Association Between Expression of Cancer Stem Cell Markers and Poor Differentiation of Hepatocellular Carcinoma: A Meta-Analysis (PRISMA).

Abstract:

:The role of cancer stem cell (CSC) markers in differentiation of hepatocellular carcinoma (HCC) remains uncertain. We conducted a meta-analysis to first investigate the association between expression of CSC markers (CD133, CD90, CD44, and EpCAM) and poor differentiation of HCC, and second, to determine if these CSC markers can be classified as biomarkers for patient classification and HCC differentiated therapy.The relevant literature was searched using PubMed, EMBASE, Elsevier, and Chinese Biological Medicine databases for association between CSC markers and HCC from January 1, 2000 to June 30, 2014. Data were synthesized using random-effect or fixed-effect models. The effect sizes were estimated by measuring odds ratios (OR) with 95% confidence interval (CI).The meta-analysis included 27 studies consisting of 2897 patients with HCC. The positive expression of CSC markers was associated with poor differentiation (OR = 2.37, 95% CI = 2.03-2.77, P < 0.00001). Similarly, the positive expression of CSC markers was only associated with HCC tissues compared with noncancerous liver tissues (OR = 9.26, 95% CI = 3.10-27.65, P < 0.0001). CD90 has a specificity of 91.9% for HCC and a sensitivity of 48.22% in predicting poor differentiation.The positive expression of CSC markers is associated with poor differentiation and aggressive phenotype of patients with HCC. The CD90 marker might be a promising target for patient with HCC classification and differentiation therapy.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Liu R,Shen Y,Nan K,Mi B,Wu T,Guo J,Li M,Lv Y,Guo H

doi

10.1097/MD.0000000000001306

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

e1306

issue

31

eissn

0025-7974

issn

1536-5964

pii

00005792-201508010-00044

journal_volume

94

pub_type

杂志文章,meta分析

相关文献

MEDICINE文献大全
  • The relationship between low serum calcium level and intracerebral hemorrhage hematoma expansion: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:To investigate the relationship between intracerebral hemorrhage hematoma expansion with low serum calcium level. METHODS:We will search the following electronic bibliographic databases: MEDLINE, Embase, PubMed, The Cochrane Library, and Web of Science. All sources have to be searched from the earliest date...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018844

    authors: Sun J,Liu W,Zhu R,Wu Y,Yang L

    更新日期:2020-01-01 00:00:00

  • CONSORT: May stereotactic intracavity administration of antibiotics shorten the course of systemic antibiotic therapy for brain abscesses?

    abstract:BACKGROUND:Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS:Between 2003...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006359

    authors: Yu X,Liu R,Wang Y,Zhao H,Chen J,Zhang J,Hu C

    更新日期:2017-05-01 00:00:00

  • Analysis of the Fibrinogen and Neutrophil-Lymphocyte Ratio in Esophageal Squamous Cell Carcinoma: A Promising Blood Marker of Tumor Progression and Prognosis.

    abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignancies in gastrointestinal tract cancers and even patients with early ESCC have a high metastatic potential. Difficulties are associated with clinically predicting tumor progression and prognosis based on conventional tumor markers determine...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001702

    authors: Arigami T,Okumura H,Matsumoto M,Uchikado Y,Uenosono Y,Kita Y,Owaki T,Mori S,Kurahara H,Kijima Y,Ishigami S,Natsugoe S

    更新日期:2015-10-01 00:00:00

  • Synergistic effect of enteral nutrition on remission induction in a patient with penetrating Crohn disease: A case report.

    abstract:RATIONALE:Crohn disease includes 3 phenotypes, inflammatory, stricturing, and penetrating. In cases where corticosteroids and immunosuppressive agents are not suitable treatment options, enteral nutrition (EN) can be used to reduce disease severity and enhance barrier defense with fewer potential adverse effects. PATI...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016750

    authors: Xie C,Lin J,Su J,Ren J

    更新日期:2019-08-01 00:00:00

  • Clinical and radiological outcomes of hemivertebra resection for congenital scoliosis in children under age 10 years: More than 5-year follow-up.

