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Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis.

Abstract：

:Tuberculosis (TB) accounted for 1.5 million deaths in 2014, and new classes of anti-TB drugs are required. We report a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against pathogenic mycobacteria. These compounds inhibit intracellular growth of Mycobacterium tuberculosis, are nontoxic to human cell lines, and are active against multidrug-resistant M. tuberculosis strains, indicating a distinct mode of action. These compounds warrant further appraisal as novel agents to control TB in humans.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Yu M,Nagalingam G,Ellis S,Martinez E,Sintchenko V,Spain M,Rutledge PJ,Todd MH,Triccas JA

doi

10.1021/acs.jmedchem.6b00432

subject

Has Abstract

pub_date

2016-06-23 00:00:00

pages

5917-21

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

59

pub_type

杂志文章

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