Abstract：
BACKGROUND:Dickkopf-3 (DKK3) may act as a tumor suppressor as it is down-regulated in various types of cancer. This study assessed the DKK3 protein expression in gastric cancer and its potential value as a prognostic marker. METHODS:DKK3 expression was evaluated by immunohistochemistry in 158 gastric cancer samples from patients who underwent gastrectomy from 2002 to 2008. Clinicopathological parameters and survival data were analyzed. RESULTS:Loss of DKK3 expression was found in 64 of 158 (40.5%) samples, and it was associated with advanced T stage (p < 0.001), lymph node metastasis (p < 0.001), UICC TNM stage (p < 0.001), tumor location (p = 0.029), lymphovascular invasion (p = 0.035), and perineural invasion (p = 0.032). Patients without DKK3 expression in tumor cells had a significantly worse disease-free and overall survival than those with DKK3 expression (p < 0.001, and p = 0.001, respectively). TNM stage (p = 0.028 and p < 0.001, respectively) and residual tumor (p < 0.001 and p = 0.003, respectively) were independent predictors of disease-free and overall survival. Based on the preoperative clinical stage assessed by computed tomography (CT), loss of DKK3 expression was predominantly associated with worse prognosis in patients with clinically node-negative advanced gastric cancer (AGC). The combination of DKK3 expression status and CT increased the accuracy of CT staging for predicting lymph node involvement from 71.5 to 80.0% in AGC patients. CONCLUSION:Loss of DKK3 protein expression was significantly associated with poor survival in patients with gastric cancer and was strongly correlated with the TNM stage. DKK3 might be a potential biomarker of lymph node involvement that can improve the predictive power of CT.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Park JM,Kim MK,Chi KC,Kim JH,Lee SH,Lee EJdoi
10.1007/s00268-014-2886-3subject
Has Abstractpub_date
2015-04-01 00:00:00pages
1018-25issue
4eissn
0364-2313issn
1432-2323journal_volume
39pub_type
杂志文章abstract：:Intraperitoneal forgotten foreign bodies are prone to create adhesions and to encapsulate, or to provoke an exudative response, with or without accompanying bacterial infection. Often a process of self-extrusion is initiated. This is also true for gossypibomas, retained surgical sponges. Presentation is possible as a ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689910084
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Our aim was to evaluate the advantages and limitations of delayed laparoscopic cholecystectomy (LC) in a tertiary center. MATERIALS AND METHODS:A retrospective analysis of all patients admitted to our institution with acute calculous cholecystitis (ACC) between January 2003 and December of 2012 was performe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3928-4
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Parathyroid cancer is rare. Differentiating parathyroid carcinoma from degenerative changes at histopathology can be difficult and studies investigating the value of single immunohistochemical markers have had variable results. In this study we aimed to investigate whether a panel of immunohistochemistry mar...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2700-2
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Flow disruptions (FDs) are deviations from the progression of care that compromise safety or efficiency. The frequency and specific causes of FDs remain poorly documented in trauma care. We undertook this study to identify and quantify the rate of FDs during various phases of trauma care. METHODS:Seven trai...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2306-0
更新日期：2014-02-01 00:00:00
abstract：:Little evidence is available regarding long-term survival of patients with gallbladder cancer that is discovered at the time of laparoscopic cholecystectomy (LC). Therefore the present study was performed to evaluate long-term outcomes of this disease. Of 1546 patients who underwent LC for benign gallbladder disease b...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7886-x
更新日期：2005-09-01 00:00:00
abstract：:A minority of patients with papillary thyroid carcinoma (PTC) is at high-risk of developing recurrent disease and death. Risk group stratification as defined by age, metastases to distant site, extrathyroidal invasion, and tumor size (AMES) criteria is frequently employed to identify high-risk patients for aggressive ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7420-6
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Tumors producing adrenocorticotropic hormone (ACTH) or corticotropin releasing hormone (CRH) often remain undiagnosed until severe Cushing's syndrome appears, and it may be difficult to distinguish from Cushing's syndrome due to pituitary tumors. Many patients suffer from disease spread, with metastases in t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0347-8
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Percutaneous needle biopsy (PNB) is the standard of care for diagnosis of breast lesions. Rates of excisional biopsy for breast diagnosis in North America have been reported at approximately 35 %, although significant regional variation exists. A target rate of PNB for diagnosis of breast abnormalities is ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3293-0
更新日期：2016-07-01 00:00:00
abstract：INTRODUCTION:Mechanical bowel obstruction cases constitute an important place in emergency health care services. In this study, bowel obstructions caused by intra-abdominal tumors were compared with those without tumoral causes. PATIENTS AND METHODS:A total of 155 cases of mechanical bowel obstruction diagnosed were r...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0440-z
更新日期：2006-07-01 00:00:00
abstract：:The goal of fluid resuscitation in the burn patient is maintenance of vital organ function at the least immediate or delayed physiological cost. To optimize fluid resuscitation in severely burned patients, the amount of fluid should be just enough to maintain vital organ function without producing iatrogenic pathologi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02067109
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Thymic carcinoma is reputed to carry a poor prognosis. Although few scholars have studied the prognosis of thymic carcinoma, the prognostic factors of patients after surgery are not well established. We analyze the prognostic significance of undetermined factors to predict the survival of patients after surg...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2492-4
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:In the last decade, robotic video-assisted thoracic surgery (R-VATS) has grown significantly and consolidated as an alternative to video-assisted thoracic surgery. The objective of this study is to present the implementation as well as the experience with R-VATS accumulated by 2 Brazilian groups. We also com...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05086-9
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Splenic trauma is a common organ injury following blunt abdominal trauma. In order to establish the contemporary epidemiology of blunt splenic trauma in Scotland and to detect risk factors associated with patient outcomes, analysis of a multi-center database of trauma patients was performed. METHODS:The stu...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9218-9
