Forms of Circulating Luteinizing Hormone Human Chorionic Gonadotropin Receptor for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy.

Abstract:

OBJECTIVE:To explore the value of circulating luteinizing human chorionic gonadotropin receptor (LHCGR) forms for the prediction of preeclampsia (PE) in the first trimester of pregnancy. METHODS:Case-control study, based on a cohort of 5,759 pregnancies, including 20 early PE, 20 late PE, and 300 controls. We recorded/measured maternal characteristics, mean arterial pressure (MAP), uterine artery (UtA) Doppler, placental growth factor (PlGF), soluble Fms-like tyrosine kinase-1 (sFtl-1), and LHCGR forms (hCG-LHCGR and soluble LHCGR), and their independent predictive values were analyzed by logistic regression. RESULTS:For early PE, the model included black ethnicity, chronic hypertension, previous PE, MAP, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, achieving detection rates (DR) of 83% at 10% of false-positive rates (FPR) [AUC: 0.961 (95% CI: 0.921-1)]. For late PE, the model included body mass index, previous PE, UtA Doppler, PlGF, sFlt-1, and LHCGR forms, with DR of 75% at 10% of FPR [AUC: 0.923 (95% CI: 0.871-0.976)]. In both early and late PE, LHCGR forms improved DR by 6-15%. CONCLUSIONS:LHCGR forms improved the prediction for early and late PE. These results should be confirmed in larger prospective studies.

journal_name

Fetal Diagn Ther

authors

Crovetto F,Figueras F,Crispi F,Triunfo S,Pugia M,Lasalvia L,Chambers AE,Mills WE,Banerjee S,Mercadé I,Casals E,Mira A,Rodriguez-Revenga Bodi L,Gratacós E

doi

10.1159/000371516

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

94-102

issue

2

eissn

1015-3837

issn

1421-9964

pii

000371516

journal_volume

38

pub_type

杂志文章
  • The changes in angiogenic gene expression in recurrent multiple chorioangiomas.

    abstract:OBJECTIVES:To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. METHODS:Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal plac...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000098708

    authors: Gallot D,Marceau G,Laurichesse-Delmas H,Vanlieferinghen P,Dechelotte PJ,Lemery D,Sapin V

    更新日期:2007-01-01 00:00:00

  • Successful in utero Percutaneous Fetoscopic Release of a Wrapped Pleuro-Amniotic Shunt around the Fetal Arm: Case Report and Review of the Literature.

    abstract:BACKGROUND AND OBJECTIVES:Fetal pleural effusions are either primary or secondary to chromosomal or structural fetal abnormalities. In both cases, thoraco-amniotic shunts may be indicated to prevent life-threatening consequences. In this report, we describe a rare complication of shunts and successful in utero manageme...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000450606

    authors: Nassr AA,Ruano R,Espinoza J,Shamshirsaz AA

    更新日期:2018-01-01 00:00:00

  • Prenatal diagnosis of X-linked ichthyosis using molecular cytogenetics.

    abstract::A case is presented in which X-linked ichthyosis was diagnosed prenatally using fluorescence in situ hybridization. Fetal sex was known by second trimester ultrasound in a woman with very low second trimester MSUE3. All of the 15 maternal peripheral blood metaphase spreads examined displayed two hybridization signals ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264422

    authors: Santolaya-Forgas J,Cohen L,Vengalil S,Field F,Rodriguez A,McCorquadale M,McCorquadale DJ

    更新日期:1997-01-01 00:00:00

  • The (Pulsed-Wave) Doppler Fetal Myocardial Performance Index: Technical Challenges, Clinical Applications and Future Research.

