Abstract:
STUDY DESIGN:A descriptive in vitro study on isolation and differentiation of human mesenchymal stem cells (MSCs) derived from the facet joints and interspinous ligaments. OBJECTIVE:To isolate cells from the facet joints and interspinous ligaments and investigate their surface marker profile and differentiation potentials. SUMMARY OF BACKGROUND DATA:Lumbar spinal canal stenosis and ossification of the posterior longitudinal ligament are progressive conditions characterized by the hypertrophy and ossification of ligaments and joints within the spinal canal. MSCs are believed to play a role in the advancement of these diseases and the existence of MSCs has been demonstrated within the ligamentum flavum and posterior longitudinal ligament. The aim of this study was to investigate whether these cells could also be found within facet joints and interspinous ligaments. METHODS:Samples were harvested from 10 patients undergoing spinal surgery. The MSCs from facet joints and interspinous ligaments were isolated using direct tissue explant technique. Cell surface antigen profilings were performed via flow cytometry. Their lineage differentiation potentials were analyzed. RESULTS:The facet joints and interspinous ligaments-derived MSCs have the tri-lineage potential to be differentiated into osteogenic, adipogenic, and chondrogenic cells under appropriate inductions. Flow cytometry analysis revealed both cell lines expressed MSCs markers. Both facet joints and interspinous ligaments-derived MSCs expressed marker genes for osteoblasts, adipocytes, and chondrocytes. CONCLUSION:The facet joints and interspinous ligaments may provide alternative sources of MSCs for tissue engineering applications. The facet joints and interspinous ligaments-derived MSCs are part of the microenvironment of the human ligaments of the spinal column and might play a crucial role in the development and progression of degenerative spine conditions.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Kristjánsson B,Limthongkul W,Yingsakmongkol W,Thantiworasit P,Jirathanathornnukul N,Honsawek Sdoi
10.1097/BRS.0000000000001178subject
Has Abstractpub_date
2016-01-01 00:00:00pages
E1-7issue
1eissn
0362-2436issn
1528-1159journal_volume
41pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:Systematic literature review and expert survey OBJECTIVE.: The aim of this study was to determine factors associated with neurologic improvement in patients with neurologic deficits secondary to metastatic epidural spinal cord compression (MESCC). Clear understanding of these factors will guide surgical de...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000001827
更新日期:2016-10-15 00:00:00
abstract:STUDY DESIGN:A cross-sectional survey among adolescents aged 15-16 years. OBJECTIVE:To evaluate whether physical activity or sedentary activities associate with neck and shoulder symptoms among adolescents. SUMMARY OF BACKGROUND DATA:Findings of associations between physical exercise and neck or shoulder pain in adol...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000261349.94823.c1
更新日期:2007-04-20 00:00:00
abstract:STUDY DESIGN:A prospective study of anterior transarticular screw (ATS) fixation patients. OBJECTIVE:To develop a method to determine screw tip position through plain radiography after percutaneous ATS fixation to prevent occipitocervical joint (OCJ) violation. SUMMARY OF BACKGROUND DATA:No studies using plain radiog...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001508
更新日期:2016-09-01 00:00:00
abstract:STUDY DESIGN:A randomized controlled trial was conducted. OBJECTIVE:To determine the efficacy of osteopathic manipulative treatment as a complementary treatment for chronic nonspecific low back pain. SUMMARY OF BACKGROUND DATA:Osteopathic manipulative treatment may be useful for acute or subacute low back pain. Howev...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.BRS.0000067110.61471.7D
更新日期:2003-07-01 00:00:00
abstract:STUDY DESIGN:An ex vivo biomechanical study using cadaveric vertebral bodies. OBJECTIVE:To determine how bone mineral density (BMD) affects mechanical strength and stiffness of the vertebral body after vertebroplasty, and to determine how the association between mechanical properties and BMD varies with amount of ceme...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318133fc73
更新日期:2007-08-15 00:00:00
abstract:STUDY DESIGN:A subanalysis study. OBJECTIVE:The purpose of this study was to determine the impact of multilevel lumbar stenosis with or without degenerative spondylolisthesis compared to single level disease on patients' baseline symptoms and clinical outcomes over time. SUMMARY OF BACKGROUND DATA:Previous studies ha...
