Abstract:
:Immune thrombocytopenic purpura (ITP) is a life-threatening complication following pegylated interferon alpha (PEG-IFN) plus ribavirin treatment, the standard treatment for hepatitis C virus (HCV) infection. We reported a rare case with late-onset ITP after withdrawal of PEG-IFN treatment.A 53-year-old male with hepatitis C developed massive gum bleeding and a severe, reversible, immune thrombocytopenia 2 weeks after cessation of PEG-IFN treatment for HCV due to anemia and depression. The platelet count decreased to 4000 cells/μL. The HCV viral load was undetectable at the end of PEG-IFN treatment and during follow-up for 5 months. Other potential autoimmune disorders were ruled out. Late-onset ITP associated with PEG-IFN treatment was diagnosed.The patient was treated successfully with steroid and azathioprine. Platelet count gradually increased to 117 × 10 cells/μL on the 18th day after admission.ITP is a rare complication in patients with hepatitis C or in patients who received PEG-IFN treatment. The particular case supported that it may occur even after withdrawal of PEG-IFN treatment. Physicians should be aware of this late-onset complication.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Hsiao CH,Tseng KC,Tseng CW,Tung CHdoi
10.1097/MD.0000000000001296subject
Has Abstractpub_date
2015-08-01 00:00:00pages
e1296issue
34eissn
0025-7974issn
1536-5964pii
00005792-201508040-00007journal_volume
94pub_type
杂志文章相关文献
MEDICINE文献大全abstract:INTRODUCTION:Echinococcosis, also called hydatid disease, is a common parasitic infection of the liver. However, echinococcus lesions rarely involve the heart, especially in children. PATIENT CONCERNS:An 8-year-old child from grazing areas of northwest China was referred to our hospital for the complaint of inpersiste...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015267
更新日期:2019-04-01 00:00:00
abstract::End-stage renal disease (ESRD) is the final stage of chronic kidney disease in which the kidney is not sufficient to meet the needs of daily life. It is necessary to understand the role of genes expression involved in ESRD patient responses to nocturnal hemodialysis (NHD) and to improve the immunity responsiveness. Th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012018
更新日期:2018-09-01 00:00:00
abstract::Right ventricular pacing often results in prolonged QRS duration (QRSd) as the result of right ventricular stimulation, and atrial fibrillation (AF) may result. The association of pacing-induced prolonged QRSd and AF in patients with permanent pacemakers is unknown.We selected 180 consecutive patients who underwent pa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009839
更新日期:2018-02-01 00:00:00
abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199401000-00003
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Femoral nerve block (FNB) is considered the preferred analgesia after anterior cruciate ligament reconstruction (ACLR), but leads to weakness in the quadriceps muscles. Adductor canal block (ACB) is a new sensory block technique that effectively relieves postoperative pain while preserving quadriceps strengt...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020776
更新日期:2020-07-10 00:00:00
abstract:BACKGROUND:Health education during pregnancy is important to improve maternal and children outcomes. However, the strategies must be specifically designed for each context and demographic characteristics. Our objective was identify health education strategies targeting pregnant women with the intention of improving res...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000016174
更新日期:2019-06-01 00:00:00
abstract:RATIONALE:Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. CAE is often associated with the presence of slow coronary flow and may lead to acute myocardial infarction (AMI), even without total occlusion. PATIENT CONCERNS AND DIAGNOSIS:We report a case of a 24-year-old ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005976
更新日期:2017-01-01 00:00:00
abstract::Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoantibodies (autoAbs)...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005225
更新日期:2016-11-01 00:00:00
abstract:RATIONALE:Vascular complications of transradial percutaneous coronary intervention (PCI) are rare and usually occur at the access site below the elbow. However, vessels along the tract of the wire or catheter can be injured at any point, causing various types of bleeding complications. PATIENT CONCERNS:A 57-year-old m...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021205
更新日期:2020-07-10 00:00:00
abstract:BACKGROUND:Unstable angina (UA) is a clinically common coronary heart disease. Zhishi xiebai guizhi decoction (ZXGD) has been widely used in the management of UA, although its effective evidence is not clear and there is no systematic review regarding its efficacy and safety. Therefore, we conduct this systematic revie...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000013965
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:B-type Raf kinase (BRAF) mutation is proved to be a critical predictive factor in papillary thyroid cancer (PTC) with aggressive characteristics. However, the association between BRAF mutation and cervical lymphatic metastasis in PTC is controversial. METHODS:We searched papers on the study of BRAF mutation...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018917
更新日期:2020-01-01 00:00:00
abstract::Echocardiography and cardiac biomarkers, such as cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) are useful tools to evaluate cardiac dysfunction. Left ventricular systolic dysfunction (LVSD) is common in pediatric severe sepsis. The aim of this study is to evaluate the prognostic ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015070
更新日期:2019-03-01 00:00:00
abstract::Previous series presented the timing between embolization and surgery in a wide range on the basis of their experience rather than supportive data. And comparative studies were limited to small samples. In addition, there is no study publishing the timing by considering both safety and efficacy of embolization. The ai...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010912
更新日期:2018-06-01 00:00:00
abstract:UNLABELLED:Cisplatin (CDDP) plus radiotherapy (RT) has been used to treat advanced laryngeal squamous cell carcinoma (LSCC) patients. Single nucleotide polymorphisms (SNPs) may be responsible for differences in chemo/radiosensitivity and side effects in those patients. We reported an advanced LSCC patient, who obtained...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000578
