Abstract：
BACKGROUND:Recurrent exacerbation of chronic external otitis represents a special challenge for the attending physician. The goal of our study was to evaluate the effectiveness of novel topical immunomodulators acting through an anti-inflammatory, nonsteroidal mechanism. PATIENTS AND METHODS:In a prospective study, in 33 patients an ear wick containing tacrolimus ointment (Protopic 0.1%) was inserted every 2-3 days. Altogether, the wick was changed three times. Therapeutic outcomes were assessed by reexaminations, video-otoscopy, and a standardized findings sheet. RESULTS:Twenty-eight patients showed significant improvement of clinical symptoms, with 13 of them showing complete healing (follow-up 10-22 months). Relapses (15 cases) were associated with significantly extended symptom-free intervals and reduced numbers of further recurrent episodes. CONCLUSIONS:Because of the safe and successful anti-inflammatory effects, topical immunomodulators represent a new alternative in chronic inflammatory stages of otherwise therapy-resistant external otitis.
journal_name
HNOjournal_title
HNOauthors
Caffier PP,Harth W,Mayelzadeh B,Haupt H,Scherer H,Sedlmaier Bdoi
10.1007/s00106-007-1615-8subject
Has Abstractpub_date
2008-05-01 00:00:00pages
530-4, 536-7issue
5eissn
0017-6192issn
1433-0458journal_volume
56pub_type
临床试验,杂志文章相关文献
HNO文献大全abstract：BACKGROUND:Digitalization is significantly changing the entire healthcare sector. Hospitals must act now in order to remain competitive. OBJECTIVE:To assess which approaches exist for digitalization along the treatment chain and how digitalization can be strategically implemented. MATERIALS AND METHODS:An analysis of...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-019-0655-1
更新日期：2019-05-01 00:00:00
abstract：:We present a retrospective study on 22 operations of exostosis of the external auditory canal in 20 patients. 8 patients were passionated by water sports. The most frequent indication for surgery (13 operations) was recurrent external otitis or ceruminal obstruction. In 7 cases the need for a wider access to the middl...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s001060050019
更新日期：2000-02-01 00:00:00
abstract：:The osteoplastic frontal sinus operation permits the complete removal of sinus mucosa and, with blockage of the frontonasal duct, the reliable obliteration of the sinus cavity. Two patients, who had had several surgical procedures for recurrent frontal sinusitis, became symptom free after this procedure. After an inte...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：PROBLEM:Although robust algorithms for registration and segmentation are available, the majority of surgical approaches to the temporal bone are nowadays made without navigation assistance. Beside instrument navigation (IN), functions such as distance control (DC) and navigated control (NC) can be used. This study anal...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-012-2558-2
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Chronic hoarseness, globus sensation or mucous obstruction are among a wide range of symptoms possibly related to laryngopharyngeal reflux (LPR). METHOD AND RESULTS:A selective literature research was carried out using PubMed, in which original articles and reviews in German and English were included. Altog...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-011-2441-6
更新日期：2012-03-01 00:00:00
abstract：:The cochlear implant surgeon would like to insert the electrodes into the cochlea as deep as possible. With the Nucleus Cochlear Implant Mini System 22 often he succeeds until even all 10 blind rings disappear in the cochlea. By coating the electrodes with hyaluronic acid (Healon) it will be facilitated and additional...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The elderly show a general reduction of their bodily and mental reactions. They become slower to react and their sensory ability decreases, e.g. hearing, vision, smell and taste. With increasing age, disturbances of the balance system are found more frequently, resulting in dysequilibrium, vertigo, lightheadedness and...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:There are controversial opinions about the incidence of hearing impairment of children and adolescents with Down's syndrome as an additional cause for obstruction in social and communicative live. Next to congenital diseases of the inner ear, functional limitations can often lead to conductive hearing disord...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-004-1205-y
更新日期：2006-03-01 00:00:00
abstract：:Ototoxic side effects of cisplatin have often been reported, but no conclusive data have been reported about carboplatin ototoxicity. We investigated the vestibular toxicity of carboplatin therapy in two groups of 18 patients with head and neck cancer. The treated group was examined before, during and after chemothera...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Disease of the cervical spine may cause vestibular vertigo. The anatomical basis for this type of cervical vertigo are the proprioceptive stretch receptors of the upper cervical joints. These are connected to the vestibular nuclei, and, thus, to ocular reactions (nystagmus). Quantitative data about this cervico-ocular...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:The aim of this multicenter clinical field study was to assess the benefits of the new Freedom 24 sound processor for cochlear implant (CI) users implanted with the Nucleus 24 cochlear implant system. The study included 48 postlingually profoundly deaf experienced CI users who demonstrated speech comprehension perform...
journal_title：HNO
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00106-008-1781-3
更新日期：2009-06-01 00:00:00
abstract：:Twenty-one patients with tumors or chronic inflammation of the parotid gland were examined both by MRI and ultrasound. The findings of MRI were compared with sonography and with the findings of other imaging methods. In most cases MRI provided valuable additional information about the structure of the gland and the ex...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Two patients with squamous cell carcinoma of the middle ear appearing 8 years after a tympanoplasty for cholesteatoma are reported. The tumours presented as a recurrent cholesteatoma and a temporal lobe abscess. The pathogenesis of these tumours is discussed. ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：BACKGROUND:According to the scientific literature, a hearing impairment which is acquired late reduces mental efficiency. OBJECTIVE:To determine by empirical examination whether hearing aids increase mental efficiency. PERSONS AND METHODS: An open controlled application study was carried out on the capacity of working...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-005-1253-y
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:The excision of sentinel lymph nodes has a growing relevance in the diagnosis of oral and oropharyngeal cancer in cases of N0 necks. The validity of sentinel node biopsy (SNB) was examined as a single surgical staging tool. PATIENTS AND METHODS:Within the framework of a multi-modal treatment scheme, SNB wit...
