Abstract:
BACKGROUND:Fatigue is a common and disabling symptom of multiple sclerosis (MS) patients. Structural changes in several brain areas have been reported to correlate with fatigue in MS patients but none consistently. OBJECTIVE:To study the association between global and regional measures of brain atrophy and fatigue in patients with early relapsing MS. METHODS:Clinically isolated syndrome and relapsing MS patients within 12 months of clinical onset were enrolled in a neuroprotection trial of riluzole versus placebo with up to 36 months of follow-up. MRI metrics included brain volumes measured by SIENAX normalized measurements [normalized brain parenchymal volume (nBPV), normalized normal-appearing white and gray matter volume (nNAWMV and nGMV)] and T2 lesion volume (T2LV). Cortical thickness, thalamic volume and cerebellar cortical volume were measured using Freesurfer's longitudinal pipeline (v5.3) and a lesion inpainting approach. Fatigue was evaluated using the Modified Fatigue Impact Scale (MFIS). Mixed model regression measured time trends and associations between imaging and fatigue severity, adjusting for age and sex. RESULTS:Forty-three patients (mean age 36 years; 31 females) were enrolled within 7.5 ± 4.9 months of symptom onset. Baseline and change over baseline in lesion volumes, grey matter, white matter, basal ganglia and total parenchymal volumes were not associated with change in MFIS score over time. Lower thalamic volume at baseline predicted increasing physical subscale of MFIS score during the study (p=0.017). There was a trend toward baseline thalamic volume and cerebellar cortical volume predicting subsequent change in total MFIS score (p=0.055 and 0.082 respectively). On-study change in thalamic or cerebellar cortical volume was not associated with on-study change in MFIS score. CONCLUSION:Global measures of tissue loss are not strongly associated with fatigue in patients with early MS. However, thalamic and cerebellar cortical atrophy may be predictive of subsequent changes in fatigue in these patients.
journal_name
Mult Scler Relat Disordjournal_title
Multiple sclerosis and related disordersauthors
Nourbakhsh B,Azevedo C,Nunan-Saah J,Maghzi AH,Spain R,Pelletier D,Waubant Edoi
10.1016/j.msard.2015.10.006subject
Has Abstractpub_date
2016-01-01 00:00:00pages
29-33eissn
2211-0348issn
2211-0356pii
S2211-0348(15)30013-4journal_volume
5pub_type
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journal_title:Multiple sclerosis and related disorders
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更新日期:2019-10-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
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journal_title:Multiple sclerosis and related disorders
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pub_type: 杂志文章,评审
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2016.10.002
更新日期:2016-11-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2014.11.007
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1016/j.msard.2018.03.014
更新日期:2018-05-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.05.005
更新日期:2018-08-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2018.02.032
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Neuromyelitis optica (NMO) is a disabling inflammatory condition that targets astrocytes in the optic nerves and spinal cord. Recent advances led to the individualization of a set of conditions now referred as NMO spectrum disorder (NMOSD). OBJECTIVE:To describe the prevalence and characteristics of NMO SD ...
journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
doi:10.1016/j.msard.2015.12.005
更新日期:2016-03-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
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更新日期:2020-07-01 00:00:00
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journal_title:Multiple sclerosis and related disorders
pub_type: 杂志文章
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