[Serum concentration of soluble vascular-cellular adhesion molecule-1 (VCAM-1) and expression of its receptor VLA-4 on the surface of peripheral blood and decidual lymphocytes of preeclamptic women].

Abstract:

INTRODUCTION:Vascular-cellular adhesion molecule-1 (VCAM-1) overexpression on the cells' surface is stimulated by pro-inflammatory cytokines, bacterial endotoxins, reactive oxygen species and lipid peroxides. In the serum also the soluble form of VCAM-1 (sVCAM-1) is present. The beta 1-integrin family molecule VLA-4 (CD49d) is natural ligand for VCAM-1. Increased concentrations of sVCAM-1 as well as overexpression of VLA-4 were observed during inflammatory reaction. THE AIM:To study sVCAM-1 serum concentrations and CD49d+ subpopulations of peripheral blood and decidual lymphocytes of the 3rd trimester healthy and preeclamptic women. MATERIALS AND METHODS:The study groups: n = 21 healthy pregnant women, n = 33 preeclamptic women (preeclampsia defined as blood pressure > 140/90 mmHg with proteinuria > 0.3 g/24 h). Clinical states of known pathogenesis which could possibly interfere with values of studied parameters were excluded. Exclusion criteria were also uterine contractions and premature rupture of amniotic membranes. Decidua was collected exclusively during elective caesarean sections. The sVCAM-1 concentration (ng/ml) was estimated using ELISA procedure, while percentage (%) of CD49d+ lymphocytes in the whole blood and homogenized decidual tissue, using flow cytometry. The results were presented as median value with 25% and 75% cut off values. Statistical analysis was performed with U-Mann-Whitney test (p < 0.05). RESULTS:Preeclamptic women presented with increased sVCAM-1 serum concentrations (532.5 (400.0/605.0) ng/ml vs. 387.0 (320.0/416.5) ng/ml, p < 0.0005), increased (%) of CD49d+ peripheral blood (92.0 (88.0/96.0)% vs. 52.9 (47.5/55.8)%, p < 0.0000001) and CD49d+ decidual lymphocytes (88.0 (84.0/90.0)% vs. 80.5 (74.0/85.6)%, p < 0.05). CONCLUSION:Described change suggest that immunological mechanisms similar to inflammatory reaction could be involved in pathogenesis of preeclampsia in peripheral blood as well as locally inside maternal-fetal interface.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Wilczyński JR,Głowacka E,Nowak M,Szpakowski A

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1335-42

issue

10

eissn

0017-0011

issn

2543-6767

journal_volume

74

pub_type

杂志文章
  • [Comparison of fetal ECG recordings using STAN S21 analyser and external ECG of newborns, in relation to enzymatic ischaemic markers and acid-base parameters in umbilical blood].

    abstract:DESIGN:Neonatal hypoxia is often responsible for myocardial ischaemia. To evaluate cardiac involvement in neonates, fetal and neonatal ECG recordings have been performed and parameters indicating heart dysfunction have been analysed. OBJECTIVES:Our interest has been focused on analysis of fetal electrocardiogram recor...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Zikitek M,Celewicz Z,Zytkiewicz B,Ronin-Walknowska E

    更新日期:2004-11-01 00:00:00

  • [Gelatinolitic and proteolytic activity of Wharton's jelly in EPH-gestosis (preeclampsia)].

    abstract::EPH-gestosis is accompanied by an extensive remodeling of the extracellular matrix of Wharton's jelly. The gelatinolytic and proteolytic activities were measured. A decrease in gelatinolityc activity and an increase in proteolytic activity in EPH-gestosis were observed. The decrease in gelatinase activity in EPH-gesto...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Sobolewski K,Galewska Z,Wolańska M,Jaworski S

    更新日期:2002-05-01 00:00:00

  • [The concentration of n-terminal propeptide of type III procollagen in umbilical cord serum--biochemical marker of newborn maturity].

    abstract::The concentration of N-terminal propeptide of type III procollagen (PIIINP) in umbilical cord serum was estimated in preterm and term newborns. The mean concentration of PIIINP was significantly higher in preterm infants, despite their lower body mass. This indicates higher rate of collagen biosynthesis in early gesta...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Rechberger T,Poniedziałek-Czajkowska E

    更新日期:1994-12-01 00:00:00

  • [Selected aspects of proteolytic activity of umbilical cord and its alterations in EPH-gestosis].

    abstract::EPH-gestosis is accompanied by an extensive remodelling of the extracellular matrix of the umbilical cord arteries, vein and Wharton's jelly. For better understanding of processes proceeding in it we decided to determine proteolytic activity in acidic pH range. Presented results suggest that cathepsin D is one of the ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Galewska Z,Wolańska M,Romanowicz L,Jaworski S