    abstract::Functional cardiovascular assessment is becoming an increasingly important tool in the study of fetal pathology. The myocardial performance index (MPI) is a parameter measuring global myocardial function. Since its introduction, several studies have proposed methods to improve its reproducibility and have constructed ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000363181

    authors: Mahajan A,Henry A,Meriki N,Hernandez-Andrade E,Crispi F,Wu L,Welsh AW

    更新日期:2015-01-01 00:00:00

  • Validation of an Enhanced Version of a Single-Nucleotide Polymorphism-Based Noninvasive Prenatal Test for Detection of Fetal Aneuploidies.

    abstract:OBJECTIVE:To validate an updated version (Version 2) of a single-nucleotide polymorphism (SNP)-based noninvasive prenatal test (NIPT) and to determine the likelihood of success when testing for fetal aneuploidies following a redraw. METHODS:Version 2 was analytically validated using 587 plasma samples with known genot...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000442931

    authors: Ryan A,Hunkapiller N,Banjevic M,Vankayalapati N,Fong N,Jinnett KN,Demko Z,Zimmermann B,Sigurjonsson S,Gross SJ,Hill M

    更新日期:2016-01-01 00:00:00

  • Changes in blood flow velocity waveforms following fetal blood sampling.

    abstract::The umbilical artery, aorta, and middle cerebral artery pulsatility indices were investigated by pulsed Doppler ultrasound in 73 fetuses at 18-37 weeks of gestation, before and after fetal blood sampling performed either at the placental cord insertion (n = 46) or at the intrahepatic vein (n = 27). At the end of the p...

    journal_title:Fetal diagnosis and therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000264251

    authors: Zoppini C,Brioschi D,Tassis B,Zuliani G,Kustermann A,Nicolini U

    更新日期:1995-09-01 00:00:00

  • A comparison of two immunoassay methods for the measurement of maternal serum placental growth factor in early pregnancy.

    abstract:OBJECTIVES:To compare the DELFIA Xpress and Quantikine ELISA placental growth factor (PlGF) immunoassay platforms by analysing the same set of early first-trimester maternal serum samples from cases with trisomy 21 and euploid controls. METHODS:Thirty-seven trisomy 21 cases and 243 euploid control serum samples, drawn...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000336661

    authors: Cowans NJ,Kisanga M,Khan A,Spencer K

    更新日期:2012-01-01 00:00:00

  • Amnioreduction: how much to drain?

    abstract:OBJECTIVES:To assess the relationship between the volume of amniotic fluid removed and the change in amniotic fluid index (AFI) and calculate an equation describing this association. MATERIALS AND METHODS:A retrospective analysis of 19 amnioreduction procedures performed in our unit. Multiple regression analysis was u...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020939

    authors: Abdel-Fattah SA,Carroll SG,Kyle PM,Soothill PW

    更新日期:1999-09-01 00:00:00

  • Fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome: a single-center experience.

    abstract:OBJECTIVE:To report the incidence of fetal and maternal complications after selective fetoscopic laser surgery for twin-to-twin transfusion syndrome (TTTS). METHODS:A total of 150 cases of TTTS were treated from January 2004 to June 2009 (period 1, 2004-2006, 62 cases; period 2, 2007 to June 2009, 88 cases). Fetal com...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000336227

    authors: Rustico MA,Lanna MM,Faiola S,Schena V,Dell'avanzo M,Mantegazza V,Parazzini C,Lista G,Scelsa B,Consonni D,Ferrazzi E

    更新日期:2012-01-01 00:00:00

  • Mid-trimester thoracoamniotic shunting for the treatment of fetal primary pleural effusions in a twin pregnancy. a case report.

    abstract::Thoracoamniotic shunting has been described as having a beneficial role in the antenatal management of primary pleural effusions in singleton pregnancies. We report a case of a twin pregnancy in which progressive pleural effusions and hydrops were diagnosed in one of the fetuses at 16 weeks of gestation. An initial ev...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000021007

    authors: Grisaru-Granovsky S,Seaward PG,Windrim R,Wyatt P,Kelly EN,Ryan G

    更新日期:2000-07-01 00:00:00

  • Dysthymic reactions of women undergoing chorionic villus sampling for prenatal diagnosis of hemoglobinopathies or karyotyping.

