Organization and mode of action of two component system signaling circuits from the various kingdoms of life.

Abstract:

:Two-component system (TCS) signaling circuits regulate numerous cellular processes in response to environmental cues in both prokaryotic and eukaryotic cells. These signaling circuits are all based on phosphoryl-group transfers between histidine and aspartate containing modules of sensor kinase and response regulator proteins. Curiously, the architecture and organization of prokaryotic and eukaryotic two-component systems reveal notable variations, raising the question of whether the input-response specificity that governs the majority of prokaryotic TCSs also governs the eukaryotic ones. In this review, we contrast the TCS architecture and signaling circuits of prokaryotes and eukaryotes, and discuss their possible consequences on signaling specificity.

journal_name

Environ Microbiol

authors

Alvarez AF,Barba-Ostria C,Silva-Jiménez H,Georgellis D

doi

10.1111/1462-2920.13397

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

3210-3226

issue

10

eissn

1462-2912

issn

1462-2920

journal_volume

18

pub_type

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