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Protective effects of agmatine on doxorubicin-induced chronic cardiotoxicity in rat.

Abstract：

:The detrimental cardio-toxic effect of doxorubicin, an effective chemotherapeutic agent, limited its clinical use. It has been claimed that doxorubicin cardio-toxicity occurs through calcium ions (Ca2+) overload and reactive oxygen species production. Agmatine, an endogenous imidazoline receptor agonist, induce uptake of cytosolic Ca2+ and cause an increase in activity of calcium pumps, including Ca2+-ATPase. Also it shows self-scavenging effect against reactive oxygen species production. Therefore, present study was designed to investigate the effects of agmatine against chronic cardio-toxicity of doxorubicin in rats. Male wistar rats were intraperitoneally injected with doxorubicin and agmatine four times a week for a month. Agmatine significantly alleviate the adverse effect of doxorubicin on left ventricular papillary muscle stimulation threshold and contractibility. Chronic co-administration of agmatine with doxorubicin blocked electrocardiographic changes induced by doxorubicin. In addition, agmatine improved body weight and decreased the mortality rate of animals by doxorubicin. Moreover, reversing the doxorubicin induced myocardial lesions was observed in animals treated by agmatine. A significant rise in the total antioxidant capacity of rat plasma was achieved in agmatine-treated animals in comparison to doxorubicin. To conclude, agmatine may improve therapeutic outcomes of doxorubicin since it exerts protective effects against doxorubicin-induced chronic cardiotoxicity in rats.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Yarmohmmadi F,Rahimi N,Faghir-Ghanesefat H,Javadian N,Abdollahi A,Pasalar P,Jazayeri F,Ejtemaeemehr S,Dehpour AR

doi

10.1016/j.ejphar.2016.12.022

subject

Has Abstract

pub_date

2017-02-05 00:00:00

pages

39-44

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(16)30790-7

journal_volume

796

pub_type

杂志文章

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