Optimal screening and donor management in a public stool bank.

Abstract:

BACKGROUND:Fecal microbiota transplantation is an effective treatment for recurrent Clostridium difficile infection and is being investigated as a treatment for other microbiota-associated diseases. To facilitate these activities, an international public stool bank has been created, which screens donors and processes stools in a standardized manner. The goal of this research is to use mathematical modeling and analysis to optimize screening and donor management at the stool bank. RESULTS:Compared to the current policy of screening active donors every 60 days before releasing their quarantined stools for sale, costs can be reduced by 10.3 % by increasing the screening frequency to every 36 days. In addition, the stool production rate varies widely across donors, and using donor-specific screening, where higher producers are screened more frequently, also reduces costs, as does introducing an interim (i.e., between consecutive regular tests) stool test for just rotavirus and C. difficile. We also derive a donor release (i.e., into the system) policy that allows the supply to approximately match an exponentially increasing deterministic demand. CONCLUSIONS:More frequent screening, interim screening for rotavirus and C. difficile, and donor-specific screening, where higher stool producers are screened more frequently, are all cost-reducing measures. If screening costs decrease in the future (e.g., as a result of bringing screening in house), a bottleneck for implementing some of these recommendations may be the reluctance of donors to undergo serum screening more frequently than monthly.

journal_name

Microbiome

journal_title

Microbiome

authors

Kazerouni A,Burgess J,Burns LJ,Wein LM

doi

10.1186/s40168-015-0140-3

subject

Has Abstract

pub_date

2015-12-17 00:00:00

pages

75

issn

2049-2618

pii

10.1186/s40168-015-0140-3

journal_volume

3

pub_type

杂志文章
  • MetaEuk-sensitive, high-throughput gene discovery, and annotation for large-scale eukaryotic metagenomics.

    abstract:BACKGROUND:Metagenomics is revolutionizing the study of microorganisms and their involvement in biological, biomedical, and geochemical processes, allowing us to investigate by direct sequencing a tremendous diversity of organisms without the need for prior cultivation. Unicellular eukaryotes play essential roles in mo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00808-x

    authors: Levy Karin E,Mirdita M,Söding J

    更新日期:2020-04-03 00:00:00

  • CloVR-ITS: Automated internal transcribed spacer amplicon sequence analysis pipeline for the characterization of fungal microbiota.

    abstract:BACKGROUND:Besides the development of comprehensive tools for high-throughput 16S ribosomal RNA amplicon sequence analysis, there exists a growing need for protocols emphasizing alternative phylogenetic markers such as those representing eukaryotic organisms. RESULTS:Here we introduce CloVR-ITS, an automated pipeline ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-6

    authors: White JR,Maddox C,White O,Angiuoli SV,Fricke WF

    更新日期:2013-02-04 00:00:00

  • Genomic insights into potential interdependencies in microbial hydrocarbon and nutrient cycling in hydrothermal sediments.

    abstract:BACKGROUND:Deep-sea hydrothermal vents are hotspots for productivity and biodiversity. Thermal pyrolysis and circulation produce fluids rich in hydrocarbons and reduced compounds that stimulate microbial activity in surrounding sediments. Several studies have characterized the diversity of Guaymas Basin (Gulf of Califo...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0322-2

    authors: Dombrowski N,Seitz KW,Teske AP,Baker BJ

    更新日期:2017-08-23 00:00:00

  • Facultative methanotrophs are abundant at terrestrial natural gas seeps.

    abstract:BACKGROUND:Natural gas contains methane and the gaseous alkanes ethane, propane and butane, which collectively influence atmospheric chemistry and cause global warming. Methane-oxidising bacteria, methanotrophs, are crucial in mitigating emissions of methane as they oxidise most of the methane produced in soils and the...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0500-x

    authors: Farhan Ul Haque M,Crombie AT,Ensminger SA,Baciu C,Murrell JC

    更新日期:2018-06-28 00:00:00

  • Antimicrobial-specific response from resistance gene carriers studied in a natural, highly diverse microbiome.

    abstract:BACKGROUND:Antimicrobial resistance (AMR) is a major threat to public health. Microorganisms equipped with AMR genes are suggested to have partially emerged from natural habitats; however, this hypothesis remains inconclusive so far. To understand the consequences of the introduction of exogenic antimicrobials into nat...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00982-y

    authors: Wicaksono WA,Kusstatscher P,Erschen S,Reisenhofer-Graber T,Grube M,Cernava T,Berg G

    更新日期:2021-01-27 00:00:00

  • Seasonal and algal diet-driven patterns of the digestive microbiota of the European abalone Haliotis tuberculata, a generalist marine herbivore.