    更新日期:2000-08-01 00:00:00

  • [Evaluation of selected parameters of lymphocyte activity in umbilical blood. I. Natural cytotoxicity].

    abstract::Natural cytotoxic activity in the umbilical blood was estimated in 52 healthy newborns. Mononuclear cells were isolated from the umbilical blood using Boym's method. The mean natural cell cytotoxicity in the examined group was 7.05 +/- 0.9 (SD). ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Kamiński P,Majewski S,Radomska M,Skopińska-Rózewska E,Szymański R,Marianowski L

    更新日期:1996-02-01 00:00:00

  • [Discrepancies between clinical and surgical--pathologic staging of cervical carcinoma].

    abstract:OBJECTIVES:Cervical cancer is the only gynecological tumor staged clinically. The aim of this study was comparison of clinical staging to surgical specimen evaluation in cervical cancer patients. DESIGN:Clinical staging of cervical cancer was compared to histopathological outcome in prospective study. MATERIALS AND M...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Obrzut B,Skret A,Marzanna O,Laczyńska-Madera M,Król P

    更新日期:2006-07-01 00:00:00

  • [Blood serum iron concentration in women using contraceptive agent Angravid-Polfa].

    abstract::The blood-serum iron concentrations were examined in women using Anagravid (Polfa) as an oral contraceptive (OC). The examined subjects used the preparation for 6 months and their results were compared with those women not using a progestogen contraceptive. The results underwent statistical analysis. It was demonst...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Mierzwiński R,Małysiak M,Swiatkowski K,Fronczek Z,Chmara J

    更新日期:1981-08-01 00:00:00

  • IL16 and IL18 gene polymorphisms in women with gestational diabetes.

    abstract:OBJECTIVES:Gestational diabetes mellitus is a carbohydrate intolerance that occurs during pregnancy. Various inflammatory mediators are considered to be risk factors leading to GDM development. Among them are pro-inflammatory cytokines, such as IL16 and IL18. The aim of this study was to examine the association between...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.5603/GP.a2017.0047

    authors: Tarnowski M,Wieczorek A,Dziedziejko V,Safranow K,Ustianowski P,Celewicz Z,Pawlik A

    更新日期:2017-01-01 00:00:00

  • [The value of peritoneal cytology in the staging of ovarian cancer].

    abstract::The results of peritoneal cytology obtained during primary surgery for stage I ovarian cancer and "second look" operations was assessed. Positive peritoneal smears were found in 10.7% of patients, while neoplastic cells were present in peritoneal fluid in 32.5% of cases. Of 144 patients undergoing "second look" surger...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Emerich J,Konefka T,Dudziak M,Sobol A

    更新日期:1997-02-01 00:00:00

  • Impact of pelvic magnetic resonance imaging findings in the indication of uterine artery embolization in the treatment of myoma.

    abstract:OBJECTIVES:To assess the impact of pelvic magnetic resonance imaging (MRI) findings in the indication for uterine-artery embolization in women with fibroids, as well as the correlation between MRI and ultrasound (US) examinations for diagnosing adenomyosis. MATERIAL AND METHODS:A retrospective observational study was ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.5603/GP.a2017.0024

    authors: Brito Pires NM,Godoi ET,Oliveira DC,Brandão SC,Abath CC,Pires P,Araujo Júnior E

    更新日期:2017-01-01 00:00:00

  • Transvaginal salpingo-oophorectomy with gasless laparoscopy - an optional pure natural orifice transluminal endoscopic surgery.

    abstract:OBJECTIVES:To establish the appropriate technique for salpingo-oophorectomy via transvaginal natural orifice transluminal endoscopic surgery (NOTES), under gasless laparoscopy. MATERIAL AND METHODS:Ten patients with clinical indication underwent gasless laparoscopic transvaginal salpingo-oophorectomy with concurrent v...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.5603/GP.2020.0001

    authors: Liu T,Chen Y,Wang X

    更新日期:2020-01-01 00:00:00

  • [Laparoscopic resection of rectovaginal endometriosis: a case report].

    abstract::Two patients aged 35 i 40 years after extensive clinical evaluation were operated by means of combined approach--laparoscopy and vaginal resection of endometriotic tumors. First laparoscopy was performed in order to dissect rectovaginal septum and separate rectum from the vagina in order to facilitate complete vaginal...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Rechberger T,Tomaszewski J,Jakowicki J

    更新日期:2000-09-01 00:00:00

  • [The management of subarachnoid hemorrhage in pregnancy].

