Abstract:
:Despite recent advances in radiochemotherapy, treatment of locally advanced head and neck squamous cell carcinoma is still challenging, and survival rates have improved only slightly. This is due to the high frequency of metastases and local and/or regional tumor recurrences that have acquired radio- or chemoresistance. MiRNAs regulate diverse processes in tumorigenesis, metastasis, and therapy resistance in head and neck squamous cell carcinoma. Hence, miRNAs are highly valued in biomarker studies. Establishment of the miRNA profiles of oropharyngeal tumors enables personalized treatment selection, since expression of distinct miRNAs can predict the response to two different radiochemotherapy regimens. Development of novel miRNA therapeutics has a high clinical potential for further improving treatment of cancerous disease. The use of nanoparticles with distinct surface modifications as miRNA vectors permits prolonged bioavailability, high efficacy in tumor targeting, and low toxicity. Nevertheless, the efficacy of miRNA therapy has only been shown in animal models to date.
journal_name
HNOjournal_title
HNOauthors
Heß AK,Weichert W,Budach V,Tinhofer Idoi
10.1007/s00106-015-0111-9subject
Has Abstractpub_date
2016-05-01 00:00:00pages
296-302issue
5eissn
0017-6192issn
1433-0458pii
10.1007/s00106-015-0111-9journal_volume
64pub_type
杂志文章,评审相关文献
HNO文献大全abstract::Millions of people worldwide suffer from hearing loss. Current treatment for patients with severe to profound hearing loss consists of cochlear implants. Providing the cochlear nerve is intact, patients generally benefit enormously from this intervention, frequently achieving significant improvements in speech compreh...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-016-0304-x
更新日期:2017-07-01 00:00:00
abstract::From a series of 35 cases with intraoperative monitoring of acoustic evoked brainstem responses 4 cases with cerebellopontine angle surgery are presented in detail. The aim of neuromonitoring is to provide the surgeon with an additional instrument to assess the functional state of the hearing pathway with objective ne...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:Systematic research on factors before the provision of hearing aids is scarce. In order to identify parameters which promote or impede the use of hearing aids, a questionnaire-based survey was conducted. SUBJECTS AND METHODS:A total of 35 randomly chosen, hard of hearing adults indicated for a hearing aid we...
journal_title:HNO
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00106-003-0987-7
更新日期:2004-09-01 00:00:00
abstract::The skull base was perforated and extensive wounds occurred in the brain during the passage of a nasogastric tube on a 48 year old woman, under general anaesthetic. The patient was treated by artificial respiration but died on the 14th day. The site of entry was the sphenoid sinus. False passage of the tube was favour...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::The incidence of intraosseous hemangiomas is very low. Most of them occur in adult females. The mandible,the zygoma,the maxilla, and the frontal and nasal bones are the areas of most frequent localization in the facial region. The intraosseous hemangioma is a benign, slowly growing,bony hard tumor causing facial defor...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-002-0678-9
更新日期:2003-02-01 00:00:00
abstract::An unusually long uvula as a cause of chronic throat irritation with the sensation of a foreign body in a 35-year old patient is reported, with symptoms relieved by partial resection of the uvula. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::The author's method of suggestion therapy can lead to a total remission of sudden deafness or to a favourable precondition for later infusion therapy (Onkovertin with Sorbit + Trental). Several examples are quoted to show that an improvement of hearing of 20 DB can be attained within 30 min over different frequencies....
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::The current article is an experience report on the establishment of an ENT clinic in Asmara/Eritrea and the organization of regular work stays for the further education of local colleagues. Objectives of the project are content and structural support for self-help and thus achievement of sustainable development aid, w...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-019-0690-y
更新日期:2019-07-01 00:00:00
abstract::Ten of 84 supraglottic carcinomas were treated by primary surgery, 32 by pre or post operative irradiation and 41 by primary irradiation and salvage surgery if recurrence developed. A comparison of the treatment results between these groups is not possible because of the lack of randomization. After follow up of 4.4 y...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::Swallowing is a dynamic process that requires more than 30 muscles in the recruitment/coordination of the lips, tongue, palate, pharynx, larynx and esophagus. The eating and swallowing procedure is learned in sensitive or critical periods: when a certain degree of maturation has been achieved, the appropriate stimulus...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-017-0388-y
更新日期:2018-07-01 00:00:00
abstract::The plasmocytoma is a tumor, which can only rarely be found in the oropharynx. In this respective case an asymmetria of the tonsils was caused by an extramedullary plasmocytoma. Even if the asymmetria of the tonsils has a harmless nature, a tumor growth always has to be considered when thinking of the differential dia...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-002-0626-8
更新日期:2002-03-01 00:00:00
abstract::The comparison of all the hearing test methods that have been advocated during recent years shows that all have severe drawbacks and are thus unsuitable for screening for hearing loss in newborns. Therefore it is better to screen by the high risk registry. All high risk children must be seen by the paedaudiologist. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract::The face plays a central role in interpersonal communication and aesthetic perception. Moreover, due to the heavy dependence of ocular function on lid anatomy, the treatment of periocular injuries, particularly those involving soft tissue loss, requires profound knowledge of both anatomy and reconstructive plastic sur...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-011-2350-8
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Recurrent exacerbation of chronic external otitis represents a special challenge for the attending physician. The goal of our study was to evaluate the effectiveness of novel topical immunomodulators acting through an anti-inflammatory, nonsteroidal mechanism. PATIENTS AND METHODS:In a prospective study, in...
