Late-Onset Immune Thrombocytopenic Purpura After Withdrawal of Interferon Treatment for Chronic Hepatitis C Infection: A Case Report.

Abstract:

:Immune thrombocytopenic purpura (ITP) is a life-threatening complication following pegylated interferon alpha (PEG-IFN) plus ribavirin treatment, the standard treatment for hepatitis C virus (HCV) infection. We reported a rare case with late-onset ITP after withdrawal of PEG-IFN treatment.A 53-year-old male with hepatitis C developed massive gum bleeding and a severe, reversible, immune thrombocytopenia 2 weeks after cessation of PEG-IFN treatment for HCV due to anemia and depression. The platelet count decreased to 4000 cells/μL. The HCV viral load was undetectable at the end of PEG-IFN treatment and during follow-up for 5 months. Other potential autoimmune disorders were ruled out. Late-onset ITP associated with PEG-IFN treatment was diagnosed.The patient was treated successfully with steroid and azathioprine. Platelet count gradually increased to 117 × 10 cells/μL on the 18th day after admission.ITP is a rare complication in patients with hepatitis C or in patients who received PEG-IFN treatment. The particular case supported that it may occur even after withdrawal of PEG-IFN treatment. Physicians should be aware of this late-onset complication.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Hsiao CH,Tseng KC,Tseng CW,Tung CH

doi

10.1097/MD.0000000000001296

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

e1296

issue

34

eissn

0025-7974

issn

1536-5964

pii

00005792-201508040-00007

journal_volume

94

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Echinococcosis in left ventricle: a case report.

    abstract:INTRODUCTION:Echinococcosis, also called hydatid disease, is a common parasitic infection of the liver. However, echinococcus lesions rarely involve the heart, especially in children. PATIENT CONCERNS:An 8-year-old child from grazing areas of northwest China was referred to our hospital for the complaint of inpersiste...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015267

    authors: Su L,Yu J,Dai C,Liu Y,Peng L

    更新日期:2019-04-01 00:00:00

  • Gene co-expression network analysis identifies the hub genes associated with immune functions for nocturnal hemodialysis in patients with end-stage renal disease.

    abstract::End-stage renal disease (ESRD) is the final stage of chronic kidney disease in which the kidney is not sufficient to meet the needs of daily life. It is necessary to understand the role of genes expression involved in ESRD patient responses to nocturnal hemodialysis (NHD) and to improve the immunity responsiveness. Th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012018

    authors: Dai H,Zhou J,Zhu B

    更新日期:2018-09-01 00:00:00

  • Association between paced QRS duration and atrial fibrillation after permanent pacemaker implantation: A retrospective observational cohort study.

    abstract::Right ventricular pacing often results in prolonged QRS duration (QRSd) as the result of right ventricular stimulation, and atrial fibrillation (AF) may result. The association of pacing-induced prolonged QRSd and AF in patients with permanent pacemakers is unknown.We selected 180 consecutive patients who underwent pa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009839

    authors: Xing F,Jiang J,Hu X,Feng C,He J,Dong Y,Ma Y,Tang A

    更新日期:2018-02-01 00:00:00

  • Hepatic outflow obstruction (Budd-Chiari syndrome). Experience with 177 patients and a review of the literature.

    abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199401000-00003

    authors: Dilawari JB,Bambery P,Chawla Y,Kaur U,Bhusnurmath SR,Malhotra HS,Sood GK,Mitra SK,Khanna SK,Walia BS

    更新日期:1994-01-01 00:00:00

  • Femoral nerve block vs adductor canal block after anterior cruciate ligament reconstruction under general anesthesia: A prospective randomized trial protocol.

    abstract:BACKGROUND:Femoral nerve block (FNB) is considered the preferred analgesia after anterior cruciate ligament reconstruction (ACLR), but leads to weakness in the quadriceps muscles. Adductor canal block (ACB) is a new sensory block technique that effectively relieves postoperative pain while preserving quadriceps strengt...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020776

    authors: Xue Q,Jiang W,Wang M,Sui J,Wang Y

    更新日期:2020-07-10 00:00:00

  • Health education strategies targeting maternal and child health: A scoping review of educational methodologies.

    abstract:BACKGROUND:Health education during pregnancy is important to improve maternal and children outcomes. However, the strategies must be specifically designed for each context and demographic characteristics. Our objective was identify health education strategies targeting pregnant women with the intention of improving res...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000016174

    authors: Herval ÁM,Oliveira DPD,Gomes VE,Vargas AMD

    更新日期:2019-06-01 00:00:00

  • Coronary artery ectasia presenting with thrombus embolization and acute myocardial infarction: A case report.

