Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion.

Abstract:

STUDY DESIGN:An established rabbit posterolateral lumbar fusion model was used to evaluate the ability of osteogenic protein-1 to overcome the inhibitory effect of nicotine. OBJECTIVE:To determine whether osteogenic protein-1 should be considered as a bone graft alternative for the patient who smokes. SUMMARY OF BACKGROUND DATA:Smoking interferes with the success of posterolateral lumbar fusion. This inhibitory effect has been attributed to nicotine and confirmed in a New Zealand white rabbit model. Osteoinductive protein-1 has been shown to induce posterolateral spine fusion reliably in the rabbit model. The effectiveness with which osteogenic protein-1 induces fusion in the presence of nicotine has not been studied previously. METHODS:Single-level posterolateral intertransverse process fusions were performed at L5-L6 in 18 New Zealand white rabbits. Either autograft or osteogenic protein-1 was used as grafting material. Nicotine was administered via subcutaneous mini-osmotic pumps. The animals were killed 5 weeks after surgery, and the resulting fusion masses were studied. RESULTS:Three rabbits (17%) were excluded because of complications. By manual palpation, two of the eight nicotine-exposed autograft rabbits (25%) and all of the nicotine-exposed osteogenic protein-1 rabbits (100%) were found to be fused. These results correlated well with those obtained from biomechanical testing. Histologically, the fusion zones of the nicotine-exposed autograft rabbits were distinctly less mature than the fusion masses of the nicotine-exposed osteogenic protein-1 rabbits. CONCLUSION:Osteoinductive protein-1 was able to overcome the inhibitory effects of nicotine in a rabbit posterolateral spine fusion model, and to induce bony fusion reliably at 5 weeks.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Patel TC,Erulkar JS,Grauer JN,Troiano NW,Panjabi MM,Friedlaender GE

doi

10.1097/00007632-200108010-00004

keywords:

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

1656-61

issue

15

eissn

0362-2436

issn

1528-1159

journal_volume

26

pub_type

杂志文章

相关文献

SPINE文献大全
  • Evaluating the Minimal Clinically Important Difference of EQ-5D-3L in Patients With Degenerative Lumbar Spinal Stenosis: A Swiss Prospective Multicenter Cohort Study.

    abstract:STUDY DESIGN:Analysis of a prospective, multicenter cohort study. OBJECTIVE:The aim of our study was to compare thresholds of published minimal clinically important differences (MCID) for the three-level EuroQol-5D health survey (EQ-5D-3L) summary index (range -0.53 to 1.00) with our anchor-based estimate and evaluate...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000003501

    authors: Burgstaller JM,Wertli MM,Ulrich NH,Pichierri G,Brunner F,Farshad M,Porchet F,Steurer J,Gravestock I,LSOS Study Group.

    更新日期:2020-09-15 00:00:00

  • Atlantoaxial instability in Lesch-Nyhan syndrome.

    abstract:STUDY DESIGN:A clinical case report of two brothers with Lesch-Nyhan syndrome found to have atlantoaxial instability is reported. OBJECTIVES:To report the clinical and radiologic findings and the operative outcome in these patients. SUMMARY OF BACKGROUND DATA:Both patients had biochemically proven Lesch-Nyhan syndrom...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199603150-00020

    authors: Shewell PC,Thompson AG

    更新日期:1996-03-15 00:00:00

  • Association of back pain frequency with mortality, coronary heart events, mobility, and quality of life in elderly women.

    abstract:STUDY DESIGN:A 5-year observational cohort design using data from a randomized controlled trial of calcium intervention. OBJECTIVE:To describe the epidemiology of back pain and determine the association of back pain frequency to mortality, coronary heart events, mobility, and quality of life in elderly women. SUMMARY...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318133fb82

    authors: Zhu K,Devine A,Dick IM,Prince RL

    更新日期:2007-08-15 00:00:00

  • Low back and neck/shoulder pain in construction workers: occupational workload and psychosocial risk factors. Part 1: Relationship to low back pain.

    abstract::The prevalence rate of musculoskeletal problems, especially low back pain and severe low back pain in a randomly selected sample of 1,773 construction workers was studied. Its relationship to physical and psychosocial factors was analyzed. The workers answered a postal questionnaire. Workload was measured by means of ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199206000-00005

    authors: Holmström EB,Lindell J,Moritz U

    更新日期:1992-06-01 00:00:00

  • Comorbid subjective health complaints in low back pain.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVES:To compare subjective health complaints in subacute patients with low back pain with reference values from a Norwegian normal population. SUMMARY OF BACKGROUND DATA:Comorbidity is common with nonspecific low back pain. We wanted to investigate if these complaints were sp...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000219947.71168.08

    authors: Hagen EM,Svensen E,Eriksen HR,Ihlebaek CM,Ursin H

    更新日期:2006-06-01 00:00:00

  • Progressive disc herniation: an investigation of the mechanism using radiologic, histochemical, and microscopic dissection techniques on a porcine model.