    abstract::The surgical treatment of congenital scoliosis under 10 years is difficult as it involves resecting vertebrae. Moreover, patient follow-up after surgery is extremely important because the patient is a child whose growth has not been completed. However, there are very few long-term follow-up studies after surgical trea...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021720

    authors: Yang JH,Chang DG,Suh SW,Kim W,Park J

    更新日期:2020-08-07 00:00:00

  • The relationship between hyperglycemia and the infection of COVID-19 in diabetic patients: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:DM is a common chronic metabolic disease. COVID-19 is an infectious disease infected by enveloped single-stranded RNA coronavirus. Meanwhile, DM is a common comorbidity of SARS-CoV-2 infection. The virus can directly or indirectly damage the pancreatic islets and cause stress hyperglycemia by causing cytokin...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000021806

    authors: Liu Y,Yang Y,Chen Y,Zhou L,Xiong Q,Xie C

    更新日期:2020-09-04 00:00:00

  • Kidney Transplantation from an extracorporeal membrane oxygenation-supported brain-dead donor: A case report.

    abstract:RATIONALE:Extracorporeal membrane oxygenation (ECMO) can deliver effective respiratory and circulatory maintenance to organ donors, improve organ function, and shorten warm ischemic time before harvesting. However, ECMO-supported brain-dead donors (DBDs) still have a high risk of acute kidney injury related to decrease...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011106

    authors: Chiang PJ,Tang SH,Li CC,Chou MH,Lin YC,Wu ST

    更新日期:2018-06-01 00:00:00

  • Docetaxel, oxaliplatin, 5FU, and trastuzumab as first-line therapy in patients with human epidermal receptor 2-positive advanced gastric or gastroesophageal junction cancer: Preliminary results of a phase II study.

    abstract::The aim of this study is to report first preliminary results of patients enrolled in a phase II study that will investigate the activity and safety of docetaxel, oxaliplatin, and 5-fluorouracil (DOF) in combination with trastuzumab in human epidermal receptor-2 (HER-2) positive patients with advanced gastric or gastro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010745

    authors: Roviello G,Petrioli R,Nardone V,Rosellini P,Multari AG,Conca R,Aieta M

    更新日期:2018-05-01 00:00:00

  • Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:This study will examine the effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells (HLCBC). METHODS:This study will search electronic bibliographic databases available in PUBMED, EMBASE, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature, China Biolog...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000020181

    authors: Li J,Liu ZY,Yu HB,Xue Q,Qu XS

    更新日期:2020-06-05 00:00:00

  • Primary malignancy in giant cell tumor of thoracic vertebrae: A case report.

    abstract:RATIONALE:Primary malignancy in giant cell tumor of bone (PMGCTB) is extremely unusual. PMGCTB in the thoracic vertebrae is particularly rare. PATIENTS CONCERNS:A 23-year-old man was admitted with a chief complaint of chest pain associated with cough for approximately 3 days. Physical examination revealed a palpable, ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011484

    authors: Yu H,Shi R,Peng ZG,Yu BH,Cui JL

    更新日期:2018-07-01 00:00:00

  • Waist-to-height ratio is better than body mass index and waist circumference as a screening criterion for metabolic syndrome in Han Chinese adults.

    abstract::Metabolic syndrome (MetS) is a major public health concern. Efficient screening requires criteria that are economical, easily accessible, and applicable for all populations. We aimed to compare the discriminating ability of body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) for the diagn...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008192

    authors: Yang H,Xin Z,Feng JP,Yang JK

    更新日期:2017-09-01 00:00:00

  • Fibromyxoid sarcoma in the retroperitoneum: A case report.

    abstract:RATIONALE:Low-grade fibromyxoid sarcoma (LGFMS) is a pathological type of fibrosing fibrosarcoma that appears as a distinctive soft tissue masse with bland histological features. It is mostly located in the deep soft tissues of the extremities. Computed tomography (CT) plays an important role in diagnosing fibrosing fi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009409

    authors: Wang G,Zhao Z,Wei J,Yang J

    更新日期:2017-12-01 00:00:00

  • Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients.

    abstract::The prognostic implication of Barcelona Clinic Liver Cancer (BCLC) substages in Asian patients with hepatocellular carcinoma (HCC) is still obscure.The aim to this study is to compare the prognoses among HCC patients in different substages of the BCLC stage 0 and A.We enrolled 1265 treatment-naive HCC patients with BC...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001929

    authors: Kao WY,Chao Y,Chang CC,Li CP,Su CW,Huo TI,Huang YH,Chang YJ,Lin HC,Wu JC

    更新日期:2015-10-01 00:00:00

  • Transabdominal preperitoneal laparoscopic approach for incarcerated inguinal hernia repair: A report of 73 cases.