    abstract:RATIONALE:Coronary artery ectasia (CAE) is characterized by an abnormal dilatation of the coronary arteries. CAE is often associated with the presence of slow coronary flow and may lead to acute myocardial infarction (AMI), even without total occlusion. PATIENT CONCERNS AND DIAGNOSIS:We report a case of a 24-year-old ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005976

    authors: Li Y,Wu C,Liu W

    更新日期:2017-01-01 00:00:00

  • Simultaneous comprehensive multiplex autoantibody analysis for rapidly progressive glomerulonephritis.

    abstract::Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoantibodies (autoAbs)...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005225

    authors: Sowa M,Trezzi B,Hiemann R,Schierack P,Grossmann K,Scholz J,Somma V,Sinico RA,Roggenbuck D,Radice A

    更新日期:2016-11-01 00:00:00

  • Fatal vascular complications during transradial percutaneous coronary intervention: A case report.

    abstract:RATIONALE:Vascular complications of transradial percutaneous coronary intervention (PCI) are rare and usually occur at the access site below the elbow. However, vessels along the tract of the wire or catheter can be injured at any point, causing various types of bleeding complications. PATIENT CONCERNS:A 57-year-old m...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021205

    authors: Choi S,Joh JH,Choe JW

    更新日期:2020-07-10 00:00:00

  • Herbal medicine (zhishi xiebai guizhi decoction) for unstable angina: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Unstable angina (UA) is a clinically common coronary heart disease. Zhishi xiebai guizhi decoction (ZXGD) has been widely used in the management of UA, although its effective evidence is not clear and there is no systematic review regarding its efficacy and safety. Therefore, we conduct this systematic revie...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000013965

    authors: Tang Y,Cai H,Zhan Z,Luo Y,Huang Y,Chen D,Chen B

    更新日期:2018-12-01 00:00:00

  • A meta-analysis evaluating the relationship between B-type Raf kinase mutation and cervical lymphatic metastasis in papillary thyroid cancer.

    abstract:BACKGROUND:B-type Raf kinase (BRAF) mutation is proved to be a critical predictive factor in papillary thyroid cancer (PTC) with aggressive characteristics. However, the association between BRAF mutation and cervical lymphatic metastasis in PTC is controversial. METHODS:We searched papers on the study of BRAF mutation...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000018917

    authors: Ma H,Wang R,Fang J,Zhong Q,Chen X,Hou L,Feng L,Chen X,Huang Z,Zhao H

    更新日期:2020-01-01 00:00:00

  • The prognostic value of left ventricular systolic function and cardiac biomarkers in pediatric severe sepsis.

    abstract::Echocardiography and cardiac biomarkers, such as cardiac troponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) are useful tools to evaluate cardiac dysfunction. Left ventricular systolic dysfunction (LVSD) is common in pediatric severe sepsis. The aim of this study is to evaluate the prognostic ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015070

    authors: Li J,Ning B,Wang Y,Li B,Qian J,Ren H,Zhang J,Hu X

    更新日期:2019-03-01 00:00:00

  • Which is the better timing between embolization and surgery for hypervascular spinal tumors, the same day or the next day?: A retrospective comparative study.

    abstract::Previous series presented the timing between embolization and surgery in a wide range on the basis of their experience rather than supportive data. And comparative studies were limited to small samples. In addition, there is no study publishing the timing by considering both safety and efficacy of embolization. The ai...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010912

    authors: Tang B,Ji T,Guo W,Tang X,Jin L,Dong S,Xie L

    更新日期:2018-06-01 00:00:00

  • Do genetic polymorphisms modulate response rate and toxicity of Cisplatin associated with radiotherapy in laryngeal squamous cell carcinoma?: a case report.

    abstract:UNLABELLED:Cisplatin (CDDP) plus radiotherapy (RT) has been used to treat advanced laryngeal squamous cell carcinoma (LSCC) patients. Single nucleotide polymorphisms (SNPs) may be responsible for differences in chemo/radiosensitivity and side effects in those patients. We reported an advanced LSCC patient, who obtained...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000578

    authors: Lopes-Aguiar L,Visacri MB,Nourani CML,Costa EFD,Nogueira GAS,Lima TRP,Pincinato EC,Moriel P,Altemani JMC,Lima CSP

