Late-Onset Immune Thrombocytopenic Purpura After Withdrawal of Interferon Treatment for Chronic Hepatitis C Infection: A Case Report.


:Immune thrombocytopenic purpura (ITP) is a life-threatening complication following pegylated interferon alpha (PEG-IFN) plus ribavirin treatment, the standard treatment for hepatitis C virus (HCV) infection. We reported a rare case with late-onset ITP after withdrawal of PEG-IFN treatment.A 53-year-old male with hepatitis C developed massive gum bleeding and a severe, reversible, immune thrombocytopenia 2 weeks after cessation of PEG-IFN treatment for HCV due to anemia and depression. The platelet count decreased to 4000 cells/μL. The HCV viral load was undetectable at the end of PEG-IFN treatment and during follow-up for 5 months. Other potential autoimmune disorders were ruled out. Late-onset ITP associated with PEG-IFN treatment was diagnosed.The patient was treated successfully with steroid and azathioprine. Platelet count gradually increased to 117 × 10 cells/μL on the 18th day after admission.ITP is a rare complication in patients with hepatitis C or in patients who received PEG-IFN treatment. The particular case supported that it may occur even after withdrawal of PEG-IFN treatment. Physicians should be aware of this late-onset complication.


Medicine (Baltimore)




Hsiao CH,Tseng KC,Tseng CW,Tung CH




Has Abstract


2015-08-01 00:00:00
















  • A comparison of bone mineral densities and body composition between Southeast Asia college students and Chinese college students.

    abstract::The aim of this study was to compare bone mineral densities (BMDs) and body composition between Southeast Asia college students and Chinese college students, in order to provide a certain reference enhancing college students' physical fitness.A total of 1694 Chinese college students (294 men and 1400 women, aged 18-22...


    pub_type: 杂志文章


    authors: Liu P,Ye Z,Lu J,Lu H,Guan L,Teng Z,Gao S,Li M

    更新日期:2016-09-01 00:00:00

  • Machine learning methods for automatic pain assessment using facial expression information: Protocol for a systematic review and meta-analysis.

    abstract:INTRODUCTION:Prediction of pain using machine learning algorithms is an emerging field in both computer science and clinical medicine. Several machine algorithms were developed and validated in recent years. However, the majority of studies in this topic was published on bioinformatics or computer science journals inst...


    pub_type: 杂志文章,meta分析


    authors: Liu D,Cheng D,Houle TT,Chen L,Zhang W,Deng H

    更新日期:2018-12-01 00:00:00

  • The Tai Chi training for middle-aged and elderly patients with knee osteoarthritis: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:Knee osteoarthritis (KOA) is a disabling joint disease with an increasingly prevalence among the older individuals. Tai Chi, one of the ancient meditative movements, has been recognized to have clinical benefits for KOA. We aim to evaluate the efficacy and safety of Tai Chi for patients with KOA through this...


    pub_type: 杂志文章


    authors: Ren R,Tang G,Tang C,Zhang J,Xiao X,Zhang Q

    更新日期:2020-05-01 00:00:00

  • Approach to diagnosis of factitious disorder with unexplained hemoptysis: A case report.

    abstract:RATIONALE:Hemoptysis or hematemesis is a common clinical symptom in adults, but is unusually to be observed in children. Hemoptysis can occur with circulatory diseases, injuries, several types of systemic diseases, or systemic factors including factitious disorder (FD), which is difficult to be diagnosed. Here, we repo...


    pub_type: 杂志文章


    authors: Yue P,Zhou K,Hua Y,Fang J,Li Y

    更新日期:2019-02-01 00:00:00

  • MicroRNA-206 predicts raised fetal growth retardation risk through the interaction with vascular endothelial growth factor in pregnancies.

    abstract::This study aimed to investigate the correlation of microRNA (miR)-206, vascular endothelial growth factor (VEGF) and miR-206/VEGF axis at different gestational ages with fetal growth retardation (FGR) risk in pregnancies.Eight hundred twenty pregnancies were consecutively recruited and their plasma samples were collec...


    pub_type: 杂志文章


    authors: Li Y,Liu J

    更新日期:2020-02-01 00:00:00

  • Cystic intraductal papillary neoplasms with infiltrating carcinoma of the intrahepatic bile duct: A case report.

    abstract:INTRODUCTION:Intraductal papillary neoplasms of the bile duct (IPNB) is a kind of rare disorder with low incidence but high misdiagnosis due to untypical symptoms and non-specific laboratory indicators. Herein, we report a case of cystic type IPNB with infiltrating carcinoma of the intrahepatic bile duct presented as a...


