Structure of the 70S ribosome from human pathogen Staphylococcus aureus.

Abstract:

:Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Khusainov I,Vicens Q,Bochler A,Grosse F,Myasnikov A,Ménétret JF,Chicher J,Marzi S,Romby P,Yusupova G,Yusupov M,Hashem Y

doi

10.1093/nar/gkw933

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

10491-10504

issue

21

eissn

0305-1048

issn

1362-4962

pii

gkw933

journal_volume

44

pub_type

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