    更新日期:2015-04-01 00:00:00

  • Bone cement spacer: a novel technique for treating a complicated case of developmental dysplasia of the hip with an injured acetabulum: Case report with 7-year follow-up.

    abstract:RATIONALE:Developmental dysplasia of the hip (DDH) has an incidence of 5 per 1000 newborns and its management depends on various factors. We present a rare case of DDH with soft tissue obliteration and a bony prominence in the center of the acetabulum after failed open reduction and acetabuloplasty. PATIENT CONCERNS:A...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018655

    authors: Alsiddiky A,Alatassi R,Alfayez S,Alhuzaimi F,Alqarni M

    更新日期:2020-01-01 00:00:00

  • Impact of surgical technique and analgesia on clinical outcomes after lung transplantation: A STROBE-compliant cohort study.

    abstract::There is paucity of data on the impact of surgical incision and analgesia on relevant outcomes.A retrospective STROBE-compliant cohort study was performed between July 2007 and August 2017 of patients undergoing lung transplantation. Gender, age, indication for lung transplantation, and the 3 types of surgical access ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022427

    authors: Giménez-Milà M,Videla S,Pallarés N,Sabaté A,Parmar J,Catarino P,Tosh W,Rafiq MU,Nalpon J,Valchanov K

    更新日期:2020-11-13 00:00:00

  • Dorsal Penile Nerve Block With Ropivacaine-Reduced Postoperative Catheter-Related Bladder Discomfort in Male Patients After Emergence of General Anesthesia: A Prospective, Randomized, Controlled Study.

    abstract::Catheter-related bladder discomfort (CRBD) is a distressing symptom complex after surgery, especially in male patients who have had urinary catheterization under general anesthesia. In this prospective, randomized, controlled trial, we compared dorsal penile nerve block (DPNB) with 0.33% ropivacaine with intravenous t...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000003409

    authors: Li JY,Yi ML,Liao R

    更新日期:2016-04-01 00:00:00

  • Different acupuncture therapies combined with rehabilitation in the treatment of scapulohumeral periarthritis: A protocol for systematic review and network meta-analysis.

    abstract:BACKGROUND:Scapulohumeral periarthritis is a disease that seriously affects human daily work and life, and greatly reduces peoples quality of life and affects human health all over the world. Now, many studies have shown that acupuncture and rehabilitation have a significant effect on scapulohumeral periarthritis. In t...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023085

    authors: Wei L,Zhu M,Peng T,Xiong W,Hou X

    更新日期:2020-12-18 00:00:00

  • Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study.

    abstract::Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases.This is a cross-sectional study. From June through August 200...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001814

    authors: Wang T,Xu M,Xu Y,Lu J,Li M,Chen Y,Wang W,Lai S,Bi Y,Ning G

    更新日期:2015-10-01 00:00:00

  • Creatine kinase in the U.S. population: Impact of demographics, comorbidities, and body composition on the normal range.

    abstract:BACKGROUND:Creatine kinase (CK) values are a critical part of the workup of suspected myopathies and are often assessed in patients that develop myalgia on statin therapy. CK elevations may influence the initiation and cessation of statin treatment, and incidentally discovered CK elevation may lead to further testing. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004344

    authors: George MD,McGill NK,Baker JF

    更新日期:2016-08-01 00:00:00

  • Ten Years' Follow-Up on Combined Palmar and Dorsal Internal Fixation of Complex Distal Radius Fractures.

    abstract::Complex distal intra-articular radial fractures (AO Type C3) are rare, but are life-changing injuries. They are usually related to high-velocity trauma mechanisms in a working male population.We surveyed a cohort of these fractures treated in our institution to assess the functional long-term outcome.Twelve consecutiv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003509

    authors: Iselin LD,Massy-Budmiger AS,Droeser RA,Mett TR,Babst R,Rikli DA

    更新日期:2016-05-01 00:00:00

  • Postural control and balance in a cohort of healthy people living in Europe: An observational study.

    abstract::In the past 20 years, posturography has been widely used in the medical field. This observational study aimed to report the values derived from posturography of a wide set of healthy subjects from various European countries using a plantar pressure platform and a standardized method of measurement.A random cluster sam...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013835

    authors: Patti A,Bianco A,Şahin N,Sekulic D,Paoli A,Iovane A,Messina G,Gagey PM,Palma A

