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Natalizumab is effective in controlling the inflammatory rebound after its discontinuation and failure of an alternative treatment.

Abstract：

:Progressive multifocal leukoencephalopathy (PML) is the most feared complication when natalizumab (NAT) is used in the treatment of relapsing multiple sclerosis (MS). JC virus serologic status is a currently established risk factor for PML. When seroconversion occurs, NAT discontinuation should be based on a solid rationale to avoid an MS inflammatory resurgence. The JC virus index value may also provide further useful information to help practitioners and patients in their decision process.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Barroso B,Miquel M,Marasescu R,Demasles S,Krim E,Bonnan M

doi

10.1016/j.msard.2015.04.005

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

380-2

issue

4

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(15)00044-9

journal_volume

4

pub_type

杂志文章

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