    abstract:STUDY DESIGN:Basic scientific investigation using radiologic, histochemical, and microscopic dissection techniques. OBJECTIVE:To document the process of mechanically induced disc herniation from repetitive loading exposure. SUMMARY OF BACKGROUND DATA:Current knowledge of the mechanism of disc herniation is limited to...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31815b64f5

    authors: Tampier C,Drake JD,Callaghan JP,McGill SM

    更新日期:2007-12-01 00:00:00

  • Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 2: Advantages of anterior decompression and fusion over laminoplasty.

    abstract:STUDY DESIGN:Retrospective study of 27 patients who underwent anterior decompression and fusion (ADF) for treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL). OBJECTIVES:To compare surgical outcome of ADF with that of laminoplasty. SUMMARY OF BACKGROUND DATA:During the p...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.brs.0000257566.91177.cb

    authors: Iwasaki M,Okuda S,Miyauchi A,Sakaura H,Mukai Y,Yonenobu K,Yoshikawa H

    更新日期:2007-03-15 00:00:00

  • Vibration modes of injured spine at resonant frequencies under vertical vibration.

    abstract:STUDY DESIGN:A detailed three-dimensional finite element model of the spine segment T12-Pelvis was developed to investigate dynamic characteristics of whole lumbar spine with injured cases. OBJECTIVE:This study investigates the motion mechanism of the human lumbar spine and the effect of component injuries on adjacent...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181b1fdf4

    authors: Guo LX,Zhang M,Zhang YM,Teo EC

    更新日期:2009-09-01 00:00:00

  • Biomechanical role of lumbar spine ligaments in flexion and extension: determination using a parallel linkage robot and a porcine model.

    abstract:STUDY DESIGN:Porcine lumbar spine specimens were cyclically loaded in flexion and extension with a pure moment. The resistance to flexion and extension of the individual spinal elements was quantified using a sequential resection procedure. OBJECTIVE:To determine the biomechanical contribution of the individual poster...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200406010-00010

    authors: Gillespie KA,Dickey JP

    更新日期:2004-06-01 00:00:00

  • Torulopsis glabrata spinal osteomyelitis involving two contiguous vertebrae. A case report.

    abstract:STUDY DESIGN:A case report and literature review of the five previous case reports. OBJECTIVES:To outline the features of Torulopsis glabrata spinal osteomyelitis, including its risk factors, diagnosis, and recommended treatments. SUMMARY OF BACKGROUND DATA:Fungal infections in general and Torulopsis glabrata in part...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-199604010-00019

    authors: Curran MP,Lenke LG

    更新日期:1996-04-01 00:00:00

  • Gas-containing "ganglion" cyst of lumbar posterior longitudinal ligament at L3. Case report.

    abstract::A case of "ganglion" cyst was found to originate from the L3 lumbar posterior longitudinal ligament at the pedicular level. The patient had moderate lumbar degenerative scoliosis. The cyst had no connection with the intervertebral disc, dural sac, facet joint or nerve root. Instead of mucous or myxoid material, it con...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-199312000-00026

    authors: Lin RM,Wey KL,Tzeng CC

    更新日期:1993-12-01 00:00:00

  • Depression is associated with a poorer outcome of lumbar spinal stenosis surgery: a two-year prospective follow-up study.

    abstract:STUDY DESIGN:Prospective clinical study. OBJECTIVE:To investigate the effect of depressive symptoms on the surgery outcome on 2-year follow-up among lumbar spinal stenosis (LSS) patients. SUMMARY OF BACKGROUND DATA:Previous research has suggested an association between preoperative depressive symptoms and a poorer su...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181dcaf4a

    authors: Sinikallio S,Aalto T,Airaksinen O,Lehto SM,Kröger H,Viinamäki H

    更新日期:2011-04-15 00:00:00

  • Predicting major adverse cardiac events in spine fusion patients: is the revised cardiac risk index sufficient?

    abstract:STUDY DESIGN:Observational cohort study. OBJECTIVE:To determine the accuracy of the Revised Cardiac Risk Index (RCRI) in predicting major adverse cardiac events in patients undergoing spine fusion surgery of 3 levels or more. SUMMARY OF BACKGROUND DATA:Preoperative cardiac testing is extensively guided by the RCRI, w...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000405

    authors: Carabini LM,Zeeni C,Moreland NC,Gould RW,Hemmer LB,Bebawy JF,Koski TR,McClendon J Jr,Koht A,Gupta DK

    更新日期:2014-08-01 00:00:00

  • Pulmonary embolism in spine surgery: a comparison of combined anterior/posterior approach versus posterior approach surgery.