更新日期:2015-04-01 00:00:00
abstract:RATIONALE:Developmental dysplasia of the hip (DDH) has an incidence of 5 per 1000 newborns and its management depends on various factors. We present a rare case of DDH with soft tissue obliteration and a bony prominence in the center of the acetabulum after failed open reduction and acetabuloplasty. PATIENT CONCERNS:A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018655
更新日期:2020-01-01 00:00:00
abstract::There is paucity of data on the impact of surgical incision and analgesia on relevant outcomes.A retrospective STROBE-compliant cohort study was performed between July 2007 and August 2017 of patients undergoing lung transplantation. Gender, age, indication for lung transplantation, and the 3 types of surgical access ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022427
更新日期:2020-11-13 00:00:00
abstract::Catheter-related bladder discomfort (CRBD) is a distressing symptom complex after surgery, especially in male patients who have had urinary catheterization under general anesthesia. In this prospective, randomized, controlled trial, we compared dorsal penile nerve block (DPNB) with 0.33% ropivacaine with intravenous t...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000003409
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Scapulohumeral periarthritis is a disease that seriously affects human daily work and life, and greatly reduces peoples quality of life and affects human health all over the world. Now, many studies have shown that acupuncture and rehabilitation have a significant effect on scapulohumeral periarthritis. In t...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023085
更新日期:2020-12-18 00:00:00
abstract::Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases.This is a cross-sectional study. From June through August 200...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001814
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Creatine kinase (CK) values are a critical part of the workup of suspected myopathies and are often assessed in patients that develop myalgia on statin therapy. CK elevations may influence the initiation and cessation of statin treatment, and incidentally discovered CK elevation may lead to further testing. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004344
更新日期:2016-08-01 00:00:00
abstract::Complex distal intra-articular radial fractures (AO Type C3) are rare, but are life-changing injuries. They are usually related to high-velocity trauma mechanisms in a working male population.We surveyed a cohort of these fractures treated in our institution to assess the functional long-term outcome.Twelve consecutiv...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003509
更新日期:2016-05-01 00:00:00
abstract::In the past 20 years, posturography has been widely used in the medical field. This observational study aimed to report the values derived from posturography of a wide set of healthy subjects from various European countries using a plantar pressure platform and a standardized method of measurement.A random cluster sam...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013835
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Perimenopausal insomnia (PI) is one of the most common complaints in women. Acupuncture is used to treat PI increasingly considering its less side effect. The subject of this study is to explore the effectiveness and safety of acupuncture for PI. METHODS:All the randomized controlled trials(RCT) literatures...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000011083
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:This study aimed to estimate the direct medical costs of managing chronic hepatitis C (CHC) and its complications based on health-care resources in South Korea. METHODS:The study design was multicenter, retrospective, non-interventional, and observational. Between September 2013 and April 2014, health-care ...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000003896
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS:Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) r...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004868
更新日期:2016-10-01 00:00:00
abstract::Factors associated with the physician workload are scarcely reported. The study aims to investigate the associated factors of on-call physician workload based on a published conceptual framework.The study was conducted in a general internal medicine unit of National Taiwan University Hospital. On-call physician worklo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004719
更新日期:2016-08-01 00:00:00
abstract::To demonstrate the mechanisms of the curative effect of Saussurea lappa ethanol extract (SLE) against prostate cancer, we evaluated the effect of SLE on the induction of apoptosis and autophagy and investigated whether SLE-induced autophagy exerts a pro-survival or pro-apoptotic effect in lymph node carcinoma of the p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007606
更新日期:2017-07-01 00:00:00
abstract::Currently interferon alfa-2b (IFNα-2b) is an approved adjuvant drug for high-risk melanoma patients that leads to an improvement in disease-free survival (DFS). However, it is unclear whether it also impacts overall survival. Widespread use of adjuvant high-dose IFNα has been tempered by its significant toxicity and i...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005375
更新日期:2016-11-01 00:00:00
abstract:RATIONALE:Frontometaphyseal dysplasia (FMD) is a dominant X-linked rare disease caused by mutations of FLNA. The distinctive features of FMD include skeletal dysplasia, facial dysmorphism, extremities anomalies, deafness, cleft palate and eye anterior segment anomalies, yet none of the complications, such as acro-osteo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011283
更新日期:2018-07-01 00:00:00
abstract::This study investigated the stress induced by well-functioning hand constraint in forced-use therapy (FUT) for children with unilateral spastic cerebral palsy (CP).Seventeen children with unilateral spastic CP (mean age 5.8 years) received FUT: 4-week unaffected upper limb immobilization with a short-arm Scotchcast an...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019016
更新日期:2020-03-01 00:00:00