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Innate lymphoid cells and the MHC.

Abstract：

:Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4(+) helper T cells and CD8(+) cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.

journal_name

HLA

journal_title

HLA

authors

Robinette ML,Colonna M

doi

10.1111/tan.12723

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5-11

issue

1

eissn

2059-2302

issn

2059-2310

journal_volume

87

pub_type

杂志文章,评审

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