Contactin‑associated protein‑like 2 expression in SH‑SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly‑glutamine tract.


:The forkhead box protein P2 (FOXP2) gene encodes an important transcription factor that contains a polyglutamine (poly‑Q) tract and a forkhead DNA binding domain. It has been observed that FOXP2 is associated with speech sound disorder (SSD), and mutations that decrease the length of the poly‑Q tract were identified in the FOXP2 gene of SSD patients. However, the exact role of poly‑Q reduction is not well understood. In the present study, constructs expressing wild‑type and poly‑Q reduction mutants of FOXP2 were generated by polymerase chain reaction (PCR) using lentiviral vectors and transfected into the SH‑SY5Y neuronal cell line. Quantitative reverse transcription (qRT)‑PCR and western blotting indicated that infected cells stably expressed high levels of FOXP2. Using this cell model, the impact of FOXP2 on the expression of contactin‑associated protein‑like 2 (CNTNAP2) were investigated, and CNTNAP2 mRNA expression levels were observed to be significantly higher in cells expressing poly‑Q‑reduced FOXP2. In addition, the expression level of CASPR2, a mammalian homolog of Drosophila Neurexin IV, was increased in cells expressing the FOXP2 mutant. Demonstration of regulation by FOXP2 indicates that CNTNAP2 may also be involved in SSD.


Mol Med Rep


Zhao Y,Liu X,Sun H,Wang Y,Yang W,Ma H




Has Abstract


2015-12-01 00:00:00












  • iASPP, a microRNA‑124 target, is aberrantly expressed in astrocytoma and regulates malignant glioma cell migration and viability.

    abstract::MicroRNAs (miRNAs) regulate biogenesis and disease development by targeting numerous mRNAs. miRNA (miR)‑124 and its direct target, inhibitor of apoptosis‑stimulating protein of p53 (iASPP), may be involved in tumor development and progression. The aim of the present study was to explore the role of miR‑124‑targeted iA...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu X,Kang J,Sun S,Luo Y,Ji X,Zeng X,Zhao S

    更新日期:2018-01-01 00:00:00

  • Altered gene expression of hepatic cytochrome P450 in a rat model of intermittent hypoxia with emphysema.

    abstract::Patients with respiratory overlap syndrome (OS), defined as concomitant chronic obstructive pulmonary disease and obstructive sleep apnea syndrome, may exhibit an increased blood concentration of ingested drugs. This poor elimination of drugs is primarily attributed to downregulated gene expression of the drug‑metabol...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yu H,Shao H,Wu Q,Sun X,Li L,Li K,Li X,Li Y,Zhang Q,Wu J,Chen H

    更新日期:2017-07-01 00:00:00

  • Isolation and phenotypic characterization of side population cells in oral squamous cell carcinoma.

    abstract::A subset of cancer stem cells termed 'side population' (SP) cells has been identified in several types of solid tumor and is known to be responsible for the failure of chemotherapy and for cancer relapse. In the present study, the oral squamous cell carcinoma (OSCC) cell line SCC‑55 was used for analysis of the SP cel...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu Y,Cui P,Chen J,Li W

    更新日期:2015-05-01 00:00:00

  • Oncostatin M promotes the osteogenic differentiation of mouse MC3T3‑E1osteoblasts through the regulation of monocyte chemotactic protein‑1.

    abstract::The present study investigated the function of oncostatin M (OSM), which may be associated with monocyte chemotactic protein‑1 (MCP‑1), on mouse MC3T3‑E1 osteoblast development and bone remodeling. Levels of MCP‑1, macrophage inflammatory protein 1α (MIP1α) and regulated upon activation normal T cell expressed and sec...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zheng W,Guan J

    更新日期:2018-09-01 00:00:00

  • Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells.

    abstract::Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl from lysine residues in histones and other proteins, which results in gene transcriptional repression and subsequent changes in signaling events. HDACs inhibitors (HDACIs) have been used to reverse the aberrant epigenetic changes associated w...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Han RF,Li K,Yang ZS,Chen ZG,Yang WC

    更新日期:2014-12-01 00:00:00

  • GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.

    abstract::GGsTOP is a novel and selective inhibitor of gamma-glutamyl transferase (GGT), a cell-surface enzyme that has a key role in glutathione homeostasis and the maintenance of cellular reactive oxygen species (ROS). ROS are essential for wound healing. However, little is known about the molecular mechanisms underlying the ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jiang Y,Wang X,Li Y,Mu S,Zhou S,Liu Y,Zhang B

    更新日期:2016-05-01 00:00:00

  • MicroRNA-100 functions as a tumor suppressor by inhibiting Lgr5 expression in colon cancer cells.

    abstract::Previous studies have demonstrated that microRNAs (miRNAs), a class of single‑stranded RNA molecules that are 18‑27 nucleotides in length, serve a critical function in tumorigenesis, including in the development of colon cancer. In the current study, miR‑100 levels were demonstrated to be reduced in colon cancer tissu...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhou MK,Liu XJ,Zhao ZG,Cheng YM