    abstract:OBJECTIVES:The aim of the study was to investigate the levels of anxiety and depression, as well as liability to depression, of women undergoing chorionic villus sampling (CVS) due to the risk of giving birth to a child suffering from hemoglobinopathy, or trisomy. METHODS:The study population consisted of 309 women wh...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000075140

    authors: Lykeridou K,Daskalakis G,Papadatou D,Vaslamatzis G,Dafni O,Antsaklis A

    更新日期:2004-03-01 00:00:00

  • Fetal heart disease: severity, associated anomalies and parental decision.

    abstract:OBJECTIVE:This study describes the association between the complexity of congenital cardiac and extracardiac malformations, and the parental decision of pregnancy continuation or termination. METHODS:Congenital heart defects (CHD) was diagnosed by ultrasound in 251 fetuses before the 24th week (23 + 6 weeks) of gestat...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000346564

    authors: Nell S,Wijngaarde CA,Pistorius LR,Slieker M,ter Heide H,Manten GT,Freund MW

    更新日期:2013-01-01 00:00:00

  • Thoraco-omphalopagus conjoined twins detected at as early as 9 weeks of gestation: transvaginal two-dimensional ultrasound, color Doppler and fetoplacental Doppler velocity waveform findings.

    abstract::Here we report a case of conjoined twins that were diagnosed antenatally by routine two-dimensional transvaginal ultrasound examination at as early as the 9th week of gestational age. The fetuses were of the thoraco-omphalopagus type and were sharing the liver, as confirmed by color Doppler. There was a reversed flow ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000093893

    authors: Basgül A,Kavak ZN,Sezen D,Basgul A,Gokaslan H

    更新日期:2006-01-01 00:00:00

  • The Influence of Blood Pressure on Fetal Aortic Distensibility: An Animal Validation Study.

    abstract:BACKGROUND/AIMS:Aortic distension waveforms describe the change in diameter or cross-sectional area over the cardiac cycle. We aimed to validate the association of aortic fractional area change (AFAC) with blood pressure (BP) in a fetal lamb model. METHODS:Four pregnant ewes underwent open fetal surgery under general ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000477396

    authors: Wohlmuth C,Moise KJ Jr,Papanna R,Gheorghe C,Johnson A,Morales Y,Gardiner HM

    更新日期:2018-01-01 00:00:00

  • Fetal hydrocephalus and intrauterine cerebral ventriculoscopy: an animal model.

    abstract:OBJECTIVE:The aim of this study was to create an animal model of obstructive ventriculomegaly in the fetal lamb at 78 days of gestation by injecting maternal blood into the lateral ventricles under ultrasound guidance. METHODS:An endoscope of 1.2 mm housed in a 1.6-mm trocar was introduced into the dilated lateral ven...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000086829

    authors: De Keersmaecker B,Vloeberghs M,Ville Y

    更新日期:2005-09-01 00:00:00

  • Meconium staining and meconium aspiration syndrome. Is there seasonal variation?

    abstract:OBJECTIVE:To determine whether the incidence of pregnancies complicated by meconium-stained amniotic fluid (MSAF) or meconium aspiration syndrome (MAS) differs with seasonal changes. METHODS:An established perinatal database was used to identify all term (> or = 37 weeks) singleton gestations resulting in a live birth...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000053911

    authors: Blackwell SC,Carreno CA,Hassan SS,Moldenhauer J,Wolfe HM,Berry SM,Kruger M,Sorokin Y

    更新日期:2001-07-01 00:00:00

  • Cell-Free DNA Analysis in Maternal Blood: Differences in Estimates between Laboratories with Different Methodologies Using a Propensity Score Approach.