    abstract:STUDY DESIGN:retrospective review. OBJECTIVE:to determine if Anterior/Posterior Combined approach spine surgery is associated with an increased risk of pulmonary embolism (PE) compared to Posterior Only approach surgery. SUMMARY OF BACKGROUND DATA:combined anterior/posterior approach spine surgery is associated with ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181cb4717

    authors: Kim HJ,Kepler C,Cunningham M,Rawlins B,Boachie-Adjei O

    更新日期:2011-01-15 00:00:00

  • Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes.

    abstract:STUDY DESIGN:Descriptive histologic analysis of spinal cord gene therapy. OBJECTIVE:To maximize protein expression in rat spinal cord using recombinant adenoassociate virus viral vector. SUMMARY OF BACKGROUND DATA:There are few reports of spinal cord genetic transfer. There have been no reports that compare technique...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000147909.59083.da

    authors: Harrop JS,Poulsen DJ,Xiao W,Freese A,During MJ

    更新日期:2004-12-15 00:00:00

  • Comparison of 30-Day Complications Between Navigated and Conventional Single-level Instrumented Posterior Lumbar Fusion: A Propensity Score Matched Analysis.

    abstract:STUDY DESIGN:Retrospective cohort comparison study. OBJECTIVE:To compare perioperative outcomes between navigated and conventional single-level instrumented posterior lumbar fusions in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database. SUMMARY OF BACKGROUND DATA:Although ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002327

    authors: Bovonratwet P,Nelson SJ,Ondeck NT,Geddes BJ,Grauer JN

    更新日期:2018-03-15 00:00:00

  • Activated macrophage-like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines.

    abstract:STUDY DESIGN:Anulus fibrosus (AF) cells obtained from patients undergoing surgery were cocultured with macrophage-like cells and production of inflammatory mediators was analyzed by quantitative assay. OBJECTIVE:To investigate the role of macrophages in AF cell production of inflammatory mediators by cytokines stimula...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318182c35f

    authors: Kim JH,Studer RK,Sowa GA,Vo NV,Kang JD

    更新日期:2008-10-01 00:00:00

  • Traumatic instabilities of the cervical spine caused by high-speed axial compression in a human model. An in vitro biomechanical study.

    abstract:STUDY DESIGN:Traumatic injury of the cervical spine was produced on human cadavers and evaluated with instability tests and radiographs. OBJECTIVE:To relate traumatic injuries of the cervical spine to instability and patterns of traumatic injury to different levels of impact energy. SUMMARY OF BACKGROUND DATA:Data fr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199903010-00006

    authors: Zhu Q,Ouyang J,Lu W,Lu H,Li Z,Guo X,Zhong S

    更新日期:1999-03-01 00:00:00

  • Gender difference in association between low back pain and metabolic syndrome: locomotive syndrome and health outcome in Aizu cohort study (LOHAS).

    abstract:STUDY DESIGN:Cross-sectional survey. OBJECTIVE.: To investigate the relationship between low back pain (LBP) and metabolic syndrome (Mets) in community-based Japanese subjects. SUMMARY OF BACKGROUND DATA.: Relatively few reports have demonstrated a relationship between general pain and Mets, and none have addressed the...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31824231b8

    authors: Ono R,Yamazaki S,Takegami M,Otani K,Sekiguchi M,Onishi Y,Hayashino Y,Kikuchi S,Konno S,Fukuhara S

    更新日期:2012-06-01 00:00:00

  • Segmental ("floating") lumbar spine fusions.

    abstract::A traditional teaching in orthopaedic surgery has been that, in cases of fusion for L4-5 discopathy or instability, one must include the lumbosacral joint. There is nothing in the literature to support this time-honored dictum. The senior author, among others, has rejected this concept; and, the authors are, therefore...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198904000-00022

    authors: Brodsky AE,Hendricks RL,Khalil MA,Darden BV,Brotzman TT

    更新日期:1989-04-01 00:00:00

  • Orthopaedic implications in the management of pediatric vertebral and spinal cord tumors: a retrospective review.

    abstract:STUDY DESIGN:Retrospective review of pediatric patients with vertebral and spinal cord tumors. OBJECTIVES:To identify clinical and radiographic features of diagnostic importance, and to evaluate the effectiveness of surgical treatment with respect to complications in pediatric patients with vertebral and spinal cord t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000085323.71376.42

    authors: Parikh SN,Crawford AH

    更新日期:2003-10-15 00:00:00

  • Arm motion speed and risk of neck pain. A preliminary communication.