    更新日期:2015-04-01 00:00:00

  • RNAi‑mediated downregulation of asparaginase‑like protein 1 inhibits growth and promotes apoptosis of human cervical cancer line SiHa.

    abstract::Asparaginase like 1 (ASRGL1) protein belongs to the N‑terminal nucleophile group, cleaving the isoaspartyl‑dipeptides and L‑asparagine by adding water. It tends to be overexpressed in cancerous tumors including ovarian cancer and breast tumors. The present study assessed the potential ability of ASRGL1 as a molecular ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Lv XF,Hong HQ,Liu L,Cui SH,Ren CC,Li HY,Zhang XA,Zhang LD,Wei TX,Liu JJ,Xing WY,Fu H,Yan SJ

    更新日期:2018-07-01 00:00:00

  • Effect of TFAM on ATP content in tachypacing primary cultured cardiomyocytes and atrial fibrillation patients.

    abstract::Atrial fibrillation (AF) is one of the most common types of arrhythmia worldwide; although a number of theories have been proposed to explain the mechanisms of AF, the treatment of AF is far from satisfactory. Energy metabolism is associated with the development of AF. Mitochondrial transcription factor A (TFAM) serve...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu Y,Zhao Y,Tang R,Jiang X,Wang Y,Gu T

    更新日期:2020-12-01 00:00:00

  • Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells.

    abstract::In the last 30 years, the 5-year-survival rate of patients with osteosarcoma has not improved as a result of the low prevalence and large tumor heterogeneity. Therefore, the development of novel drugs for the treatment of osteosarcoma is urgently required. The present study aimed to identify potential novel drugs for ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zou Y,Yang J,Jiang D

    更新日期:2015-11-01 00:00:00

  • Neuroprotective role of icariin in experimental spinal cord injury via its antioxidant, anti‑neuroinflammatory and anti‑apoptotic properties.

    abstract::Icariin is a type of flavonoid derived from the Chinese herbal plant Epimedium sagittatum Maxim. Mounting evidence has confirmed the beneficial effects of icariin in neurological diseases, including spinal cord injury (SCI). The aim of the present study was to investigate the neuroprotective effects of icariin in SCI ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Jia G,Zhang Y,Li W,Dai H

    更新日期:2019-10-01 00:00:00

  • Prognostic and predictive roles of microRNA‑411 and its target STK17A in evaluating radiotherapy efficacy and their effects on cell migration and invasion via the p53 signaling pathway in cervical cancer.

    abstract::Cervical cancer is one of the most common gynecological malignancies worldwide. However, the pathogenesis of cervical cancer remains to be fully elucidated. Increasing evidence shows that microRNAs (miRNAs) may be involved in the pathogenesis of cervical cancer. The present study tested the hypothesis that the overexp...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wei W,Liu C

    更新日期:2020-01-01 00:00:00

  • Complement factor H‑related 3 overexpression affects hepatocellular carcinoma proliferation and apoptosis.

    abstract::Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome. However, to the best of our knowledge, the role of CFHR3 in hepatocellular carcinoma (HCC) re...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liu H,Zhang L,Wang P

    更新日期:2019-09-01 00:00:00

  • Gene expression profile of mesenchymal stromal cells after co-culturing with injured liver tissue.

    abstract::Mesenchymal stromal cells (MSCs) are a potential cell source for the development of therapeutic products. Recent studies have shown that the transplantation of MSCs to damaged organs, including the heart, liver and kidneys, results in the restoration of the damaged tissues. However, the mechanisms underlying this rege...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Cho KA,Ju SY,Ryu KH,Woo SY

    更新日期:2009-01-01 00:00:00

  • Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury.

    abstract::Aquaporin 4 (AQP4) is a widely distributed membrane protein, which is found in glial cells, ependymocytes and capillary endothelial cells in the brain, and particularly in the choroid plexus. AQP4 is a key regulator of water metabolism, and changes in its expression following brain injury are associated with pathologi...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhang C,Chen J,Lu H

    更新日期:2015-11-01 00:00:00

  • Hypoxia‑mediated activation of autophagic flux inhibits apoptosis of keratinocytes via blocking tumor necrosis factor‑related apoptosis‑inducing ligand.

    abstract::Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is toxic against transformed tumor cells. Cornification is the terminal differentiation of keratinocytes and a specific form of programmed cell death caused by TRAIL that occurs in keratinocytes. Apoptosis can also be triggered when TRAIL induces expressi...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Kim SW,Park SY

    更新日期:2016-01-01 00:00:00

  • Low shear stress induces endothelial cell apoptosis and monocyte adhesion by upregulating PECAM‑1 expression.

    abstract::Low shear stress serves an important role in the initiation and progression of atherosclerotic lesions, with an impact on progression, but its detailed mechanisms are .not yet fully known. The present study aimed to investigate endothelial cell (EC) apoptosis, as well as monocyte adhesion induced by low shear stress a...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Xie X,Wang F,Zhu L,Yang H,Pan D,Liu Y,Qu X,Gu Y,Li X,Chen S

    更新日期:2020-06-01 00:00:00

  • Cathepsin S regulates renal fibrosis in mouse models of mild and severe hydronephrosis.

