Abstract：
:Two groups of rats (a control group and the group examined) were administered intraperitoneally supraphysiological doses of hCG in order to induce a "down regulation" effect on the level of receptors LH and to achieve the desensibilization of Leydig cells. The authors tried to find out at which stage of sequence of changes from receptor stimulation to hormone production there appears a state of cellular resistance to further stimulation. Sections of the nucleus were incubated with various substances influencing steridogenesis (LH, hCG, dbcAMP, 22-R-OH-cholesterol, NAD + NADP + G-6-P + G-6-PDH). An index of the influence of the above substances on the synthesis of androgens were amounts of pregnenolon as the first and testosterone as the final stage of hormonal changes marked radioimmunologically in nucleus homogenates and incubating media. It was shown that the resistance of Leydig cells to further stimulation in the group of animals that were given high doses of hCG is the result of enzymatic blocks in testosterone synthesis. The first block is "late" block of 17 alpha-hydroxylase and 17-20 desmolase, disturbing transforming of 21-carbon steriods into 19-carbon androgens. When the dose of hCG increases, there appears the second block, the so called "early" block, disturbing mitochondrial synthesis of pregnenolon. It was found that exogenic cofactors are in a position, at least partially, to restore the activity of blocked enzymes.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Grochowski D,Szamatowicz Msubject
Has Abstractpub_date
1989-05-01 00:00:00pages
252-60issue
5eissn
0017-0011issn
2543-6767journal_volume
60pub_type
杂志文章abstract：:The aim of the work were changes of serum ferritin and iron concentrations in women with leiomyoma of the uterus treated surgically. We took the growth of the leiomyomatous uterus under concern. We observed the lower serum ferritin and iron concentrations before the surgical treatment, and the correlation with the gro...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:Sensibility and specificity of transvaginal ultrasonography and diagnostic hysteroscopy were compared in 211 infertile women. Examinations were performed between 1996-2000 in I-st Department of Obstetrics and Gynecology Warsaw Medical University--Poland. Comparing results we concluded high compatibility of transvagina...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Scientific journals are ranked and evaluated to measure their relative importance and influence on science within a specific field. One of the tools most widely used to evaluate and compare journals is the Thomson Reuters Impact Factor In Poland a specific value of a scientist's Impact Factor is required for academic ...
journal_title：Ginekologia polska
pub_type： 社论
doi：
更新日期：2011-08-01 00:00:00
abstract：:Legal abortions have reduced the number of miscarriages by 20%, and of abandoned children by 56%; but at the same time, can be hazardous to the mother both initially (loss of blood, punctured uterus, damaged cervix) and later (infections in the reproductive system, infertility, extrauterine pregnancy, psychological di...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:32 patients with hydatid mole were subjected to serological tests to determine the concentration of chorionic gonadotropin (HCG) in the urine. The patients were divided into 2 groups, depending on the duration of the amenorrhea. Group 1 (20 cases) showed a uterus size not exceeding the volume of the 12th week of ges...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：OBJECTIVES:The objective of the study was to investigate the detection rates of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, Gardnerella vaginalis, Escherichia coli, Streptococcus agalactiae and Enterococcus faecalis, showing no clinical signs of an on...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1588
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVES:It is controversial whether pelvic organ prolapse and stress urinary incontinence (SUI) should be treated simultaneously with a single surgery or separately with two procedures. The pre-pubic four-arm NAZCA-TC® mesh was invented to treat cystocele and SUI with a single procedure. The objective of this study ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2017.0105
更新日期：2017-01-01 00:00:00
abstract：:Two patients aged 35 i 40 years after extensive clinical evaluation were operated by means of combined approach--laparoscopy and vaginal resection of endometriotic tumors. First laparoscopy was performed in order to dissect rectovaginal septum and separate rectum from the vagina in order to facilitate complete vaginal...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVES:We investigated how maternal endothelial function is affected by pregestational (Type 1) diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) and/or chronic hypertension (chHT) or gestational hypertension (PIH). METHODS:We conducted a prospective, observational study involving 78 participants wit...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/62209
更新日期：2016-01-01 00:00:00
abstract：UNLABELLED:In our study the management and outcomes in 211 women with premature rupture of the membranes at term was analyzed. According to the time elapsed since PROM to delivery the study group was divided into four groups: within 6 h, within 6-12 h, within 12-24 h and over 24 h after PROM. The analysis was focused o...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-10-01 00:00:00
abstract：:EPH-gestosis is accompanied by an extensive remodeling of the extracellular matrix of Wharton's jelly. The gelatinolytic and proteolytic activities were measured. A decrease in gelatinolityc activity and an increase in proteolytic activity in EPH-gestosis were observed. The decrease in gelatinase activity in EPH-gesto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:127 pregnant patients between 20 and 37 week of gestation were studied. Cervical estimation was done by using transvaginal ultrasonography. An accurate estimation was possible in all investigation patients. Statistically significant distinctions in uterine cervical length during pregnancy progress were noticed (p < 0....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to establish optimal diagnostic and therapeutic scheme and to assess the efficacy of intrauterine therapy of hydrocephalus. MATERIAL AND METHODS:The study was carried out between 1992-2012 on the total of 222 fetuses with hydro- cephalus, using Orbis-Sigma and ACCU-Flow valves (168 c...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：UNLABELLED:The aim of the study was to assess the significance of some perinatal risk factors and neonatal complications in occurrence of nosocomial infections in the population of NICU patients. MATERIAL AND METHODS:Analysis of risk factors was performed in all patients treated in the years 2005-2008 in NICU Departme...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2009-08-01 00:00:00
