Dose paradigms for inhaled vapors of primary carcinogens and their impact on risk assessment.

Abstract:

:In the assessment of risk, several factors affect predictions: selection of reactive agent, selection of tumor incidence data, modeling of dose, scaling across species, adjustment for differences in duration and frequency of exposure, and selection of the most suitable risk extrapolation model. If the endpoints, exposure regimen, and the model for risk extrapolation are constant, then the review of dose paradigms will illustrate the effect of dose modeling on risk, since by definition the reactive agent is the primary carcinogen. The response incidence in lifetime inhalation bioassays of two primary carcinogens, ethylene oxide and formaldehyde, was used with different dose paradigms to estimate risk from maximum lifetime occupational exposures. The dose paradigms that will be considered include: concentration, concentration time product, retained dose, integrated blood concentration, and tissue exposure. The basis for across-species scaling and the assumptions underlying each dose paradigm were discussed.

journal_name

Health Phys

journal_title

Health physics

authors

Beliles RP,Parker JC

doi

10.1097/00004032-198907001-00046

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

333-40

eissn

0017-9078

issn

1538-5159

journal_volume

57 Suppl 1

pub_type

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