journal_title：HNO
pub_type： 临床试验,杂志文章
doi：10.1007/s00106-004-1191-0
更新日期：2005-06-01 00:00:00
abstract：:Abnormal eustachian tube function has been a major problem in improving hearing with middle ear surgery. In 13 patients, a newly developed gold tube conductor was placed in the eustachian tube via the middle ear cavity. Patients were examined 2-50 months postoperatively, at which time middle ear aeration was found to ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:In order to overcome the disadvantages of hearing aids, a significant amount of research aimed at replacing them by implanted ossicular-coupled electronic hearing devices is being carried out. The technical and audiological demands on the electromechanical transducer of an implantable hearing aid for moderate to sever...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s001060050156
更新日期：1997-10-01 00:00:00
abstract：:There are many benign and malignant tumors of the epipharynx, which makes differential diagnosis difficult. As a very rare differential diagnosis, a schwannoma is possible. The origin of the tumor is most likely a small branch of a sensitive nerve of the glossopharyngeal nerve or the trigeminus nerve. A clear differen...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-012-2583-1
更新日期：2013-05-01 00:00:00
abstract：:Although the history of intraoperative neuromonitoring (IONM) dates back to the 19th century, the method did not evolve further than the mere differentiation of nerves until recently. Only the development of continuous IONM (cIONM) has allowed for non-stop analysis of excitation amplitude and latency during surgical p...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-020-00824-1
更新日期：2020-08-01 00:00:00
abstract：:Due to the frequency of this phenomenon and the often considerable distress caused to the affected person, competent advice, diagnosis and treatment of snoring in adults is of particular importance. The aim of this guideline is to promote high-quality medical care for patients affected by this problem. According to th...
journal_title：HNO
pub_type： 杂志文章,实务指引
doi：10.1007/s00106-010-2103-0
更新日期：2010-03-01 00:00:00
abstract：:A retrospective study of 199 surgically treated skin carcinomas showed that the majority of the insufficiently resected tumors had a maximum diameter of 10 mm. A surgical concept is presented which allows reliable histological control of the tumor margins and an exact resection of any residual carcinoma. This therapeu...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：OBJECTIVE:In this study, an objective version of the postlaryngectomy telephone test (PLTT) for measuring speech intelligibility based on automatic speech recognition is presented. METHODS:Thirty-one patients with tracheoesophageal substitute voice (25 men and six women, 63.4+/-8.7 years) were evaluated by 11 naïve li...
journal_title：HNO
pub_type： 临床试验,杂志文章
doi：10.1007/s00106-008-1698-x
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Cleft lip and palate are the most common malformation in the orofacial region. The type and dimension of the cleft determine the functional limitations of respiration, swallowing, speech, articulation and hearing. In addition, cosmetic and communicative restrictions influence the cognitive, social and educat...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-003-0843-9
更新日期：2003-06-01 00:00:00
abstract：:The Groningen voice prosthesis is a self-retaining silicone device, placed in the tracheooesophageal wall as a primary procedure during laryngectomy or some time after surgery. Prosthetic vocal rehabilitation was successful in 80% of the patients. Indications, contra-indications, advantages, disadvantages and complica...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:From the technical point of view, cochlear implant (CI) surgery in adults is a well established procedure. Pre- and postoperative evaluation, surgical approach and rehabilitation programs are standardized, presenting CI as a low risk procedure with rare complications similar to those of middle ear surgery. Modern adva...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-003-0893-z
更新日期：2003-07-01 00:00:00
abstract：:Nowadays the cochlear implant (CI) offers a new method of hearing, especially for deaf patients who do not benefit from conventional hearing aids. However, it may be difficult to get used to this kind of hearing advice. CI users have special problems in interpreting strange acoustic sensations and relating them to aud...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1989-06-01 00:00:00
abstract：:The overall incidence of severe head, face and neck injuries as seen from the German Trauma Registry of the National Association of German Trauma Surgeons is 81.3%. The leading causes of death among these patients are hemorrhage and severe traumatic brain injury. The aim of prehospital emergency medical care is to sta...
journal_title：HNO
pub_type： 杂志文章,评审
doi：10.1007/s00106-011-2353-5
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Tissue engineering is a promising method for the generation of chondrogenic grafts for reconstructive surgery. In cultured chondrocytes, the dedifferentiation of cells seems unavoidable for multiplication. METHODS:In this study, we investigated the expression of distinct markers during the dedifferentiation...
journal_title：HNO
pub_type： 杂志文章
doi：10.1007/s00106-005-1322-2
更新日期：2006-04-01 00:00:00
abstract：:On the basis of certain fundamental data for pathological hearing in children and its effects on speech development an attempt is made to summarise the most important considerations regarding the primary choice of a device and the subsequent procedures of fitting to optimise the benefits over a range of ages, from the...
journal_title：HNO
pub_type： 杂志文章,评审
doi：
更新日期：1989-10-01 00:00:00
abstract：:We report two patients with voice disorders after parathyroidectomy without thyroidectomy and paresis of the recurrent nerve. The connection between hypoparathyroidismus and laryngeal tetany is discussed. ...
journal_title：HNO
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