    pub_type: 杂志文章


    authors: Ma Z,Zhao F,Pan J,Lin G,Chen B,Fu W

    更新日期:2020-01-01 00:00:00

  • Correlation of fatigue with other disease related and psychosocial factors in patients with rheumatoid arthritis treated with tocilizumab: ACT-AXIS study.

    abstract::To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to s...


    pub_type: 杂志文章,多中心研究


    authors: Corominas H,Alegre C,Narváez J,Fernández-Cid CM,Torrente-Segarra V,Gómez MR,Pan FM,Morlà RM,Martínez FJR,Gómez-Centeno A,Ares LL,Molina RG,González-Albo SP,Dalmau-Carolà J,Pérez-García C,Álvarez CB,Ercole L,Terrancle MÁ

    更新日期:2019-06-01 00:00:00

  • Diurnal variations in blood flow at optic nerve head and choroid in healthy eyes: diurnal variations in blood flow.

    abstract::To investigate the diurnal variations of the ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine the relationship of the diurnal variations between the ocular blood flow and other ocular parameters.This prospective cross-sectional study was conducted at Nagoya University Hospital....


    pub_type: 杂志文章


    authors: Iwase T,Yamamoto K,Ra E,Murotani K,Matsui S,Terasaki H

    更新日期:2015-02-01 00:00:00

  • Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report.

    abstract:RATIONALE:Bariatric surgery is the recommended treatment for morbid obesity because of its rapid and sustained body weight loss effect. Nutrient deficiency-related neurological complications after bariatric surgery are often disabling. Thus, early recognition of these complications is important. Neurological complicati...


    pub_type: 杂志文章


    authors: Chang HW,Yang PY,Han TI,Meng NH

    更新日期:2019-03-01 00:00:00

  • Comparison of neuroendoscopic surgery and craniotomy for supratentorial hypertensive intracerebral hemorrhage: A meta-analysis.

    abstract:BACKGROUND:In recent years, neuroendoscopy has been used as a method for treating intracerebral hemorrhages (ICHs). However, the efficacy and safety of neuroendoscopic surgery is still controversial compared with that of craniotomy. Our aim was to compare the outcomes of neuroendoscopic surgery and craniotomy in patien...


    pub_type: 杂志文章,meta分析


    authors: Ye Z,Ai X,Hu X,Fang F,You C

    更新日期:2017-09-01 00:00:00

  • CXC motif chemokine receptor 4 gene polymorphism and cancer risk.

    abstract:BACKGROUND:Previous epidemiological studies have reported the relationship between CXC motif chemokine receptor 4 (CXCR4) synonymous polymorphism (rs2228014), and risk of cancer, but the results remained conflicting and controversial. Therefore, this study was devised to evaluate the genetic effects of the rs2228014 po...


    pub_type: 杂志文章,meta分析,评审


    authors: Wu Y,Zhang C,Xu W,Zhang J,Zheng Y,Lu Z,Liu D,Jiang K

    更新日期:2016-12-01 00:00:00

  • Takotsubo syndrome triggered by change in position in a patient with thoracic vertebral fracture: A case report.

    abstract:RATIONALE:Takotsubo syndrome (TTS) is characterized by recovery of wall motion abnormalities and acute left ventricular dysfunction, which are often caused by acute physical or emotional stressors. It is rarely reported that TTS can be precipitated by change in position in the patient in the operating room. We report a...


    pub_type: 杂志文章


    authors: Zhang Z,Kong H,Zhang SY,Guan TT

    更新日期:2021-01-15 00:00:00

  • Genetic association between cluster of differentiation 86 variations and sepsis risk: A case-control study.

    abstract::The aim of this study was to investigate the correlation between cluster of differentiation 86 (CD86) gene rs1129055 and rs2715267 single nucleotide polymorphisms and sepsis susceptibility.One hundred twenty-five sepsis patients and 120 healthy controls were enrolled in this case-control study. CD86 polymorphisms rs11...


    pub_type: 杂志文章


    authors: Zou X,Cai J,Li B,Wu S

    更新日期:2019-10-01 00:00:00

  • Complications associated with Brucella melitensis infection: a study of 530 cases.