    abstract::To investigate the efficacy, key technical points, and complication management of the transabdominal preperitoneal (TAPP) approach for incarcerated inguinal hernia repair. Seventy-three patients with incarcerated inguinal hernias underwent TAPP surgery in our department between Jan 2010 and Dec 2015. A retrospective r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005686

    authors: Yang S,Zhang G,Jin C,Cao J,Zhu Y,Shen Y,Wang M

    更新日期:2016-12-01 00:00:00

  • Expression of IL-17 and its gene promoter methylation status are associated with the progression of chronic hepatitis B virus infection.

    abstract::To explore interleukin-17 (IL-17) and its epigenetic regulation during the progression of chronic hepatitis B virus (HBV) infection.A total of 162 patients with chronic HBV infection, including 75 with chronic hepatitis B (CHB), 54 with hepatitis B-associated liver cirrhosis and 33 with hepatitis B-associated hepatoce...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015924

    authors: Tian CH,Dai J,Zhang W,Liu Y,Yang Y

    更新日期:2019-06-01 00:00:00

  • Low-dose methotrexate-induced vulvar edema: A case report.

    abstract:RATIONALE:Methotrexate (MTX) is an antimetabolite of folic acid, which is used for management of ectopic pregnancy. MTX-related toxicity may include cutaneous mucosal damage, bone marrow suppression, gastrointestinal disorders (gastritis, diarrhea, hematitis), liver and kidney function damage, pulmonary toxicity, cardi...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000016895

    authors: Jia G,Chai W,He Z,Liu X,Wen Y,Cui L,Gong F

    更新日期:2019-08-01 00:00:00

  • The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis.

    abstract::Although published studies have reported the association between MTHFR C677T (rs 1801133), A1298C (rs 1801131), and MTRR A66G (rs1801394) polymorphisms and male infertility in Asian populations, the results are conflicting. In order to accurately evaluate the relevance, a meta-analysis was performed.We searched for po...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014283

    authors: Shi TL,Wu Y,Li Y,Chen ZF,Ma YN,Zhang ZT,Zhang YH,Zhang L

    更新日期:2019-02-01 00:00:00

  • Relation between injury of the periaqueductal gray and central pain in patients with mild traumatic brain injury: Observational study.

    abstract::The periaqueductal gray (PAG) plays a pivotal role in pain modulation. We attempted to examine the relation between injury of the PAG and central pain in patients with mild traumatic brain injury (TBI).Sixty-one patients with mild TBI with central pain and 31 healthy control subjects were recruited for this study. Vis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004017

    authors: Jang SH,Park SM,Kwon HG

    更新日期:2016-06-01 00:00:00

  • Echinococcosis in left ventricle: a case report.

    abstract:INTRODUCTION:Echinococcosis, also called hydatid disease, is a common parasitic infection of the liver. However, echinococcus lesions rarely involve the heart, especially in children. PATIENT CONCERNS:An 8-year-old child from grazing areas of northwest China was referred to our hospital for the complaint of inpersiste...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015267

    authors: Su L,Yu J,Dai C,Liu Y,Peng L

    更新日期:2019-04-01 00:00:00

  • Significant efficacy and well safety of apatinib combined with radiotherapy in NSCLC: Case report.

    abstract:RATIONALE:The outcomes of locally advanced non-small cell lung cancer (NSCLC) remain poor, in particular, the frail elderly patients cannot tolerate chemotherapy. The new efficient, safe, and more specific treatments are needed. Radiation combined with targeted therapy is the focus of research in recent years. Apatinib...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009276

    authors: Zhao C,Zhang Q,Qiao W

    更新日期:2017-12-01 00:00:00

  • Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2.

    abstract::This study aimed to introduce this surgical technique laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass (LDJB-LSG), and to confirm this new surgical technique was safe in the treatment of type 2 diabetes mellitus (T2DM) of patients with body mass index (BMI) higher than 27.5 kg/m...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011537

    authors: Li YX,Fang DH,Liu TX

    更新日期:2018-08-01 00:00:00

  • Step Counter Use and Sedentary Time in Adults: A Meta-Analysis.

