Abstract:
:The aim of this multicenter clinical field study was to assess the benefits of the new Freedom 24 sound processor for cochlear implant (CI) users implanted with the Nucleus 24 cochlear implant system. The study included 48 postlingually profoundly deaf experienced CI users who demonstrated speech comprehension performance with their current speech processor on the Oldenburg sentence test (OLSA) in quiet conditions of at least 80% correct scores and who were able to perform adaptive speech threshold testing using the OLSA in noisy conditions. Following baseline measures of speech comprehension performance with their current speech processor, subjects were upgraded to the Freedom 24 speech processor. After a take-home trial period of at least 2 weeks, subject performance was evaluated by measuring the speech reception threshold with the Freiburg multisyllabic word test and speech intelligibility with the Freiburg monosyllabic word test at 50 dB and 70 dB in the sound field. The results demonstrated highly significant benefits for speech comprehension with the new speech processor. Significant benefits for speech comprehension were also demonstrated with the new speech processor when tested in competing background noise.In contrast, use of the Abbreviated Profile of Hearing Aid Benefit (APHAB) did not prove to be a suitably sensitive assessment tool for comparative subjective self-assessment of hearing benefits with each processor. Use of the preprocessing algorithm known as adaptive dynamic range optimization (ADRO) in the Freedom 24 led to additional improvements over the standard upgrade map for speech comprehension in quiet and showed equivalent performance in noise. Through use of the preprocessing beam-forming algorithm BEAM, subjects demonstrated a highly significant improved signal-to-noise ratio for speech comprehension thresholds (i.e., signal-to-noise ratio for 50% speech comprehension scores) when tested with an adaptive procedure using the Oldenburg sentences in the clinical setting S(0)N(CI), with speech signal at 0 degrees and noise lateral to the CI at 90 degrees . With the convincing findings from our evaluations of this multicenter study cohort, a trial with the Freedom 24 sound processor for all suitable CI users is recommended. For evaluating the benefits of a new processor, the comparative assessment paradigm used in our study design would be considered ideal for use with individual patients.
journal_name
HNOjournal_title
HNOauthors
Müller-Deile J,Kortmann T,Hoppe U,Hessel H,Morsnowski Adoi
10.1007/s00106-008-1781-3subject
Has Abstractpub_date
2009-06-01 00:00:00pages
567-74issue
6eissn
0017-6192issn
1433-0458journal_volume
57pub_type
临床试验,杂志文章,多中心研究相关文献
HNO文献大全abstract::Surgery of the maxillary sinus is one of the commonest in otorhinolaryngology. The classical Caldwell-Luc procedure however is not infrequently followed by infraorbital or some other facial neuralgia or discomfort. In 1976,246 patients were assessed for revision maxillary sinus surgery, and the symptomatology, clinica...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::This year also saw a great number of phase II and III studies presented at the ASCO Annual Meeting, in which new drugs (monoclonal antibodies, small molecules) were investigated as an alternative to or in combination with established mono- and polychemotherapy in patients with recurrences or distance metastases from h...
journal_title:HNO
pub_type:
doi:10.1007/s00106-015-0055-0
更新日期:2015-09-01 00:00:00
abstract::Several different theories exist about the origin of kinetosis and the space adaptation syndrome, with individual sensitivities differing significantly. One explanation involves the hypothesis of a different otolith mass between the right and left statolith organ and especially a difference in the utricles. A differen...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050106
更新日期:1997-04-01 00:00:00
abstract::Obstructive sleep apnea (OSA) is a common disease in children. It is defined by the onset of snoring, hypopneas or apneas with impaired sleep and daytime function. Obstruction of the upper airway during sleep is the underlying pathogenetic mechanism. It is caused either by an anatomic obstruction, increased airway col...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-010-2214-7
更新日期:2010-12-01 00:00:00
abstract::Extracranial meningiomas are rare tumors of the lateral skull base. A 37-year-old woman presented with tinnitus und progressive hearing loss of her right ear. A painful mass lesion was also palpable in her mandibular angle. CT and MRI scans revealed an intracranial mass with extension to the lateral skull base. These ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050358
更新日期:1999-01-01 00:00:00
abstract::The aim of this study was to confirm the hypothesis based on clinical observations of a causal relationship between arterial hypotension and sudden hearing loss of lower frequencies. A noninvasive system was used that enables repeated blood pressure measurements at programmable time intervals. With this method 24-hour...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Madelung's disease, also known as benign symmetrical lipomatosis, is a rare proliferative disorder of unknown etiology that was first mentioned by Brodie in 1846. Characterized by multiple symmetrical deposits of unencapsulated fat in the head and neck region, the disease is most common in middle-aged men with a histo...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-002-0629-5
更新日期:2002-12-01 00:00:00
abstract::The effect of different vasodilating drugs on the perilymphatic oxygen content in the cat has been examined by means of the polarographic method. The drugs used such as Papaverin, Rheomacrodex, Ronicol, Praxilen and Lasix have had no significant effect on the oxygen concentration in the perilymph. Histamin, 7% Na2CO3 ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1978-03-01 00:00:00
abstract::Malignancies of the nose, paranasal sinuses and anterior skull base are characterized by their hidden locations and late clinical manifestation. This explains why most of the patients at the University of Tübingen were diagnosed in an advanced tumor stage (15 T1/T2; 33 T3/T4). Surgical treatment was possible in 35 cas...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Transtympanic electrocochleography (ECoG) enables auditory evoked potentials to be recorded directly from the peripheral organ, and ECoG recordings can be used as a routine during operations. Examples of cochlear and eighth nerve monitoring in middle ear, inner ear, and cerebellopontine angle surgery are given. This m...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::A 42-year-old woman presented with persistent headaches, vertigo, vomiting and transient periods of unconsciousness. Examination revealed a spheno-nasopharyngeal encephalocele lying between the ethmoid bone and the sphenoid sinus. It was possible to push the prolapse gently back by a transmaxillary procedure and to cl...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Endoscopic sinus surgery is the procedure of choice for treating chronic rhinosinusitis. This paper describes a new minimally invasive method to restore ostium patency without removing tissue: the balloon sinuplasty technique. PATIENTS AND METHODS:Two patients were treated with the new procedure. One patien...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-007-1637-2
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Patients with single-sided deafness (SSD) are limited by their asymmetric hearing in various areas of everyday life. OBJECTIVE:The aim of this investigation was to perform an age-correlated comparison of the hearing threshold of the better ear of SSD patients with a normal-hearing (NH) reference cohort. In ...