    abstract:BACKGROUND:Holobionts have a digestive microbiota with catabolic abilities allowing the degradation of complex dietary compounds for the host. In terrestrial herbivores, the digestive microbiota is known to degrade complex polysaccharides from land plants while in marine herbivores, the digestive microbiota is poorly c...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0430-7

    authors: Gobet A,Mest L,Perennou M,Dittami SM,Caralp C,Coulombet C,Huchette S,Roussel S,Michel G,Leblanc C

    更新日期:2018-03-27 00:00:00

  • Prolonged use of a proton pump inhibitor reduces microbial diversity: implications for Clostridium difficile susceptibility.

    abstract:BACKGROUND:The role of the gut microbiome in arresting pathogen colonization and growth is important for protection against Clostridium difficile infection (CDI). Observational studies associate proton pump inhibitor (PPI) use and CDI incidence. We hypothesized that PPI use affected the distal gut microbiome over time,...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-2-42

    authors: Seto CT,Jeraldo P,Orenstein R,Chia N,DiBaise JK

    更新日期:2014-11-25 00:00:00

  • Correction to: Stochastic processes shape microeukaryotic community assembly in a subtropical river across wet and dry seasons.

    abstract::Following publication of the original article [1], the authors reported an error in Figure 1 and a text on page 13. In Figure 1, some areas are missing and the correct figure is presented here. On page 13, the sentence should be updated to the following (change has been indicated in bold italics). ...

    journal_title:Microbiome

    pub_type: 已发布勘误

    doi:10.1186/s40168-019-0763-x

    authors: Chen W,Ren K,Isabwe A,Chen H,Liu M,Yang J

    更新日期:2019-11-14 00:00:00

  • Correction to: Microbiome definition re-visited: old concepts and new challenges.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:Microbiome

    pub_type: 已发布勘误

    doi:10.1186/s40168-020-00905-x

    authors: Berg G,Rybakova D,Fischer D,Cernava T,Vergès MC,Charles T,Chen X,Cocolin L,Eversole K,Corral GH,Kazou M,Kinkel L,Lange L,Lima N,Loy A,Macklin JA,Maguin E,Mauchline T,McClure R,Mitter B,Ryan M,Sarand I,Smidt H

    更新日期:2020-08-20 00:00:00

  • Interactive effects of temperature, organic carbon, and pipe material on microbiota composition and Legionella pneumophila in hot water plumbing systems.

    abstract:BACKGROUND:Several biotic and abiotic factors have been reported to influence the proliferation of microbes, including Legionella pneumophila, in hot water premise plumbing systems, but their combined effects have not been systematically evaluated. Here, we utilize simulated household water heaters to examine the effec...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0348-5

    authors: Proctor CR,Dai D,Edwards MA,Pruden A

    更新日期:2017-10-04 00:00:00

  • Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.

    abstract:BACKGROUND:The degree to which host genetic variation can modulate microbial communities in humans remains an open question. Here, we performed a genetic mapping study of the microbiome in two accessible upper airway sites, the nasopharynx and the nasal vestibule, during two seasons in 144 adult members of a founder po...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0227-5

    authors: Igartua C,Davenport ER,Gilad Y,Nicolae DL,Pinto J,Ober C

    更新日期:2017-02-01 00:00:00

  • Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

    abstract:BACKGROUND:Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0451-2

    authors: Dai Z,Coker OO,Nakatsu G,Wu WKK,Zhao L,Chen Z,Chan FKL,Kristiansen K,Sung JJY,Wong SH,Yu J

    更新日期:2018-04-11 00:00:00

  • Shifts among Eukaryota, Bacteria, and Archaea define the vertical organization of a lake sediment.

    abstract:BACKGROUND:Lake sediments harbor diverse microbial communities that cycle carbon and nutrients while being constantly colonized and potentially buried by organic matter sinking from the water column. The interaction of activity and burial remained largely unexplored in aquatic sediments. We aimed to relate taxonomic co...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0255-9

    authors: Wurzbacher C,Fuchs A,Attermeyer K,Frindte K,Grossart HP,Hupfer M,Casper P,Monaghan MT

    更新日期:2017-04-08 00:00:00

  • MetaCHIP: community-level horizontal gene transfer identification through the combination of best-match and phylogenetic approaches.

    abstract:BACKGROUND:Metagenomic datasets provide an opportunity to study horizontal gene transfer (HGT) on the level of a microbial community. However, current HGT detection methods cannot be applied to community-level datasets or require reference genomes. Here, we present MetaCHIP, a pipeline for reference-independent HGT ide...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0649-y

    authors: Song W,Wemheuer B,Zhang S,Steensen K,Thomas T

    更新日期:2019-03-04 00:00:00

  • An integrated meta-omics approach reveals substrates involved in synergistic interactions in a bisphenol A (BPA)-degrading microbial community.

