Abstract:
:Oncology is one of the areas of medicine with the most active research being conducted on new drugs. New pharmacological entities frequently enter the clinical arena, and therefore, the safety profile of anticancer products deserves continuous monitoring. However, only very severe and (unusual) suspected adverse drug reactions (ADRs) are usually reported, since cancer patients develop ADRs very frequently and some practical selectivity must be used. Notably, a recent study was able to identify 76 serious ADRs reported in updated drug labels of oncologic drugs and 50% of them (n = 38) were potentially fatal. Of these, 49 and 58%, respectively, were not described in initial drug labels. The aims of this article are to provide an overview about spontaneous reporting of ADRs of oncologic drugs and to discuss the available methods to analyze the safety of anticancer drugs using databases of spontaneous ADR reporting.
journal_name
Expert Rev Clin Pharmacoljournal_title
Expert review of clinical pharmacologyauthors
Tuccori M,Montagnani S,Capogrosso-Sansone A,Mantarro S,Antonioli L,Fornai M,Blandizzi Cdoi
10.1586/17512433.2015.974555subject
Has Abstractpub_date
2015-01-01 00:00:00pages
61-75issue
1eissn
1751-2433issn
1751-2441journal_volume
8pub_type
杂志文章,评审abstract::In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the ischemic myocardium, it results in further reperfusion injury and extension of the infarction. The main hypothesis for the mechanism of reperfus...
journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1586/ecp.09.41
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abstract::Osteoarthritis is a progressive disease that affects millions of people worldwide, but for which there are no curative options and indeed a limited number of medical treatment options. The American College of Rheumatology recommendations suggest administering either a traditional NSAID or a COX-2-selective inhibitor f...
journal_title:Expert review of clinical pharmacology
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doi:10.1586/17512433.1.3.345
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1586/ecp.10.3
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1586/17512433.2016.1129273
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1586/17512433.2014.904201
更新日期:2014-05-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1586/17512433.2014.945910
更新日期:2014-09-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1586/17512433.2.1.37
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Drug-resistant forms of tuberculosis are a major public health problem with a serious global impact. Although there have recently been two new drugs introduced for the treatment of drug-resistant TB (bedaquiline and delamanid), the current therapeutic armamentarium is limited. Because treatment of drug-res...
journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1080/17512433.2016.1208562
更新日期:2016-10-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1586/ecp.10.18
更新日期:2010-05-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1080/17512433.2017.1313110
更新日期:2017-06-01 00:00:00
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-07-01 00:00:00
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1586/17512433.2014.922866
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:Pharmacological inhibition of immune checkpoint receptors or their ligands represents a transformative breakthrough in the management of multiple cancers. However, immune checkpoint inhibitors have yet to be FDA-approved for the management of metastatic prostate cancer (PCa), the commonest non-cutaneous ma...
journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
doi:10.1080/17512433.2018.1464388
更新日期:2018-05-01 00:00:00
abstract::Globally, it is possible that less than half of all patients are treated in compliance with guidelines and more than half of all patients fail to take their medicines as prescribed or dispensed. Such inappropriate use is wasteful of resources and causes patient harm in terms of lack of satisfactory outcome, serious ad...
journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,meta分析,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::The problem of adverse drug reactions is a well-documented global public health problem. Recent withdrawals of several widely used prescription medications in the USA and other countries have raised concerns among patients, clinicians, scientists and policy makers. The increasing interest and concern regarding withdra...
journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章
doi:10.1586/17512433.1.2.251
更新日期:2008-03-01 00:00:00