    abstract::We carried out a prospective study of 530 patients older than 14 years of age with brucellosis. We describe the incidence and clinical features of the focal forms of the disease, analyzing some of the possible factors associated with their appearance. One hundred sixty-nine patients (31.9%) had a focal form or complic...


    pub_type: 杂志文章


    authors: Colmenero JD,Reguera JM,Martos F,Sánchez-De-Mora D,Delgado M,Causse M,Martín-Farfán A,Juárez C

    更新日期:1996-07-01 00:00:00

  • Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes.

    abstract::Intrahepatic cholestasis of pregnancy (ICP) increases adverse perinatal outcome (APO) incidence. Whether successful treatment of severe ICP reduces APO risk is unclear.This retrospective, single-center study in China enrolled consecutive women with ICP who had term delivery (≥37 weeks, singleton) between August 2013 a...


    pub_type: 杂志文章


    authors: Yang J,Chen C,Liu M,Zhang S

    更新日期:2019-07-01 00:00:00

  • Bilateral stellate ganglion block for migraine: A case report.

    abstract:RATIONALE:Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine...


    pub_type: 杂志文章


    authors: Moon S,Lee J,Jeon Y

    更新日期:2020-05-01 00:00:00

  • Spleen stiffness and volume help to predict posthepatectomy liver failure in patients with hepatocellular carcinoma.

    abstract::Posthepatectomy liver failure (PHLF) is the main cause of perioperative death, and liver cirrhosis is one of the most important risk factors for PHLF. Spleen stiffness (SS) is a novel ultrasonic indicator for liver cirrhosis and portal hypertension, however, it is not clear that whether it has a significant influence ...


    pub_type: 杂志文章


    authors: Peng W,Zhang XY,Li C,Wen TF,Yan LN,Yang JY

    更新日期:2019-05-01 00:00:00

  • Superb microvascular imaging evaluating joint lesion scores in rheumatoid arthritis compared with power Doppler imaging: A meta-analysis.

    abstract:BACKGROUND:To compare superb microvascular imaging with power Doppler imaging for evaluating joint lesion scores in rheumatoid arthritis based on high quality clinical cohort or case control studies. METHODS:We searched Medline (via PubMed), Web of Science, Cochrane Library, Embase, and Chinese Biomedical Literature D...


    pub_type: 杂志文章,meta分析


    authors: Lin M,Wang C

    更新日期:2020-09-11 00:00:00

  • Impact of a systematic evaluation of connective tissue disease on diagnosis approach in patients with interstitial lung diseases.

    abstract::To date, there is no clear agreement regarding which is the best method to detect a connective tissue disease (CTD) during the initial diagnosis of interstitial lung diseases (ILD). The aim of our study was to explore the impact of a systematic diagnostic strategy to detect CTD-associated ILD (CTD-ILD) in clinical pra...


    pub_type: 杂志文章


    authors: Hernandez-Gonzalez F,Prieto-González S,Brito-Zeron P,Cuerpo S,Sanchez M,Ramirez J,Agustí C,Lucena CM,Paradela M,Grafia I,Espinosa G,Sellares J

    更新日期:2020-01-01 00:00:00

  • Influence of early extensive posterior decompression on hyponatremia and cardiopulmonary dysfunction after severe traumatic cervical spinal cord injury: A clinical observational study.

    abstract::Retrospective single institution observational study.The aim of the present study was to analyze the influence of early extensive posterior decompression on complications in patients with severe traumatic cervical spinal cord injury (tcSCI).Cervical SCI is associated with a high prevalence of hyponatremia and cardiopu...


    pub_type: 杂志文章


    authors: Yang C,Wang G,Xu S,Li G,Wang Q

    更新日期:2020-07-17 00:00:00

  • Body mass index is a practical preoperative nutritional index for postoperative infectious complications after intestinal resection in patients with Crohn's disease.

    abstract::The patients with Crohn's disease (CD) are often accompanied with nutritional deficiencies. Compared with other intestinal benign disease, patients with CD have the higher risk of developing postoperative complications following intestinal resection. The aim of this study was to investigate the risk factors for postop...


    pub_type: 杂志文章


    authors: Zhu Y,Zhou W,Qi W,Liu W,Chen M,Zhu H,Xiang J,Xie Q,Chen P

    更新日期:2017-06-01 00:00:00

  • Drug dependence in patients with chronic pain: A retrospective study.

    abstract::Drug dependence, which can exist concurrently with chronic pain, is seen as one of the major causes of rapidly increasing medical expenses. However, drug dependence in patients with chronic pain has not been evaluated. The aim of this study was to identify the risk factors for drug dependence in patients with chronic ...