    abstract:BACKGROUND:Understanding microbial interactions in engineering bioprocesses is important to enhance and optimize performance outcomes and requires dissection of the multi-layer complexities of microbial communities. However, unraveling microbial interactions as well as substrates involved in complex microbial communiti...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0634-5

    authors: Yu K,Yi S,Li B,Guo F,Peng X,Wang Z,Wu Y,Alvarez-Cohen L,Zhang T

    更新日期:2019-02-06 00:00:00

  • Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.

    abstract:BACKGROUND:The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of multicellular organisms as "metaorganisms." The goal of the Collaborative Research Center "Origin and...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0743-1

    authors: Rausch P,Rühlemann M,Hermes BM,Doms S,Dagan T,Dierking K,Domin H,Fraune S,von Frieling J,Hentschel U,Heinsen FA,Höppner M,Jahn MT,Jaspers C,Kissoyan KAB,Langfeldt D,Rehman A,Reusch TBH,Roeder T,Schmitz RA,Schulenb

    更新日期:2019-09-14 00:00:00

  • Clustering co-abundant genes identifies components of the gut microbiome that are reproducibly associated with colorectal cancer and inflammatory bowel disease.

    abstract:BACKGROUND:Whole-genome "shotgun" (WGS) metagenomic sequencing is an increasingly widely used tool for analyzing the metagenomic content of microbiome samples. While WGS data contains gene-level information, it can be challenging to analyze the millions of microbial genes which are typically found in microbiome experim...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0722-6

    authors: Minot SS,Willis AD

    更新日期:2019-08-01 00:00:00

  • Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis.

    abstract:BACKGROUND:Bacterial vaginosis (BV), the most common vaginal condition of reproductive-aged women, is associated with a highly diverse and heterogeneous microbiota. Here we present a proof-of-principle analysis to uncover the function of the microbiota using meta-RNA-seq to uncover genes and pathways that potentially d...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-12

    authors: Macklaim JM,Fernandes AD,Di Bella JM,Hammond JA,Reid G,Gloor GB

    更新日期:2013-04-12 00:00:00

  • Microbial diversity and community composition of caecal microbiota in commercial and indigenous Indian chickens determined using 16s rDNA amplicon sequencing.

    abstract:BACKGROUND:The caecal microbiota plays a key role in chicken health and performance, influencing digestion and absorption of nutrients, and contributing to defence against colonisation by invading pathogens. Measures of productivity and resistance to pathogen colonisation are directly influenced by chicken genotype, bu...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0501-9

    authors: Pandit RJ,Hinsu AT,Patel NV,Koringa PG,Jakhesara SJ,Thakkar JR,Shah TM,Limon G,Psifidi A,Guitian J,Hume DA,Tomley FM,Rank DN,Raman M,Tirumurugaan KG,Blake DP,Joshi CG

    更新日期:2018-06-23 00:00:00

  • Wild bees and their nests host Paenibacillus bacteria with functional potential of avail.

    abstract:BACKGROUND:In previous studies, the gram-positive firmicute genus Paenibacillus was found with significant abundances in nests of wild solitary bees. Paenibacillus larvae is well-known for beekeepers as a severe pathogen causing the fatal honey bee disease American foulbrood, and other members of the genus are either s...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0614-1

    authors: Keller A,Brandel A,Becker MC,Balles R,Abdelmohsen UR,Ankenbrand MJ,Sickel W

    更新日期:2018-12-22 00:00:00

  • Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants.

    abstract:BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns and contribute to adverse skin attributes such as premature skin aging and pigmentary disorder. However, little information is available on the potential roles of chronic urban PAH pollutant exposure on the cutaneous micr...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00874-1

    authors: Leung MHY,Tong X,Bastien P,Guinot F,Tenenhaus A,Appenzeller BMR,Betts RJ,Mezzache S,Li J,Bourokba N,Breton L,Clavaud C,Lee PKH

    更新日期:2020-06-26 00:00:00

  • Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease.

    abstract:BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disorder with no absolute cure. The evidence of the involvement of gut microbiota in PD pathogenesis suggests the need to identify certain molecule(s) derived from the gut microbiota, which has the potential to manage PD. Osteocalcin (OCN), an osteoblast-secret...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00988-6

    authors: Hou YF,Shan C,Zhuang SY,Zhuang QQ,Ghosh A,Zhu KC,Kong XK,Wang SM,Gong YL,Yang YY,Tao B,Sun LH,Zhao HY,Guo XZ,Wang WQ,Ning G,Gu YY,Li ST,Liu JM