    abstract::As a member of the cysteine protease family, cathepsin S (CTSS) serves an important role in diseases such as cancer, arthritis and atherosclerosis. Nevertheless, its role in renal fibrosis is unknown. In the present study, the effects of CTSS on renal fibrosis in mild (group M) and severe (group S) hydronephrosis were...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Yao X,Cheng F,Yu W,Rao T,Li W,Zhao S,Zhou X,Ning J

    更新日期:2019-07-01 00:00:00

  • SirT1 activator represses the transcription of TNF‑α in THP‑1 cells of a sepsis model via deacetylation of H4K16.

    abstract::Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)‑α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell model of sepsis, com...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Chen GD,Yu WD,Chen XP

    更新日期:2016-12-01 00:00:00

  • Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress.

    abstract::Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li R,Li X,Wu H,Yang Z,Fei L,Zhu J

    更新日期:2019-12-01 00:00:00

  • Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG.

    abstract::Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer‑associated mortality in the world. However, its mechanisms of occurrence and development have not been clearly elucidated. Furthermore, there is no effective tumor marker for GC. Using DNA microarray analysis, the present stu...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Duan S,Gong B,Wang P,Huang H,Luo L,Liu F

    更新日期:2018-10-01 00:00:00

  • MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1.

    abstract::MicroRNAs (miRNAs) have been discovered to have pivotal roles in regulating the drug resistance of various types of human cancer, including cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Fewer studies have explored the roles of miR-106a in NSCLC-cell resistance to DDP and its precise molecular mecha...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Ma Y,Li X,Cheng S,Wei W,Li Y

    更新日期:2015-01-01 00:00:00

  • Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells.

    abstract::The newly identified C1q/tumor necrosis factor (TNF)-related protein-6 (CTRP6) is a highly conserved paralog of adiponectin with modulatory effects on metabolism and inflammation. However, the role of CTRP6 in cerebral ischemia/reperfusion (I/R) injury remains unknown. The aim of the present study was to explore the p...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Li Y,Sun J,Gu L,Gao X

    更新日期:2020-07-01 00:00:00

  • Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.

    abstract::Circadian rhythms comprise of daily oscillations in a variety of biological processes and are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer progression, and understanding natural oscillations in cellular growth control, tumor suppression and cancer treatment, may reveal ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Couto P,Miranda D,Vieira R,Vilhena A,De Marco L,Bastos-Rodrigues L

    更新日期:2014-07-01 00:00:00

  • Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2.

    abstract::Gestational diabetes mellitus (GDM) is a type of diabetes mellitus (DM) that occurs during pregnancy. The present study aimed to investigate the roles of microRNA (miR)‑195‑5p and enhancer of zeste homolog 2 (EZH2) in GDM, and their potential association. Human umbilical vein endothelial cells (HUVECs) were collected ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Liao X,Zhou Z,Zhang X

    更新日期:2020-08-01 00:00:00

  • Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction.

    abstract::Oxidative stress leads to dysfunction in pancreatic cells, causing a reduction in insulin secretion following exposure to glucose. Toll-like receptor 4 (TLR4) may be activated by exposure to lipopolysaccharide (LPS) stress. TLR4 may mediate the initiation of inflammatory and immune defense responses; however, the impo...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang X,Ge QM,Bian F,Dong Y,Huang CM

    更新日期:2017-02-01 00:00:00

  • Antitumor and anti-angiogenic activity of the recombinant human disintegrin domain of A disintegrin and metalloproteinase 15.

    abstract::A disintegrin and metalloproteinases (ADAMs), a family of transmembrane glycoproteins, are expressed in numerous tissues and organs, and have been implicated in a variety of physiological and pathological processes. ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain. In the prese...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Hou Y,Chu M,Cai Y,Lei J,Chen Y,Zhu R,Gong X,Ma X,Jin J

    更新日期:2015-08-01 00:00:00

  • Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-α gene expression and cytokine release in vitro.

    abstract::Anti-tumor therapies based on anti-inflammatory effects have been considered in cancer treatment. Survival, proliferation and, resultantly, invasion and metastasis of tumor cells are regulated by local inflammatory mediators. Primary inflammatory cytokines, such as tumor necrosis factor (TNF), are targets for anticanc...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Dexheimer GM,Becker Delving LKO,de Oliveira HS,Biolchi V,Goettert MI,Pozzobon A

    更新日期:2017-05-01 00:00:00

  • Protective effects of probucol on Ox-LDL-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via LOX‑1/ROS/MAPK signaling.

    abstract::Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

    更新日期:2018-01-01 00:00:00

  • Comparative proteomic analysis of heat stress proteins associated with rat sperm maturation.

    abstract::Heat stress is demonstrated to have an effect on the function of the male testis, however, limited information has been reported on its effects on sperm maturation. In the present study, a comparative proteomic analysis was performed on the rat caput epididymal fluids responsible for sperm maturation, to identify key ...

    journal_title:Molecular medicine reports

    pub_type: 杂志文章


    authors: Wang X,Liu F,Gao X,Liu X,Kong X,Wang H,Li J

    更新日期:2016-04-01 00:00:00