Bupropion-SR plus naltrexone-SR for the treatment of mild-to-moderate obesity.


:Naltrexone-bupropion is a recently approved drug combination for chronic weight management. In this article, we discuss the rationale for its use as a combination followed by a comprehensive review of safety and efficacy data from major preclinical, phase II and III clinical trials.


Ali KF,Shukla AP,Aronne LJ




Has Abstract


2016-01-01 00:00:00












  • Design and analysis considerations for thorough QT studies employing conventional (10 s, 12-lead) ECG recordings.

    abstract::The QT interval from the ECG cannot be measured precisely. The relationship of the QT interval to the RR interval within individuals across time and different RR values, and across individuals eludes complete understanding. Intrinsic beat-to-beat variability in QT interval corrected for heart rate (QTc interval) is no...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Beasley CM Jr,Dmitrienko A,Mitchell MI

    更新日期:2008-11-01 00:00:00

  • Pharmacological management of diabetic dyslipidemia.

    abstract:INTRODUCTION:Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Filippatos TD,Florentin M,Georgoula M,Elisaf MS

    更新日期:2017-02-01 00:00:00

  • A clinical perspective on escalating or de-escalating adjuvant therapy in HER2+ breast cancer.

    abstract::Introduction: Patients with early HER2-positive breast cancer (BC) benefit from HER2-targeted systemic therapy. The endorsed standard adjuvant treatment for patients with early HER2-positive breast cancer is chemotherapy plus trastuzumab administered for 1 year. Areas covered: Several trials have investigated modifica...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Esposito A,Viale G,Criscitiello C,Curigliano G

    更新日期:2019-01-01 00:00:00

  • Evolution of the inclusion/exclusion criteria and primary endpoints in pivotal trials of biologics and small oral molecules for the treatment of psoriasis.

    abstract::Introduction: Primary endpoints and inclusion/exclusion criteria of biologics and small oral molecules for psoriasis treatment have been evolving due to a better understanding of the pathogenesis and potential risks.Areas covered: We analyzed the designs of key phase 3 pivotal trials of all biologics and small oral mo...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Hsu SH,Tsai TF

    更新日期:2020-03-01 00:00:00

  • Pharmacodynamics of TNF-α inhibitors in psoriasis.

    abstract::Over the last two decades, research developments have revolutionized our understanding of the pathogenesis of psoriasis and of the contribution of several cytokines in the manifestation of the disease. The key role of TNF-α in the pathogenesis of psoriasis has been extensively studied and its therapeutic action, initi...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Vergou T,Moustou AE,Sfikakis PP,Antoniou C,Stratigos AJ

    更新日期:2011-07-01 00:00:00

  • The genetics of vascular incidents associated with second-generation antipsychotic administration.

    abstract::Second-generation antipsychotics (SGA) have been associated with risk of stroke in elderly patients, but the molecular and genetic background under this association has been poorly investigated. The aim of the present study was to prioritize a list of genes with an SGA altered expression in order to characterize the g...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Cocchi E,Drago A,de Ronchi D,Serretti A

    更新日期:2014-01-01 00:00:00

  • Novel disease-modifying therapeutics for the treatment of Alzheimer's disease.

    abstract::Alzheimer's disease is the most common cause of dementia and is becoming a global health concern. Despite a well-established understanding of the molecular mechanism involved in its pathogenesis, and millions of dollars of investment in drug discovery and clinical trials, no single molecule has yet been approved for i...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Léger GC,Massoud F

    更新日期:2013-07-01 00:00:00

  • Evolution of diagnostic approaches in betalactam hypersensitivity.

    abstract:INTRODUCTION:Betalactams are the most widely used drugs against infections and the primary cause of antibiotic hypersensitivity reactions. Reaction patterns for different betalactams have been changing in accordance with consumption trends, and vary among countries. As a consequence, in vivo and in vitro tests have had...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Fernandez TD,Mayorga C,Salas M,Barrionuevo E,Posadas T,Ariza A,Laguna JJ,Moreno E,Torres MJ,Doña I,Montañez MI

    更新日期:2017-06-01 00:00:00

  • Participants' written informed consent in low-risk pragmatic clinical trials with medicines.

    abstract::Introduction: An important gap within modern medicine is the lack of enough comparative effectiveness research of marketed medicines. Low-risk pragmatic randomized controlled trials (pRCTs) are those conducted resembling usual clinical practice that poses no or minimal incremental risk compared with normal clinical pr...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Dal-Ré R

    更新日期:2020-03-01 00:00:00

  • Brimonidine tartrate for the treatment of facial flushing and erythema in rosacea.

    abstract::Rosacea is a chronic inflammatory dermatologic condition that can often be disfiguring with significant negative impact on patients' quality of life. Sanrosa (brimonidine tartate) is a novel therapeutic agent targeting the facial flushing and erythema of rosacea through its α₂ adrenergic receptor agonist activity. The...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Tong LX,Moore AY