    abstract:OBJECTIVES:To evaluate the failure rate and performance of cell-free DNA (cfDNA) testing, mainly in terms of detection rates for trisomy 21, performed by 2 laboratories using different analytical methods. METHODS:cfDNA testing was performed on 2,870 pregnancies with the HarmonyTM Prenatal Test using the targeted digit...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000489124

    authors: Bevilacqua E,Jani JC,Letourneau A,Duiella SF,Kleinfinger P,Lohmann L,Resta S,Cos Sanchez T,Fils JF,Mirra M,Benachi A,Costa JM

    更新日期:2019-01-01 00:00:00

  • Competing risks model in screening for preeclampsia by biophysical and biochemical markers at 30-33 weeks' gestation.

    abstract:OBJECTIVE:To assess the risk for preeclampsia (PE) by maternal characteristics, uterine artery pulsatility index (Ut-PI), mean arterial pressure (MAP), serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) at 30-33 weeks' gestation. METHODS:This was a screening study in singleton pregnan...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000362518

    authors: Garcia-Tizon Larroca S,Tayyar A,Poon LC,Wright D,Nicolaides KH

    更新日期:2014-01-01 00:00:00

  • Lung function following first-trimester amniocentesis or chorion villus sampling.

    abstract::Functional residual capacity (FRC) was measured at 2-8 (median 4) weeks of age in 100 infants whose mothers had entered a randomized trial of amniocentesis versus chorion villus sampling (CVS) at 10-13 weeks gestation. At measurement all of the infants were well and none had respiratory problems. No significant differ...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263638

    authors: Thompson PJ,Greenough A,Nicolaides KH

    更新日期:1991-01-01 00:00:00

  • Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia.

    abstract::Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are diseases in which chest-occupying lesions can result in severe pulmonary hypoplasia. However, significant postnatal mortality due to pulmonary hypertension (PH) is more often seen in patients with CDH. We analyzed prenatal ec...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000434643

    authors: Derderian SC,Jayme CM,Cheng LS,Keller RL,Moon-Grady AJ,MacKenzie TC

    更新日期:2016-01-01 00:00:00

  • Prenatal diagnosis of cystic neuroblastoma.

    abstract::Cystic adrenal masses are unusual in the fetus. The most common diagnosis for adrenal cyst is hemorrhage. We report 2 cases of cystic neuroblastoma diagnosed prenatally by ultrasound. In each case, diagnosis was confirmed in the neonatal period first by scintigraphy, then by histology. Differential diagnosis and manag...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263946

    authors: Dreyfus M,Neuhart D,Baldauf JJ,Casanova R,Becmeur F,Ritter J

    更新日期:1994-07-01 00:00:00

  • Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery.

    abstract:OBJECTIVE:To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure. METHODS:Retrospective chart review of 54 children that underwent fMMC closure at our institution prior to the NIHCD-MOMS trial. Neonatal LENF was compared to predicted f...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000197359

    authors: Danzer E,Gerdes M,Bebbington MW,Sutton LN,Melchionni J,Adzick NS,Wilson RD,Johnson MP

    更新日期:2009-01-01 00:00:00

  • Screening of fetal stem cells for infection and cytogenetic abnormalities.

    abstract::Fetal stem cell transplantation may rely on material from therapeutic abortions. It is essential that the stem cell transplant does not transmit any microorganisms that may affect the fetus and that genetically abnormal cells are avoided. To evaluate such contamination, human fetal stem cells collected February 1992 -...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000264065

    authors: Ek S,Westgren M,Pschera H,Seiger A,Sundström E,Bui TH,Ringdén O

    更新日期:1994-11-01 00:00:00

  • Age of gestation (size) at embryonic demise: tailoring counseling for lethal versus potentially viable aneuploidy.

