Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance index.

Abstract:

BACKGROUND:The prognostic importance of high-sensitivity cardiac troponin T (hs-cTnT) has recently been reported in patients with heart failure. The myocardial performance index (MPI), which combines parameters of both systolic and diastolic ventricular function, provides a better marker of left ventricular dysfunction in hypertensive patients with preserved left ventricular ejection fraction (LVEF). AIM:We aimed to investigate the relationship between hs-cTnT and tissue Doppler-derived MPI in newly diagnosed hypertensive patients with preserved LVEF. METHODS:We studied 306 patients with newly diagnosed hypertension. The patients were divided into two groups according to their median MPI values: MPIlo and MPIhigh groups. The MPI was calculated from the pulsed-wave Doppler recordings. Left ventricular mass index (LVMI) was determined according to the Devereux formula. hs-cTnT, uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were measured in all patients. RESULTS:Hs-cTnT, hs-CRP, and uric acid levels were higher in the MPIhigh group compared with the MPIlow group (p < 0.05, for all). The LVMI values in the MPIhigh group were higher than in the MPIlow group (p < 0.05). MPI was independently associated with age, uric acid, hs-cTnT, and LVMI in multivariate analysis. Multivariate logistic regression analysis showed that MPI and LVMI were independent predictors of high hs-cTnT level in newly diagnosed hypertensive patients with preserved LVEF. CONCLUSION:Hs-cTnT was independently associated with LV dysfunction and LV hypertrophy assessed with MPI in newly diagnosed hypertensive patients.

journal_name

Herz

journal_title

Herz

authors

Kaypakli O,Gür M,Gözükara MY,Uçar H,Kivrak A,Şeker T,Şahin DY,Elbasan Z,Türkoğlu C,Çayli M

doi

10.1007/s00059-015-4322-3

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1004-10

issue

7

eissn

0340-9937

issn

1615-6692

pii

10.1007/s00059-015-4322-3

journal_volume

40

pub_type

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