    更新日期:2014-09-01 00:00:00

  • Efficacy and safety of etoricoxib in the treatment of osteoarthritis.

    abstract::Osteoarthritis is a progressive disease that affects millions of people worldwide, but for which there are no curative options and indeed a limited number of medical treatment options. The American College of Rheumatology recommendations suggest administering either a traditional NSAID or a COX-2-selective inhibitor f...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Sebba A

    更新日期:2008-05-01 00:00:00

  • Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future.

    abstract:INTRODUCTION:Large-scale epidemiological studies on Greenlandic, Canadian and Alaskan Eskimos have examined the health benefits of omega-3 fatty acids consumed as part of the diet, and found statistically significant relative reduction in cardiovascular risk in people consuming omega-3 fatty acids. Areas covered: This ...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Watanabe Y,Tatsuno I

    更新日期:2017-08-01 00:00:00

  • Statin intolerance: more questions than answers.

    abstract::The dramatic effectiveness of statins in improving the course of atherosclerotic cardiovascular disease tends to overshadow questions of statin intolerance. Thus after more than 25 years of clinical statin use, intolerance remains a poorly understood, frustrating issue for patients and providers. It has been extraordi...

    journal_title:Expert review of clinical pharmacology

    pub_type: 社论


    authors: Guyton JR,Campbell KB,Lakey WC

    更新日期:2014-01-01 00:00:00

  • Crofelemer for the symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy.

    abstract::Chronic diarrhea remains a common condition that affects people infected with human immunodeficiency virus (HIV) despite the widespread use of potent antiretroviral therapy. It is important that providers control this condition, as the persistence of diarrhea affects the quality of life of patients and may contribute ...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Castro JG,Chin-Beckford N

    更新日期:2015-01-01 00:00:00

  • Pegloticase and the patient with treatment-failure gout.

    abstract::Gout is an inflammatory arthritis characterized by sudden, painful inflammation. Gout can affect any joint in an asymmetric distribution. Gouty attacks may be isolated or can be followed by years of recurrent flares. Over time, elevated serum urate levels and tophaceous deposits can lead to deformity and disability fr...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Dave AJ,Kelly VM,Krishnan E

    更新日期:2012-09-01 00:00:00

  • Letermovir for the prevention of cytomegalovirus infection in adult cytomegalovirus-seropositive hematopoietic stem cell transplant recipients.

    abstract:INTRODUCTION:Allogeneic hematopoietic cell transplants (allo-HCT) recipients are at the high-risk of reactivation of cytomegalovirus (CMV), and reactivation is associated with significant morbidity and mortality. Although available anti-CMV therapies may be effective for the prevention of CMV, they are plagued by unacc...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Foolad F,Aitken SL,Chemaly RF

    更新日期:2018-10-01 00:00:00

  • Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in women of childbearing age: risks versus benefits.

    abstract::Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are effective and widely used antihypertensive drugs. Exposure to these agents is known to be harmful to the fetus in the second and third trimesters of pregnancy. Concerns have also been raised about the risk of congenital malfo...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Pucci M,Sarween N,Knox E,Lipkin G,Martin U

    更新日期:2015-03-01 00:00:00

  • The role of xenobiotic-metabolizing enzymes in the placenta: a growing research field.

    abstract::Introduction: The placenta is a temporary and unique organ that allows for the physical connection between a mother and fetus; this organ regulates the transport of gases and nutrients mediating the elimination of waste products contained in the fetal circulation. The placenta performs metabolic and excretion function...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Blanco-Castañeda R,Galaviz-Hernández C,Souto PCS,Lima VV,Giachini FR,Escudero C,Damiano AE,Barragán-Zúñiga LJ,Martínez-Aguilar G,Sosa-Macías M

    更新日期:2020-03-01 00:00:00

  • Use of strong opioids for chronic pain in osteoarthritis: an insight into the Latin American reality.

    abstract:INTRODUCTION:Osteoarthritis is the most common cause of arthritis and one of the main causes of chronic pain. Although opioids are frequently employed for chronic pain treatment, their usage for osteoarthritis pain remains controversial due to the associated adverse effects. Most guidelines reserve their use for refrac...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Ruiz Iban MA,Benavides J,Forero JP,Bittelman S,Martinez R,Mite MA,Diaz Heredia J,Ulloa S,Lizárraga Ferrand MM

    更新日期:2018-01-01 00:00:00

  • Ocular dysfunctions and toxicities induced by antiepileptic medications: Types, pathogenic mechanisms, and treatment strategies.

