Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio).

Abstract:

:The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition.

journal_name

Anim Cogn

journal_title

Animal cognition

authors

Pinheiro-da-Silva J,Silva PF,Nogueira MB,Luchiari AC

doi

10.1007/s10071-016-1034-x

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

159-169

issue

2

eissn

1435-9448

issn

1435-9456

pii

10.1007/s10071-016-1034-x

journal_volume

20

pub_type

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