journal_title:HNO
pub_type: 临床试验,杂志文章
doi:10.1007/s00106-007-1615-8
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:Balloon dilation of the Eustachian tube has recently been introduced as a novel and minimally invasive method for treating chronic obstructive Eustachian tube dysfunction. For the first time worldwide, we assessed the role of this technique in a large cohort of children with Eustachian tube dysfunction that d...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-015-0050-5
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Central auditory processing disorders (CAPD) are associated with reduced discriminatory abilities of the auditory system. One of these abilities is directional hearing, which is based on the evaluation of interaural signal differences. Since these differences affect also the binaural difference potentials (B...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-006-1455-y
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:In contrast to alcohol- and nicotine-induced head and neck tumors, human papillomavirus (HPV)-positive oropharyngeal carcinoma rather affects younger patients, and the incidence of this entity is continuously increasing. Due to the significantly better prognosis of HPV-positive oropharyngeal carcinoma, vario...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-020-00955-5
更新日期:2020-10-13 00:00:00
abstract::Extrapolated DPOAE growth functions can be applied in ENT diagnostics for a specific assessment of cochlear dysfunction. In screening newborn hearing, they are able to detect transitory sound conductive hearing loss and thus help to reduce the rate of false positive TEOAE responses in the early postnatal period. Since...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-004-1179-9
更新日期:2005-02-01 00:00:00
abstract::Angioedema is characterized by subcutaneous or submucosal swelling, which often affects the lips, tongue and oral or pharyngeal sites. Laryngeal oedema can be potentially life-threatening. The pathogenesis of angioedema is thought to involve the release of histamine and other mediators with subsequent extravasation of...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Specific anosmia, the inability to perceive a specific odor, while olfactory perception is otherwise intact, is known as a rather seldom phenomenon. By testing the prevalence of specific anosmia to 20 different odors in a sample of 1600 people, we were able to estimate the general prevalence of anosmia. This revealed ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-016-0119-9
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Digitalization has become a part of everyday life and digital applications offer an opportunity to promote health. In Germany, hearing rehabilitation after cochlear implantation (CI) typically takes place in specialized audiology centers. However, a variety of new auditory training programs have been develop...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-020-00898-x
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Comorbid physical and psychological complaints are more common in patients with dysphonia than in the general population. In a prospective randomized study the effects of structured psychosomatic diagnostics and verbal intervention on the satisfaction of patients with dysphonia were investigated. MATERIALS ...
journal_title:HNO
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00106-009-1949-5
更新日期:2009-09-01 00:00:00
abstract::The aim of this multicenter clinical field study was to assess the benefits of the new Freedom 24 sound processor for cochlear implant (CI) users implanted with the Nucleus 24 cochlear implant system. The study included 48 postlingually profoundly deaf experienced CI users who demonstrated speech comprehension perform...
journal_title:HNO
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00106-008-1781-3
更新日期:2009-06-01 00:00:00
abstract::A review is made of the difficulties of audiometric diagnosis resulting from inadequate anatomical, physiological and pathological knowledge of the auditory system and from discrepancies in audiometric technique. Even with a broad battery of tests there is in 20-40% of cases an inconsistent audiometric pattern, which ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::A parotid mass in a 62-year-old woman presented intraoperatively as a highly malignant tumor with facial nerve infiltration. Classification by means of rapid section histology was not possible. Immunohistochemical studies were necessary to diagnose this rare case of myoepithelial carcinoma of the parotid gland. We per...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-010-2112-z
更新日期:2010-11-01 00:00:00
abstract::The detailed evaluation of anatomy and pathology of the temporal bone requires imaging modalities that are superior to plain x-ray films. Conventional polytomography has today largely been replaced by high-resolution CT. High-resolution CT provides excellent demonstration of the delicate bony structures and provides s...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1988-03-01 00:00:00
abstract::The importance of spiral-CT is clinically accepted for diagnosing spreading disease and for making a decision about the therapy strategy for head and neck tumors. Its importance for follow-up after radiotherapy was examined in 26 patients with irradiated laryngeal tumors. Using spiral-CT multiple signs of alterations ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050377
更新日期:1999-03-01 00:00:00
abstract::A microphone constructed for implantation in the posterior wall of the auditory canal and a piezoelectric transducer serving as the main components of an implantable hearing aid were temporally implanted in five patients during middle ear surgery under local anesthesia. The microphone was positioned beneath the skin o...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050166
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Controversy surrounds the question of which technique should be preferred for tonsillectomy in order to reduce postoperative morbidity in terms of pain, bleeding, activity and return to normal diet. This study reviews the current literature on coblation tonsillectomy (CTE). MATERIALS AND METHODS:All studies...
journal_title:HNO
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00106-006-1523-3
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Autologous transplants comprising skin and cartilage, so-called composite grafts (cgs), are an important reconstructive tool for multilayered defects of the nose. A cg from the auricular cavum conchae needs to fulfill both functional and esthetic demands. OBJECTIVE:This article illustrates the indications f...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-016-0126-x
更新日期:2016-05-01 00:00:00