Chronic myeloid leukemia: reminiscences and dreams.

abstract：:Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear ...

journal_title：Haematologica

authors： Heringer-Walther S,Eckert K,Schumacher SM,Uharek L,Wulf-Goldenberg A,Gembardt F,Fichtner I,Schultheiss HP,Rodgers K,Walther T

更新日期：2009-06-01 00:00:00

abstract：:The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for relapsed/refractory diffuse large B-cell lymphoma patients treated on the Canadian Cancer Trials Group (CCTG) LY12 prospective study. In 91 cases, sufficient histologic mater...

journal_title：Haematologica

authors： Bosch M,Akhter A,Chen BE,Mansoor A,Lebrun D,Good D,Crump M,Shepherd L,Scott DW,Stewart DA

更新日期：2018-02-01 00:00:00

abstract：:In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations, as defined by surface markers, have shown equal abilities to reconstitute leukemia upon transplant...

journal_title：Haematologica

authors： Trentin L,Queudeville M,Eckhoff SM,Hasan N,Münch V,Boldrin E,Seyfried F,Enzenmüller S,Debatin KM,Meyer LH

更新日期：2018-06-01 00:00:00

abstract：:Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in...

journal_title：Haematologica

authors： Eclache V,Da Rocha A,Le Roux G,Fenaux P

更新日期：2008-02-01 00:00:00

abstract：:Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...

journal_title：Haematologica

authors： Rafel M,Cobo F,Cervantes F,Bosch F,Campo E,Montserrat E

更新日期：1998-06-01 00:00:00

abstract：:In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fuse...

journal_title：Haematologica

authors： Gorello P,Brandimarte L,La Starza R,Pierini V,Bury L,Rosati R,Martelli MF,Vandenberghe P,Wlodarska I,Mecucci C

更新日期：2008-09-01 00:00:00

abstract：:Multipotent stromal cells have immunomodulatory capacities and have been used in transplantation and autoimmune diseases. One of the effects of multipotent stromal cells involves the inhibition of dendritic cell differentiation. Since interleukin-6 and interleukin-10 are known to play a role in inhibiting immature den...

journal_title：Haematologica

authors： Melief SM,Geutskens SB,Fibbe WE,Roelofs H

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The genetic subtype is currently detected by different diagnostic procedures which differ in success rate and/or specificity. DESIGN AND METHODS:We examined the potential of gene e...

journal_title：Haematologica

authors： Balgobind BV,Van den Heuvel-Eibrink MM,De Menezes RX,Reinhardt D,Hollink IH,Arentsen-Peters ST,van Wering ER,Kaspers GJ,Cloos J,de Bont ES,Cayuela JM,Baruchel A,Meyer C,Marschalek R,Trka J,Stary J,Beverloo HB,Pieters R

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:High levels of erythrocyte destruction in sickle cell anemia (SCA) result in chronic hyperbilirubinemia, with cholelithiasis occurring in a subset of patients. We investigated whether susceptibility to cholelithiasis in SCA was associated with the promoter polymorphism of the 5?-diphosphate-gl...

journal_title：Haematologica

authors： Chaar V,Kéclard L,Diara JP,Leturdu C,Elion J,Krishnamoorthy R,Clayton J,Romana M

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Loss of heterozygosity (LOH) on the long arm of chromosome 7 (7q) has been frequently reported in several types of human cancer including hematologic malignancies. Moreover, monosomy of chromosome 7 and 7q deletions have been associated in acute myeloid leukemia (AML) with aggressive disease a...

journal_title：Haematologica

authors： Basiricò R,Pirrotta R,Fabbiano F,Mirto S,Cascio L,Pagano M,Cammarata G,Magrin S,Santoro A

更新日期：2003-04-01 00:00:00

abstract：:As in other malignancies, peripheral blood progenitor cells (PBPC) have almost completely replaced bone marrow as the source of stem cells for autologous transplantation in multiple myeloma. PBPC collection could be optimized either by reducing contamination by the malignant clone or by increasing hematopoietic qualit...

journal_title：Haematologica

authors： Harousseau JL

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The degree of globin chain imbalance and tissue hypoxia are important determinants of clinical severity in thalassemia syndromes. Thus phenotypic expression may be modified by interaction of alpha- and beta-thalassemia defects, level and type of hemoglobin synthesized and oxygen release to the...