    abstract::The incidence of chromosomal abnormalities in spontaneous abortions is much higher than commonly appreciated. Using postmortem chorionic villus sampling (as we have previously described), our much increased yield of results allows us to divide embryos into two groups based upon potential viability. Embryonic size at t...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000263821

    authors: Drugan A,Johnson MP,Isada NB,Evans MI

    更新日期:1993-05-01 00:00:00

  • Perinatal outcomes of fetal abdominal cysts and comparison of prenatal and postnatal diagnoses.

    abstract:INTRODUCTION:The differential diagnosis of an abdominal cyst can be challenging, and an accurate diagnosis is crucial for optimal antenatal management. The aim of this study was to compare the ante- and postnatal diagnoses of cases with abdominal cyst and to determine the diagnostic accuracy of ultrasonography. MATERI...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000318191

    authors: Ozyuncu O,Canpolat FE,Ciftci AO,Yurdakok M,Onderoglu LS,Deren O

    更新日期:2010-01-01 00:00:00

  • Preterm prelabor rupture of membranes and fetal survival after minimally invasive fetal surgery: a systematic review of the literature.

    abstract:OBJECTIVE:Iatrogenic preterm prelabor rupture of membranes (iPPROM; <37 weeks of gestation) is a major complication of fetal surgery. Little information is available about risk factors and incidence. METHODS:We systematically reviewed reported iPPROM rates, gestational age at delivery and fetal survival after represen...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章,评审

    doi:10.1159/000331165

    authors: Beck V,Lewi P,Gucciardo L,Devlieger R

    更新日期:2012-01-01 00:00:00

  • Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction.

    abstract::Large placental chorioangiomas (>4 cm) can precipitate severe polyhydramnios, fetal anemia, growth restriction, high-output cardiac failure, hydrops, and fetal demise. We report a case of a large chorioangioma that was treated in a stepwise fashion with amnioreduction to ameliorate maternal discomfort, followed by fet...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000331944

    authors: Jones K,Tierney K,Grubbs BH,Pruetz JD,Detterich J,Chmait RH

    更新日期:2012-01-01 00:00:00

  • Demonstration of the Pericallosal Artery at 11-13 Weeks of Gestation Using 3D Ultrasound.

    abstract:OBJECTIVE:To assess the sonographic visualization of the pericallosal arteries in normal fetuses at 11-13 weeks of gestation using 3D ultrasound. METHODS:We prospectively enrolled women with a singleton pregnancy undergoing ultrasound at 11-13 weeks of gestation. A 3D volume with high-definition power Doppler was acqu...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000366156

    authors: Conturso R,Contro E,Bellussi F,Youssef A,Pacella G,Martelli F,Rizzo N,Pilu G,Ghi T

    更新日期:2015-01-01 00:00:00

  • Beckwith-Wiedemann syndrome presenting with an elevated triple screen in the second trimester of pregnancy.

    abstract:BACKGROUND:Beckwith-Wiedemann syndrome (BWS) is a distinct clinical syndrome with unique features, generally diagnosed postnatally. CASE:A 26-year-old patient, gravida 4, para 3-0-0-3, was noted to have an abnormal maternal serum screen. Amniocentesis with imaging studies were remarkable only for a two-vessel umbilica...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000095837

    authors: Aagaard-Tillery KM,Buchbinder A,Boente MP,Ramin KD

    更新日期:2007-01-01 00:00:00

  • Efficiency of ultrasound and biochemical markers for Down's syndrome risk screening. A prospective study.

    abstract:OBJECTIVE:To evaluate the sequential combination of ultrasound screening for fetal aneuploidy at 11-14 weeks with maternal biochemistry at 12-14 and 15-18 weeks of gestation. METHODS:A prospective study including 1,656 women, with a singleton pregnancy booked before 13 weeks of gestation. Nuchal translucency (NT) thic...

    journal_title:Fetal diagnosis and therapy

    pub_type: 杂志文章

    doi:10.1159/000020900

    authors: Benattar C,Audibert F,Taieb J,Ville Y,Roberto A,Lindenbaum A,Frydman R

    更新日期:1999-03-01 00:00:00