journal_title:Spine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/BRS.0b013e3181bdafb9
更新日期:2010-02-15 00:00:00
abstract:STUDY DESIGN:A clinical series of patients with unilateral radiculopathy treated with the anterior cervical foraminotomy procedure. OBJECTIVE:To establish procedural techniques and clinical and radiologic outcomes for the anterior cervical foraminotomy procedure. SUMMARY OF BACKGROUND DATA:Cervical radiculopathy is t...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200004150-00002
更新日期:2000-04-15 00:00:00
abstract:STUDY DESIGN:An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine. OBJECTIVE:To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes. SUMMARY OF BACK...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200108010-00004
更新日期:2001-08-01 00:00:00
abstract:STUDY DESIGN:Systematic review of randomized clinical trials. OBJECTIVES:To assess the efficacy of spinal manipulation for patients with low back pain. SUMMARY OF BACKGROUND DATA:The management of low back pain remains controversial. Spinal manipulation is a widely used treatment option for low back pain. Recently is...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199612150-00013
更新日期:1996-12-15 00:00:00
abstract:STUDY DESIGN:Multiple center study to evaluate cerebrospinal fluid (CSF) concentrations of nitric oxide metabolites [NOx] in relation to neurologic severity and prognosis in spinal cord injury (SCI). OBJECTIVE:To examine whether CSF [NOx] correlates with neurologic severity and recovery in SCI. SUMMARY OF BACKGROUND ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181abda1d
更新日期:2009-08-15 00:00:00
abstract:STUDY DESIGN:This was a population-based retrospective study. OBJECTIVE:To fully estimate the costs of the Hong Kong scoliosis screening program through a large, population-based study. SUMMARY OF BACKGROUND DATA:School screening for scoliosis has often been criticized for having high costs. In fact, the screening co...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181cbcc10
更新日期:2010-12-15 00:00:00
abstract::A patient with idiopathic hypertrophic spinal pachymeningitis (HSP) with predominant involvement of the cervical and thoracic dura is reported. Serial magnetic resonance (MR) images detected isolated thickening and ridges of the dura mater. There has been no report describing the serial changes of MR images in idiopat...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199403000-00021
更新日期:1994-03-01 00:00:00
abstract:STUDY DESIGN:A case of spinal chronic subdural hematoma (SCSDH) in association with anticoagulant therapy was treated surgically. OBJECTIVE:To clarify the etiopathogenesis, clinical presentation, and surgical outcomes of SCSDH. SUMMARY OF BACKGROUND DATA:Intracranial chronic subdural hematoma is a well-recognized com...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000202760.30257.88
更新日期:2006-03-15 00:00:00
abstract:STUDY DESIGN:Case report and clinical discussion. OBJECTIVE:To describe a rare case of metastatic pulmonary intimal sarcoma presenting as cauda equine syndrome. SUMMARY OF BACKGROUND DATA:Pulmonary artery sarcoma is a rare tumor, frequently misdiagnosed as pulmonary embolism, and although it is highly aggressive, met...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817cf7ef
更新日期:2008-07-01 00:00:00
abstract:STUDY DESIGN:Case series. OBJECTIVE:To describe the outcomes of workers' compensation (WC) claimants who have had a lumbar intradiscal electrothermal therapy (IDET) procedure. SUMMARY OF BACKGROUND DATA:IDET was developed as a less invasive treatment alternative to fusion after failure of conservative treatment for d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000092376.41688.1a
更新日期:2004-02-15 00:00:00
abstract:STUDY DESIGN:Subgroup analysis of a prospective multicenter study. OBJECTIVE:Outcome analysis of nonoperatively treated elderly patients with type II odontoid fractures, including assessment of consequence of a fracture nonunion. SUMMARY OF BACKGROUND DATA:Odontoid fractures are among the most common fractures in the...
journal_title:Spine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/BRS.0000000000000009
更新日期:2013-12-15 00:00:00
abstract:STUDY DESIGN:A fully randomized experiment was conducted in a laboratory with a breath-by-breath monitor to control accurately the two factors of breathing maneuvers: breathholding duration and air volume within the thoracic cavity. OBJECTIVES:To resolve the controversy in previous reports about the effect of breathho...