    更新日期:2018-12-01 00:00:00

  • Acupuncture for perimenopausal insomnia: A systematic review and meta-analysis protocol.

    abstract:BACKGROUND:Perimenopausal insomnia (PI) is one of the most common complaints in women. Acupuncture is used to treat PI increasingly considering its less side effect. The subject of this study is to explore the effectiveness and safety of acupuncture for PI. METHODS:All the randomized controlled trials(RCT) literatures...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000011083

    authors: Guo T,Jia M,Jin Y,Xu N,Peng T

    更新日期:2018-06-01 00:00:00

  • Estimation of direct medical cost related to the management of chronic hepatitis C and its complications in South Korea.

    abstract:BACKGROUND:This study aimed to estimate the direct medical costs of managing chronic hepatitis C (CHC) and its complications based on health-care resources in South Korea. METHODS:The study design was multicenter, retrospective, non-interventional, and observational. Between September 2013 and April 2014, health-care ...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000003896

    authors: Kim DY,Yoon KT,Kim W,Lee JI,Hong SH,Lee D,Jang JW,Choi JW,Kim I,Paik YH

    更新日期:2016-07-01 00:00:00

  • Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis.

    abstract:BACKGROUND:This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS:Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) r...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004868

    authors: Yang Y,Wu H,Zhou J

    更新日期:2016-10-01 00:00:00

  • Influence of patient and provider factors on the workload of on-call physicians: A general internal medicine cohort observational study.

    abstract::Factors associated with the physician workload are scarcely reported. The study aims to investigate the associated factors of on-call physician workload based on a published conceptual framework.The study was conducted in a general internal medicine unit of National Taiwan University Hospital. On-call physician worklo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004719

    authors: Hsu NC,Huang CC,Jerng JS,Hsu CH,Yang MC,Chang RE,Ko WJ,Yu CJ

    更新日期:2016-08-01 00:00:00

  • Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells.

    abstract::To demonstrate the mechanisms of the curative effect of Saussurea lappa ethanol extract (SLE) against prostate cancer, we evaluated the effect of SLE on the induction of apoptosis and autophagy and investigated whether SLE-induced autophagy exerts a pro-survival or pro-apoptotic effect in lymph node carcinoma of the p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007606

    authors: Tian X,Song HS,Cho YM,Park B,Song YJ,Jang S,Kang SC

    更新日期:2017-07-01 00:00:00

  • Preferences of German melanoma patients for interferon (IFN) α-2b toxicities (the DeCOG "GERMELATOX survey") versus melanoma recurrence to quantify patients' relative values for adjuvant therapy.

    abstract::Currently interferon alfa-2b (IFNα-2b) is an approved adjuvant drug for high-risk melanoma patients that leads to an improvement in disease-free survival (DFS). However, it is unclear whether it also impacts overall survival. Widespread use of adjuvant high-dose IFNα has been tempered by its significant toxicity and i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005375

    authors: Kaehler KC,Blome C,Forschner A,Gutzmer R,Haalck T,Heinzerling L,Kornek T,Livingstone E,Loquai C,Maul LV,Lang BM,Schadendorf D,Stade B,Terheyden P,Utikal J,Wagner T,Hauschild A,Garbe C,Augustin M

    更新日期:2016-11-01 00:00:00

  • Whole genome sequencing and 6-year follow-up of a mother and daughter with frontometaphyseal dysplasia associated with keratitis, xerosis, poikiloderma, and acro-osteolysis: A case report.

    abstract:RATIONALE:Frontometaphyseal dysplasia (FMD) is a dominant X-linked rare disease caused by mutations of FLNA. The distinctive features of FMD include skeletal dysplasia, facial dysmorphism, extremities anomalies, deafness, cleft palate and eye anterior segment anomalies, yet none of the complications, such as acro-osteo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011283

    authors: Xie H,Xue L,Hua W,Jia B,Zhang L,Li L

    更新日期:2018-07-01 00:00:00

  • Does well-functioning hand constraint induce stress in forced-use therapy for children with unilateral cerebral palsy?

    abstract::This study investigated the stress induced by well-functioning hand constraint in forced-use therapy (FUT) for children with unilateral spastic cerebral palsy (CP).Seventeen children with unilateral spastic CP (mean age 5.8 years) received FUT: 4-week unaffected upper limb immobilization with a short-arm Scotchcast an...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019016

    authors: Ko EJ,Sung IY,Yuk JS

    更新日期:2020-03-01 00:00:00