Abstract:
BACKGROUND:Proton pump inhibitors are usually safe, although serious adverse effects can occur. We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration. METHODS:A 45-year-old Korean male visited our emergency room because of persistent lower chest discomfort that started 10 hours before. He had been diagnosed with diabetes and coronary heart disease, but discontinued oral hypoglycemic agents 1 month earlier. He continued to take medications for coronary heart disease. There was no abnormality on an electrocardiogram or in cardiac enzymes. Initial laboratory findings did not show abnormalities for muscle enzymes. Esomeprozole 40 mg was administrated intravenously for the control of his ambiguous chest discomfort. Then, 12 hours later, he complained of abrupt severe right buttock pain. An area of tender muscle swelling 8 cm in diameter was seen on his right buttock area. Creatine kinase and lactate dehydrogenase were elevated to 40,538 and 1326 U/L, respectively. A bone scan using 20 mCi of Tc-hydroxymethylene diphosphonate was compatible with rhabdomyolysis. RESULTS:His muscular symptoms, signs, and laboratory findings improved markedly with conservative management, including hydration and urine alkalinization. He is being followed in the outpatient department with no evidence of recurrence. CONCLUSION:We should keep in mind that single-dose intravenous administration of esomeprazole can induce rhabdomyolysis.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Jeon DH,Kim Y,Kim MJ,Cho HS,Bae EJ,Chang SH,Park DJdoi
10.1097/MD.0000000000004313subject
Has Abstractpub_date
2016-07-01 00:00:00pages
e4313issue
29eissn
0025-7974issn
1536-5964pii
00005792-201607190-00050journal_volume
95pub_type
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