    abstract::Although step counters are increasingly being used in walking programmes to promote sedentary behavior changes in adults, their effectiveness remains unknown. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness of step counter use in reducing sedentary time among adults...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000001412

    authors: Qiu S,Cai X,Ju C,Sun Z,Yin H,Zügel M,Otto S,Steinacker JM,Schumann U

    更新日期:2015-09-01 00:00:00

  • Effect of morphine added to multimodal cocktail on infiltration analgesia in total knee arthroplasty: A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The local injection of multimodal cocktail is currently commonly used in the treatment of postoperative pain after total knee arthroplasty (TKA). It is still inconclusive whether the morphine added to the intraoperative injection mixture could make some difference. This meta-analysis aimed to evaluate the ef...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017503

    authors: Zhang Y,Mi F,Zhao H,Xie D,Shi X

    更新日期:2019-10-01 00:00:00

  • Primary pulmonary myoepithelial carcinoma in a young woman: A case report and review of literature.

    abstract:RATIONALE:Myoepithelial carcinoma mainly occurs in the salivary glands, but myoepithelial carcinoma of the lung is extremely rare neoplasm whose biological behavior and clinical course still remain to be fully elucidated. Although considered as low-grade carcinoma, these tumors have a high rate of recurrence or distant...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000010049

    authors: Zhou X,Yu M,Zhuo H,Zhang S

    更新日期:2018-03-01 00:00:00

  • Falsely elevated thyroglobulin and calcitonin due to rheumatoid factor in non-relapsing thyroid carcinoma: A case report.

    abstract:RATIONALE:Thyroglobulin (Tg) is an accurate indicator of clinical outcome after total thyroidectomy in patients with differentiated thyroid carcinoma. Usually, Tg levels agree with whole body scan. However, in some patient, discordant results were found, often because of Tg immunoassay interference. Several reports ind...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014178

    authors: Lupoli GA,Barba L,Liotti A,La Civita E,Lupoli R,Riccio E,Portella G,Formisano P,Beguinot F,Terracciano D

    更新日期:2019-02-01 00:00:00

  • Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty: A GRADE analysis and meta-analysis.

    abstract:BACKGROUND:The efficacy and safety of oral tranexamic acid (TXA) remain controversial because of the small number of clinical studies. The aim of the present study was to compare the efficacy and safety of oral TXA with intravenous TXA in patients undergoing total hip arthroplasty and total knee arthroplasty in a syste...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000022999

    authors: Sun C,Zhang X,Chen L,Deng J,Ma Q,Cai X,Yang H

    更新日期:2020-10-30 00:00:00

  • Ultrasound is highly specific in diagnosing compensated cirrhosis in chronic hepatitis C patients in real world clinical practice.

    abstract::Ultrasound is routinely used during the evaluation of liver cirrhosis. Inter-observer variability is considered a major drawback. This retrospective study investigated the accuracy of ultrasound in diagnosing compensated cirrhosis (i.e., modified Knodell F3, F4) in chronic hepatitis C (CHC) patients in real world clin...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016270

    authors: Yen YH,Kuo FY,Chen CH,Hu TH,Lu SN,Wang JH,Hung CH

    更新日期:2019-07-01 00:00:00

  • Primary cutaneous anaplastic large-cell lymphoma: A case report.

    abstract:RATIONALE:Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface. PATIENT CONCERNS:This is the case of a 73-year-old man who r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009645

    authors: Abed K,Stopa Z,Siewert-Gutowska M

    更新日期:2018-01-01 00:00:00

  • Preoperative Volume-Based PET Parameter, MTV2.5, as a Potential Surrogate Marker for Tumor Biology and Recurrence in Resected Pancreatic Cancer.

    abstract::This study aims to evaluate the role of volume-based positron emission tomography parameters as potential surrogate markers for tumor recurrence in resected pancreatic cancer. Between January 2008 and October 2012, medical records of patients who underwent surgical resection for pancreatic ductal adenocarcinoma and co...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002595

    authors: Kang CM,Lee SH,Hwang HK,Yun M,Lee WJ

    更新日期:2016-03-01 00:00:00

  • The high prevalence of subclinical atherosclerosis in patients with ankylosing spondylitis without clinically evident cardiovascular disease.

    abstract::We conducted the present study to determine whether subclinical macrovascular atherosclerotic disease was present in patients with ankylosing spondylitis (AS) without clinical history of cardiovascular disease. We also sought to establish whether demographic or clinical features of the disease may influence the develo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0b013e3181c10773

    authors: Gonzalez-Juanatey C,Vazquez-Rodriguez TR,Miranda-Filloy JA,Dierssen T,Vaqueiro I,Blanco R,Martin J,Llorca J,Gonzalez-Gay MA

    更新日期:2009-11-01 00:00:00