abstract：:Uterine septum is the major intrauterine disorder associated with infertility and recurrent abortions. The aim of the study was to find out what is the effectiveness of hysteroscopic intrauterine septum resection in terms of reproductive outcome and in comparison with conventional procedure. The mean follow up period ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:We present a case of vaginal vault prolapse after hysterectomy associated with cystocoele with central and lateral defect and stress urinary incontinence, that was treated surgically with employment of sacrospinous colpopexy through anterior approach (from paravesical space), combined with anterior colporrhaphy by dou...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:The efficiency of glycemia control was compared in two groups of insulin dependent diabetic pregnancies treated with insulin, with and without the aid of the Camit-Diacomp system. The efficiency of glycemia control was analysed in all three trimesters of pregnancy. Mean diurnal fluctuations of glycemia levels in both ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:This case report describes a 40-year-old woman, primigravida. On 13,3 weeks of gestation we diagnosed an abnormal flow pattern in the umbilical artery and abnormal hyperechogenic structure in fetal abdomen. In next sonographic examination on 16 weeks of gestation we diagnosed ventriculomegaly and ahydramnion. We also ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：UNLABELLED:The aim of the study was evaluation, whether cord blood insulin (Ic) and erythropoietin (EPO) levels differ in accordance with mode of delivery: cesarean section (CS) or vaginal delivery (VD). MATERIAL AND METHODS:The study was performed in the diabetic group consisted of 148 newborns of diabetic mothers (N...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:Concentrations of Vitamin-C in the urine were determined in 35 women, 25 with normal ovulation and 10 with anovulatory cycles, in an attempt to evaluate the day of ovulation. The concentration was determined daily for 8 days after the oral administration of 500 mg of ascorbic acid. Results were confirmed by comparin...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1977-08-01 00:00:00
abstract：:Ovarian cancer remains to be a real challenge in spite of considerable progress in many areas of modern medicine. The use of genetic testing for detecting mutations of the BRCA genes has been offering clinical scrutiny between mutated versions of the BRCA genes and higher risk of both breast and ovarian cancer A popul...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the outcomes of treatment in patients suffering from recurrent spontaneous abortion and antiphospholipid syndrome. MATERIALS AND METHODS:148 observed women suffering from recurrent abortion with presence of lupus anticoagulant antibodies (LA) and/or high moderate concentration of anticardiolipin ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-10-01 00:00:00
abstract：:Concentrations of iron, zinc and copper were determined in public hair of women with threatened abortion and in full-term pregnancy. The aim of the studies was to find differences between the levels of studied elements in public hair of women with threatened abortion and in full-term pregnancy and to test whether pari...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：UNLABELLED:About 30% of women population in Poland is already in the perimenopausal age. HRT (hormonal replacement therapy) is the best way of diminishing the unfavorable symptoms of this state. AIM OF STUDY:The effect of HRT on ROI production by neutrophils before and after HRT, to determinate it's antioxidative infl...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:The course of actinomycetic infections in two females with IUD is presented. Both patients needed surgery. Literature review taking into a special consideration laboratory diagnosis has been performed. Infection caused by other than Actinomyces israelii species was observed. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：INTRODUCTION:Vascular-cellular adhesion molecule-1 (VCAM-1) overexpression on the cells' surface is stimulated by pro-inflammatory cytokines, bacterial endotoxins, reactive oxygen species and lipid peroxides. In the serum also the soluble form of VCAM-1 (sVCAM-1) is present. The beta 1-integrin family molecule VLA-4 (C...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES:Evaluation of safety and effectiveness of POP (pelvic organ prolapse) treatment with the use of polypropylene mesh depending on type of mesh and application technique. MATERIALS AND METHODS:We carried out a retrospective study and compared the frequency of perioperative complications and treatment results t...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1610
更新日期：2013-07-01 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a common complication of pregnancy In the course of pregnancy elevated levels of hormones and other proteins having insulin-antagonistic effects lead to higher insulin resistance in peripheral tissues, followed by hyperinsulinemia. Risk factors for the development of GDM have bee...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/2429
更新日期：2015-05-01 00:00:00
abstract：:The questionnaire included 220 men from childless married couples who referred to the Department of Reproduction and Andrology of the Medical Academy in Lublin for 4 months in 1992. The treatment period of childlessness in those couples ranged from several months to 17 years. The authors tried to establish if, and to ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:The aim of the following work was to evaluate vaginal and cervical colonization in patients with threatening preterm labor and comparing the frequency of colonization of the term and preterm labor groups. MATERIAL AND METHODS:532 pregnant women with threatening preterm labor were included into the clinical ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2010-11-01 00:00:00