    abstract::Subarachnoid haemorrhage (SAH) from an intracranial aneurysm or arteriovenous malformation is a grave complication of pregnancy. Authors critically analyzed 12 cases of verified SAH during pregnancy from an 11 identified and 1 unidentified cerebral vascular malformation. Aneurysms were responsible for SAH in 7, and ar...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Zukiel R,Jankowski R,Tokarz F

    更新日期:1992-04-01 00:00:00

  • [Treatment of cervical pregnancy with systemic methotrexate and KCI solution injection into the gestational sac--case report and review of literature].

    abstract::We report a case of a 6-week cervical pregnancy successfully treated with systemic methotrexate and gestational sac biopsy with 15%-calcium chloride solution injection. Serial monitoring of human chorionic gonadotropin levels, combined with ultrasound examinations, confirmed spontaneous miscarriage. Applied treatment ...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Polak G,Stachowicz N,Morawska D,Kotarski J

    更新日期:2011-05-01 00:00:00

  • [Colposcopy images of cervix in women with Gardnerella vaginalis infection].

    abstract::Among micro-organisms infecting vagina whose dominant genus is GV anaerobic bacteria are often present. There are reports that GV infections of vagina and uterine cervix, apart from their well-known negative role in obstetrics practice can play a role in carcinogenic processes of uterine cervix. The aim of the study w...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Rokita W,Malarewicz A

    更新日期:1997-10-01 00:00:00

  • [Collagen degradation products in amniotic fluid].

    abstract::It was found that amniotic fluid (38-42 Hbd) contains hydroxyproline in concentration about 10 micrograms/ml. Gel filtration and dialysis demonstrated that most of hydroxyproline exists in a form of low molecular weight products. Furthermore, it was found that amniotic fluid contains a protein which eluates during gel...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Gogiel T,Bielecki DA

    更新日期:1996-09-01 00:00:00

  • [Stage IIb invasive carcinoma of the cervix during pregnancy--personal experience and contemporary opinions on this topic].

    abstract::Five cases of the cervical cancer in stage II b coexisting with pregnancy were presented. All patients were treated by radical radiotherapy consisting of external beam irradiation and brachytherapy. The spontaneous abortion or premature labor occurred during radiation after the dose 30.6-32 Gy of irradiation was deliv...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Bidziński M,Zieliński J,Panek G

    更新日期:2002-01-01 00:00:00

  • [Gene therapy applications in gynecologic malignances management].

    abstract::Gene therapy is an innovative way of treating genetic disorders, which enables removal or repair of genetic defects. Strategies of gene therapy offer new perspectives in treating cancer diseases. Numerous methods for specifically removing tumor cells are currently used. They can be divided into five main strategies: c...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Gromadzka A,Kubiczak M,Jankowska A

    更新日期:2010-01-01 00:00:00

  • Evaluation of asthma course in pregnancy.

    abstract::The prevalence of asthma has been rising in recent decades. It is the most common disease among pregnant women andaffects ca. 12% of this population. The course of asthma in pregnancy may change. In 1/3 of patients, it worsens; in 1/3 ofpatients, the symptoms are milder; in 1/3 of patients, it remains unchanged. Well-...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:10.5603/GP.2019.0080

    authors: Rey A,Jassem E,Chelminska M

    更新日期:2019-01-01 00:00:00

  • Long-term outcomes of radical and conservative surgery for late diagnosed tubal pregnancies.

    abstract:OBJECTIVE:To investigate long-term postoperative outcomes of conservative and radical surgery in ectopic tubal pregnancies, and evaluate the results of these techniques. METHODS:A total of 145 patients that operated for tubal pregnancy between January 2006 and January 2009 were reviewed. Data on patient age, reproduct...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Ozler A,Turgut A,Evsen MS,Sak ME,Soydinç HE,Başaranoğlu S,Celik Y,Taner MZ

    更新日期:2012-04-01 00:00:00

  • [Flow cytometry application in the evaluation of antisperm antibodies in sera samples of infertile people and prepubertal boys with gonadal disorders].

    abstract:OBJECTIVES:The aim of the following study was to assess antisperm antibodies in sera samples of infertile men and women, as well as from prepubertal boys by means of flow cytometry. MATERIAL AND METHODS:We tested sera samples of infertile and fertile adult populations, prepubertal boys with gonadal disorders and healt...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Kamieniczna M,Havryluk A,Nakonechnyj A,Boyko J,Chopyak V,Kurpisz M

    更新日期:2010-08-01 00:00:00

  • Malignant melanoma of the vulva: 2 case reports.

    abstract::It was described two cases of vulvar melanoma malignum. Both women after primary radical treatment, unfortunately died. It was discussed the classification of melanoma malignum, the efficiency of treatment nowadays and the problems in diagnosis. General results of treatment are poor. It is due to tendency for spreadin...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Michalska M,Sajdak S,Obrebowska A,Spaczyński M