    abstract:STUDY DESIGN:A sample of 486 Helsinki City Council workers, 35 to 54 years of age, was examined twice at a 1-year interval. OBJECTIVES:To investigate the speed of repetitive arm motion for its ability to predict neck pain. SUMMARY OF BACKGROUND DATA:Psychomotor factors have been suggested to play a role in the etiolo...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199709150-00006

    authors: Laurén H,Luoto S,Alaranta H,Taimela S,Hurri H,Heliövaara M

    更新日期:1997-09-15 00:00:00

  • Beneficial influence of titanium mesh cage on infection healing and spinal reconstruction in hematogenous septic spondylitis: a retrospective analysis of surgical outcome of twenty-five consecutive cases and review of literature.

    abstract:STUDY DESIGN:Single institution, single surgeon retrospective review. OBJECTIVE:To investigate if the use of titanium mesh cage on the site of infection could be beneficial for successful outcome of the operative treatment for pyogenic spondylitis. SUMMARY OF BACKGROUND DATA:There is a controversy concerning the opti...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e318187875e

    authors: Korovessis P,Repantis T,Iliopoulos P,Hadjipavlou A

    更新日期:2008-10-01 00:00:00

  • Segmental spinal instrumentation. A study of the mechanical properties of materials used for sublaminar fixation.

    abstract::Segmental spinal instrumentation with sublaminar fixation is widely used but a variety of materials and techniques are being employed for both scoliosis and other spinal surgery. This study addresses the question as to which is best. Both the materials and the methods of securing them were studied. The materials teste...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Crawford RJ,Sell PJ,Ali MS,Dove J

    更新日期:1989-06-01 00:00:00

  • Tandem interbody fusion grafting after cervical vertebrectomy.

    abstract:STUDY DESIGN:A case is presented with clinical and radiologic follow-up assessment to evaluate the possible effectiveness of tandem interbody fusion grafting. OBJECTIVE:To design a technique for rescuing a long iliac crest bone autograft that is too short or must be shortened because of the undesirable shape some long...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200106010-00023

    authors: Telfeian AE,Marcotte P

    更新日期:2001-06-01 00:00:00

  • Low profile pelvic fixation with the sacral alar iliac technique in the pediatric population improves results at two-year minimum follow-up.

    abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:Anchor stability and prominence are problems with pelvic fixation in pediatric spinal deformity surgery. We compared the new sacral alar iliac (SAI) fixation technique (with a starting point in the sacral ala and in-line anchors deep under the midline muscle flap) with othe...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181e03881

    authors: Sponseller PD,Zimmerman RM,Ko PS,Pull Ter Gunne AF,Mohamed AS,Chang TL,Kebaish KM

    更新日期:2010-09-15 00:00:00

  • Neck and shoulder pains in relation to physical activity and sedentary activities in adolescence.

    abstract:STUDY DESIGN:A cross-sectional survey among adolescents aged 15-16 years. OBJECTIVE:To evaluate whether physical activity or sedentary activities associate with neck and shoulder symptoms among adolescents. SUMMARY OF BACKGROUND DATA:Findings of associations between physical exercise and neck or shoulder pain in adol...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000261349.94823.c1

    authors: Auvinen J,Tammelin T,Taimela S,Zitting P,Karppinen J

    更新日期:2007-04-20 00:00:00

  • Measurement techniques for lower cervical spine injuries: consensus statement of the Spine Trauma Study Group.

    abstract:STUDY DESIGN:Literature review. OBJECTIVES:It was the purpose of the Spine Trauma Study Group to compile a collection of clinically useful imaging methods used in lower cervical spine trauma and to describe in detail how these measurements should be made. SUMMARY OF BACKGROUND DATA:Injury detection, description, and ...

    journal_title:Spine

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1097/01.brs.0000201273.39058.dd

    authors: Bono CM,Vaccaro AR,Fehlings M,Fisher C,Dvorak M,Ludwig S,Harrop J

    更新日期:2006-03-01 00:00:00

  • Decision making in the surgical treatment of cervical spine metastases.

    abstract:STUDY DESIGN:Qualitative systematic review of the literature. OBJECTIVE:To determine whether surgical indications and techniques are influenced by the region of the cervical spine (occipitocervical, midcervical, and cervicothoracic junctions). SUMMARY OF BACKGROUND DATA:There are distinct differences in the anatomic ...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181bae1d2

    authors: Fehlings MG,David KS,Vialle L,Vialle E,Setzer M,Vrionis FD

    更新日期:2009-10-15 00:00:00

  • Traumatic lumbosacral spondyloptosis treated five months after injury occurrence: a case report.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:To describe a case of traumatic lumbosacral spondyloptosis and present a literature review. SUMMARY OF BACKGROUND DATA:Traumatic spondyloptosis is a very rare injury caused by high-energy trauma. Eight cases of traumatic spondyloptosis of L5-S1 have been reported, including only ...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e318268c08a

    authors: Wangtaphan W,Oo M,Paholpak P,Wang Z,Sakakibara T,Kasai Y

    更新日期:2012-10-15 00:00:00