    pub_type: 杂志文章


    authors: Tetsunaga T,Tetsunaga T,Nishida K,Kanzaki H,Misawa H,Takigawa T,Shiozaki Y,Ozaki T

    更新日期:2018-10-01 00:00:00

  • Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature.

    abstract::Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentat...


    pub_type: 杂志文章


    authors: Bardwick PA,Zvaifler NJ,Gill GN,Newman D,Greenway GD,Resnick DL

    更新日期:1980-07-01 00:00:00

  • Excision of sebaceous cyst by intraoral approach: A case report.

    abstract:RATIONALE:Surgical removal of a sebaceous cyst is usually accomplished through an external incision, which inevitably results in a scar. Herein, we described an intraoral approach for excising sebaceous cysts located in the lip or cheek near lip commissure, to avoid a skin scar. PATIENT CONCERNS:Removal of the cyst bu...


    pub_type: 杂志文章


    authors: Chen B,Lu H,Ren C,Ma L,Hu X,Qi H,Gao Z

    更新日期:2017-12-01 00:00:00

  • Diagnosis of hereditary diffuse leukoencephalopathy with neuroaxonal spheroids based on next-generation sequencing in a family: Case report and literature review.

    abstract:RATIONALE:Hereditary diffuse leukoencephalopathy with neuroaxonal spheroids (HDLS) is a rare disease with white matter lesions of the central nervous system, and it usually has autosomal dominant inheritance. Its pathogenesis and causes are complex, and it has obvious clinical and genetic heterogeneities; also, it is c...


    pub_type: 杂志文章,评审


    authors: Shi T,Li J,Tan C,Chen J

    更新日期:2019-05-01 00:00:00

  • Risk factors for death in children with critical and severe hand-foot-and-mouth disease in Chongqing, China: An observational study.

    abstract::Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China.We perfo...


    pub_type: 杂志文章


    authors: Zheng G,Cao J,Yu J,Zhang Z,Liu Q,Chen J

    更新日期:2017-12-01 00:00:00

  • Down syndrome with primary thyroid diffuse large B-cell lymphoma and Hashimoto thyroiditis: A CARE compliant case report.

    abstract:RATIONALE:Adult patients with Down syndrome (DS) commonly develop Hashimoto thyroiditis (HT). However, primary diffuse large B-cell lymphoma (DLBCL) of the thyroid is uncommon, and its simultaneous occurrence with HT is very rare. To our knowledge, coexisting DLBCL and HT in a patient with DS has not been reported in t...


    pub_type: 杂志文章


    authors: Wei L,Zhao N,Li Y,Zheng X,Zhang H,Zhang Z

    更新日期:2019-08-01 00:00:00

  • The myocardial protective effect of monosodium phosphate cardioplegia in cardiopulmonary bypass in infants with an atrial septal defect.

    abstract::This study aimed to investigate the myocardial protective effect of liquid sodium phosphocreatine cardiac arrest in extracorporeal circulation surgery treating infants with atrial septal defects.Eighty-four infants with atrial septal defects who required extracorporeal circulation surgery treatment at our hospital fro...


    pub_type: 杂志文章


    authors: Yang F,Wang J,Zhai B

    更新日期:2020-07-10 00:00:00

  • Infective Endocarditis and Cancer Risk: A Population-Based Cohort Study.

    abstract::This study investigated the possible relationship between endocarditis and overall and individual cancer risk among study participants in Taiwan.We used data from the National Health Insurance program of Taiwan to conduct a population-based, observational, and retrospective cohort study. The case group consisted of 14...


    pub_type: 杂志文章


    authors: Sun LM,Wu JN,Lin CL,Day JD,Liang JA,Liou LR,Kao CH

    更新日期:2016-03-01 00:00:00

  • Early severe coronary heart disease and ischemic heart failure in homozygous familial hypercholesterolemia: A case report.

    abstract:RATIONALE:Familial hypercholesterolemia (FH) is a common inherited cause of coronary heart disease (CHD) and premature death in an early age. Nevertheless, an ischemic heart failure (IHF) associated with FH seems to be rare, and an early diagnosis and therapy could influence the prognosis. PATIENT CONCERNS:In this 13-...


    pub_type: 杂志文章


    authors: Kuang H,Zhou X,Li L,Yi Q,Shou W,Lu T

    更新日期:2018-10-01 00:00:00