journal_title：Haematologica

authors： Traeger-Synodinos J,Papassotiriou I,Vrettou C,Skarmoutsou C,Stamoulakatou A,Kanavakis E

更新日期：2001-04-01 00:00:00

abstract：:This study reports a case of granulocytic sarcoma that developed in the epidural zone 25 days before clinical evidence of an acute promyelocytic leukemia. The case presented the diagnostic difficulties that are common to all aleukemic granulocytic sarcomas. Moreover, it highlights the very rare association between gra...

journal_title：Haematologica

authors： Tosi A,De Paoli A,Fava S,Luoni M,Sironi M,Tocci A,Assi A,Cassi E

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The efficacy and safety of added dexamethasone were assessed in patients with relapsed and/or refractory multiple myeloma who had a suboptimal response to bortezomib alone. DESIGN AND METHODS:In two previously reported, open-label, multicenter phase 2 studies, bortezomib 1.0 or 1.3 mg/m2 was ...

journal_title：Haematologica

authors： Jagannath S,Richardson PG,Barlogie B,Berenson JR,Singhal S,Irwin D,Srkalovic G,Schenkein DP,Esseltine DL,Anderson KC,SUMMIT\/CREST Investigators.

更新日期：2006-07-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased risk of lymphoma. Despite frequent hematologic abnormalities, literatur...

journal_title：Haematologica

authors： Xie Y,Pittaluga S,Price S,Raffeld M,Hahn J,Jaffe ES,Rao VK,Maric I

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Vgamma9Vdelta2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vgamma9Vdelta2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers ...

journal_title：Haematologica

authors： Gomes AQ,Correia DV,Grosso AR,Lança T,Ferreira C,Lacerda JF,Barata JT,Silva MG,Silva-Santos B

更新日期：2010-08-01 00:00:00

abstract：:Inherited factor VIl (FVII) deficiency is a rare autosomal recessive coagulation disorder characterized by a wide genet-ic heterogeneity and a poor relationship between FVII activity (FVII:C) levels and severity of the hemorrhagic diathesis. Given both the rarity and the heterogeneity of this disorder,genotype-phenoty...

journal_title：Haematologica

authors： Giansily-Blaizot M,Aguilar-Martinez P,Schved JF

更新日期：2002-03-01 00:00:00

abstract：:Mucormycosis is an emerging cause of infectious morbidity and mortality in patients with hematologic malignancies. However, there are no recommendations to guide diagnosis and management. The European Conference on Infections in Leukemia assigned experts in hematology and infectious diseases to develop evidence-based ...

journal_title：Haematologica

authors： Skiada A,Lanternier F,Groll AH,Pagano L,Zimmerli S,Herbrecht R,Lortholary O,Petrikkos GL,European Conference on Infections in Leukemia.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cord blood (CB) is a valuable source of stem cells. Most CB units are still cryopreserved in single bags in the world's CB banks. Thawing a single CB unit, dividing it into two parts, expanding the smaller one and refreezing the other would optimize ex vivo expansion of CB progenitors prior to...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Saracco P,Doria A,Fazio L,Albiani R,Cordero Di Montezemolo L,Perugini L,Incarbone E

更新日期：2003-01-01 00:00:00

abstract：:Differentiation of erythroblasts to mature red blood cells involves dynamic changes of the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in acti...

journal_title：Haematologica

authors： Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloprol...

journal_title：Haematologica

authors： Olcaydu D,Rumi E,Harutyunyan A,Passamonti F,Pietra D,Pascutto C,Berg T,Jäger R,Hammond E,Cazzola M,Kralovics R

更新日期：2011-03-01 00:00:00

abstract：:Some prospective studies showed that rabbit antithymocyte globulin was inferior to horse antithymocyte globulin as first-line therapy for patients with severe aplastic anemia. We retrospectively analyzed the clinical outcome of 455 children with severe aplastic anemia who received horse antithymocyte globulin (n=297) ...

journal_title：Haematologica

authors： Jeong DC,Chung NG,Cho B,Zou Y,Ruan M,Takahashi Y,Muramatsu H,Ohara A,Kosaka Y,Yang W,Kim HK,Zhu X,Kojima S