    更新日期:2021-01-31 00:00:00

  • Differential dynamics of microbial community networks help identify microorganisms interacting with residue-borne pathogens: the case of Zymoseptoria tritici in wheat.

    abstract:BACKGROUND:Wheat residues are a crucial determinant of the epidemiology of Septoria tritici blotch, as they support the sexual reproduction of the causal agent Zymoseptoria tritici. We aimed to characterize the effect of infection with this fungal pathogen on the microbial communities present on wheat residues and to i...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0736-0

    authors: Kerdraon L,Barret M,Laval V,Suffert F

    更新日期:2019-08-30 00:00:00

  • Rhizosphere microbiomes diverge among Populus trichocarpa plant-host genotypes and chemotypes, but it depends on soil origin.

    abstract:BACKGROUND:Plants have developed defense strategies for phytopathogen and herbivore protection via coordinated metabolic mechanisms. Low-molecular weight metabolites produced within plant tissues, such as salicylic acid, represent one such mechanism which likely mediates plant - microbe interactions above and below gro...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-019-0668-8

    authors: Veach AM,Morris R,Yip DZ,Yang ZK,Engle NL,Cregger MA,Tschaplinski TJ,Schadt CW

    更新日期:2019-05-18 00:00:00

  • Hybridization capture reveals microbial diversity missed using current profiling methods.

    abstract:BACKGROUND:Microorganisms comprise the majority of living organisms on our planet. For many years, exploration of the composition of microbial communities has been performed through the PCR-based study of the small subunit rRNA gene due to its high conservation across the domains of life. The application of this method...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-018-0442-3

    authors: Gasc C,Peyret P

    更新日期:2018-03-27 00:00:00

  • Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model.

    abstract:BACKGROUND:This proof-of-principle study examines whether postnatal, low-dose exposure to environmental chemicals modifies the composition of gut microbiome. Three chemicals that are widely used in personal care products-diethyl phthalate (DEP), methylparaben (MPB), triclosan (TCS)-and their mixture (MIX) were administ...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-016-0173-2

    authors: Hu J,Raikhel V,Gopalakrishnan K,Fernandez-Hernandez H,Lambertini L,Manservisi F,Falcioni L,Bua L,Belpoggi F,L Teitelbaum S,Chen J

    更新日期:2016-06-14 00:00:00

  • Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota.

    abstract:BACKGROUND:The use of culture-independent nucleic acid techniques, such as ribosomal RNA gene cloning library analysis, has unveiled the tremendous microbial diversity that exists in natural environments. In sharp contrast to this great achievement is the current difficulty in cultivating the majority of bacterial spec...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/2049-2618-1-4

    authors: Gao W,Navarroli D,Naimark J,Zhang W,Chao SH,Meldrum DR

    更新日期:2013-01-09 00:00:00

  • Group therapy on in utero colonization: seeking common truths and a way forward.

    abstract::The human microbiome refers to the genetic composition of microorganisms in a particular location in the human body. Emerging evidence over the past many years suggests that the microbiome constitute drivers of human fate almost at par with our genome and epigenome. It is now well accepted after decades of disbelief t...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00968-w

    authors: Silverstein RB,Mysorekar IU

    更新日期:2021-01-12 00:00:00

  • Seasonal, spatial, and maternal effects on gut microbiome in wild red squirrels.

    abstract:BACKGROUND:Our understanding of gut microbiota has been limited primarily to findings from human and laboratory animals, but what shapes the gut microbiota in nature remains largely unknown. To fill this gap, we conducted a comprehensive study of gut microbiota of a well-studied North American red squirrel (Tamiasciuru...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-017-0382-3

    authors: Ren T,Boutin S,Humphries MM,Dantzer B,Gorrell JC,Coltman DW,McAdam AG,Wu M

    更新日期:2017-12-21 00:00:00

  • Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020.

    abstract::The inaugural "Microbiome for Mars" virtual workshop took place on July 13, 2020. This event assembled leaders in microbiome research and development to discuss their work and how it may relate to long-duration human space travel. The conference focused on surveying current microbiome research, future endeavors, and h...

    journal_title:Microbiome

    pub_type: 杂志文章

    doi:10.1186/s40168-020-00951-5

    authors: LaPelusa M,Donoviel D,Branzini SE,Carlson PE Jr,Culler S,Cheema AK,Kaddurah-Daouk R,Kelly D,de Cremoux I,Knight R,Krajmalnik-Brown R,Mayo SL,Mazmanian SK,Mayer EA,Petrosino JF,Garrison K

    更新日期:2021-01-04 00:00:00