoea, 5HT4 agonists for the treatment of constipation and 5HT1 agonists for the t...

journal_title：British journal of clinical pharmacology

authors： Spiller R

更新日期：2002-07-01 00:00:00

abstract：AIMS:To explore inter- and intra-volunteer variability for the dose of intravenous tyramine eliciting a 20 mmHg increase in systolic blood pressure from baseline (TYR20) and to evaluate potential tachyphylaxis. METHODS:Twelve healthy volunteers received blinded placebo-controlled ascending and descending sequences of ...

journal_title：British journal of clinical pharmacology

authors： Cantarini MV,Watkins CL,Growcott J,Hughes AM

更新日期：2004-05-01 00:00:00

abstract：AIMS:Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on parameters of glucoregulation. We sought to investigate whether these a...

journal_title：British journal of clinical pharmacology

authors： van Doorn M,Kemme M,Ouwens M,van Hoogdalem EJ,Jones R,Romijn H,de Kam M,Schoemaker R,Burggraaf K,Cohen A

更新日期：2006-10-01 00:00:00

abstract：:The burgeoning problem of malaria in the developing world and the relentless march of drug resistance demand that we continue to seek new chemotherapeutic strategies. Given the enormous expense of developing and marketing new chemical entities, we often rely on an increased understanding of the pharmacology of older d...

journal_title：British journal of clinical pharmacology

authors： Edwards G,Biagini GA

更新日期：2006-06-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：:1 The anticholinergic effects of atropine and two antihistamines (terfenadine and mequitazine) were investigated vs placebo in a double-blind study. 2 Salivary secretion, basal pupil diameter, pilocarpine (0.25%) induced miosis and heart rate were determined in eight healthy volunteers, seven male and one female, aged...

journal_title：British journal of clinical pharmacology

authors： Brion N,Beaumont D,Advenier C

更新日期：1988-01-01 00:00:00

abstract：:1. The population pharmacokinetics of lisinopril were investigated using data collected from two multicentre trials of lisinopril in the treatment of hypertension in elderly patients (n = 40) and patients with renal disease (n = 20). 2. Lisinopril was started at doses of 2.5-5 mg daily and increased at 2-4 weekly inte...

journal_title：British journal of clinical pharmacology

authors： Thomson AH,Kelly JG,Whiting B

更新日期：1989-01-01 00:00:00