更新日期：2014-04-01 00:00:00

abstract：:We report on a patient affected by multicentric Castleman's disease who developed an acute immunohemolytic anemia due to warm antibody. The clinical course was characterized by refractoriness to the steroidal treatment and by a dramatic improvement of the hematological and objective picture following combination chemo...

journal_title：Haematologica

authors： Liberato NL,Bollati P,Chiofalo F,Filipponi M,Poli M

更新日期：1996-01-01 00:00:00

abstract：:To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 month...

journal_title：Haematologica

authors： Yanada M,Takeuchi J,Sugiura I,Akiyama H,Usui N,Yagasaki F,Nishii K,Ueda Y,Takeuchi M,Miyawaki S,Maruta A,Narimatsu H,Miyazaki Y,Ohtake S,Jinnai I,Matsuo K,Naoe T,Ohno R,Japan Adult Leukemia Study Group.

更新日期：2008-02-01 00:00:00

abstract：:Anti-CD20-containing chemotherapy regimens have become the standard of care for patients with follicular lymphoma needing cytotoxic therapy. Four randomized trials demonstrated a clinical benefit for patients treated with rituximab. However, no long-term follow up (i.e. > 5 years) of these trials is yet available. Bet...

journal_title：Haematologica

authors： Bachy E,Houot R,Morschhauser F,Sonet A,Brice P,Belhadj K,Cartron G,Audhuy B,Fermé C,Feugier P,Sebban C,Delwail V,Maisonneuve H,Le Gouill S,Lefort S,Brousse N,Foussard C,Salles G,Groupe d'Etude des Lymphomes de l'Adult

更新日期：2013-07-01 00:00:00

abstract：:Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological processes. Indeed, t...

journal_title：Haematologica

authors： Vilar R,Fish RJ,Casini A,Neerman-Arbez M

更新日期：2020-01-31 00:00:00

abstract：:This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 pati...

journal_title：Haematologica

authors： Bellei M,Foss FM,Shustov AR,Horwitz SM,Marcheselli L,Kim WS,Cabrera ME,Dlouhy I,Nagler A,Advani RH,Pesce EA,Ko YH,Martinez V,Montoto S,Chiattone C,Moskowitz A,Spina M,Biasoli I,Manni M,Federico M,International T-c

更新日期：2018-07-01 00:00:00

abstract：:In the European Intergroup EURO-LB02 trial, children and adolescents with lymphoblastic lymphoma underwent the non-Hodgkin lymphoma Berlin-Frankfurt-Münster protocol without prophylactic cranial radiotherapy. The primary aims of this trial were to test whether replacing prednisone with dexamethasone during induction i...

journal_title：Haematologica

authors： Landmann E,Burkhardt B,Zimmermann M,Meyer U,Woessmann W,Klapper W,Wrobel G,Rosolen A,Pillon M,Escherich G,Attarbaschi A,Beishuizen A,Mellgren K,Wynn R,Ratei R,Plesa A,Schrappe M,Reiter A,Bergeron C,Patte C,Bertran

更新日期：2017-12-01 00:00:00

abstract：:Over the past 20 years we have studied 1781 patients with beta-thalassemia syndromes of which 1481 Yugoslav, 166 Bulgarian, 102 Turkish and 32 Albanian. In this paper we summarize the data on the heterogeneity and molecular basis of beta-thal, delta beta-thal and Lepore hemoglobinopathy in these four nationalities liv...

journal_title：Haematologica

authors： Efremov GD

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVES:Perceiving the need for rigorous recommendations to facilitate decisions concerning the management of patients with multiple myeloma (MM), the Italian Society of Hematology (SIE) and the two affiliate societies (SIES and GITMO) commissioned a project to develop guidelines for the therapy of MM using evidence...

journal_title：Haematologica

authors： Barosi G,Boccadoro M,Cavo M,Corradini P,Marchetti M,Massaia M,Merlini G,Tosi P,Tura S,Italian Society of Hematology.,Italian Society of Experimental Hematology.,Italian Group for Bone Marrow Transplantation.

更新日期：2004-06-01 00:00:00