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Neurosurgical capacity is extremely deficient in East African countries where 27 neurosurgeons serve more than 250 million people. To build capacity, the Duke University Medical Center and New Mulago Hospital in Uganda applied a two-pronged twinning approach that placed usable surplus equipment in a developi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1080-0
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:The psychiatric population has been reported to be accompanied with a higher morbidity and mortality in several situations. However, little is known about the effect of co-morbid psychiatric disorders on surgical risk during major digestive surgery for malignancies. Our purpose in the present study, therefor...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9267-0
更新日期：2007-12-01 00:00:00
abstract：:The present article summarizes scientific observations of the endocrine pancreas anatomy and physiology into a unifying hypothesis. The data were generated over the years by surgical fellows using human and rat isolated perfused pancreas models and in vivo islet microcirculation models. The endocrine pancreas secretes...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680020339
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:Postoperative ileus is a common problem with significant clinical and economic consequences. We hypothesized that Gastrografin may have therapeutic utility by accelerating the recovery of postoperative ileus after colorectal surgery. The aim of this trial was to study the impact of oral Gastrografin administ...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-015-3260-9
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Incidental gallbladder cancer (GBC) is frequently discovered on the specimen when cholecystectomy for a benign disease is performed. The objective of the present study was to assess the management of incidental GBC patients in a French registry. METHODS:Data on patients with GBC treated between 1998 and 200...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1134-3
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:Rectus sheath hematoma is rare. It can present to physicians in many specialties, but invariably the surgeon is contacted regarding management. It is frequently difficult to diagnose, which can result in delay of treatment or unnecessary surgery. Its incidence is on the rise. METHODS:We present a series o...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-0702-9
更新日期：2006-11-01 00:00:00
abstract：:The major goal of wound healing biology is to determine how a wound can be induced to repair damaged tissue faster and more efficiently. Enhancement of dermal and epidermal regeneration is an extremely important goal for the treatment of many different types of wounds. Exogenous application of growth factors to the wo...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-004-2062-2
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate and investigate the complications of carotid endarterectomy (CEA) and carotid artery stenting (CAS) by performing a meta-analysis based on prospective randomized controlled trials (RCTs). METHODS:We performed a search of multiple electronic databases for RCTs containing...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-008-9862-8
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus (DM) is a known risk factor for worse outcomes after emergency abdominal surgery (EAS). However, it is unclear if the type of diabetes treatment (insulin or oral agents) has any effect on outcomes after EAS. METHODS:Matched cohort study utilizing the ACS NSQIP database. Patients with DM un...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3469-2
更新日期：2016-07-01 00:00:00
abstract：:Surgical oncology is one of the most frequently studied surgical specialties with regard to disparities in quality of care. There is variation in the care received according to nonclinical factors such as age, race and ethnicity, education, income, and even geographic region. Differences exist with regard to who gets ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9383-x
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Currently, there are no objective reports evaluating the quality of the South African surgical training. The aim of this study is to evaluate the current state of surgical training in South Africa from an external impartial point of view and to rate the experience of short-term supernumerary registrars and f...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05034-7
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:The commonest surgical treatment used for peptic ulcer perforation is omental patching. If, however, the perforation leaks, it rarely heals by itself due to persistence of duodenal fistula (DF). We present our experience with a T-tube placed into the DF for better outcome of the patients. METHODS:All patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2196-1
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Nodal involvement of papillary thyroid carcinoma (PTC) commonly occurs in the paratracheal region and the internal jugular chain. Lymph node metastasis in the parapharyngeal space (PPS) is rare. In this report, we describe our experience and surgical outcomes of patients with PPS metastasis of PTC. METHODS:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3321-0
更新日期：2016-02-01 00:00:00
abstract：:Fourteen patients with liver tumor malignancy and sixteen patients with malignant melanoma localized to one limb were studied regarding leukocyte activation with the release of polymorphonuclear neutrophilic (PMN) elastase and of neopterin and formation of cytokines (TNF-alpha and IL-6) during the surgical treatment. ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00299787
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND:Hepatic resection for hepatocellular carcinoma (HCC) patients with liver cirrhosis and severe hypersplenic thrombocytopenia is risky and controversial. METHODS:From 1989 to 2005, 341 patients underwent hepatic resection for HCC in our hospital. Of these, 15 patients were concomitant with severe thrombocytop...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9442-3
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Total mesorectal excision (TME) and preoperative chemoradiation therapy (PCRT) for rectal cancer are used sequentially in our center. The aim of this study was to evaluate survival of patients with stage II/III rectal cancer chronologically and to determine whether therapeutic advances associated with TME an...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2168-5
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Stapled anopexia was introduced as a surgical method in 1993. Long-term data with special interest in functional results and relapse symptoms are rarely presented. Urinary discomfort and problems with fecal urge incontinence are addressed as severe side effects. We present our long-term results (using data f...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9818-z
更新日期：2009-02-01 00:00:00