journal_title:Spine
pub_type:
doi:10.1097/00007632-200210010-00014
更新日期:2002-10-01 00:00:00
abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To test the hypothesis that spinal cord lesions cause postoperative upper extremity palsy. SUMMARY OF BACKGROUND DATA:Postoperative paresis, so-called C5 palsy, of the upper extremities is a common complication of cervical surgery. Although there are several hypotheses r...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/01.brs.0000257576.84646.49
更新日期:2007-03-15 00:00:00
abstract:STUDY DESIGN:Animal experimental study. OBJECTIVE:The aim of this study was to investigate the optimal time of hydrogel injection for regenerating intervertebral disc degeneration (IDD) based on T1ρ magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA:Currently, different approaches are being pursued to regen...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003667
更新日期:2020-11-15 00:00:00
abstract:STUDY DESIGN:Fifty-seven patients with dens fractures were identified from 1986 to 1996 at the authors' institution. Forty-six were available for reevaluation by two independent observers with a mean follow-up period of 26 months. OBJECTIVE:To determine by age and fracture type which treatment regimen provided the bes...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199809010-00006
更新日期:1998-09-01 00:00:00
abstract:STUDY DESIGN:Basic science, biologic study. OBJECTIVE:To determine the potential benefits of using resveratrol (RSV) for intervertebral disc (IVD) matrix repair and regeneration. SUMMARY OF BACKGROUND DATA:The phytoestrogen RSV is a natural compound found in various plants including grapes and red wines. RSV has been...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181883883
更新日期:2008-11-15 00:00:00
abstract:STUDY DESIGN:Prospective analysis of resource utilization (RU) after lumbar surgery. OBJECTIVE:To determine contributions of patient psychosocial variables to RU, specifically length of stay (LOS) and discharge destination. SUMMARY OF BACKGROUND DATA:Associations between demographic/clinical variables and RU are well...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002312
更新日期:2018-02-15 00:00:00
abstract:STUDY DESIGN:Retrospective literature review. OBJECTIVE:To assess the quality of randomized controlled trial reporting in spine surgery. SUMMARY OF BACKGROUND DATA:The use of the Consolidated Standards of Reporting Trials (CONSORT) criteria in clinical trials aims to improve adherence to a set of generally accepted p...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3181f2aef0
更新日期:2011-07-15 00:00:00
abstract:STUDY DESIGN:A prospective assessment, performed using the Health Status Questionnaire, of the outcomes for 28 patients with cervical radiculopathy treated with one- or two-level anterior cervical discectomy and fusion. OBJECTIVE:To assess patient outcome using the Health Status Questionnaire after one- or two-level a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200004010-00007
更新日期:2000-04-01 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To quantify variability in undesirable outcomes among studies of lumbar interbody fusion using stand-alone cage devices, and to determine whether author conflicts of interest contribute to variability. SUMMARY OF BACKGROUND DATA:Promising early studies of lumbar fusion with s...
journal_title:Spine
pub_type: 杂志文章,meta分析
doi:10.1097/01.brs.0000255809.95593.3b
更新日期:2007-02-15 00:00:00
abstract::Twenty-two adolescent patients with severe (more than 50%) slip were surgically treated. Eleven were reduced with Magerl/Dick transpedicular screw devices and fused posteriorly from L4 to S1, and 2 weeks later anteriorly L5-S1; the other 11 were fused in situ L4-S1 (6 patients) or L5-S1 (5 patients) using a circumfere...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199306000-00014
更新日期:1993-06-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:To validate the precision of four predictive scoring systems for spinal metastatic disease and evaluate whether they underestimate or overestimate survival. SUMMARY OF BACKGROUND DATA:Metastatic spine disease is a common complication to malignancies. Several scoring ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003289
更新日期:2020-03-15 00:00:00
abstract:STUDY DESIGN:Retrospective radiographical study. OBJECTIVE:To compare the sex differences in curve patterns and radiographical characteristics in patients who have adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA:Sex differences in AIS have been documented in the incidence of curve progression, respo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3182511d0c
更新日期:2012-08-15 00:00:00
abstract:STUDY DESIGN:Total excision of a large dumbbell cervicothoracic intra- and extraspinal meningioma that had grown into the posterior mediastinum is described. This excision involved a two-step neurosurgical-thoracosurgical procedure within a short interval. OBJECTIVES:To document that the described laminectomy and thor...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200107010-00026
更新日期:2001-07-01 00:00:00
abstract:STUDY DESIGN:Multicenter review of prospectively collected data. OBJECTIVE:The purpose of this study was to evaluate the incidence of distal adding-on and associated risk factors in each of the 2 Lenke 1A curve patterns. SUMMARY OF BACKGROUND DATA:Previous work has demonstrated 2 distinct Lenke 1A curve patterns on t...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e31824bac7a
更新日期:2012-07-15 00:00:00