CNS demyelination during tofacitinib therapy: First report.

Abstract:

:Iatrogenic demyelination is a distinct clinical subtype of central nervous system inflammatory disorders. The Janus kinase inhibitor, tofacitinib, is an oral disease-modifying antirheumatic drug that has shown contradictory effects on multiple sclerosis in animal models. In this report, we describe a novel case of reversible multifocal CNS demyelination in a patient with seropositive rheumatoid arthritis on tofacitinib. Although the mechanism is not completely understood, activation of T17 cells by tofacitinib and the subsequent increased production of interleukin-17 could be the cause. Moreover, a link between TNF-α and JAK/STAT pathways has been suggested, which may further explain the occurrence of iatrogenic demyelination in this case.

authors

Massoud F,Ismail II,Al-Hashel JY,Abboud H

doi

10.1016/j.msard.2020.102568

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

102568

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(20)30642-8

journal_volume

46

pub_type

信件
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