Abstract:
:We describe LincSNP 2.0 (http://bioinfo.hrbmu.edu.cn/LincSNP), an updated database that is used specifically to store and annotate disease-associated single nucleotide polymorphisms (SNPs) in human long non-coding RNAs (lncRNAs) and their transcription factor binding sites (TFBSs). In LincSNP 2.0, we have updated the database with more data and several new features, including (i) expanding disease-associated SNPs in human lncRNAs; (ii) identifying disease-associated SNPs in lncRNA TFBSs; (iii) updating LD-SNPs from the 1000 Genomes Project; and (iv) collecting more experimentally supported SNP-lncRNA-disease associations. Furthermore, we developed three flexible online tools to retrieve and analyze the data. Linc-Mart is a convenient way for users to customize their own data. Linc-Browse is a tool for all data visualization. Linc-Score predicts the associations between lncRNA and disease. In addition, we provided users a newly designed, user-friendly interface to search and download all the data in LincSNP 2.0 and we also provided an interface to submit novel data into the database. LincSNP 2.0 is a continually updated database and will serve as an important resource for investigating the functions and mechanisms of lncRNAs in human diseases.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Ning S,Yue M,Wang P,Liu Y,Zhi H,Zhang Y,Zhang J,Gao Y,Guo M,Zhou D,Li X,Li Xdoi
10.1093/nar/gkw945subject
Has Abstractpub_date
2017-01-04 00:00:00pages
D74-D78issue
D1eissn
0305-1048issn
1362-4962pii
gkw945journal_volume
45pub_type
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