    abstract:INTRODUCTION:Ocular dysfunctions and toxicities induced by antiepileptic drugs (AEDs) are rarely reviewed and not frequently received attention by treating physicians compared to other adverse effects (e.g. endocrinologic, cognitive and metabolic). However, some are frequent and progressive even in therapeutic concentr...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Hamed SA

    更新日期:2019-04-01 00:00:00

  • Hydrogen sulfide in the endocrine and reproductive systems.

    abstract::Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Zhu XY,Gu H,Ni X

    更新日期:2011-01-01 00:00:00

  • Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling.

    abstract:INTRODUCTION:In pediatric pharmacotherapy, many drugs are still used off-label, and their efficacy and safety is not well characterized. Different efficacy and safety profiles in children of varying ages may be anticipated, due to developmental changes occurring across pediatric life. AREAS COVERED:Beside pharmacokine...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Brussee JM,Calvier EA,Krekels EH,Välitalo PA,Tibboel D,Allegaert K,Knibbe CA

    更新日期:2016-09-01 00:00:00

  • Immunotherapy for gastric cancers: emerging role and future perspectives.

    abstract:INTRODUCTION:The broad use of immunotherapy is revolutionizing the treatment paradigms of many solid tumors. Although chemotherapy remains the treatment backbone for advanced gastric cancer, improvements in its molecular characterization and progresses in understanding its underpinning biology have supported clinical d...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bonotto M,Garattini SK,Basile D,Ongaro E,Fanotto V,Cattaneo M,Cortiula F,Iacono D,Cardellino GG,Pella N,Fasola G,Antonuzzo L,Silvestris N,Aprile G

    更新日期:2017-06-01 00:00:00

  • Selecting immuno-oncology-based drug combinations - what should we be considering?

    abstract:INTRODUCTION:Checkpoint inhibitor immunotherapy has revolutionized the treatment of many advanced stage cancers. Preexisting immunity is necessary for a response to these agents, which are most effective in inflamed tumors since they principally act by reinforcing preexisting antitumor T-cell responses. An important go...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Festino L,Vanella V,Trojaniello C,Ascierto PA

    更新日期:2018-10-01 00:00:00

  • Clinical applications of pharmacogenomics to adverse drug reactions.

    abstract::The problem of adverse drug reactions is a well-documented global public health problem. Recent withdrawals of several widely used prescription medications in the USA and other countries have raised concerns among patients, clinicians, scientists and policy makers. The increasing interest and concern regarding withdra...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Issa AM

    更新日期:2008-03-01 00:00:00

  • Pharmacological resources, diagnostic approach and coordination of care in joint hypermobility-related disorders.

    abstract:INTRODUCTION:Joint hypermobility (JH) is the hallmark of many hereditary soft connective tissue disorders, including Ehlers-Danlos syndromes and related disorders, disorders of the TGFβ-pathway, lateral meningocele syndrome, arterial tortuosity syndrome, and cutis laxa syndromes. Contemporary practice separates individ...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Baban A,Castori M

    更新日期:2018-07-01 00:00:00

  • Assessing pharmacological interventions for bone metastases: the need for more patient-centered outcomes.

    abstract::Bone metastases are associated with a broad spectrum of clinical sequelae. Pain, reduced mobility, skeletal complications and treatment-related events reduce quality of life. Numerous randomized controlled trials have evaluated pharmacological interventions to treat bone metastases. The primary outcomes used have evol...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Ford JA,Mowatt G,Jones R

    更新日期:2012-05-01 00:00:00

  • An update on repurposed medications for the treatment of drug-resistant tuberculosis.

    abstract:INTRODUCTION:Drug-resistant forms of tuberculosis are a major public health problem with a serious global impact. Although there have recently been two new drugs introduced for the treatment of drug-resistant TB (bedaquiline and delamanid), the current therapeutic armamentarium is limited. Because treatment of drug-res...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Mafukidze A,Harausz E,Furin J

    更新日期:2016-10-01 00:00:00

  • Zanamivir for the treatment of avian influenza infections in humans.

    abstract::Zanamivir is currently not recommended by the WHO for the first-line treatment of human influenza A (H5N1) infections. Zanamivir pharmacokinetics and antiviral efficacy were reviewed to assess the basis for this recommendation. Following inhalation of 10 mg zanamivir in healthy humans, the drug is widely distributed t...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章


    authors: Reece PA

    更新日期:2010-01-01 00:00:00

  • Optimization of anti-TNF therapy in patients with Inflammatory Bowel Disease.

    abstract::After the introduction of anti-tumor necrosis factor (anti-TNF) agents, the clinical outcome of patients with Inflammatory Bowel Disease (IBD) has improved significantly. However, use of anti-TNF therapy is complicated by loss of response. In order to maintain remission, adequate serum levels are required. Hence, ther...

    journal_title:Expert review of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Strik AS,Bots SJ,D'Haens G,Löwenberg M

    更新日期:2016-01-01 00:00:00