journal_title:HNO
pub_type: 杂志文章,多中心研究
doi:10.1007/s00106-019-00739-6
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Tissue engineering is a promising method for the generation of chondrogenic grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. METHODS:In this study, we investigated the expression of distinct markers during the dedifferentiation...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1322-2
更新日期:2006-04-01 00:00:00
abstract:: ...
journal_title:HNO
pub_type: 社论
doi:10.1007/s00106-018-0579-1
更新日期:2018-12-01 00:00:00
abstract::Angioedema is characterized by subcutaneous or submucosal swelling, which often affects the lips, tongue and oral or pharyngeal sites. Laryngeal oedema can be potentially life-threatening. The pathogenesis of angioedema is thought to involve the release of histamine and other mediators with subsequent extravasation of...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::A 3 year old child with recurrent pneumococcal meningitis and a congenital cyst of the oval window is presented. An aqueous middle ear effusion was found and scintigraphy demonstrated a middle ear CSF leak. Surgical exploration revealed a cyst originating from the stapes footplate. The origin of this malformation is d...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1978-12-01 00:00:00
abstract::The development of a middle ear cholesteatoma is usually associated with chronic inflammation and displacement of the mucosa present by the invading squamous epithelium. To analyze the clinically different behaviors of both epithelia, we used immunohistochemical methods to study the distribution and expression of inte...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050138
更新日期:1997-08-01 00:00:00
abstract::The aims of follow-up of head and neck cancer patients are the detection of new tumour manifestations, management of impairments after tumour therapy, psychological care and the evaluation of therapeutic efficacy. The extent, success and cost-benefit ratio of follow-up are currently under discussion. We recommend inte...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-006-1422-7
更新日期:2006-09-01 00:00:00
abstract::Disturbances of the swallowing process can occur at any age and might lead to choking. However, the risk of dysphagia increases with advanced age. This is not only due to a higher incidence of diseases that cause dysphagia, but also to age-related changes in the mechanisms of swallowing. Aging affects all of the anato...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-014-2864-y
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The incidence of squamous cell carcinomas in the upper aerodigestive tract has increased worldwide. The main risk factors are chronic tobacco and alcohol consumption. The detection of high-risk persons is important because early diagnosis of these tumors provides a good chance for permanent hea...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060170094
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:A new German speech audiometry test was developed using 26 nouns that are most likely part of the lexicon of 2‑year-old children. The test was a picture-pointing task using a four-alternative non-forced choice method. MATERIALS AND METHODS:In total, 179 children aged 2 years 11 months to 6 years 9 months wer...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-019-00788-x
更新日期:2020-07-01 00:00:00
abstract::Orbital complications of various pathogenesis include impairment or loss of vision inhibition of globe motility and exophthalmos, and are treated best by an interdisciplinary team. Preoperative strategy should include information about underlying diseases, since success of treatment is related to diagnosis. To analyse...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Immediate operative reposition of traumatic eardrum perforations has been found to give better morphological results when compared with spontaneous healing. The operative technique and results of healing in 32 patients treated at the ENT Department, University Hospital, Zürich, are discussed. ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract::The term "flow motion" stands for the phenomenon of spontaneous and autonomous rhythmic variations of the contractile state of the smooth muscles of small dermal vessels. There also have been a few observations of variations in the microcirculation of the mucosa, but they have not been evaluated in detail to date. The...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050044
更新日期:1996-09-01 00:00:00
abstract::The conservative treatment of idiopathic sudden deafness generally shows good results. There are, however, some cases resistant to therapy which may be treated surgically by vestibulotomy. Reports are made on personal experiences as well as those of other authors. Vestibulotomy is recommended for those patients in who...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:The Oldenburg children's rhyme test (OlKi) was designed and optimized for speech intelligibility measurements for primary school pupils in silence [8, 3]. In the optimization, the intelligibility of the particular test words was equalized. METHODS:The evaluation of the test with 147 primary school pupils wi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1304-4
更新日期:2006-03-01 00:00:00
abstract::Even today, a wide variety of techniques are performed in parotid pleomorphic adenoma surgery, ranging from enucleation to total parotidectomy. This study reports the results of our experiences. Among a total of 587 surgically treated parotid lesions at the Homburg/Saar University ENT Department from 1968 through 1991...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the Western World. It belongs to the low-grade non-Hodgkin lymphomas and is characterized by clonal reproduction of mature small-cell non-functional B-lymphocytes. CLL affects men somewhat more often than women and the average age at onset is ov...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-011-2340-x
更新日期:2012-04-01 00:00:00
abstract::We report the case of a 56-year-old female patient with a giant tumor on the left side of the neck, which appeared to be localised outside the large salivary glands. Due to the extensive vascularisation seen on MRI, digital subtraction angiography was performed. To reduce intraoperative bleeding, the vasculature was e...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-1954-8
更新日期:2010-02-01 00:00:00