    更新日期:1998-05-01 00:00:00

  • [Usefulness of selected circulating biochemical markers in diagnosis and monitoring of endometriosis].

    abstract::A review of the literature for searching of biochemical marker of endometriosis is presented. The investigations with CA 125, antiendometrial antibodies, placental protein 14 and others have not established a sensitive screening test for predicting endometriosis, especially in early stages of the disease. Most authors...

    journal_title:Ginekologia polska

    pub_type: 杂志文章,评审

    doi:

    authors: Wieczorek J,Matuszewski W,Kokocińska D

    更新日期:1999-03-01 00:00:00

  • Iatrogenic and spontaneous late preterm twins--which are at higher risk of neonatal complications?

    abstract:OBJECTIVES:To evaluate data regarding neonatal mortality and short term morbidity among iatrogenic late preterm (ILP) and spontaneous late preterm (SLP) twin births, and to estimate whether medical interventions - induction of labor in this particular context, are associated with better or poorer outcomes. MATERIAL AN...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.17772/gp/1600

    authors: Kosińska-Kaczyńska K,Szymusik I,Kaczyński B,Bomba-Opoń D,Wegrzyn P,Dźwigała B,Wielgoś M

    更新日期:2013-06-01 00:00:00

  • Evolution in the approach to overlooked ureteral injuries after gynecological surgery.

    abstract:OBJECTIVES:To analyzed the therapeutic results for patients with overlooked iatrogenic ureteral injuries after gynecological surgery, treated at the department since 1990. Before the era of endourology, ureteral injuries were operated on immediately after making a diagnosis. This approach was changed after the populari...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.5603/GP.2016.0069

    authors: Borkowski T,Judycki J,Borkowski A,Czaplicki M,Radziszewski P

    更新日期:2016-01-01 00:00:00

  • [The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. I. Effect of cofactors on the synthesis of steroid hormones in the interstitial gland of rats].

    abstract::The authors evaluated the influence of NAD, NADP, G-6-P and G-6-PDH on the synthesis of steroid hormones in the interstitial gland of the rat. The animals were killed by decapitation, and sections of the nucleus weighing altogether 20 mg were incubated with NAD (0.4 mM), NADP (0.4 mM), G-6-P (3.5 mM) and G-6-PDH (2 j....

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Grochowski D,Szamatowicz M

    更新日期:1989-05-01 00:00:00

  • [Management in premature rupture of the membranes (PROM) at term--own experiences].

    abstract:UNLABELLED:In our study the management and outcomes in 211 women with premature rupture of the membranes at term was analyzed. According to the time elapsed since PROM to delivery the study group was divided into four groups: within 6 h, within 6-12 h, within 12-24 h and over 24 h after PROM. The analysis was focused o...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Semczuk-Sikora A,Sawulicka-Oleszczuk H,Semczuk M

    更新日期:2001-10-01 00:00:00

  • [Nucleated red blood cells as an early marker of intraventricular haemorrhage in newborn infants].

    abstract:INTRODUCTION:The aim of the paper was to evaluate the usability of nucleated blood cells count in newborn infants in the first 12 hours after their birth as an early marker of intraventricular haemorrhage. MATERIAL AND METHODS:The retrospective research included 210 newborns (both born at term??? and prematurely), del...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Krajewski P,Kalinka J,Welfel E,Kwiatkowska M,Pokrzywnicka M

    更新日期:2007-12-01 00:00:00

  • Ultrasonography for the prediction of extension of trophoblastic infiltration into the tubal wall in ampullary pregnancy.

    abstract:OBJECTIVE:Predictive factors of damage to the Fallopian tube may guide the treatment for patients with tubal pregnancy. The purpose of this study was to evaluate the predictive value of ultrasonographic findings in patients affected by ampullary pregnancy for the determination of the depth of trophoblastic infiltration...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:10.17772/gp/1893

    authors: Erol O,Süren D,Karaca M,Sezer C

    更新日期:2015-01-01 00:00:00

  • [Diagnostic significance of index alpha-amylase/glucose in amniotic fluid in prediction of fetal maturity].

    abstract::An increase in alpha-amylase activity with parallel decrease in glucose concentration in amniotic fluid is observed during pregnancy. This interdependence is a theoretical basis for using an alpha-amylase/glucose index in fetal maturity evaluation. The aim of the study was to investigate usefulness of the alpha-amylas...

    journal_title:Ginekologia polska

    pub_type: 杂志文章

    doi:

    authors: Krasomski G,Sałacińska B,Broniarczyk D,Swiatkowska E

    更新日期:2001-09-01 00:00:00